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License agreements - Agenus (Details) $ / shares in Units, $ in Thousands, shares in Millions |  |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended
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Feb. 14, 2017 USD ($) $ / shares | Feb. 01, 2017 USD ($) $ / shares shares | Feb. 28, 2017 USD ($) | Nov. 30, 2015 item | Feb. 28, 2015 | Jan. 31, 2015 item | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Jun. 30, 2017 USD ($) | Jun. 30, 2018 USD ($) | Jun. 30, 2017 USD ($) | Dec. 31, 2017 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  |  |  | $ 131,330 |  |  | $ 131,330 |  | $ 134,356 | [1]
Research and development expense |  |  |  |  |  |  | 298,089 |  | $ 201,786 | 601,192 | $ 609,706 |  |
Unrealized (gain) loss on long term investments |  |  |  |  |  |  | (34,641) |  | (19,574) | (11,962) | (25,388) |  |
Cash and cash equivalents |  |  |  |  |  |  | 928,517 |  |  | $ 928,517 |  | 899,509 | [1]
Agenus |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Number of program targets | item |  |  |  | 3 |  | 4 |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  | 15.00% |  |  |
Period of notice for termination of license agreement |  |  | 12 months |  |  |  |  |  |  |  |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  | 6.00% |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  |  |  | 12.00% |  |  |
Additional milestone payments under the license agreement |  |  | $ 510,000 |  |  |  |  |  |  |  |  |  |
Agenus | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment under license agreement |  |  |  |  |  |  |  |  |  |  |  | 20,000 |
Additional milestone payments under the license agreement |  |  |  |  |  |  | 5,000 |  |  | $ 5,000 |  |  |
Agenus |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  |  |  | 40,300 |  |  | 40,300 |  | 57,900 |
Research and development expense |  |  |  |  |  |  | $ 900 |  | 11,200 | $ 2,800 | 18,900 |  |
Shares owned following stock purchase (as a percent) |  |  | 11.00% |  | 9.00% |  |  |  |  |  |  |  |
Ownership percentage (as a percent) |  |  |  |  |  |  | 17.00% |  |  | 17.00% |  |  |
Unrealized (gain) loss on long term investments |  |  |  |  |  |  | $ (43,300) |  | 4,400 | $ (17,600) | (3,300) |  |
Total revenues |  |  |  |  |  |  |  | $ 1,600 |  |  |  |  |
Net income (loss) |  |  |  |  |  |  |  | 54,300 |  |  |  |  |
Cash and cash equivalents |  |  |  |  |  |  |  | 52,300 |  |  |  |  |
Operating expenses |  |  |  |  |  |  |  | $ 43,400 |  |  |  |  |
Agenus | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  |  |  | $ 900 |  |  | $ 900 |  | $ 3,200 |
Agenus | Stock purchase agreement |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  | 10.0 |  |  |  |  |  |  |  |  |  |  |
Purchase price of common stock |  | $ 60,000 |  |  |  |  |  |  |  |  |  |  |
Per share price | $ / shares | $ 4.40 | $ 6.00 |  |  |  |  |  |  |  |  |  |  |
Discount for lack of marketability | $ 4,500 |  |  |  |  |  |  |  |  |  |  |  |
Fair value of shares on the issuance date | 39,500 |  |  |  |  |  |  |  |  |  |  |  |
Total consideration paid | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  |  |  |  |  | $ 39,500 |  | 39,500 |  |
Research and development expense |  |  |  |  |  |  |  |  |  |  | $ 20,500 |  |
[1] | The condensed consolidated balance sheet at December 31, 2017 has been derived from the audited financial statements at that date.

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