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v3.23.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Millions | 3 Months Ended
--- | ---
Mar. 31, 2023 | Mar. 31, 2022
Cash flow from operating activities: |  |
Net income | $ 387.6 | $ 218.5
Adjustments to reconcile net income to net cash flow from operating activities: |  |
Depreciation and amortization | 112.3 | 143.1
Excess and obsolescence charges related to inventory | 17.4 | 281.5
Share-based compensation | 75.6 | 67.6
Contingent consideration | 0.0 | (7.1)
Deferred income taxes | (64.5) | 1.0
(Gain) loss on strategic investments | 79.6 | 191.1
(Gain) loss on equity method investments | 0.0 | 3.3
Other | 31.4 | 43.3
Changes in operating assets and liabilities, net: |  |
Accounts receivable | 77.2 | (87.5)
Due from anti-CD20 therapeutic programs | 37.6 | 22.9
Inventory | 27.9 | (142.6)
Accrued expense and other current liabilities | (295.0) | (461.6)
Income tax assets and liabilities | 65.0 | 101.9
Other changes in operating assets and liabilities, net | (96.8) | (213.6)
Net cash flow provided by (used in) operating activities | 455.3 | 161.8
Cash flows from investing activities: |  |
Purchases of property, plant and equipment | (66.6) | (57.9)
Proceeds from sales and maturities of marketable securities | 406.7 | 543.6
Purchases of marketable securities | (1,321.2) | (1,133.5)
Acquisitions of intangible assets | (5.0) | 0.0
Proceeds from sales of strategic investments | 33.8 | 0.0
Other | (0.7) | (0.2)
Net cash flow provided by (used in) investing activities | (953.0) | (648.0)
Cash flows from financing activities: |  |
Payments related to issuance of stock for share-based compensation arrangements, net | (60.1) | (20.8)
Net (distribution) contribution to noncontrolling interest | 0.2 | 0.2
Other | 16.5 | 4.1
Net cash flow provided by (used in) financing activities | (43.4) | (16.5)
Net increase (decrease) in cash and cash equivalents | (541.1) | (502.7)
Effect of exchange rate changes on cash and cash equivalents | 20.0 | (9.4)
Cash and cash equivalents, beginning of the period | 3,419.3 | 2,261.4
Cash and cash equivalents, end of the period | $ 2,898.2 | $ 1,749.3

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