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License agreements - Merus (Details) $ / shares in Units, $ in Thousands, € in Millions, shares in Millions |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Jan. 23, 2017 USD ($) $ / shares | Feb. 28, 2017 USD ($) | Jan. 31, 2017 USD ($) item | Dec. 31, 2016 USD ($) $ / shares shares | Jun. 30, 2018 USD ($) | Jun. 30, 2017 USD ($) | Jun. 30, 2018 USD ($) | Jun. 30, 2017 USD ($) | Dec. 31, 2017 EUR (€) | Dec. 31, 2017 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  | $ 131,330 |  | $ 131,330 |  |  | $ 134,356 | [1]
Research and development expense |  |  |  |  | 298,089 | $ 201,786 | 601,192 | $ 609,706 |  |  |
Unrealized (gain) loss on long term investments |  |  |  |  | (34,641) | (19,574) | (11,962) | (25,388) |  |  |
Merus |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Number of independent programs | item |  |  | 11 |  |  |  |  |  |  |  |
Number of preclinical discovery programs | item |  |  | 2 |  |  |  |  |  |  |  |
Number of programs under the resulting products are co-funded for development | item |  |  | 2 |  |  |  |  |  |  |  |
Associated future global development costs , if elected to co-develop (as a percent) |  |  | 35.00% |  |  |  |  |  |  |  |
Upfront payment under license agreement |  | $ 120,000 |  |  |  |  |  |  |  |  |
Merus | U.S. |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Profit sharing (as a percent) |  |  | 50.00% |  |  |  |  |  |  |  |
Percentage of profit (losses) |  |  | 50.00% |  |  |  |  |  |  |  |
Merus | Minimum |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 6.00% |  |  |  |  |  |  |  |
Merus | Minimum | Non-U.S. |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 6.00% |  |  |  |  |  |  |  |
Merus | Maximum |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Number of additional preclinical discovery programs | item |  |  | 9 |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 10.00% |  |  |  |  |  |  |  |
Percentage of additional royalties |  |  | 4.00% |  |  |  |  |  |  |  |
Percentage of reverse royalty |  |  | 4.00% |  |  |  |  |  |  |  |
Merus | Maximum | Non-U.S. |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 10.00% |  |  |  |  |  |  |  |
Merus | Maximum | Development and Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 100,000 |  |  |  |  |  |  |  |
Merus | Maximum | Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 250,000 |  |  |  |  |  |  |  |
Merus |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Per share price of common stock | $ / shares | $ 24.50 |  |  |  |  |  |  |  |  |  |
Discount for lack of marketability | $ 5,600 |  |  |  |  |  |  |  |  |  |
Fair value of shares on the issuance date | 72,800 |  |  |  |  |  |  |  |  |  |
Total consideration paid | 80,000 |  |  |  |  |  |  |  |  |  |
Long term investment | 72,800 |  |  |  |  |  |  |  |  |  |
Research and development expense | $ 7,200 |  |  |  | 2,800 | 1,500 | 5,200 | 2,600 |  |  |
Fair market value of our long term investments |  |  |  |  | $ 72,800 |  | $ 72,800 |  |  | 62,100 |
Ownership percentage (as a percent) |  |  |  |  | 14.00% |  | 14.00% |  |  |  |
Unrealized (gain) loss on long term investments |  |  |  |  | $ 13,500 | $ (23,900) | $ 10,800 | $ (22,000) |  |  |
Total revenues | € |  |  |  |  |  |  |  |  | € 13.6 |  |
Net income (loss) | € |  |  |  |  |  |  |  |  | € (73.0) |  |
Merus | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  | $ 2,400 |  | $ 2,400 |  |  | $ 2,100 |
Merus | Stock purchase agreement |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  |  |  | 3.2 |  |  |  |  |  |  |
Purchase price of common stock |  |  |  | $ 80,000 |  |  |  |  |  |  |
Per share price | $ / shares |  |  |  | $ 25.00 |  |  |  |  |  |  |
Lock-up period | 18 months |  |  |  |  |  |  |  |  |  |
Standstill period |  |  |  |  |  |  | 3 years |  |  |  |
Percentage of total shares allowed to sell during any 12-month period (as a percent) | 33.00% |  |  |  |  |  |  |  |  |  |
Percentage of total shares allowed to sell during any three-month period (as a percent) | 10.00% |  |  |  |  |  |  |  |  |  |
[1] | The condensed consolidated balance sheet at December 31, 2017 has been derived from the audited financial statements at that date.

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 + Details
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