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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017
Revenues: |  |  |  |
Total revenues | $ 449,683 | $ 381,534 | $ 1,353,481 | $ 1,092,060
Costs and expenses: |  |  |  |
Cost of product revenues (including definite-lived intangible amortization) | 24,795 | 22,036 | 67,757 | 57,120
Research and development | 292,527 | 269,557 | 893,719 | 879,263
Selling, general and administrative | 96,522 | 91,265 | 326,049 | 268,560
Change in fair value of acquisition-related contingent consideration | 4,720 | (16,343) | 18,708 | (1,914)
Total costs and expenses | 418,564 | 366,515 | 1,306,233 | 1,203,029
Income (loss) from operations | 31,119 | 15,019 | 47,248 | (110,969)
Other income (expense), net | 10,211 | 5,494 | 20,481 | 10,707
Interest expense | (405) | (204) | (1,188) | (6,527)
Unrealized gain (loss) on long term investments | (9,949) | 23,045 | (21,911) | (2,343)
Expense related to senior note conversions |  |  |  | (54,881)
Income (loss) before provision (benefit) for income taxes | 30,976 | 43,354 | 44,630 | (164,013)
Provision (benefit) for income taxes | 1,800 | 7,300 | 4,200 | (500)
Net income (loss) | $ 29,176 | $ 36,054 | $ 40,430 | $ (163,513)
Net income (loss) per share: |  |  |  |
Basic | $ 0.14 | $ 0.17 | $ 0.19 | $ (0.81)
Diluted | $ 0.14 | $ 0.17 | $ 0.19 | $ (0.81)
Shares used in computing net income (loss) per share: |  |  |  |
Basic | 212,627 | 206,796 | 212,172 | 202,399
Diluted | 215,964 | 212,610 | 215,516 | 202,399
Product revenues, net |  |  |  |
Revenues: |  |  |  |
Total revenues | $ 367,715 | $ 322,029 | $ 1,067,744 | $ 878,503
Product royalty revenues |  |  |  |
Revenues: |  |  |  |
Total revenues | 61,923 | 44,487 | 165,592 | 108,477
Milestone revenues |  |  |  |
Revenues: |  |  |  |
Total revenues | 20,000 | 15,000 | 120,000 | 105,000
Other revenues |  |  |  |
Revenues: |  |  |  |
Total revenues | $ 45 | $ 18 | $ 145 | $ 80

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