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v3.19.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Millions | 6 Months Ended
--- | ---
Jun. 30, 2019 | Jun. 30, 2018
Cash flows from operating activities: |  |
Net income | $ 2,902.9 | $ 2,086.2
Adjustments to reconcile net income to net cash flows from operating activities: |  |
Depreciation, amortization and impairments | 238.1 | 340.4
Acquired in-process research and development | 0.0 | 85.0
Share-based compensation | 98.0 | 81.7
Contingent consideration | 8.5 | 3.7
Loss on assets and liabilities held for sale | 113.2 | 0.0
Deferred income taxes | 71.6 | (57.4)
Unrealized (gain) loss on strategic investments | 199.2 | (1.0)
Other | 91.1 | 45.1
Changes in operating assets and liabilities, net: |  |
Accounts receivable | (2.9) | (187.2)
Inventory | (108.7) | 40.1
Accrued expenses and other current liabilities | 216.1 | (13.3)
Income tax assets and liabilities | 306.9 | 183.4
Other changes in operating assets and liabilities, net | (80.3) | 8.7
Net cash flows provided by operating activities | 3,423.5 | 2,556.4
Cash flows from investing activities: |  |
Proceeds from sales and maturities of marketable securities | 3,255.8 | 6,802.7
Purchases of marketable securities | (2,075.1) | (4,774.3)
Contingent consideration paid related to Fumapharm AG acquisition | (300.0) | (900.0)
Acquisition of Nightstar Therapeutics plc, net of cash acquired | (744.4) | 0.0
Purchases of property, plant and equipment | (314.0) | (381.5)
Acquired in-process research and development | 0.0 | (85.0)
Acquisitions of intangible assets | 0.0 | (3.0)
Purchase of Ionis Pharmaceuticals, Inc. stock | 0.0 | (462.9)
Proceeds from sales of strategic investments | 309.7 | 0.0
Other | 4.0 | (2.1)
Net cash flows provided by investing activities | 128.0 | 198.1
Cash flows from financing activities: |  |
Purchases of treasury stock | (3,057.3) | (3,000.0)
Payments related to issuance of stock for share-based compensation arrangements, net | (23.6) | (14.3)
Net distribution to noncontrolling interest | 4.3 | (38.9)
Other | 21.6 | (6.9)
Net cash flows used in financing activities | (3,055.0) | (3,060.1)
Net increase (decrease) in cash and cash equivalents | 496.5 | (305.6)
Effect of exchange rate changes on cash and cash equivalents | (2.3) | 18.0
Cash and cash equivalents, beginning of the period | 1,224.6 | 1,573.8
Cash and cash equivalents, end of the period | $ 1,723.4 | $ 1,250.2

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