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Intangible Assets and Goodwill (Tables) | 9 Months Ended
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Sep. 30, 2019
Goodwill and Intangible Assets Disclosure [Abstract] |
Intangible assets | Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:
|  |  | As of September 30, 2019 |  | As of December 31, 2018
(In millions) | Estimated Life |  | Cost |  | Accumulated Amortization |  | Net |  | Cost |  | Accumulated Amortization |  | Net
Out-licensed patents | 13-23 years |  | $ | 543.3 |  |  | $ | (542.5 | ) |  | $ | 0.8 |  |  | $ | 543.3 |  |  | $ | (542.3 | ) |  | $ | 1.0 |
Developed technology | 15-28 years |  | 3,005.3 |  |  | (2,764.6 | ) |  | 240.7 |  |  | 3,005.3 |  |  | (2,734.8 | ) |  | 270.5 |
In-process research and development | Indefinite until commercialization |  | 954.8 |  |  | — |  |  | 954.8 |  |  | 476.0 |  |  | — |  |  | 476.0 |
Trademarks and tradenames | Indefinite |  | 64.0 |  |  | — |  |  | 64.0 |  |  | 64.0 |  |  | — |  |  | 64.0 |
Acquired and in-licensed rights and patents | 4-18 years |  | 3,638.7 |  |  | (1,506.6 | ) |  | 2,132.1 |  |  | 3,638.7 |  |  | (1,330.2 | ) |  | 2,308.5 |
Total intangible assets |  |  | $ | 8,206.1 |  |  | $ | (4,813.7 | ) |  | $ | 3,392.4 |  |  | $ | 7,727.3 |  |  | $ | (4,607.3 | ) |  | $ | 3,120.0 |
Estimated future amortization for acquired intangible assets | Based upon this most recent analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:
(In millions) | As of September 30, 2019
2019 (remaining three months) | $ | 65.0 |
2020 | 255.0 |
2021 | 215.0 |
2022 | 215.0 |
2023 | 220.0 |
2024 | 210.0 |
Summary of roll forward of the changes in goodwill | The following table provides a roll forward of the changes in our goodwill balance:
(In millions) | As of September 30, 2019
Goodwill, beginning of period | $ | 5,706.4 |
Increase in goodwill | 112.6 |
Elimination of goodwill allocated to Hillerød, Denmark manufacturing operations | (69.5 | )
Other | (3.4 | )
Goodwill, end of period | $ | 5,746.1 |

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