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License agreements - Lilly (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended 100 Months Ended
Mar. 31, 2016
USD ($)
Jul. 31, 2010
Dec. 31, 2009
USD ($)
item
Mar. 31, 2018
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2012
USD ($)
Dec. 31, 2010
USD ($)
Mar. 31, 2018
USD ($)
License agreements                    
Research and Development Expense       $ 303,103 $ 407,920          
Revenues       382,300            
Product royalty revenues                    
License agreements                    
Revenues       47,700            
Eli Lilly                    
License agreements                    
Upfront payment received under license agreement     $ 90,000              
Research and Development Expense       12,500 9,400          
Number of deliverables under license agreement | item     2              
Product royalties in accounts receivable       $ 6,400   $ 4,600       $ 6,400
Eli Lilly | Maximum                    
License agreements                    
Associated future royalty payments from the initiation of a Phase IIb trial, if elected to not co-develop, percentage       20.00%            
Eli Lilly | Phase IIB                    
License agreements                    
Funding of future development costs (as a percent)   30.00%   30.00%            
Eli Lilly | Pre-specified Events | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement     $ 665,000              
Eli Lilly | Development Milestones                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone           30,000       129,000
Eli Lilly | Development Milestones | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement     150,000              
Eli Lilly | Development Milestones | Phase III                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone               $ 50,000    
Eli Lilly | Development Milestones | Phase IIA                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone                 $ 30,000  
Eli Lilly | Development Milestones | Phase IIB                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone                 $ 19,000  
Eli Lilly | Regulatory Milestones                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone                   $ 135,000
Eli Lilly | Regulatory Milestones | JAPAN                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone           15,000        
Eli Lilly | Regulatory Milestones | U.S.                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone             $ 35,000      
Eli Lilly | Regulatory Milestones | Europe                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone           $ 65,000 $ 20,000      
Eli Lilly | Regulatory Milestones | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement     365,000              
Eli Lilly | Commercialization Milestones | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement     $ 150,000              
Eli Lilly | GVHD                    
License agreements                    
Upfront payment under license agreement $ 35,000                  
Additional milestone payments under the license agreement $ 40,000                  
Eli Lilly | Milestone revenues                    
License agreements                    
Revenues       $ 0 65,000          
Eli Lilly | Product royalty revenues                    
License agreements                    
Revenues       $ 6,400 $ 400