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Other Consolidated Financial Statement Detail (Details) - USD ($)
$ in Millions
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Other Income (Expense), Net      
Interest income $ 31.2 $ 26.7  
Interest expense (47.9) (50.5)  
Gain (loss) on investments, net 376.4 (14.4)  
Foreign exchange gains (losses), net (2.2) (1.0)  
Other, net (0.2) (1.8)  
Total other income (expense), net 357.3 $ (41.0)  
Accrued Expenses and Other      
Revenue-related reserves for discounts and allowances 1,083.4   $ 1,051.3
Collaboration expenses 216.6   261.6
Royalties and licensing fees 195.0   224.7
Employee compensation and benefits 160.8   320.9
Current portion of contingent consideration obligations 147.3   444.8
Construction in progress 99.7   125.2
Other 708.0   609.3
Total accrued expenses and other 2,435.0   2,861.2
Component of accrued expenses and other      
Accrued Expenses and Other      
Revenue-related reserves for discounts and allowances $ 907.6   $ 874.7