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v3.19.3

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Millions | 9 Months Ended
--- | ---
Sep. 30, 2019 | Sep. 30, 2018
Cash flows from operating activities: |  |
Net income | $ 4,448.8 | $ 3,529.1
Adjustments to reconcile net income to net cash flows from operating activities: |  |
Depreciation, amortization and impairments | 567.6 | 686.9
Acquired in-process research and development | 0.0 | 112.5
Share-based compensation | 143.9 | 119.0
Contingent consideration | 66.3 | 91.6
Loss on divestiture of Hillerød, Denmark manufacturing operations | 95.5 | 0.0
Deferred income taxes | 28.4 | (44.8)
Unrealized (gain) loss on strategic investments | 189.8 | 136.9
Loss on equity method investment | 63.5 | 0.0
Other | 87.4 | 68.7
Changes in operating assets and liabilities, net: |  |
Accounts receivable | (2.4) | (254.0)
Inventory | (47.3) | 31.9
Accrued expenses and other current liabilities | 109.1 | (100.7)
Income tax assets and liabilities | 64.6 | 315.6
Other changes in operating assets and liabilities, net | (61.0) | (81.0)
Net cash flows provided by operating activities | 5,118.4 | 4,292.3
Cash flows from investing activities: |  |
Proceeds from sales and maturities of marketable securities | 3,867.6 | 7,994.7
Purchases of marketable securities | (4,052.1) | (6,093.8)
Contingent consideration paid related to Fumapharm AG acquisition | (300.0) | (1,200.0)
Acquisition of Nightstar Therapeutics plc, net of cash acquired | (744.4) | 0.0
Proceeds from Sale of Property, Plant, and Equipment | 923.7 | 0.0
Purchases of property, plant and equipment | (404.1) | (544.7)
Acquired in-process research and development | 0.0 | (112.5)
Acquisitions of intangible assets | 0.0 | (3.0)
Purchase of Ionis Pharmaceuticals, Inc. stock | 0.0 | (462.9)
Proceeds from sales of strategic investments | 476.0 | 0.0
Other | 4.6 | (1.2)
Net cash flows used in investing activities | (237.9) | (421.0)
Cash flows from financing activities: |  |
Purchases of treasury stock | (3,775.2) | (3,000.0)
Payments related to issuance of stock for share-based compensation arrangements, net | (16.9) | (6.7)
Repayments of Long-term Debt | 0.0 | (3.2)
Net distribution to noncontrolling interest | 4.3 | (36.9)
Other | 43.8 | 11.8
Net cash flows used in financing activities | (3,744.0) | (3,035.0)
Net increase (decrease) in cash and cash equivalents | 1,136.5 | 836.3
Effect of exchange rate changes on cash and cash equivalents | 17.2 | 23.4
Cash and cash equivalents, beginning of the period | 1,224.6 | 1,573.8
Cash and cash equivalents, end of the period | $ 2,343.9 | $ 2,386.7

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