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License agreements - Calithera (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions			1 Months Ended		3 Months Ended		12 Months Ended
	Jan. 01, 2018	Jan. 30, 2017	Mar. 31, 2017	Jan. 31, 2017	Mar. 31, 2019	Mar. 31, 2018	Dec. 31, 2017	Dec. 31, 2018		Jan. 01, 2017
License agreements
Long term investment					$ 120,188			$ 99,199	[1]
Research and development expense					270,545	$ 303,103
Net income					102,312	(41,140)
Unrealized gain (loss) on long term investments					20,989	22,679
Calithera
License agreements
Funding of future development costs (as a percent)				70.00%
Upfront payment made under license agreement				$ 45,000
Potential milestone payments to be made with profit sharing in effect				430,000
Potential milestone payments to be made with profit sharing terminated				$ 750,000
Milestone payment made under license agreement			$ 12,000
Research and development expense					4,600	2,600
Calithera | Accrued and other liabilities
License agreements
Accrued and other liabilities					3,200
Calithera | U.S.
License agreements
Percentage of profit (losses)				60.00%
Calithera | Other Comprehensive Income
License agreements
Unrealized gain (loss) on long term investments					4,700	$ (3,500)
Calithera | Calithera | Accrued and other liabilities
License agreements
Accrued and other liabilities								2,600
Calithera | Stock purchase agreement
License agreements
Purchase of common stock under Stock Purchase Agreement (in shares )				1.7
Purchase price of common stock										$ 8,000
Per share price		$ 6.75								$ 4.65
Fair market value of our long term investments		$ 11,600			$ 11,600			$ 6,900
Total consideration paid		53,000
Upfront license fees		45,000
Stock purchase price		$ 8,000
Long term investment							$ 11,600
Research and development expense							$ 41,400
Ownership percentage (as a percent)					4.00%
Calithera | ASU 2016-01
License agreements
Net income	$ 2,800
[1] The condensed consolidated balance sheet at December 31, 2018 has been derived from the audited financial statements at that date.

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