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Concentrations of Credit Risk (Details)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Milestone Revenues | Customer Concentration Risk | Collaboration Partner A
Concentration of risk
Percentage of concentration risk	33.00%	37.00%	40.00%
Milestone Revenues | Customer Concentration Risk | Collaboration Partner B
Concentration of risk
Percentage of concentration risk	67.00%	63.00%	60.00%
Net Product Revenues | Customer Concentration Risk | Customer A
Concentration of risk
Percentage of concentration risk	20.00%	24.00%	25.00%
Net Product Revenues | Customer Concentration Risk | Customer B
Concentration of risk
Percentage of concentration risk	14.00%	15.00%	17.00%
Net Product Revenues | Customer Concentration Risk | Customer C
Concentration of risk
Percentage of concentration risk	15.00%	13.00%	13.00%
Net Product Revenues | Customer Concentration Risk | Customer D
Concentration of risk
Percentage of concentration risk	11.00%	8.00%	9.00%
Accounts Receivable | Credit Concentration Risk | Collaboration Partner A and B
Concentration of risk
Percentage of concentration risk	42.00%	47.00%
Accounts Receivable | Credit Concentration Risk | Customer A, B, C and D
Concentration of risk
Percentage of concentration risk	30.00%	25.00%

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