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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenues:      
Total revenues $ 1,881,883 $ 1,536,216 $ 1,105,719
Costs and expenses:      
Cost of product revenues (including definite-lived intangible amortization) 94,123 79,479 58,187
Research and development 1,197,957 1,326,134 581,861
Selling, general and administrative 434,407 366,286 303,251
Change in fair value of acquisition-related contingent consideration 26,173 7,704 17,422
Total costs and expenses 1,752,660 1,779,603 960,721
Income (loss) from operations 129,223 (243,387) 144,998
Other income (expense), net 31,760 17,153 4,412
Interest expense (1,543) (6,900) (38,745)
Unrealized loss on long term investments (44,093) (24,275) (3,261)
Expense related to senior note conversions   (54,881)  
Income (loss) before provision for income taxes 115,347 (312,290) 107,404
Provision for income taxes 5,854 852 3,182
Net income (loss) $ 109,493 $ (313,142) $ 104,222
Net income (loss) per share:      
Basic $ 0.52 $ (1.53) $ 0.55
Diluted $ 0.51 $ (1.53) $ 0.54
Shares used in computing net income (loss) per share:      
Basic 212,383,000 204,580,000 187,873,000
Diluted 215,635,000 204,580,000 194,125,000
Product revenues, net      
Revenues:      
Total revenues $ 1,466,900 $ 1,200,312 $ 882,404
Product royalty revenues      
Revenues:      
Total revenues 234,780 160,791 110,711
Milestone and contract revenues      
Revenues:      
Total revenues 180,000 175,000 112,512
Other revenues      
Revenues:      
Total revenues $ 203 $ 113 $ 92