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Property and equipment, net - Property and equipment, net (Details) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Property and equipment, net
Property and Equipment, gross	$ 451,788	$ 422,982
Less accumulated depreciation and amortization	(113,457)	(103,231)
Property and Equipment, net	338,331	319,751	[1]
Office equipment
Property and equipment, net
Property and Equipment, gross	15,199	16,955
Laboratory equipment
Property and equipment, net
Property and Equipment, gross	63,339	61,697
Computer equipment
Property and equipment, net
Property and Equipment, gross	58,389	55,436
Land
Property and equipment, net
Property and Equipment, gross	10,068	10,122
Building and leasehold improvements
Property and equipment, net
Property and Equipment, gross	213,529	213,196
Operating lease right-of-use assets
Property and equipment, net
Property and Equipment, gross	24,334
Finance lease right-of-use assets
Property and equipment, net
Property and Equipment, gross	2,332
Construction in Progress
Property and equipment, net
Property and Equipment, gross	$ 64,598	$ 65,576
[1] The condensed consolidated balance sheet at December 31, 2018 has been derived from the audited financial statements at that date.

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Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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