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License agreements - Novartis (Details) $ in Millions | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended | 104 Months Ended
--- | --- | --- | --- | --- | ---
Apr. 30, 2016 USD ($) | Sep. 30, 2014 USD ($) | Jan. 31, 2010 USD ($) | Dec. 31, 2009 USD ($) | Nov. 30, 2009 USD ($) item | Jun. 30, 2018 USD ($) | Jun. 30, 2017 USD ($) | Jun. 30, 2018 USD ($) | Jun. 30, 2017 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Dec. 31, 2013 USD ($) | Dec. 31, 2012 USD ($) | Dec. 31, 2011 USD ($) | Dec. 31, 2010 USD ($) | Jun. 30, 2018 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | $ 521.5 |  | $ 903.8 |  |  |  |  |  |  |  |  |  |
Milestone revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 100.0 |  | 100.0 |  |  |  |  |  |  |  |  |  |
Novartis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | $ 210.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received under license agreement |  |  |  | $ 150.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Immediate milestone payment received under license agreement |  |  | $ 60.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of deliverables under license agreement | item |  |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |
Reimbursable costs recorded as deferred revenue |  |  |  | $ 10.9 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reimbursable costs included in accounts receivable |  |  |  |  |  | 1.3 |  | 1.3 |  | $ 1.6 |  |  |  |  |  |  |  | $ 1.3
Research and development expenses reimbursed |  |  |  |  |  | 0.7 | $ 0.8 | 1.2 | $ 1.5 |  |  |  |  |  |  |  |  |
Product royalties in accounts receivable |  |  |  |  |  | 47.1 |  | 47.1 |  | 47.7 |  |  |  |  |  |  |  | 47.1
Novartis | Pre-specified Events | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | $ 1,200.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 132.0
Novartis | Development Milestones | Phase III |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50.0 |
Novartis | Development Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | 174.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 215.0
Novartis | Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | 495.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 60.0
Novartis | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | $ 500.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | LY3009104 | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  | $ 5.0 | $ 7.0 | $ 25.0 |  | $ 15.0 |  |
Novartis | GVHD | Development Milestones | Phase III |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  | 25.0 |  |  |  |  |  |  |  |
Novartis | GVHD | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 75.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | GVHD | Development and Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  | $ 5.0 |  |  |  |  |  |  |
Novartis | JAKAFI | U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalties payable on net sales |  |  |  |  |  | 16.9 | 13.0 | 27.3 | 20.8 |  |  |  |  |  |  |  |  |
Novartis | JAKAFI | Regulatory Milestones | Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  | $ 40.0 | 25.0 | 60.0 |  | $ 40.0 |  |  |
Novartis | JAKAFI | Regulatory Milestones | JAPAN |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  | $ 25.0 |  |  |  |  |
Novartis | JAKAFI | Regulatory Milestones | U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10.0 |  |
Novartis | JAKAVI |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 47.1 | 33.9 | $ 88.4 | 62.7 |  |  |  |  |  |  |  |  |
Novartis | JAKAVI | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  | 12.00% |  |  |  |  |  |  |  |  |  |
Novartis | JAKAVI | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  |  | 14.00% |  |  |  |  |  |  |  |  |  |
Novartis | JAKAVI | Regulatory Milestones | Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  | $ 60.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | JAKAVI | Regulatory Milestones | JAPAN |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  | 15.0 |  |  |  |  |  |
Novartis | JAKAVI | Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  | 40.0 |  | 20.0 |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  | $ 600.0 |  | $ 300.0 |  |  |  |  |  |
Novartis | Milestone revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | $ 0.0 | $ 0.0 | $ 0.0 | $ 25.0 |  |  |  |  |  |  |  |  |

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