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License agreements - Novartis (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended | 113 Months Ended
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Apr. 30, 2016 USD ($) | Sep. 30, 2014 USD ($) | Jan. 31, 2010 USD ($) | Dec. 31, 2009 USD ($) | Nov. 30, 2009 USD ($) item | Mar. 31, 2019 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Dec. 31, 2013 USD ($) | Dec. 31, 2012 USD ($) | Dec. 31, 2011 USD ($) | Dec. 31, 2010 USD ($) | Mar. 31, 2019 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | $ 497,857 | $ 382,282 |  |  |  |  |  |  |  |  |  |
JAKAFI |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 375,611 | 313,720 |  |  |  |  |  |  |  |  |  |
Novartis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | $ 210,000 |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received under license agreement |  |  |  | $ 150,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Immediate milestone payment received under license agreement |  |  | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of deliverables under license agreement | item |  |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |
Reimbursable costs recorded as deferred revenue |  |  |  | $ 10,900 |  |  |  |  |  |  |  |  |  |  |  |  |
Reimbursable costs included in accounts receivable |  |  |  |  |  | 500 |  | $ 700 |  |  |  |  |  |  |  |  | $ 500
Research and development expenses reimbursed |  |  |  |  |  | 600 | 500 |  |  |  |  |  |  |  |  |  |
Product royalties in accounts receivable |  |  |  |  |  | 45,600 |  | 55,400 |  |  |  |  |  |  |  |  | 45,600
Novartis | Pre-specified Events | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | $ 1,200,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 132,000
Novartis | Development Milestones | Phase III |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000 |
Novartis | Development Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | 174,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 215,000
Novartis | Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | 495,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 120,000
Novartis | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  |  |  | $ 500,000 |  |  |  |  |  |  |  |  |  |  |  |
Novartis | Development and Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 0 | 0 |  |  |  |  |  |  |  |  |  |
Novartis | LY3009104 | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  | $ 5,000 | $ 7,000 | $ 25,000 |  | $ 15,000 |  |
Novartis | GVHD | Development Milestones | Phase III |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  | $ 25,000 |  |  |  |  |  |  |  |
Novartis | GVHD | Development and Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement | $ 75,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis | GVHD | Development and Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  | $ 5,000 |  |  |  |  |  |  |
Novartis | JAKAFI | U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalties payable on net sales |  |  |  |  |  | 13,400 | 10,400 |  |  |  |  |  |  |  |  |  |
Royalties payable |  |  |  |  |  | 13,400 |  | 18,600 |  |  |  |  |  |  |  |  | $ 13,400
Novartis | JAKAFI | Regulatory Milestones | U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,000 |  |
Novartis | JAKAVI |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | $ 45,600 | $ 41,300 |  |  |  |  |  |  |  |  |  |
Novartis | JAKAVI | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  | 12.00% |  |  |  |  |  |  |  |  |  |  |
Novartis | JAKAVI | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  | 14.00% |  |  |  |  |  |  |  |  |  |  |
Novartis | JAKAVI | Regulatory Milestones | Europe |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  | $ 60,000 |  |  |  |  |  |  |  | $ 40,000 | 25,000 | 60,000 |  | $ 40,000 |  |  |
Novartis | JAKAVI | Regulatory Milestones | JAPAN |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  | 15,000 | $ 25,000 |  |  |  |  |
Novartis | JAKAVI | Commercialization Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | 60,000 | 40,000 |  | 20,000 |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  | $ 900,000 | $ 600,000 |  | $ 300,000 |  |  |  |  |  |

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