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Collaborative and Other Relationships - Collaborations (Details) $ / shares in Units, shares in Millions, $ in Millions | 1 Months Ended | 3 Months Ended | 6 Months Ended |
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Jun. 30, 2021 USD ($) | Nov. 30, 2020 USD ($) $ / shares shares | Feb. 29, 2020 USD ($) $ / shares shares | Jun. 30, 2021 USD ($) | Jun. 30, 2020 USD ($) | Mar. 31, 2020 USD ($) | Jun. 30, 2021 USD ($) product $ / shares | Jun. 30, 2020 USD ($) | Jan. 31, 2020 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Research and Development Expense (Excluding Acquired in Process Cost) |  |  |  | $ 585.1 | $ 647.6 |  | $ 1,099.3 | $ 1,123.9 |
Eisai |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Number of product candidates | product |  |  |  |  |  |  | 2 |  |
Percentage of future development costs related to Eisai |  |  |  | 45.00% | 45.00% |  |  |  |
Loss on research and development contracts terminated with Eisai |  |  |  |  |  | $ 45.0 |  |  |
Additional milestone payment |  |  |  |  | $ 75.0 |  |  |  |
Eisai | BAN2401 and Elenbecestat |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Expense Incurred By Collaboration |  |  |  | $ 62.2 | 33.9 |  | $ 117.7 | 77.5 |
Expense reflected within statements of income |  |  |  | 31.1 | 17.0 |  | 58.8 | 38.7 |
Eisai | ADUHELM |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Expense reflected within statements of income |  |  |  | 45.0 | 33.8 |  | 45.0 | 33.8 |
Additional milestone payment | $ 100.0 |  |  | 100.0 | 75.0 |  | 100.0 | 75.0 |
Denali Therapeutics |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Global licensing collaboration agreement, amount, shares purchased (in shares) |  |  |  |  |  |  | $ 465.0 |  |
Global licensing collaboration agreement, shares purchased per share (in usd per share) | $ / shares |  |  |  |  |  |  | $ 34.94 |  |
Upfront and milestone payments made to collaborative partner |  |  |  |  |  |  | $ 560.0 |  |
Global Licensing Collaboration Agreement, Research, Development, Regulatory and Commercial Milestone Payments |  |  |  |  |  |  | 1,100.0 |  |
Research and development expense |  |  |  |  |  |  | $ 41.3 |  |
Samsung Bioepis |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Upfront and milestone payments made to collaborative partner |  |  |  |  |  | 100.0 |  |  |
Collaboration agreement term |  |  |  |  |  |  | 5 years |  |
Research and development expense |  |  |  |  |  | $ 63.0 |  |  |
Prepaid research and development expenses |  |  |  |  |  |  |  |  | $ 37.0
Additional milestone payment |  |  |  | 15.0 |  |  |  |  |
Sage Therapeutics Inc. |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Global licensing collaboration agreement, amount, shares purchased (in shares) |  | $ 650.0 |  |  |  |  |  |  |
Global licensing collaboration agreement, shares, purchased (in shares) | shares |  | 6.2 |  |  |  |  |  |  |
Upfront and milestone payments made to collaborative partner |  | $ 875.0 |  |  |  |  |  |  |
Global Licensing Collaboration Agreement, Research, Development, Regulatory and Commercial Milestone Payments |  | 1,600.0 |  |  |  |  |  |  |
Research and development expense |  | $ 209.0 |  |  |  |  |  |  |
Global licensing collaboration agreement, purchase price per share (in usd per share) | $ / shares |  | $ 104.14 |  |  |  |  |  |  |
Sangamo Therapeutics, Inc. Agreement |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Global licensing collaboration agreement, amount, shares purchased (in shares) |  |  | $ 225.0 |  |  |  |  |  |
Global licensing collaboration agreement, shares, purchased (in shares) | shares |  |  | 24.0 |  |  |  |  |  |
Global licensing collaboration agreement, shares purchased per share (in usd per share) | $ / shares |  |  | $ 9.21 |  |  |  |  |  |
Upfront and milestone payments made to collaborative partner |  |  | $ 125.0 |  |  |  |  |  |
Global Licensing Collaboration Agreement, Research, Development, Regulatory and Commercial Milestone Payments |  |  | 2,400.0 |  |  |  |  |  |
Global Licensing Collaboration Agreement, Payment, Selection of Targets |  |  | 80.0 |  |  |  |  |  |
Global Licensing Collaboration Agreement, Payment, Achievement of First Commercial Sale Milestones |  |  | 1,900.0 |  |  |  |  |  |
Global Licensing Collaboration Agreement, Payment, Achievement of Specific Sales Based Milestones |  |  | 380.0 |  |  |  |  |  |
Research and development expense |  |  | $ 83.0 |  |  |  |  |  |
Term of collaboration agreement |  |  |  |  |  |  | 5 years |  |
Other research and discovery |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Research and Development Expense (Excluding Acquired in Process Cost) |  |  |  | 77.2 | 9.6 |  | $ 77.2 | 9.6 |
Research and development | Eisai | ADUHELM |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Expense incurred by the collaboration |  |  |  | 42.1 | 35.9 |  | 89.1 | 55.0 |
Expense reflected within statements of income |  |  |  | 23.2 | 19.7 |  | 49.0 | 30.3 |
Research and development | Denali Therapeutics |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Expense incurred by the collaboration |  |  |  | 10.4 | 0.0 |  | 18.7 | 0.0 |
Expense reflected within statements of income |  |  |  | 6.2 | 0.0 |  | 11.2 | 0.0 |
Research and development | Sage Therapeutics Inc. |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Expense incurred by the collaboration |  |  |  | 54.0 | 0.0 |  | 93.8 | 0.0 |
Expense reflected within statements of income |  |  |  | 27.0 | 0.0 |  | 46.9 | 0.0 |
Research and development | UCB Pharma S.A. [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Expense incurred by the collaboration |  |  |  | 16.1 | 6.5 |  | 33.0 | 25.5 |
Expense reflected within statements of income |  |  |  | 8.1 | 3.2 |  | 16.5 | 12.7 |
Selling, general and administrative | Eisai | BAN2401 and Elenbecestat |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Expense incurred by the collaboration |  |  |  | 4.3 | 1.4 |  | 10.0 | 6.3 |
Expense reflected within statements of income |  |  |  | 2.1 | 0.7 |  | 5.0 | 3.2 |
Selling, general and administrative | Eisai | ADUHELM |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Expense incurred by the collaboration |  |  |  | 125.6 | 45.2 |  | 237.4 | 67.9 |
Expense reflected within statements of income |  |  |  | 67.6 | 25.2 |  | 127.9 | 37.5 |
Selling, general and administrative | Sage Therapeutics Inc. |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |
Expense incurred by the collaboration |  |  |  | 10.5 | 0.0 |  | 15.8 | 0.0 |
Expense reflected within statements of income |  |  |  | $ 5.2 | $ 0.0 |  | $ 7.9 | $ 0.0 |

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