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Collaborative and Other Relationships - Alkermes (Details) - USD ($) $ in Millions | 1 Months Ended | 12 Months Ended
--- | --- | ---
Oct. 31, 2019 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Collaborative arrangements and non-collaborative arrangement transactions |  |  |  |
Inventory and purchase commitment charges |  | $ 2,278.3 | $ 2,109.7 | $ 1,805.2
Potential future milestone payments commitment to third party approximately |  | 9,300.0 |  |
Research and development |  | $ 2,231.1 | 2,501.2 | 3,990.9
VUMERITY | Alkermes |  |  |  |
Collaborative arrangements and non-collaborative arrangement transactions |  |  |  |
Percentage of royalties as per collaboration | 15.00% | 15.00% |  |
Royalties payable period, post FDA approval | 5 years |  |  |
Inventory and purchase commitment charges |  | $ 83.0 | $ 61.6 | $ 12.9

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- Definition The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 924 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 11.L) -URI https://asc.fasb.org/extlink&oid=6472922&loc=d3e499488-122856 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.2(a),(d)) -URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227 + Details
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- Definition The costs incurred in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, excluding in-process research and development acquired in a business combination consummated during the period. Excludes software research and development, which has a separate concept. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI https://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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