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Stock compensation (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Stock compensation
Stock compensation expense	$ 40.6	$ 36.2
Stock Compensation Expense Capitalized	$ 0.1
Weighted-average fair value assumptions
Valuation method	Black-Scholes valuation model
Dividend yield (as a percent)	0.00%
Research and Development Expense [Member]
Stock compensation
Stock compensation expense	$ 27.4	24.2
Selling, General and Administrative Expenses [Member]
Stock compensation
Stock compensation expense	13.0	$ 12.0
Cost of product revenues
Stock compensation
Stock compensation expense	$ 0.2
Employee Stock
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	2.27%	2.26%
Average expected life (in years)	3 months	3 months
Volatility (as a percent)	34.00%	36.00%
Weighted-average fair value (in dollars per share)	$ 13.31	$ 18.17
Stock Options
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	2.51%	2.42%
Average expected life (in years)	5 years 3 months 29 days	5 years 6 months 11 days
Volatility (as a percent)	45.00%	45.00%
Weighted-average fair value (in dollars per share)	$ 31.50	$ 41.59
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 133.9
Vesting period of recognition of the unrecognized compensation cost of nonvested awards	1 year 8 months 12 days
Restricted Stock Units (RSUs)
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 59.6
Vesting period of recognition of the unrecognized compensation cost of nonvested awards	1 year 7 months 6 days
Performance Stock Units (PSUs)
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 27.7
Vesting period of recognition of the unrecognized compensation cost of nonvested awards	2 years 8 months 12 days

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Unrecognized cost of unvested share-based compensation awards.

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Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Expected term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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