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Other Consolidated Financial Statement Detail - Narrative (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Business Acquisition [Line Items] |  |  |
Unrealized (gains) losses recognized on equity securities | $ 264.7 | $ 831.4 | $ (681.8)
Other long-term liabilities | 944.2 | 1,320.5 |
Accrued income taxes | 541.7 | 664.5 |
Denali, Ionis, Sage, and Sangamo |  |  |
Business Acquisition [Line Items] |  |  |
Unrealized (gains) losses recognized on equity securities | $ (278.0) | $ (819.6) |

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