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Property and Equipment - Property and equipment, net (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Property and equipment, net
Property and Equipment, gross	$ 422,982	$ 334,427
Less accumulated depreciation and amortization	(103,231)	(74,664)
Property and Equipment, net	319,751	259,763
Depreciation expense including amortization expense of leasehold improvements	32,300	24,600	$ 14,200
Office equipment
Property and equipment, net
Property and Equipment, gross	16,955	14,665
Laboratory equipment
Property and equipment, net
Property and Equipment, gross	61,697	45,048
Computer equipment
Property and equipment, net
Property and Equipment, gross	55,436	48,733
Land
Property and equipment, net
Property and Equipment, gross	10,122	5,350
Building and leasehold improvements
Property and equipment, net
Property and Equipment, gross	213,196	209,260
Construction in Progress
Property and equipment, net
Property and Equipment, gross	$ 65,576	$ 11,371

X

- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 360
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
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-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.14)
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- Definition

The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
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+ References

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