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Other Consolidated Financial Statement Detail - Accrued Expense and Other (Details) - USD ($) $ in Millions | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | --- | --- | ---
SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Line Items] |  |  |  |
Revenue-related reserves for discounts and allowances | $ 1,035.0 | $ 935.3 | $ 1,276.0 | $ 1,198.9
Total accrued expense and other | 2,521.4 | 2,535.2 |  |
Component of accrued expense and other |  |  |  |
SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Line Items] |  |  |  |
Revenue-related reserves for discounts and allowances | 891.6 | 802.1 |  |
Employee compensation and benefits | 395.6 | 345.1 |  |
Collaboration expense | 277.9 | 324.7 |  |
Royalties and licensing fees | 209.4 | 234.7 |  |
Other | $ 746.9 | $ 828.6 |  |

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