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Fair value of financial instruments - Rollforward of Level 3 liabilities (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Rollforward of Level 3 liabilities
Change in fair value of contingent consideration	$ 7,303	$ 7,073	$ 13,988	$ 14,429
ARIAD Pharmaceuticals
Rollforward of Level 3 liabilities
Contingent consideration earned during the period but not yet paid	(6,300)
Payments made during the period	(6,700)
Fair Value | Level 3
Rollforward of Level 3 liabilities
Balance at beginning of period			287,000
Contingent consideration earned during the period but not yet paid			(6,303)
Payments made during the period			(6,685)
Change in fair value of contingent consideration			13,988
Balance at end of period	$ 288,000		$ 288,000

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- Definition

Amount of decrease in the value of a contingent consideration liability attributable to consideration earned by the acquiree in a business combination.

+ References

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- Definition

Amount of increase (decrease) in the value of a contingent consideration liability, including, but not limited to, differences arising upon settlement.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 30
-Section 50
-Paragraph 4
-Subparagraph (a)(1)
-URI http://asc.fasb.org/extlink&oid=35744584&loc=d3e7008-128479

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- Definition

Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(2)
-URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258

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- Definition

Fair value of financial obligations, including, but not limited to, debt instruments, derivative liabilities, federal funds purchased and sold under agreements to repurchase, securities loaned or sold under agreements to repurchase, financial instruments sold not yet purchased, guarantees, line of credit, loans and notes payable, servicing liability, and trading liabilities.

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