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Marketable Securities - Fair value on a recurring basis (Details) - USD ($) $ in Thousands	3 Months Ended			12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Sep. 30, 2017	Dec. 31, 2018	Dec. 31, 2017	Jun. 01, 2016
Fair value of financial instruments
Assets transfers from Level 1 to Level 2	$ 0			$ 0
Assets transfers from Level 2 to Level 1	0			0
Assets transfers into Level 3				0
Assets transfers out of Level 3				0
Liabilities transfers from Level 1 to Level 2	0			0
Liabilities transfers from Level 2 to Level 1	0			0
Liabilities transfers into Level 3				0
Liabilities transfers out of Level 3				0
Long term investments	99,199			99,199	$ 134,356
ARIAD
Fair value of financial instruments
Acquisition-related contingent consideration						$ 293,000
Roll forward of Level 3 liabilities
Contingent consideration earned during the period but not yet paid				13,200
ARIAD | Account payable
Roll forward of Level 3 liabilities
Contingent consideration earned during the period but not yet paid		$ (6,700)
ARIAD | Accrued and other current liabilities
Roll forward of Level 3 liabilities
Contingent consideration earned during the period but not yet paid	(6,500)				(6,600)
Level 3
Fair value of financial instruments
Lack of expected future sales royalties payable			$ 24,000
Level 3 | Fair Value
Roll forward of Level 3 liabilities
Balance at the beginning of the period				287,000	301,000
Contingent consideration earned during the period but not yet paid				(13,184)	(6,618)
Payments made during the period				(12,988)	(15,086)
Change in fair value of contingent consideration				26,173	7,704
Balance at the end of the period	287,001			287,001	287,000
Recurring | Fair Value
Fair value of financial instruments
Cash and cash equivalents	1,163,980			1,163,980	899,509
Debt securities (corporate and government)	274,343			274,343	270,136
Long term investments	99,199			99,199	134,356
Total assets	1,537,522			1,537,522	1,304,001
Acquisition-related contingent consideration	287,001			287,001	287,000
Total liabilities	287,001			287,001	287,000
Recurring | Level 1
Fair value of financial instruments
Cash and cash equivalents	1,163,980			1,163,980	899,509
Long term investments	99,199			99,199	134,356
Total assets	1,263,179			1,263,179	1,033,865
Recurring | Level 2
Fair value of financial instruments
Debt securities (corporate and government)	274,343			274,343	270,136
Total assets	274,343			274,343	270,136
Recurring | Level 3
Fair value of financial instruments
Acquisition-related contingent consideration	287,001			287,001	287,000
Total liabilities	$ 287,001			$ 287,001	$ 287,000

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