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Property and equipment, net - Property and equipment, net (Details) - USD ($) $ in Thousands	Jun. 30, 2018	Dec. 31, 2017
Property and equipment, net
Property and Equipment, gross	$ 355,374	$ 334,427
Less accumulated depreciation and amortization	(87,788)	(74,664)
Property and Equipment, net	267,586	259,763	[1]
Office equipment
Property and equipment, net
Property and Equipment, gross	16,361	14,674
Laboratory equipment
Property and equipment, net
Property and Equipment, gross	57,409	48,807
Computer equipment
Property and equipment, net
Property and Equipment, gross	54,191	51,351
Land
Property and equipment, net
Property and Equipment, gross	5,350	5,350
Building and leasehold improvements
Property and equipment, net
Property and Equipment, gross	$ 222,063	$ 214,245
[1] The condensed consolidated balance sheet at December 31, 2017 has been derived from the audited financial statements at that date.

X

- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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