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Consolidated Statements of Cash Flows - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Cash flows from operating activities: |  |  |
Net income | $ 5,888.5 | $ 4,474.0 | $ 2,670.1
Adjustments to reconcile net income to net cash flows from operating activities: |  |  |
Depreciation, amortization and impairments | 680.6 | 1,016.6 | 1,081.0
Acquired in-process research and development | 0.0 | 112.5 | 120.0
Share-based compensation | 182.3 | 157.5 | 128.0
Deferred income taxes | 67.1 | 108.3 | 91.7
(Gain) loss on fair value remeasurement of contingent consideration | (63.7) | (12.3) | 62.7
Income (Loss) from Individually Significant Component Disposed of or Held-for-sale, Excluding Discontinued Operations, Attributable to Parent, before Income Tax | 55.3 | 0.0 | 0.0
Other | 69.2 | (69.1) | 162.1
Changes in operating assets and liabilities, net: |  |  |
Accounts receivable | 68.8 | (205.2) | (435.6)
Due from anti-CD20 therapeutic programs | (63.3) | 5.7 | (232.0)
Inventory | (19.2) | (52.1) | (94.5)
Accrued expenses and other current liabilities | 240.2 | 465.5 | (227.4)
Income tax assets and liabilities | 16.1 | 321.7 | 1,303.9
Other liabilities | (43.3) | (135.4) | (79.0)
Net cash flows provided by operating activities | 7,078.6 | 6,187.7 | 4,551.0
Cash flows from investing activities: |  |  |
Proceeds from sales and maturities of marketable securities | 6,007.0 | 9,173.7 | 5,565.9
Purchases of marketable securities | (5,252.6) | (7,694.8) | (5,355.2)
Contingent consideration related to Fumapharm AG acquisition | (300.0) | (1,500.0) | (1,200.0)
Payments to Acquire Businesses, Net of Cash Acquired | (744.4) | 0.0 | 0.0
Proceeds from Sale of Property, Plant, and Equipment | 923.7 | 0.0 | 0.0
Payments to Acquire in Process Research and Development | 0.0 | (112.5) | (120.0)
Purchases of property, plant and equipment | (514.5) | (770.6) | (867.4)
Acquisitions of intangible assets | (155.0) | (3.0) | (975.4)
Payments to Acquire Other Investments | 0.0 | (462.9) | 0.0
Payments to increase investment in Samsung Bioepis | 0.0 | (676.6) | 0.0
Proceeds from Sale of Available-for-sale Securities, Equity | 479.3 | 0.0 | 0.0
Other | 27.0 | 0.4 | (11.0)
Net cash flows provided by (used in) investing activities | 470.5 | (2,046.3) | (2,963.1)
Cash flows from financing activities: |  |  |
Purchases of treasury stock | (5,868.3) | (4,352.6) | (1,365.4)
Net contribution (distribution) to noncontrolling interests | 4.3 | (36.4) | (134.1)
Repayments of borrowings | 0.0 | (3.2) | (560.9)
Net cash contribution to Bioverativ, Inc. | 0.0 | 0.0 | (302.7)
Contingent consideration payments | 0.0 | (58.2) | (3.0)
Other | 3.6 | (21.6) | (13.9)
Net cash flows used in financing activities | (5,860.4) | (4,472.0) | (2,380.0)
Net increase (decrease) in cash and cash equivalents | 1,688.7 | (330.6) | (792.1)
Effect of exchange rate changes on cash and cash equivalents | 0.4 | (18.6) | 39.4
Cash and cash equivalents, beginning of the year | 1,224.6 | 1,573.8 | 2,326.5
Cash and cash equivalents, end of the year | $ 2,913.7 | $ 1,224.6 | $ 1,573.8

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