XML 191 R137.htm IDEA: XBRL DOCUMENT v3.20.4
Collaborative and Other Relationships - Other Arrangements (Details) - USD ($)
$ / shares in Units, shares in Millions, $ in Millions
1 Months Ended 12 Months Ended
Nov. 30, 2020
Sep. 30, 2020
Feb. 29, 2020
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Collaborative arrangements and non-collaborative arrangement transactions            
Research and development       $ 3,990.9 $ 2,280.6 $ 2,597.2
Sage Therapeutics            
Collaborative arrangements and non-collaborative arrangement transactions            
Global licensing collaboration, shares purchased, amount $ 650.0          
Global licensing collaboration, shares purchased (in shares) 6.2          
Global licensing collaboration, purchase price per share (in dollars per share) $ 104.14          
Research and development expense asset acquired $ 209.0          
Upfront and milestone payments made to collaborative partner 875.0          
Global licensing collaboration, development and commercial milestone payments $ 1,600.0          
Denali Therapeutics            
Collaborative arrangements and non-collaborative arrangement transactions            
Global licensing collaboration, shares purchased, amount   $ 465.0        
Global licensing collaboration, shares purchased (in shares)   13.0        
Global licensing collaboration, purchase price per share (in dollars per share)   $ 34.94        
Research and development expense asset acquired   $ 41.3        
Upfront and milestone payments made to collaborative partner   560.0        
Global licensing collaboration, development and commercial milestone payments   $ 1,100.0        
Research and development       8.8    
Sangamo Therapeutics, Inc. Agreement            
Collaborative arrangements and non-collaborative arrangement transactions            
Global licensing collaboration, shares purchased, amount     $ 225.0      
Global licensing collaboration, shares purchased (in shares)     24.0      
Global licensing collaboration, purchase price per share (in dollars per share)     $ 9.21      
Research and development expense asset acquired     $ 83.0      
Upfront and milestone payments made to collaborative partner     125.0      
Global licensing collaboration, development and commercial milestone payments     2,400.0      
Research and development       $ 6.4    
Term of collaboration agreement       5 years    
Global licensing collaboration, payment, selection of targets     80.0      
Global licensing collaboration, payment,first milestone     1,900.0      
Global licensing collaboration, payment, sales based milestone     $ 380.0      
Other research and discovery            
Collaborative arrangements and non-collaborative arrangement transactions            
Research and development       $ 92.1 $ 77.0 $ 48.6