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Fair value of financial instruments - Fair value on a recurring basis (Details) (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Dec. 31, 2018
Fair value of financial instruments        
Assets transfers from Level 1 to Level 2 $ 0      
Assets transfers from Level 2 to Level 1 0      
Assets transfers into Level 3 0      
Assets transfers out of Level 3 0      
Liabilities transfers from Level 1 to Level 2 0      
Liabilities transfers from Level 2 to Level 1 0      
Liabilities transfers into Level 3 0      
Liabilities transfers out of Level 3 0      
Long term investments 120,188 $ 99,199 [1]   $ 99,199 [1]
ARIAD        
Roll forward of Level 3 liabilities        
Contingent consideration earned during the period but not yet paid (6,700)     (13,200)
ARIAD | Account payable        
Roll forward of Level 3 liabilities        
Contingent consideration earned during the period but not yet paid     $ (6,700)  
ARIAD | Accrued and other current liabilities        
Roll forward of Level 3 liabilities        
Contingent consideration earned during the period but not yet paid (6,700) (6,500)    
Level 3 | Fair Value        
Roll forward of Level 3 liabilities        
Balance at the beginning of the period 287,001      
Contingent consideration earned during the period but not yet paid (6,672)      
Change in fair value of contingent consideration 6,671      
Balance at the end of the period 287,000 287,001   287,001
Recurring | Fair Value        
Fair value of financial instruments        
Cash and cash equivalents 1,299,704 1,163,980   1,163,980
Debt securities (corporate and government) 281,320 274,343   274,343
Long term investments 120,188 99,199   99,199
Total assets 1,701,212 1,537,522   1,537,522
Acquisition-related contingent consideration 287,000 287,001   287,001
Total liabilities 287,000 287,001   287,001
Recurring | Level 1        
Fair value of financial instruments        
Cash and cash equivalents 1,299,704 1,163,980   1,163,980
Long term investments 120,188 99,199   99,199
Total assets 1,419,892 1,263,179   1,263,179
Recurring | Level 2        
Fair value of financial instruments        
Debt securities (corporate and government) 281,320 274,343   274,343
Total assets 281,320 274,343   274,343
Recurring | Level 3        
Fair value of financial instruments        
Acquisition-related contingent consideration 287,000 287,001   287,001
Total liabilities $ 287,000 $ 287,001   $ 287,001
[1] The condensed consolidated balance sheet at December 31, 2018 has been derived from the audited financial statements at that date.