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Accrued and other current liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Accrued and Other Current Liabilities
Royalties	$ 20,077	$ 25,087
Clinical related costs	65,874	98,607
Sales allowances	69,359	44,770
Construction in progress	16,087	7,673
Finance lease liabilities		18,696
Operating lease liabilities	10,245
Other current liabilities	39,905	34,568
Total accrued and other current liabilities	$ 211,302	$ 229,401	[1]
[1] The condensed consolidated balance sheet at December 31, 2018 has been derived from the audited financial statements at that date.

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Carrying value as of the balance sheet date of obligations incurred through that date and payable for clinical related costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Carrying value as of the balance sheet date of obligations incurred through that date and payable for royalties. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Amount equal to the present value (the principal) at the beginning of the lease term of minimum lease payments during the lease term (excluding that portion of the payments representing executory costs such as insurance, maintenance, and taxes to be paid by the lessor, together with any profit thereon) net of payments or other amounts applied to the principal through the balance sheet date.

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