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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Millions | 6 Months Ended
--- | ---
Jun. 30, 2024 | Jun. 30, 2023
Cash flow from operating activities: |  |
Net income | $ 977.0 | $ 980.9
Adjustments to reconcile net income to net cash flow from operating activities: |  |
Depreciation and amortization | 306.4 | 229.7
Excess and obsolescence charges related to inventory | 44.4 | 36.8
Amortization of acquired inventory step-up | 134.2 | 0.0
Share-based compensation | 143.4 | 147.1
Deferred income taxes | (47.1) | (170.9)
(Gain) loss on strategic investments | 61.6 | (26.8)
Gain on sale of priority review voucher, net | 88.6 | 0.0
Other | 65.0 | 60.5
Changes in operating assets and liabilities, net of effects of business acquired: |  |
Inventory | (188.2) | (65.1)
Accrued expense and other current liabilities | (115.6) | (127.1)
Income tax assets and liabilities | (7.7) | (82.4)
Other changes in operating assets and liabilities, net | (103.0) | (55.5)
Net cash flow provided by (used in) operating activities | 1,179.0 | 942.3
Cash flow from investing activities: |  |
Purchases of property, plant and equipment | (79.4) | (137.6)
Proceeds from sales and maturities of marketable securities | 0.0 | 1,682.2
Purchases of marketable securities | 0.0 | (4,120.3)
Proceeds from sale of equity interest in Samsung Bioepis | 406.8 | 788.1
Proceeds from sale of priority review voucher | 103.0 | 0.0
Acquisitions of intangible assets | (84.1) | (21.0)
Proceeds from sales of strategic investments | 57.5 | 103.2
Other | (3.3) | (1.1)
Net cash flow provided by (used in) investing activities | 400.5 | (1,706.5)
Cash flow from financing activities: |  |
Payments related to issuance of stock for share-based compensation arrangements, net | (40.8) | (54.6)
Repayment of borrowings | 650.0 | 0.0
Net (distribution) contribution to noncontrolling interest | 0.0 | 1.7
Other | 6.0 | (0.3)
Net cash flow provided by (used in) financing activities | (684.8) | (53.2)
Net increase (decrease) in cash and cash equivalents | 894.7 | (817.4)
Effect of exchange rate changes on cash and cash equivalents | (35.7) | 15.9
Cash and cash equivalents, beginning of the period | 1,049.9 | 3,419.3
Cash and cash equivalents, end of the period | 1,908.9 | 2,617.8
Nonrelated Party |  |
Changes in operating assets and liabilities, net of effects of business acquired: |  |
Accounts receivable | 12.3 | 21.8
Related Party |  |
Changes in operating assets and liabilities, net of effects of business acquired: |  |
Accounts receivable | $ (15.1) | $ (6.7)

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