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Other Consolidated Financial Statement Detail (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Other Income (Expense), Net          
Interest income $ 2.7 $ 7.6 $ 5.6 $ 32.0  
Interest expense (56.4) (66.0) (121.1) (110.3)  
Gain (loss) on investments, net 153.9 106.8 (282.7) 29.5  
Foreign exchange gains (losses), net (0.8) 10.4 (9.4) (8.5)  
Other, net (3.0) 4.2 (2.9) (0.2)  
Total other income (expense), net 96.4 63.0 (410.5) (57.5)  
Equity Securities, FV-NI, Gain (Loss), Alternative [Abstract]          
Net gains (losses) recognized during the period on equity securities 154.3 102.9 (281.8) 42.0  
Less: Net gains (losses) realized during the period on equity securities 0.4 0.0 6.6 0.0  
Unrealized gains (losses) recognized during the period on equity securities 153.9 $ 102.9 (288.4) $ 42.0  
Accrued Expenses and Other          
Revenue-related reserves for discounts and allowances 1,202.3   1,202.3   $ 1,276.0
Collaboration expense 242.5   242.5   333.8
Royalties and licensing fees 240.3   240.3   218.5
Collaboration expense 383.4   383.4   389.9
Current portion of contingent consideration obligations 0.0   0.0   149.6
Derivative liabilities 72.4   72.4   181.5
Other 760.3   760.3   791.4
Total accrued expense and other 2,741.0   2,741.0   3,145.3
Ionis, Sangamo, Denali and Sage          
Equity Securities, FV-NI, Gain (Loss), Alternative [Abstract]          
Unrealized gains (losses) recognized during the period on equity securities 263.0        
Component of accrued expenses and other          
Accrued Expenses and Other          
Revenue-related reserves for discounts and allowances $ 1,042.1   $ 1,042.1   $ 1,080.6