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v3.20.4

Consolidated Statements of Cash Flows - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Cash flows from operating activities: |  |  |
Net income | $ 4,060.5 | $ 5,888.5 | $ 4,474.0
Adjustments to reconcile net income to net cash flows from operating activities: |  |  |
Depreciation and amortization | 457.2 | 464.7 | 650.5
Impairment of intangible assets | 209.7 | 215.9 | 366.1
Acquired in-process research and development | 75.0 | 0.0 | 112.5
Share-based compensation | 198.3 | 182.3 | 157.5
Contingent consideration | (86.3) | (63.7) | (12.3)
(Gain)/loss on divestiture of Hillerod, Denmark manufactuing operations | (92.5) | 55.3 | 0.0
Deferred income taxes | 149.0 | 67.1 | 108.3
Unrealized (gain) loss on strategic investments | (681.8) | (147.3) | (124.8)
Loss on equity method investment | (3.3) | 77.4 | 0.0
Other | 131.2 | 139.1 | 55.7
Changes in operating assets and liabilities, net: |  |  |
Accounts receivable | 2.8 | 68.8 | (205.2)
Due from anti-CD20 therapeutic programs | 176.7 | (63.3) | 5.7
Inventory | (316.3) | (19.2) | (52.1)
Accrued expenses and other current liabilities | 154.2 | 240.2 | 465.5
Income tax assets and liabilities | (67.5) | 16.1 | 321.7
Other changes in operating assets and liabilities, net | (137.1) | (43.3) | (135.4)
Net cash flows provided by operating activities | 4,229.8 | 7,078.6 | 6,187.7
Cash flows from investing activities: |  |  |
Proceeds from sales and maturities of marketable securities | 7,299.4 | 6,007.0 | 9,173.7
Purchases of marketable securities | (6,397.7) | (5,252.6) | (7,694.8)
Contingent consideration paid related to Fumapharm AG acquisition | 0.0 | (300.0) | (1,500.0)
Acquisition of Nightstar Therapeutics plc, net of cash acquired | 0.0 | (744.4) | 0.0
Proceeds from divesiture of Hillerod, Denmark manufacturing operations | 0.0 | 923.7 | 0.0
Purchases of property, plant and equipment | (424.8) | (514.5) | (770.6)
Acquired in-process research and development | (75.0) | 0.0 | (112.5)
Acquisitions of intangible assets | (52.0) | (155.0) | (3.0)
Investment in Samsung Bioepis | 0.0 | 0.0 | (676.6)
Proceeds from sales of strategic investments | 74.9 | 479.3 | 0.0
Other | (26.9) | 27.0 | 0.4
Net cash flows provided by (used in) investing activities | (608.6) | 470.5 | (2,046.3)
Cash flows from financing activities: |  |  |
Purchase of treasury stock | (6,679.1) | (5,868.3) | (4,352.6)
Payments related to issuance of stock for share-based compensation arrangements, net | (4.6) | 0.0 | 0.0
Proceeds from borrowings | 2,967.4 | 0.0 | 0.0
Repayments of borrowings | (1,500.0) | 0.0 | (3.2)
Net contribution (distribution) to noncontrolling interest |  | 4.3 |
Net contribution (distribution) to noncontrolling interest | (71.0) |  | (36.4)
Contingent consideration payments | 0.0 | 0.0 | (58.2)
Other | 14.6 | 3.6 | (21.6)
Net cash flows (used in) financing activities | (5,272.7) | (5,860.4) | (4,472.0)
Net increase (decrease) in cash and cash equivalents | (1,651.5) | 1,688.7 | (330.6)
Effect of exchange rate changes on cash and cash equivalents | 69.0 | 0.4 | (18.6)
Cash and cash equivalents, beginning of the year | 2,913.7 | 1,224.6 | 1,573.8
Cash and cash equivalents, end of the year | 1,331.2 | 2,913.7 | 1,224.6
Ionis Pharmaceuticals |  |  |
Cash flows from investing activities: |  |  |
Purchase of subsidiaries and affiliates | 0.0 | 0.0 | (462.9)
Sangamo Therapeutics, Inc. Agreement |  |  |
Cash flows from investing activities: |  |  |
Purchase of subsidiaries and affiliates | (141.8) | 0.0 | 0.0
Denali Therapeutics |  |  |
Cash flows from investing activities: |  |  |
Purchase of subsidiaries and affiliates | (423.7) | 0.0 | 0.0
Sage Therapeutics |  |  |
Cash flows from investing activities: |  |  |
Purchase of subsidiaries and affiliates | $ (441.0) | $ 0.0 | $ 0.0

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