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License agreements - Novartis (Details) $ in Thousands	1 Months Ended					3 Months Ended		12 Months Ended									113 Months Ended
	Apr. 30, 2016 USD ($)	Sep. 30, 2014 USD ($)	Jan. 31, 2010 USD ($)	Dec. 31, 2009 USD ($)	Nov. 30, 2009 USD ($) item	Mar. 31, 2019 USD ($)	Mar. 31, 2018 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Dec. 31, 2016 USD ($)	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)	Dec. 31, 2012 USD ($)	Dec. 31, 2011 USD ($)	Dec. 31, 2010 USD ($)	Mar. 31, 2019 USD ($)
License agreements
Revenues						$ 497,857	$ 382,282
JAKAFI
License agreements
Revenues						375,611	313,720
Novartis
License agreements
Upfront and immediate milestone payment to be received under license agreement					$ 210,000
Upfront payment received under license agreement				$ 150,000
Immediate milestone payment received under license agreement			$ 60,000
Number of deliverables under license agreement | item					2
Reimbursable costs recorded as deferred revenue				$ 10,900
Reimbursable costs included in accounts receivable						500		$ 700									$ 500
Research and development expenses reimbursed						600	500
Product royalties in accounts receivable						45,600		55,400									45,600
Novartis | Pre-specified Events | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement					$ 1,200,000
Novartis | Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																	132,000
Novartis | Development Milestones | Phase III
License agreements
Amount recognized and received for the achievement of a predefined milestone																$ 50,000
Novartis | Development Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement					174,000
Novartis | Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																	215,000
Novartis | Regulatory Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement					495,000
Novartis | Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone																	120,000
Novartis | Commercialization Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement					$ 500,000
Novartis | Development and Commercialization Milestones
License agreements
Revenues						0	0
Novartis | LY3009104 | Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone											$ 5,000	$ 7,000	$ 25,000		$ 15,000
Novartis | GVHD | Development Milestones | Phase III
License agreements
Amount recognized and received for the achievement of a predefined milestone									$ 25,000
Novartis | GVHD | Development and Regulatory Milestones | Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement	$ 75,000
Novartis | GVHD | Development and Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone										$ 5,000
Novartis | JAKAFI | U.S.
License agreements
Royalties payable on net sales						13,400	10,400
Royalties payable						13,400		18,600									$ 13,400
Novartis | JAKAFI | Regulatory Milestones | U.S.
License agreements
Amount recognized and received for the achievement of a predefined milestone															$ 10,000
Novartis | JAKAVI
License agreements
Revenues						$ 45,600	$ 41,300
Novartis | JAKAVI | Minimum
License agreements
Royalty payments on future global net sales (as a percent)						12.00%
Novartis | JAKAVI | Maximum
License agreements
Royalty payments on future global net sales (as a percent)						14.00%
Novartis | JAKAVI | Regulatory Milestones | Europe
License agreements
Amount recognized and received for the achievement of a predefined milestone		$ 60,000								$ 40,000	25,000	60,000		$ 40,000
Novartis | JAKAVI | Regulatory Milestones | JAPAN
License agreements
Amount recognized and received for the achievement of a predefined milestone											15,000	$ 25,000
Novartis | JAKAVI | Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone								60,000	40,000		20,000
Revenues								$ 900,000	$ 600,000		$ 300,000

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