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License Agreements - Lilly (Details) $ in Thousands	1 Months Ended			3 Months Ended								12 Months Ended					109 Months Ended
	Mar. 31, 2016 USD ($)	Jul. 31, 2010	Dec. 31, 2009 USD ($) item	Dec. 31, 2018 USD ($)	Sep. 30, 2018 USD ($)	Jun. 30, 2018 USD ($)	Mar. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Sep. 30, 2017 USD ($)	Jun. 30, 2017 USD ($)	Mar. 31, 2017 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Dec. 31, 2016 USD ($)	Dec. 31, 2012 USD ($)	Dec. 31, 2010 USD ($)	Dec. 31, 2018 USD ($)
License agreements
Research and Development Expense												$ 1,197,957	$ 1,326,134	$ 581,861
Revenues				$ 528,402	$ 449,683	$ 521,516	$ 382,282	$ 444,156	$ 381,534	$ 326,444	$ 384,082	1,881,883
U.S.
License agreements
Revenues												1,800,000	1,500,000	1,100,000
Europe
License agreements
Revenues												79,900	66,900	29,600
Product royalty revenues
License agreements
Revenues												$ 234,780	160,791	110,711
Product royalty revenues | Non-U.S.
License agreements
Revenues				69,200	$ 61,900	$ 56,000	$ 47,700	52,300	$ 44,500	$ 34,800	$ 29,200
Eli Lilly
License agreements
Upfront payment received under license agreement			$ 90,000
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop (as a percentage)												30.00%
Research and Development Expense												$ 68,600	40,800	27,300
Number of deliverables under license agreement | item			2
Revenues												120,000	110,000	67,500
Product royalties in accounts receivable				14,000				4,600				14,000	4,600				$ 14,000
Eli Lilly | Non-U.S.
License agreements
Revenues												40,100	9,100
Eli Lilly | Phase IIB
License agreements
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop (as a percentage)		30.00%	30.00%
Eli Lilly | Pre-specified Events | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement			$ 665,000
Eli Lilly | Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone												20,000	30,000				149,000
Eli Lilly | Development Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement			150,000
Eli Lilly | Development Milestones | Phase III
License agreements
Amount recognized and received for the achievement of a predefined milestone															$ 50,000
Eli Lilly | Development Milestones | Phase IIA
License agreements
Amount recognized and received for the achievement of a predefined milestone																$ 30,000
Eli Lilly | Development Milestones | Phase IIB
License agreements
Amount recognized and received for the achievement of a predefined milestone																$ 19,000
Eli Lilly | Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone												$ 100,000		35,000			235,000
Eli Lilly | Regulatory Milestones | JAPAN
License agreements
Amount recognized and received for the achievement of a predefined milestone													15,000
Eli Lilly | Regulatory Milestones | Europe
License agreements
Amount recognized and received for the achievement of a predefined milestone													65,000	$ 20,000
Eli Lilly | Regulatory Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement			365,000
Eli Lilly | Commercialization Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement			$ 150,000
Royalty payments on future global net sales (as a percent)												20.00%
Eli Lilly | Accrued and other liabilities
License agreements
Accrued and other liabilities				$ 23,100				$ 13,600				$ 23,100	13,600				$ 23,100
Eli Lilly | GVHD
License agreements
Upfront payment received under license agreement	$ 35,000
Research and development expenses reimbursed													$ 35,000
Additional milestone payment received under license agreement	$ 40,000

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