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License agreements - Agenus (Details) $ / shares in Units, $ in Thousands, shares in Millions |  |  | 1 Months Ended | 3 Months Ended |  |
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Feb. 14, 2017 USD ($) $ / shares | Feb. 01, 2017 USD ($) $ / shares shares | Feb. 28, 2017 USD ($) | Nov. 30, 2015 item | Feb. 28, 2015 | Jan. 31, 2015 item | Mar. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Mar. 31, 2018 USD ($) | Mar. 31, 2017 USD ($) | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  |  |  | $ 120,188 | $ 99,199 | [1] |  |  |  |
Research and development expense |  |  |  |  |  |  | 270,545 |  |  | $ 303,103 |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  |  |  | 20,989 |  |  | 22,679 |  |  |
Current assets |  |  |  |  |  |  | 1,904,500 | 1,832,254 | [1] |  |  |  |
Current liabilities |  |  |  |  |  |  | 364,515 | 425,277 | [1] |  |  |  |
Cash and cash equivalents |  |  |  |  |  |  | $ 1,299,704 | 1,163,980 | [1] |  |  |  |
Agenus |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Number of program targets | item |  |  |  | 3 |  | 4 |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  | 15.00% |  |  |  |  |  |
Period of notice for termination of license agreement |  |  | 12 months |  |  |  |  |  |  |  |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  | 6.00% |  |  |  |  |  |
Agenus | Development, Regulatory and Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments on future global net sales (as a percent) |  |  |  |  |  |  | 12.00% |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  | $ 510,000 |  |  |  |  |  |  |  |  |  |
Agenus | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment under license agreement |  |  | $ 20,000 |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  |  |  |  |  |  |  |  |  |  |  | $ 5,000 | $ 5,000
Agenus |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  |  |  | $ 52,600 | 42,300 |  |  |  |  |
Research and development expense |  |  |  |  |  |  | $ 10,200 |  |  | 1,900 |  |  |
Shares owned following stock purchase (as a percent) |  |  | 11.00% |  | 9.00% |  |  |  |  |  |  |  |
Ownership percentage (as a percent) |  |  |  |  |  |  | 13.00% |  |  |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  |  |  | $ 10,500 |  |  | $ 25,800 |  |  |
Total revenues |  |  |  |  |  |  |  | 6,500 |  |  |  |  |
Net income (loss) |  |  |  |  |  |  |  | 48,800 |  |  |  |  |
Agenus | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  |  |  | $ 4,700 | $ 2,300 |  |  |  |  |
Agenus | Stock purchase agreement |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares |  | 10.0 |  |  |  |  |  |  |  |  |  |  |
Purchase price of common stock |  | $ 60,000 |  |  |  |  |  |  |  |  |  |  |
Per share price | $ / shares | $ 4.40 | $ 6.00 |  |  |  |  |  |  |  |  |  |  |
Discount for lack of marketability | $ 4,500 |  |  |  |  |  |  |  |  |  |  |  |
Fair value of shares on the issuance date | 39,500 |  |  |  |  |  |  |  |  |  |  |  |
Total consideration paid | $ 60,000 |  |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  |  |  |  |  |  |  | $ 39,500 |  |
Research and development expense |  |  |  |  |  |  |  |  |  |  | $ 20,500 |  |
[1] | The condensed consolidated balance sheet at December 31, 2018 has been derived from the audited financial statements at that date.

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