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Stockholders’ Equity - Stock options outstanding (Details) | 12 Months Ended
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Dec. 31, 2018 $ / shares shares
Options Outstanding |
Number Outstanding (in shares) | shares | 12,285,159
Options Exercisable |
Number Exercisable (in shares) | shares | 7,194,171
Range of Exercise Prices $2.80 - $17.79 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | $ 2.80
Exercise price, upper range limit (in dollars per share) | $ 17.79
Options Outstanding |
Number Outstanding (in shares) | shares | 588,741
Weighted Average Remaining Contractual Life | 3 months 22 days
Weighted Average Exercise Price (in dollars per share) | $ 16.48
Options Exercisable |
Number Exercisable (in shares) | shares | 588,741
Weighted Average Exercise Price (in dollars per share) | $ 16.48
Range of Exercise Prices $17.89 - $18.32 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | 17.89
Exercise price, upper range limit (in dollars per share) | $ 18.32
Options Outstanding |
Number Outstanding (in shares) | shares | 1,474,120
Weighted Average Remaining Contractual Life | 1 year 1 month 2 days
Weighted Average Exercise Price (in dollars per share) | $ 18.31
Options Exercisable |
Number Exercisable (in shares) | shares | 1,474,120
Weighted Average Exercise Price (in dollars per share) | $ 18.31
Range of Exercise Prices $18.97 - $64.55 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | 18.97
Exercise price, upper range limit (in dollars per share) | $ 64.55
Options Outstanding |
Number Outstanding (in shares) | shares | 1,652,452
Weighted Average Remaining Contractual Life | 3 years 1 month 13 days
Weighted Average Exercise Price (in dollars per share) | $ 49.41
Options Exercisable |
Number Exercisable (in shares) | shares | 1,439,924
Weighted Average Exercise Price (in dollars per share) | $ 47.60
Range of Exercise Prices $65.36 - $68.40 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | 65.36
Exercise price, upper range limit (in dollars per share) | $ 68.40
Options Outstanding |
Number Outstanding (in shares) | shares | 142,566
Weighted Average Remaining Contractual Life | 8 years 8 months 12 days
Weighted Average Exercise Price (in dollars per share) | $ 66.34
Options Exercisable |
Number Exercisable (in shares) | shares | 19,555
Weighted Average Exercise Price (in dollars per share) | $ 67.39
Range of Exercise Prices $68.62 - $68.62 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | 68.62
Exercise price, upper range limit (in dollars per share) | $ 68.62
Options Outstanding |
Number Outstanding (in shares) | shares | 1,426,578
Weighted Average Remaining Contractual Life | 9 years 4 months 21 days
Weighted Average Exercise Price (in dollars per share) | $ 68.62
Range of Exercise Prices $68.82 - $81.16 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | 68.82
Exercise price, upper range limit (in dollars per share) | $ 81.16
Options Outstanding |
Number Outstanding (in shares) | shares | 1,234,047
Weighted Average Remaining Contractual Life | 4 years 2 months 27 days
Weighted Average Exercise Price (in dollars per share) | $ 73.59
Options Exercisable |
Number Exercisable (in shares) | shares | 892,781
Weighted Average Exercise Price (in dollars per share) | $ 73.69
Range of Exercise Prices $83.83 - $94.63 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | 83.83
Exercise price, upper range limit (in dollars per share) | $ 94.63
Options Outstanding |
Number Outstanding (in shares) | shares | 1,701,957
Weighted Average Remaining Contractual Life | 7 years 8 months 23 days
Weighted Average Exercise Price (in dollars per share) | $ 88.55
Options Exercisable |
Number Exercisable (in shares) | shares | 894,810
Weighted Average Exercise Price (in dollars per share) | $ 87.36
Range of Exercise Prices $95.34 - $95.76 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | 95.34
Exercise price, upper range limit (in dollars per share) | $ 95.76
Options Outstanding |
Number Outstanding (in shares) | shares | 1,578,529
Weighted Average Remaining Contractual Life | 6 years 1 month 2 days
Weighted Average Exercise Price (in dollars per share) | $ 95.62
Options Exercisable |
Number Exercisable (in shares) | shares | 780,898
Weighted Average Exercise Price (in dollars per share) | $ 95.76
Range of Exercise Prices $100.81 - $113.64 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | 100.81
Exercise price, upper range limit (in dollars per share) | $ 113.64
Options Outstanding |
Number Outstanding (in shares) | shares | 1,462,739
Weighted Average Remaining Contractual Life | 7 years 7 months 17 days
Weighted Average Exercise Price (in dollars per share) | $ 112.39
Options Exercisable |
Number Exercisable (in shares) | shares | 636,592
Weighted Average Exercise Price (in dollars per share) | $ 111.63
Range of Exercise Prices $115.19 - $138.52 |
Stock options outstanding |
Exercise price, lower range limit (in dollars per share) | 115.19
Exercise price, upper range limit (in dollars per share) | $ 138.52
Options Outstanding |
Number Outstanding (in shares) | shares | 1,023,430
Weighted Average Remaining Contractual Life | 8 years 1 month 2 days
Weighted Average Exercise Price (in dollars per share) | $ 128.30
Options Exercisable |
Number Exercisable (in shares) | shares | 466,750
Weighted Average Exercise Price (in dollars per share) | $ 128.88

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