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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Cash flows from operating activities:      
Net income (loss) $ 109,493 $ (313,142) $ 104,222
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:      
Depreciation and amortization 54,969 52,178 58,425
In-process research and development impairment   12,000  
Stock-based compensation 148,153 133,055 96,201
Expense related to senior note conversions   54,881  
Deferred income taxes (459)    
Other, net 344 290 472
Unrealized loss on long term investments 44,093 24,275 3,261
Change in fair value of acquisition-related contingent consideration 26,173 7,704 17,422
Changes in operating assets and liabilities:      
Accounts receivable (41,299) (117,541) (23,947)
Prepaid expenses and other assets (33,412) (31,367) (13,069)
Inventory 4,043 4,851 4,047
Accounts payable 36,156 (7,928) 43,758
Accrued and other liabilities (12,027) 87,756 26,476
Deferred revenue-collaborative agreements     (12,512)
Net cash provided by (used in) operating activities 336,227 (92,988) 304,756
Cash flows from investing activities:      
Acquisition of business, net of cash acquired     (142,856)
Purchase of long term investments (8,936) (123,891)  
Capital expenditures (73,483) (111,021) (120,277)
Purchases of marketable securities (159,932) (260,780) (57,372)
Sale and maturities of marketable securities 155,928 145,714 88,017
Net cash used in investing activities (86,423) (349,978) (232,488)
Cash flows from financing activities:      
Proceeds from issuance of common stock under stock plans 29,942 66,764 49,973
Proceeds from issuance of common stock, net   649,387  
Cash paid in connection with senior note conversions   (8,934)  
Direct financing arrangements repayments     (445)
Payment of contingent consideration (15,285) (17,007) (4,906)
Net cash provided by financing activities 14,657 690,210 44,622
Effect of exchange rates on cash, cash equivalents, restricted cash and investments 91 (39) (9)
Net increase in cash, cash equivalents, restricted cash and investments 264,552 247,205 116,881
Cash, cash equivalents, restricted cash and investments at beginning of period 900,434 653,229 536,348
Cash, cash equivalents, restricted cash and investments at end of period 1,164,986 900,434 653,229
Supplemental Schedule of Cash Flow Information      
Interest paid 268 314 7,218
Income taxes paid 5,417 6,305 927
Unpaid purchases of property and equipment 7,673 5,643 10,989
Convertible Senior Notes 0.375 Percent Due 2018      
Supplemental Schedule of Cash Flow Information      
Reclassification to common stock and additional paid in capital in connection with conversions or exchange of convertible senior notes $ 7,695 351,044 5
Convertible Senior Notes 1.25 Percent Due 2020      
Supplemental Schedule of Cash Flow Information      
Reclassification to common stock and additional paid in capital in connection with conversions or exchange of convertible senior notes   $ 330,011 $ 4