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Intangible Assets and Goodwill (Tables) | 3 Months Ended
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Mar. 31, 2019
Goodwill and Intangible Assets Disclosure [Abstract] |
Intangible assets | Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:
|  |  | As of March 31, 2019 |  | As of December 31, 2018
(In millions) | Estimated Life |  | Cost |  | Accumulated Amortization |  | Net |  | Cost |  | Accumulated Amortization |  | Net
Out-licensed patents | 13-23 years |  | $ | 543.3 |  |  | $ | (542.4 | ) |  | $ | 0.9 |  |  | $ | 543.3 |  |  | $ | (542.3 | ) |  | $ | 1.0 |
Developed technology | 15-23 years |  | 3,005.3 |  |  | (2,744.1 | ) |  | 261.2 |  |  | 3,005.3 |  |  | (2,734.8 | ) |  | 270.5 |
In-process research and development | Indefinite until commercialization |  | 480.5 |  |  | — |  |  | 480.5 |  |  | 476.0 |  |  | — |  |  | 476.0 |
Trademarks and tradenames | Indefinite |  | 64.0 |  |  | — |  |  | 64.0 |  |  | 64.0 |  |  | — |  |  | 64.0 |
Acquired and in-licensed rights and patents | 4-18 years |  | 3,638.7 |  |  | (1,389.1 | ) |  | 2,249.6 |  |  | 3,638.7 |  |  | (1,330.2 | ) |  | 2,308.5 |
Total intangible assets |  |  | $ | 7,731.8 |  |  | $ | (4,675.6 | ) |  | $ | 3,056.2 |  |  | $ | 7,727.3 |  |  | $ | (4,607.3 | ) |  | $ | 3,120.0 |
Estimated future amortization for acquired intangible assets | Based upon this most recent analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:
(In millions) | As of March 31, 2019
2019 (remaining nine months) | $ | 200.0 |
2020 | 290.0 |
2021 | 250.0 |
2022 | 250.0 |
2023 | 230.0 |
2024 | 190.0 |
Summary of roll forward of the changes in goodwill | The following table provides a roll forward of the changes in our goodwill balance:
(In millions) | As of March 31, 2019
Goodwill, beginning of period | $ | 5,706.4 |
Reclassification of goodwill to assets held for sale | (69.5 | )
Other | 2.8 |
Goodwill, end of period | $ | 5,639.7 |

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