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License agreements - Lilly (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 106 Months Ended
--- | --- | --- | --- | --- | ---
Mar. 31, 2016 USD ($) | Jul. 31, 2010 | Dec. 31, 2009 USD ($) item | Sep. 30, 2018 USD ($) | Sep. 30, 2017 USD ($) | Sep. 30, 2018 USD ($) | Sep. 30, 2017 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2012 USD ($) | Dec. 31, 2010 USD ($) | Sep. 30, 2018 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Expense |  |  |  | $ 292,527 | $ 269,557 | $ 893,719 | $ 879,263 |  |  |  |  |
Revenues |  |  |  | 449,700 |  | 1,353,500 |  |  |  |  |  |
Milestone revenues |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  | 20,000 |  | 120,000 |  |  |  |  |  |
Product royalty revenues |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  | 61,900 |  | 165,600 |  |  |  |  |  |
Eli Lilly |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received under license agreement |  |  | $ 90,000 |  |  |  |  |  |  |  |  |
Research and Development Expense |  |  |  | 18,900 | 9,100 | 45,600 | 27,200 |  |  |  |  |
Number of deliverables under license agreement | item |  |  | 2 |  |  |  |  |  |  |  |  |
Product royalties in accounts receivable |  |  |  | $ 11,100 |  | $ 11,100 |  | $ 4,600 |  |  |  | $ 11,100
Eli Lilly | Maximum |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Associated future royalty payments from the initiation of a Phase IIb trial, if elected to not co-develop, percentage |  |  |  |  |  | 20.00% |  |  |  |  |  |
Eli Lilly | Phase IIB |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  | 30.00% |  | 30.00% |  | 30.00% |  |  |  |  |  |
Eli Lilly | Pre-specified Events | Maximum |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | $ 665,000 |  |  |  |  |  |  |  |  |
Eli Lilly | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | $ 20,000 |  | 30,000 |  |  |  | 149,000
Eli Lilly | Development Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | 150,000 |  |  |  |  |  |  |  |  |
Eli Lilly | Development Milestones | Phase III |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  | $ 50,000 |  |
Eli Lilly | Development Milestones | Phase IIA |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  | $ 30,000 |
Eli Lilly | Development Milestones | Phase IIB |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  | $ 19,000 |
Eli Lilly | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  | 100,000 |  |  |  |  |  | $ 235,000
Eli Lilly | Regulatory Milestones | JAPAN |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | 15,000 |  |  |  |
Eli Lilly | Regulatory Milestones | U.S. |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  | $ 35,000 |  |  |
Eli Lilly | Regulatory Milestones | Europe |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | $ 65,000 | $ 20,000 |  |  |
Eli Lilly | Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | 365,000 |  |  |  |  |  |  |  |  |
Eli Lilly | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | $ 150,000 |  |  |  |  |  |  |  |  |
Eli Lilly | GVHD |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment under license agreement | $ 35,000 |  |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement | $ 40,000 |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | Milestone revenues |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  | $ 20,000 | 15,000 | 120,000 | 80,000 |  |  |  |  |
Eli Lilly | Product royalty revenues |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  | $ 11,000 | $ 3,200 | $ 26,200 | $ 4,500 |  |  |  |  |

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