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Intangible Assets and Goodwill (Tables) | 6 Months Ended
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Jun. 30, 2019
Goodwill and Intangible Assets Disclosure [Abstract] |
Intangible assets | Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:
|  |  | As of June 30, 2019 |  | As of December 31, 2018
(In millions) | Estimated Life |  | Cost |  | Accumulated Amortization |  | Net |  | Cost |  | Accumulated Amortization |  | Net
Out-licensed patents | 13-23 years |  | $ | 543.3 |  |  | $ | (542.4 | ) |  | $ | 0.9 |  |  | $ | 543.3 |  |  | $ | (542.3 | ) |  | $ | 1.0 |
Developed technology | 15-23 years |  | 3,005.3 |  |  | (2,754.1 | ) |  | 251.2 |  |  | 3,005.3 |  |  | (2,734.8 | ) |  | 270.5 |
In-process research and development | Indefinite until commercialization |  | 1,175.6 |  |  | — |  |  | 1,175.6 |  |  | 476.0 |  |  | — |  |  | 476.0 |
Trademarks and tradenames | Indefinite |  | 64.0 |  |  | — |  |  | 64.0 |  |  | 64.0 |  |  | — |  |  | 64.0 |
Acquired and in-licensed rights and patents | 4-18 years |  | 3,638.7 |  |  | (1,449.1 | ) |  | 2,189.6 |  |  | 3,638.7 |  |  | (1,330.2 | ) |  | 2,308.5 |
Total intangible assets |  |  | $ | 8,426.9 |  |  | $ | (4,745.6 | ) |  | $ | 3,681.3 |  |  | $ | 7,727.3 |  |  | $ | (4,607.3 | ) |  | $ | 3,120.0 |
Estimated future amortization for acquired intangible assets | Based upon this most recent analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:
(In millions) | As of June 30, 2019
2019 (remaining six months) | $ | 130.0 |
2020 | 255.0 |
2021 | 215.0 |
2022 | 215.0 |
2023 | 220.0 |
2024 | 210.0 |
Summary of roll forward of the changes in goodwill | The following table provides a roll forward of the changes in our goodwill balance:
(In millions) | As of June 30, 2019
Goodwill, beginning of period | $ | 5,706.4 |
Increase to goodwill | 112.6 |
Reclassification of goodwill to assets held for sale | (69.5 | )
Other | (0.3 | )
Goodwill, end of period | $ | 5,749.2 |

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- Definition Tabular disclosure of goodwill by reportable segment and in total which includes a rollforward schedule. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=108376223&loc=d3e13816-109267 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 20 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=108376223&loc=d3e13854-109267 + Details
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