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License Agreements - Novartis (Details) $ in Thousands	1 Months Ended				3 Months Ended								12 Months Ended									110 Months Ended
	Apr. 30, 2016 USD ($)	Jan. 31, 2010 USD ($)	Dec. 31, 2009 USD ($)	Nov. 30, 2009 USD ($) item	Dec. 31, 2018 USD ($)	Sep. 30, 2018 USD ($)	Jun. 30, 2018 USD ($)	Mar. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Sep. 30, 2017 USD ($)	Jun. 30, 2017 USD ($)	Mar. 31, 2017 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Dec. 31, 2016 USD ($)	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)	Dec. 31, 2012 USD ($)	Dec. 31, 2011 USD ($)	Dec. 31, 2010 USD ($)	Dec. 31, 2018 USD ($)
License agreements
Revenues					$ 528,402	$ 449,683	$ 521,516	$ 382,282	$ 444,156	$ 381,534	$ 326,444	$ 384,082	$ 1,881,883
Europe
License agreements
Revenues													79,900	$ 66,900	$ 29,600
U.S.
License agreements
Revenues													1,800,000	1,500,000	1,100,000
JAKAFI
License agreements
Revenues													1,386,964	1,133,392	852,816
Novartis
License agreements
Upfront and immediate milestone payment to be received under license agreement				$ 210,000
Upfront payment received under license agreement			$ 150,000
Immediate milestone payment received under license agreement		$ 60,000
Revenues													60,000	65,000	45,000
Number of deliverables under license agreement | item				2
Reimbursable costs recorded as deferred revenue			$ 10,900
Reimbursable costs included in accounts receivable					700				1,600				700	1,600								$ 700
Research and development expenses reimbursed													3,200	3,000	700
Product royalties in accounts receivable					55,400				47,700				55,400	47,700								55,400
Novartis | Pre-specified Events | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				$ 1,200,000
Novartis | Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																						132,000
Novartis | Development Milestones | Phase III
License agreements
Amount recognized and received for the achievement of a predefined milestone																					$ 50,000
Novartis | Development Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				174,000
Novartis | Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																						215,000
Novartis | Regulatory Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				495,000
Novartis | Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																						120,000
Novartis | Commercialization Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				$ 500,000
Novartis | LY3009104 | Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																$ 5,000	$ 7,000	$ 25,000		$ 15,000
Novartis | GVHD | Development Milestones | Phase III
License agreements
Amount recognized and received for the achievement of a predefined milestone														25,000
Novartis | GVHD | Development and Regulatory Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement	$ 75,000
Novartis | GVHD | Development and Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone															5,000
Novartis | JAKAFI | U.S.
License agreements
Revenues													63,000	50,500	36,800
Royalties payable					$ 18,600				$ 14,800				18,600	14,800								$ 18,600
Novartis | JAKAFI | Regulatory Milestones | U.S.
License agreements
Amount recognized and received for the achievement of a predefined milestone																				$ 10,000
Novartis | JAKAVI
License agreements
Revenues													$ 194,700	151,700	110,700
Novartis | JAKAVI | Minimum
License agreements
Royalty payments on future global net sales (as a percent)													12.00%
Novartis | JAKAVI | Maximum
License agreements
Royalty payments on future global net sales (as a percent)													14.00%
Novartis | JAKAVI | Regulatory Milestones | Europe
License agreements
Amount recognized and received for the achievement of a predefined milestone															$ 40,000	25,000	60,000		$ 40,000
Novartis | JAKAVI | Regulatory Milestones | JAPAN
License agreements
Amount recognized and received for the achievement of a predefined milestone																15,000	$ 25,000
Novartis | JAKAVI | Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone													$ 60,000	40,000		20,000
Revenues													$ 900,000	$ 600,000		$ 300,000

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