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License Agreements - Syros (Details)
$ / shares in Units, $ in Thousands, shares in Millions
1 Months Ended 12 Months Ended
Jan. 31, 2018
USD ($)
item
$ / shares
shares
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Jan. 08, 2018
$ / shares
License agreements          
Long term investment   $ 99,199 $ 134,356    
Research and development expense   1,197,957 1,326,134 $ 581,861  
Unrealized gain (loss) on long term investments   (44,093) $ (24,275) $ (3,261)  
Syros Pharmaceuticals, Inc.          
License agreements          
Number of program targets | item 7        
Upfront payment under license agreement $ 10,000        
Fair value of shares on the issuance date   $ 5,200      
Ownership percentage (as a percent)   3.00%      
Unrealized gain (loss) on long term investments   $ (3,700)      
Syros Pharmaceuticals, Inc. | Stock purchase agreement          
License agreements          
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares 0.8        
Purchase price of common stock $ 10,000        
Per share price | $ / shares $ 12.61       $ 9.77
Lock-up period 12 months        
Discount for lack of marketability $ 100        
Fair value of shares on the issuance date 7,600        
Long term investment 7,600        
Research and development expense $ 2,400        
Syros Pharmaceuticals, Inc. | Amended stock purchase agreement          
License agreements          
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares 0.1        
Purchase price of common stock $ 1,400        
Per share price | $ / shares $ 9.55        
Syros Pharmaceuticals, Inc. | Maximum          
License agreements          
Target selection and option exercise fee payment $ 54,000        
Syros Pharmaceuticals, Inc. | Development and Regulatory Milestones | Maximum          
License agreements          
Additional milestone payments under the license agreement 50,000        
Syros Pharmaceuticals, Inc. | Commercialization Milestones | Maximum          
License agreements          
Additional milestone payments under the license agreement $ 65,000