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Organization and Summary of Significant Accounting Policies (Details)
$ in Thousands
3 Months Ended 12 Months Ended
Sep. 30, 2017
USD ($)
Dec. 31, 2018
USD ($)
item
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Jan. 01, 2018
USD ($)
Organization and Business          
Number of operating segments | item   1      
Concentrations of Credit Risk          
Number of issuer to which company limits the amount of credit exposure other than US Government guaranteed securities | item   1      
Number of financial investment to which company limits the amount of credit exposure other than US Government guaranteed securities | item   1      
Impairment of Long-Lived Assets          
Write-off of the acquired IPR&D $ 12,000   $ 12,000    
Revenue Recognition          
Accrued sales allowances   $ 44,800 34,700    
Percentage of Medicare Part D insurance coverage gap mandate to be funded by manufacturers   50.00%      
Research and development expense   $ 1,197,957 1,326,134 $ 581,861  
Accrued research and development costs   98,600 $ 110,000    
ASU No. 2016-02          
Recent Accounting Pronouncements          
Financing lease right-of-use assets   26,000      
Financing liability   $ 18,700      
Calithera | ASU 2016-01          
Recent Accounting Pronouncements          
Decrease in accumulated deficit         $ 2,800
JAKAFI          
Inventory          
Shelf life for finished goods inventory, maximum   36 months      
ICLUSIG          
Inventory          
Shelf life for finished goods inventory, maximum   24 months      
ICLUSIG | Licensed IP          
Revenue Recognition          
Amortization period   12 years 6 months