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Other Consolidated Financial Statement Detail - Accrued Expense and Other (Details) - USD ($)
$ in Millions
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Line Items]        
Revenue-related reserves for discounts and allowances $ 1,035.0 $ 935.3 $ 1,276.0 $ 1,198.9
Total accrued expense and other 2,521.4 2,535.2    
Component of accrued expense and other        
SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Line Items]        
Revenue-related reserves for discounts and allowances 891.6 802.1    
Employee compensation and benefits 395.6 345.1    
Collaboration expense 277.9 324.7    
Royalties and licensing fees 209.4 234.7    
Other $ 746.9 $ 828.6