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Income Taxes - Reconciliation of income taxes (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes |  |  |
Provision (benefit) at U.S. federal statutory rate | $ 24,223 | $ (109,302) | $ 37,591
Unbenefited net operating losses and tax credits | (51,861) | (99,254) | (47,410)
Excess tax benefits related to share-based compensation | (8,233) | (81,021) | (29,541)
Deferred tax impact of Tax Cuts and Jobs Act of 2017 |  | 196,751 |
Foreign tax rate differential | 37,061 | 86,777 | 39,975
Non-deductible officer compensation | 4,114 | 6,351 | 2,061
Other | 550 | 550 | 506
Provision (benefit) for income taxes | $ 5,854 | $ 852 | $ 3,182
Federal corporate tax rate (as a percent) | 21.00% | 35.00% |
Deferred tax assets: |  |  |
Net operating loss carry forwards | $ 148,142 | $ 259,189 |
Federal and state research credits | 402,798 | 333,311 |
Capitalized research and development | 53,871 | 37,044 |
Deferred revenue and accruals | 9,443 | 11,721 |
Non-cash compensation | 58,194 | 44,647 |
Acquisition-related contingent consideration | 43,676 | 41,831 |
Intangibles, net | 93,730 | 94,249 |
Long term investments | 23,621 | 12,244 |
Other | 22,211 | 12,815 |
Total gross deferred tax assets | 855,686 | 847,051 |
Less valuation allowance for deferred tax assets | (836,992) | (834,783) |
Net deferred tax assets | 18,694 | 12,268 |
Deferred tax liabilities: |  |  |
Property and equipment | (17,424) | (11,463) |
Total gross deferred tax liabilities | (17,424) | (11,463) |
Net deferred income taxes | $ 1,270 | $ 805 |

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