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v3.19.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Millions | 3 Months Ended
--- | ---
Mar. 31, 2019 | Mar. 31, 2018
Cash flows from operating activities: |  |
Net income | $ 1,408.8 | $ 1,171.2
Adjustments to reconcile net income to net cash flows from operating activities: |  |
Depreciation, amortization and impairments | 121.1 | 168.9
Acquired in-process research and development | 0.0 | 10.0
Share-based compensation | 45.7 | 43.4
Contingent consideration | (11.5) | 5.6
Loss on assets and liabilities held for sale | 115.5 | 0.0
Deferred income taxes | 228.0 | 53.1
Unrealized (gain) loss on strategic investments | (375.0) | 0.0
Other | 50.7 | 31.7
Changes in operating assets and liabilities, net: |  |
Accounts receivable | (136.6) | (134.0)
Inventory | (129.0) | (2.6)
Accrued expenses and other current liabilities | 138.4 | 121.8
Income tax assets and liabilities | 170.3 | 257.6
Other changes in operating assets and liabilities, net | (171.1) | (20.0)
Net cash flows provided by operating activities | 1,459.5 | 1,457.1
Cash flows from investing activities: |  |
Proceeds from sales and maturities of marketable securities | 1,489.2 | 4,068.9
Purchases of marketable securities | (825.0) | (1,919.2)
Contingent consideration paid related to Fumapharm AG acquisition | (300.0) | (600.0)
Purchases of property, plant and equipment | (127.1) | (194.7)
Acquired in-process research and development | 0.0 | (10.0)
Other | (1.7) | (1.6)
Net cash flows provided by investing activities | 238.8 | 1,346.6
Cash flows from financing activities: |  |
Purchases of treasury stock | (655.8) | (250.0)
Payments related to issuance of stock for share-based compensation arrangements, net | (32.2) | (21.2)
Other | 8.7 | 2.6
Net cash flows used in financing activities | (679.3) | (268.6)
Net increase (decrease) in cash and cash equivalents | 1,019.0 | 2,535.1
Effect of exchange rate changes on cash and cash equivalents | 0.4 | 0.9
Cash and cash equivalents, beginning of the period | 1,224.6 | 1,573.8
Cash and cash equivalents, end of the period | $ 2,243.2 | $ 4,108.0

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