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Interim Consolidated Financial Information (Unaudited) - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Interim Consolidated Financial Information (Unaudited)
Revenues	$ 528,402	$ 449,683	$ 521,516	$ 382,282	$ 444,156	$ 381,534	$ 326,444	$ 384,082	$ 1,881,883
Product revenues, net
Interim Consolidated Financial Information (Unaudited)
Revenues	399,200	367,700	365,500	334,500	321,800	322,000	291,700	264,800	1,466,900	$ 1,200,312	$ 882,404
Product royalty revenues
Interim Consolidated Financial Information (Unaudited)
Revenues									234,780	160,791	110,711
Product royalty revenues | Non-U.S.
Interim Consolidated Financial Information (Unaudited)
Revenues	69,200	61,900	56,000	47,700	52,300	44,500	34,800	29,200
Milestone and contract revenues
Interim Consolidated Financial Information (Unaudited)
Revenues	$ 60,000	$ 20,000	$ 100,000	$ 0	$ 70,000	$ 15,000	$ 0	$ 90,000	$ 180,000	$ 175,000	$ 112,512

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 32
-Paragraph 2A
-URI http://asc.fasb.org/extlink&oid=82859839&loc=SL82860478-203043

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-Publisher FASB
-Name Accounting Standards Codification
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-Section 50
-Paragraph 4
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-URI http://asc.fasb.org/extlink&oid=82913847&loc=SL49130543-203045

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-Publisher FASB
-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=82913847&loc=SL49130545-203045

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