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License agreements - Merus (Details) $ / shares in Units, $ in Thousands, € in Millions, shares in Millions |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Jan. 23, 2017 USD ($) $ / shares | Feb. 28, 2017 USD ($) | Jan. 31, 2017 USD ($) item | Dec. 31, 2016 USD ($) $ / shares shares | Mar. 31, 2019 USD ($) | Dec. 31, 2018 EUR (€) | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2018 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  | $ 120,188 |  |  |  | $ 99,199 | [1]
Research and development expense |  |  |  |  | 270,545 |  | $ 303,103 |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  | 20,989 |  | 22,679 |  |  |
Current assets |  |  |  |  | 1,904,500 |  |  |  | 1,832,254 | [1]
Current liabilities |  |  |  |  | 364,515 |  |  |  | 425,277 | [1]
Merus |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Number of independent programs | item |  |  | 11 |  |  |  |  |  |  |
Number of preclinical discovery programs | item |  |  | 2 |  |  |  |  |  |  |
Number of programs under the resulting products are co-funded for development | item |  |  | 1 |  |  |  |  |  |  |
Associated future global development costs , if elected to co-develop (as a percent) |  |  | 35.00% |  |  |  |  |  |  |
Upfront payment under license agreement |  | $ 120,000 |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  | 2,600 |  | 2,400 |  |  |
Merus | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  | 2,500 |  |  |  | 2,900 |
Merus | U.S. |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Profit sharing (as a percent) |  |  | 50.00% |  |  |  |  |  |  |
Percentage of profit (losses) |  |  | 50.00% |  |  |  |  |  |  |
Merus | Minimum |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 6.00% |  |  |  |  |  |  |
Merus | Minimum | U.S. |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 6.00% |  |  |  |  |  |  |
Merus | Minimum | Non-U.S. |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 6.00% |  |  |  |  |  |  |
Merus | Maximum |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Number of additional preclinical discovery programs | item |  |  | 10 |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 10.00% |  |  |  |  |  |  |
Percentage of reverse royalty |  |  | 4.00% |  |  |  |  |  |  |
Merus | Maximum | U.S. |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 10.00% |  |  |  |  |  |  |
Percentage of additional royalties |  |  | 4.00% |  |  |  |  |  |  |
Merus | Maximum | Non-U.S. |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  | 10.00% |  |  |  |  |  |  |
Merus | Maximum | Development and Regulatory Milestones |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 100,000 |  |  |  |  |  |  |
Merus | Maximum | Commercialization Milestones |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 250,000 |  |  |  |  |  |  |
Merus |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Total revenues | € |  |  |  |  |  | € 8.5 |  |  |  |
Net income (loss) | € |  |  |  |  |  | € (0.5) |  |  |  |
Merus | Stock purchase agreement |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  |  |  | 3.2 |  |  |  |  |  |
Purchase price of common stock |  |  |  | $ 80,000 |  |  |  |  |  |
Per share price | $ / shares | $ 24.50 |  |  | $ 25.00 |  |  |  |  |  |
Lock-up period | 18 months |  |  |  |  |  |  |  |  |
Standstill period | 3 years |  |  |  |  |  |  |  |  |
Percentage of total shares allowed to sell during any 12-month period (as a percent) | 33.00% |  |  |  |  |  |  |  |  |
Percentage of total shares allowed to sell during any three-month period (as a percent) | 10.00% |  |  |  |  |  |  |  |  |
Discount for lack of marketability | $ 5,600 |  |  |  |  |  |  |  |  |
Fair value of shares on the issuance date | 72,800 |  |  |  |  |  |  |  |  |
Total consideration paid | $ 80,000 |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  |  |  |  | $ 72,800 |  |
Research and development expense |  |  |  |  |  |  |  | $ 7,200 |  |
Fair market value of our long term investments |  |  |  |  | $ 47,300 |  |  |  | $ 44,800 |
Ownership percentage (as a percent) |  |  |  |  | 14.00% |  |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  | $ 2,500 |  | $ (2,800) |  |  |
[1] | The condensed consolidated balance sheet at December 31, 2018 has been derived from the audited financial statements at that date.

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