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Fair value of financial instruments - Rollforward of Level 3 liabilities (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017 | Dec. 31, 2017
Rollforward of Level 3 liabilities |  |  |  |  |
Change in fair value of contingent consideration | $ 4,720 | $ (16,343) | $ 18,708 | $ (1,914) |
ARIAD Pharmaceuticals |  |  |  |  |
Rollforward of Level 3 liabilities |  |  |  |  |
Contingent consideration earned during the period but not yet paid | (6,700) |  | (6,300) |  | $ (6,600)
Fair Value | Level 3 |  |  |  |  |
Rollforward of Level 3 liabilities |  |  |  |  |
Balance at beginning of period |  |  | 287,000 |  |
Contingent consideration earned during the period but not yet paid |  |  | (13,023) |  |
Payments made during the period |  |  | (6,685) |  |
Change in fair value of contingent consideration |  |  | 18,708 |  |
Balance at end of period | $ 286,000 |  | $ 286,000 |  | $ 287,000

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- Definition Amount of increase (decrease) in the value of a contingent consideration liability, including, but not limited to, differences arising upon settlement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 30 -Section 50 -Paragraph 4 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=35744584&loc=d3e7008-128479 + Details
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- Definition Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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- Definition Fair value of financial obligations, including, but not limited to, debt instruments, derivative liabilities, federal funds purchased and sold under agreements to repurchase, securities loaned or sold under agreements to repurchase, financial instruments sold not yet purchased, guarantees, line of credit, loans and notes payable, servicing liability, and trading liabilities. + References No definition available. + Details
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