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License agreements - MacroGenics (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended
Nov. 30, 2018
Sep. 30, 2018
Dec. 31, 2017
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
License agreements            
Research and development       $ 270,545 $ 303,103  
MacroGenics            
License agreements            
Upfront payment under license agreement     $ 150,000      
Research and development $ 5,000 $ 10,000   9,400 $ 6,500  
MacroGenics | Accrued and other liabilities            
License agreements            
Accrued and other liabilities       $ 4,400   $ 3,200
Minimum | MacroGenics            
License agreements            
Royalty payments on future global net sales (as a percent)     15.00%      
Maximum | MacroGenics            
License agreements            
Royalty payments on future global net sales (as a percent)     24.00%      
Development and Regulatory Milestones | Maximum | MacroGenics            
License agreements            
Additional milestone payments under the license agreement     $ 420,000      
Commercialization Milestones | Maximum | MacroGenics            
License agreements            
Additional milestone payments under the license agreement     $ 330,000