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Segment Information (Details) - USD ($)
$ in Millions
 3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Revenue, Major Customer [Line Items]                      
Product Revenues $ 3,671.3 $ 3,600.1 $ 3,616.7 $ 3,489.8 $ 3,526.3 $ 3,439.0 $ 3,356.5 $ 3,131.1 $ 14,377.9 $ 13,452.9 $ 12,273.9
Geographic information                      
Long-lived assets 3,674.3       3,601.2       3,674.3 3,601.2 3,182.4
U.S                      
Geographic information                      
Long-lived assets 1,493.2       1,152.7       1,493.2 1,152.7 1,226.9
Europe                      
Geographic information                      
Long-lived assets 2,162.9       2,442.8       2,162.9 2,442.8 1,948.2
Asia                      
Geographic information                      
Long-lived assets 6.2       3.9       6.2 3.9 5.2
Other                      
Geographic information                      
Long-lived assets 12.0       1.8       12.0 1.8 2.1
Revenues from anti-cd20 therapeutic programs                      
Revenue, Major Customer [Line Items]                      
Product Revenues 600.8 595.8 576.4 517.4 534.9 511.7 490.4 443.2 2,290.4 1,980.2 1,559.2
Revenues from anti-cd20 therapeutic programs | U.S                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 2,211.9 1,903.4 1,475.6
Revenues from anti-cd20 therapeutic programs | Europe                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 0.2 0.2 0.6
Revenues from anti-cd20 therapeutic programs | Asia                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 0.0 0.0 0.0
Revenues from anti-cd20 therapeutic programs | Other                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 78.3 76.6 83.0
Other revenue                      
Revenue, Major Customer [Line Items]                      
Product Revenues 145.7 109.6 160.0 292.4 165.7 147.2 108.6 164.4 707.7 585.9 360.0
Other revenue | U.S                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 585.8 457.0 249.5
Other revenue | Europe                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 9.7 32.7 67.8
Other revenue | Asia                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 112.2 96.2 42.7
Other revenue | Other                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 0.0 0.0 0.0
Product, net                      
Revenue, Major Customer [Line Items]                      
Product Revenues $ 2,924.8 $ 2,894.7 $ 2,880.3 $ 2,680.0 $ 2,825.7 $ 2,780.1 $ 2,757.5 $ 2,523.5 11,379.8 10,886.8 10,354.7
Product, net | U.S                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 6,713.8 6,800.5 7,017.1
Product, net | Europe                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 3,794.5 3,370.3 2,844.8
Product, net | Asia                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 320.3 281.2 160.1
Product, net | Other                      
Revenue, Major Customer [Line Items]                      
Product Revenues                 $ 551.2 $ 434.8 $ 332.7