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Accrued and other current liabilities (Details) - USD ($) $ in Thousands | Mar. 31, 2019 | Dec. 31, 2018
--- | --- | ---
Accrued and Other Current Liabilities |  |  |
Royalties | $ 20,077 | $ 25,087 |
Clinical related costs | 65,874 | 98,607 |
Sales allowances | 69,359 | 44,770 |
Construction in progress | 16,087 | 7,673 |
Finance lease liabilities |  | 18,696 |
Operating lease liabilities | 10,245 |  |
Other current liabilities | 39,905 | 34,568 |
Total accrued and other current liabilities | $ 211,302 | $ 229,401 | [1]
[1] | The condensed consolidated balance sheet at December 31, 2018 has been derived from the audited financial statements at that date.

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