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Stockholders’ Equity - Option activity (Details) - Stock Options - USD ($)
$ / shares in Units, $ in Millions
 1 Months Ended 6 Months Ended 12 Months Ended
Jul. 31, 2016
Jun. 30, 2016
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Shares Available For Grant          
Outstanding at the beginning of the period (in shares)     3,909,701    
Additional authorization (in shares)     5,000,000    
Options granted (in shares)     (3,245,314)    
Options cancelled (in shares)     813,190    
Outstanding at the end of the period (in shares)     6,477,577 3,909,701  
Shares Subject to Outstanding Options, Shares          
Outstanding at the beginning of the period (in shares)     11,206,553    
Options granted (in shares)     3,245,314    
Options exercised (in shares)     (1,353,518)    
Options cancelled (in shares)     (813,190)    
Outstanding at the end of the period (in shares)     12,285,159 11,206,553  
Shares Subject to Outstanding Options, Weighted Average Exercise Price          
Outstanding at the beginning of the period (in dollars per share)     $ 68.36    
Options granted (in dollars per share)     78.64    
Options exercised (in dollars per share)     22.42    
Options cancelled (in dollars per share)     94.82    
Outstanding at the end of the period (in dollars per share)     $ 74.39 $ 68.36  
Termination period 10 years 7 years      
Vesting period 4 years 3 years      
Stock option, other disclosures          
Options exercisable and vested (in shares)     7,194,171 7,250,283 7,995,735
Intrinsic value of options exercised     $ 73.9 $ 264.2 $ 137.0
Intrinsic value of vested options     $ 118.5    
Vesting after one year          
Shares Subject to Outstanding Options, Weighted Average Exercise Price          
Vesting period 1 year 1 year      
Vesting Percentage 25.00% 33.00%      
Remainder vesting          
Shares Subject to Outstanding Options, Weighted Average Exercise Price          
Vesting period 36 months 24 months