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Other Consolidated Financial Statement Detail (Details) - USD ($)
$ in Millions
 3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Dec. 31, 2020
Other Income (Expense), Net      
Interest income $ 2.9 $ 24.4  
Interest expense (64.7) (44.3)  
Gain (loss) on investments, net (436.6) (77.3)  
Foreign exchange gains (losses), net (8.6) (18.9)  
Other, net 0.1 (4.4)  
Total other income (expense), net (506.9) (120.5)  
Equity Securities, FV-NI, Gain (Loss), Alternative [Abstract]      
Net gains (losses) recognized during the period on equity securities (436.1) (60.9)  
Less: Net gains (losses) recognized during the period on equity securities sold during the period 6.2 0.0  
Unrealized gains (losses) recognized during the period on equity securities (442.3) $ (60.9)  
Accrued Expenses and Other      
Revenue-related reserves for discounts and allowances 1,166.4   $ 1,276.0
Collaboration expense 207.4   333.8
Royalties and licensing fees 212.5   218.5
Collaboration expense 390.7   389.9
Current portion of contingent consideration obligations 0.0   149.6
Derivative liabilities 88.6   181.5
Other 700.1   791.4
Total accrued expense and other 2,592.3   3,145.3
Component of accrued expenses and other      
Accrued Expenses and Other      
Revenue-related reserves for discounts and allowances $ 993.0   $ 1,080.6