XML 94 R80.htm IDEA: XBRL DOCUMENT v3.10.0.1
Income Taxes - Reconciliation of income taxes (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes      
Provision (benefit) at U.S. federal statutory rate $ 24,223 $ (109,302) $ 37,591
Unbenefited net operating losses and tax credits (51,861) (99,254) (47,410)
Excess tax benefits related to share-based compensation (8,233) (81,021) (29,541)
Deferred tax impact of Tax Cuts and Jobs Act of 2017   196,751  
Foreign tax rate differential 37,061 86,777 39,975
Non-deductible officer compensation 4,114 6,351 2,061
Other 550 550 506
Provision (benefit) for income taxes $ 5,854 $ 852 $ 3,182
Federal corporate tax rate (as a percent) 21.00% 35.00%  
Deferred tax assets:      
Net operating loss carry forwards $ 148,142 $ 259,189  
Federal and state research credits 402,798 333,311  
Capitalized research and development 53,871 37,044  
Deferred revenue and accruals 9,443 11,721  
Non-cash compensation 58,194 44,647  
Acquisition-related contingent consideration 43,676 41,831  
Intangibles, net 93,730 94,249  
Long term investments 23,621 12,244  
Other 22,211 12,815  
Total gross deferred tax assets 855,686 847,051  
Less valuation allowance for deferred tax assets (836,992) (834,783)  
Net deferred tax assets 18,694 12,268  
Deferred tax liabilities:      
Property and equipment (17,424) (11,463)  
Total gross deferred tax liabilities (17,424) (11,463)  
Net deferred income taxes $ 1,270 $ 805