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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Cash flows from operating activities: |  |  |
Net income (loss) | $ 109,493 | $ (313,142) | $ 104,222
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: |  |  |
Depreciation and amortization | 54,969 | 52,178 | 58,425
In-process research and development impairment |  | 12,000 |
Stock-based compensation | 148,153 | 133,055 | 96,201
Expense related to senior note conversions |  | 54,881 |
Deferred income taxes | (459) |  |
Other, net | 344 | 290 | 472
Unrealized loss on long term investments | 44,093 | 24,275 | 3,261
Change in fair value of acquisition-related contingent consideration | 26,173 | 7,704 | 17,422
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (41,299) | (117,541) | (23,947)
Prepaid expenses and other assets | (33,412) | (31,367) | (13,069)
Inventory | 4,043 | 4,851 | 4,047
Accounts payable | 36,156 | (7,928) | 43,758
Accrued and other liabilities | (12,027) | 87,756 | 26,476
Deferred revenue-collaborative agreements |  |  | (12,512)
Net cash provided by (used in) operating activities | 336,227 | (92,988) | 304,756
Cash flows from investing activities: |  |  |
Acquisition of business, net of cash acquired |  |  | (142,856)
Purchase of long term investments | (8,936) | (123,891) |
Capital expenditures | (73,483) | (111,021) | (120,277)
Purchases of marketable securities | (159,932) | (260,780) | (57,372)
Sale and maturities of marketable securities | 155,928 | 145,714 | 88,017
Net cash used in investing activities | (86,423) | (349,978) | (232,488)
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock under stock plans | 29,942 | 66,764 | 49,973
Proceeds from issuance of common stock, net |  | 649,387 |
Cash paid in connection with senior note conversions |  | (8,934) |
Direct financing arrangements repayments |  |  | (445)
Payment of contingent consideration | (15,285) | (17,007) | (4,906)
Net cash provided by financing activities | 14,657 | 690,210 | 44,622
Effect of exchange rates on cash, cash equivalents, restricted cash and investments | 91 | (39) | (9)
Net increase in cash, cash equivalents, restricted cash and investments | 264,552 | 247,205 | 116,881
Cash, cash equivalents, restricted cash and investments at beginning of period | 900,434 | 653,229 | 536,348
Cash, cash equivalents, restricted cash and investments at end of period | 1,164,986 | 900,434 | 653,229
Supplemental Schedule of Cash Flow Information |  |  |
Interest paid | 268 | 314 | 7,218
Income taxes paid | 5,417 | 6,305 | 927
Unpaid purchases of property and equipment | 7,673 | 5,643 | 10,989
Convertible Senior Notes 0.375 Percent Due 2018 |  |  |
Supplemental Schedule of Cash Flow Information |  |  |
Reclassification to common stock and additional paid in capital in connection with conversions or exchange of convertible senior notes | $ 7,695 | 351,044 | 5
Convertible Senior Notes 1.25 Percent Due 2020 |  |  |
Supplemental Schedule of Cash Flow Information |  |  |
Reclassification to common stock and additional paid in capital in connection with conversions or exchange of convertible senior notes |  | $ 330,011 | $ 4

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