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Stockholders’ Equity - Stock options outstanding (Details)	12 Months Ended
	Dec. 31, 2018 $ / shares shares
Options Outstanding
Number Outstanding (in shares) | shares	12,285,159
Options Exercisable
Number Exercisable (in shares) | shares	7,194,171
Range of Exercise Prices $2.80 - $17.79
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	$ 2.80
Exercise price, upper range limit (in dollars per share)	$ 17.79
Options Outstanding
Number Outstanding (in shares) | shares	588,741
Weighted Average Remaining Contractual Life	3 months 22 days
Weighted Average Exercise Price (in dollars per share)	$ 16.48
Options Exercisable
Number Exercisable (in shares) | shares	588,741
Weighted Average Exercise Price (in dollars per share)	$ 16.48
Range of Exercise Prices $17.89 - $18.32
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	17.89
Exercise price, upper range limit (in dollars per share)	$ 18.32
Options Outstanding
Number Outstanding (in shares) | shares	1,474,120
Weighted Average Remaining Contractual Life	1 year 1 month 2 days
Weighted Average Exercise Price (in dollars per share)	$ 18.31
Options Exercisable
Number Exercisable (in shares) | shares	1,474,120
Weighted Average Exercise Price (in dollars per share)	$ 18.31
Range of Exercise Prices $18.97 - $64.55
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	18.97
Exercise price, upper range limit (in dollars per share)	$ 64.55
Options Outstanding
Number Outstanding (in shares) | shares	1,652,452
Weighted Average Remaining Contractual Life	3 years 1 month 13 days
Weighted Average Exercise Price (in dollars per share)	$ 49.41
Options Exercisable
Number Exercisable (in shares) | shares	1,439,924
Weighted Average Exercise Price (in dollars per share)	$ 47.60
Range of Exercise Prices $65.36 - $68.40
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	65.36
Exercise price, upper range limit (in dollars per share)	$ 68.40
Options Outstanding
Number Outstanding (in shares) | shares	142,566
Weighted Average Remaining Contractual Life	8 years 8 months 12 days
Weighted Average Exercise Price (in dollars per share)	$ 66.34
Options Exercisable
Number Exercisable (in shares) | shares	19,555
Weighted Average Exercise Price (in dollars per share)	$ 67.39
Range of Exercise Prices $68.62 - $68.62
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	68.62
Exercise price, upper range limit (in dollars per share)	$ 68.62
Options Outstanding
Number Outstanding (in shares) | shares	1,426,578
Weighted Average Remaining Contractual Life	9 years 4 months 21 days
Weighted Average Exercise Price (in dollars per share)	$ 68.62
Range of Exercise Prices $68.82 - $81.16
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	68.82
Exercise price, upper range limit (in dollars per share)	$ 81.16
Options Outstanding
Number Outstanding (in shares) | shares	1,234,047
Weighted Average Remaining Contractual Life	4 years 2 months 27 days
Weighted Average Exercise Price (in dollars per share)	$ 73.59
Options Exercisable
Number Exercisable (in shares) | shares	892,781
Weighted Average Exercise Price (in dollars per share)	$ 73.69
Range of Exercise Prices $83.83 - $94.63
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	83.83
Exercise price, upper range limit (in dollars per share)	$ 94.63
Options Outstanding
Number Outstanding (in shares) | shares	1,701,957
Weighted Average Remaining Contractual Life	7 years 8 months 23 days
Weighted Average Exercise Price (in dollars per share)	$ 88.55
Options Exercisable
Number Exercisable (in shares) | shares	894,810
Weighted Average Exercise Price (in dollars per share)	$ 87.36
Range of Exercise Prices $95.34 - $95.76
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	95.34
Exercise price, upper range limit (in dollars per share)	$ 95.76
Options Outstanding
Number Outstanding (in shares) | shares	1,578,529
Weighted Average Remaining Contractual Life	6 years 1 month 2 days
Weighted Average Exercise Price (in dollars per share)	$ 95.62
Options Exercisable
Number Exercisable (in shares) | shares	780,898
Weighted Average Exercise Price (in dollars per share)	$ 95.76
Range of Exercise Prices $100.81 - $113.64
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	100.81
Exercise price, upper range limit (in dollars per share)	$ 113.64
Options Outstanding
Number Outstanding (in shares) | shares	1,462,739
Weighted Average Remaining Contractual Life	7 years 7 months 17 days
Weighted Average Exercise Price (in dollars per share)	$ 112.39
Options Exercisable
Number Exercisable (in shares) | shares	636,592
Weighted Average Exercise Price (in dollars per share)	$ 111.63
Range of Exercise Prices $115.19 - $138.52
Stock options outstanding
Exercise price, lower range limit (in dollars per share)	115.19
Exercise price, upper range limit (in dollars per share)	$ 138.52
Options Outstanding
Number Outstanding (in shares) | shares	1,023,430
Weighted Average Remaining Contractual Life	8 years 1 month 2 days
Weighted Average Exercise Price (in dollars per share)	$ 128.30
Options Exercisable
Number Exercisable (in shares) | shares	466,750
Weighted Average Exercise Price (in dollars per share)	$ 128.88

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The floor of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.

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Weighted average remaining contractual term of outstanding stock options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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