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License agreements - Calithera (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jan. 01, 2018 | Jan. 30, 2017 | Mar. 31, 2017 | Jan. 31, 2017 | Mar. 31, 2019 | Mar. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2018 | Jan. 01, 2017
License agreements |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  | $ 120,188 |  |  | $ 99,199 | [1] |
Research and development expense |  |  |  |  | 270,545 | $ 303,103 |  |  |  |
Net income |  |  |  |  | 102,312 | (41,140) |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  | 20,989 | 22,679 |  |  |  |
Calithera |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  |  | 70.00% |  |  |  |  |  |
Upfront payment made under license agreement |  |  |  | $ 45,000 |  |  |  |  |  |
Potential milestone payments to be made with profit sharing in effect |  |  |  | 430,000 |  |  |  |  |  |
Potential milestone payments to be made with profit sharing terminated |  |  |  | $ 750,000 |  |  |  |  |  |
Milestone payment made under license agreement |  |  | $ 12,000 |  |  |  |  |  |  |
Research and development expense |  |  |  |  | 4,600 | 2,600 |  |  |  |
Calithera | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  | 3,200 |  |  |  |  |
Calithera | U.S. |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Percentage of profit (losses) |  |  |  | 60.00% |  |  |  |  |  |
Calithera | Other Comprehensive Income |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  | 4,700 | $ (3,500) |  |  |  |
Calithera | Calithera | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  |  |  |  | 2,600 |  |
Calithera | Stock purchase agreement |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) |  |  |  | 1.7 |  |  |  |  |  |
Purchase price of common stock |  |  |  |  |  |  |  |  |  | $ 8,000
Per share price |  | $ 6.75 |  |  |  |  |  |  |  | $ 4.65
Fair market value of our long term investments |  | $ 11,600 |  |  | $ 11,600 |  |  | $ 6,900 |  |
Total consideration paid |  | 53,000 |  |  |  |  |  |  |  |
Upfront license fees |  | 45,000 |  |  |  |  |  |  |  |
Stock purchase price |  | $ 8,000 |  |  |  |  |  |  |  |
Long term investment |  |  |  |  |  |  | $ 11,600 |  |  |
Research and development expense |  |  |  |  |  |  | $ 41,400 |  |  |
Ownership percentage (as a percent) |  |  |  |  | 4.00% |  |  |  |  |
Calithera | ASU 2016-01 |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |
Net income | $ 2,800 |  |  |  |  |  |  |  |  |
[1] | The condensed consolidated balance sheet at December 31, 2018 has been derived from the audited financial statements at that date.

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