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v3.21.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Millions | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Cash flow from operating activities: |  |
Net income | $ 1,748.1 | $ 3,702.9
Adjustments to reconcile net income to net cash flow from operating activities: |  |
Depreciation and amortization | 353.0 | 347.5
Impairment of intangible assets | 629.3 | 19.3
Acquired in-process research and development | 18.0 | 75.0
Share-based compensation | 179.8 | 149.3
Contingent consideration | (49.1) | (23.5)
Deferred income taxes | (750.1) | 211.9
(Gain) loss on strategic investments | 710.5 | 41.8
(Gain) loss on equity method investment | (17.2) | 14.7
Other | 201.0 | 110.1
Changes in operating assets and liabilities, net: |  |
Accounts receivable | 157.8 | (135.7)
Due from anti-CD20 therapeutic programs | 13.5 | 63.0
Inventory | (322.6) | (270.6)
Accrued expense and other current liabilities | (243.3) | 372.9
Income tax assets and liabilities | 260.5 | 15.3
Other changes in operating assets and liabilities, net | (87.6) | (97.0)
Net cash flow provided by operating activities | 2,801.6 | 4,596.9
Cash flows from investing activities: |  |
Purchases of property, plant and equipment | (206.5) | (338.8)
Proceeds from sales and maturities of marketable securities | 2,028.1 | 5,240.7
Purchases of marketable securities | (2,372.6) | (4,649.1)
Proceeds from divestiture of Hillerød, Denmark manufacturing operations | 28.1 | 0.0
Acquired in-process research and development | (18.0) | (75.0)
Acquisitions of intangible assets | (1.9) | (37.0)
Proceeds from sales of strategic investments | 91.2 | 0.5
Other | 0.6 | (18.0)
Net cash flow used in investing activities | (451.0) | (442.2)
Cash flows from financing activities: |  |
Purchases of treasury stock | (1,800.0) | (6,279.1)
Payments related to issuance of stock for share-based compensation arrangements, net | (8.3) | (11.8)
Repayment of borrowings and premiums paid on debt exchange | (170.0) | 0.0
Proceeds from borrowings | 0.0 | 2,967.3
Repayment of borrowings | 0.0 | (1,500.0)
Cash proceeds from settlement of swap | 0.0 | 0.0
Net distribution to noncontrolling interest | (94.8) | (70.9)
Other | (22.9) | 22.9
Net cash flow used in financing activities | (2,096.0) | (4,871.6)
Net increase (decrease) in cash and cash equivalents | 254.6 | (716.9)
Effect of exchange rate changes on cash and cash equivalents | (44.0) | 28.0
Cash and cash equivalents, beginning of the period | 1,331.2 | 2,913.7
Cash and cash equivalents, end of the period | 1,541.8 | 2,224.8
Sangamo |  |
Cash flows from investing activities: |  |
Payments subsidiary and affiliates stock | 0.0 | (141.8)
Denali Therapeutics |  |
Cash flows from investing activities: |  |
Payments subsidiary and affiliates stock | $ 0.0 | $ (423.7)

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