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Concentration of credit risk (Details)	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018
Milestone Revenues | Customer Concentration Risk | Collaboration Partner B
Concentration of risk
Percentage of concentration risk		100.00%		100.00%
Milestone Revenues | Customer Concentration Risk | Collaboration Partner C
Concentration of risk
Percentage of concentration risk	100.00%		100.00%
Net Product Revenues | Customer Concentration Risk | Customer A
Concentration of risk
Percentage of concentration risk	20.00%	21.00%	19.00%	21.00%
Net Product Revenues | Customer Concentration Risk | Customer B
Concentration of risk
Percentage of concentration risk	13.00%	15.00%	14.00%	14.00%
Net Product Revenues | Customer Concentration Risk | Customer C
Concentration of risk
Percentage of concentration risk	16.00%	14.00%	16.00%	14.00%
Net Product Revenues | Customer Concentration Risk | Customer D
Concentration of risk
Percentage of concentration risk	11.00%	12.00%	12.00%	11.00%
Accounts Receivable | Credit Concentration Risk | Collaboration Partner A and B
Concentration of risk
Percentage of concentration risk					42.00%
Accounts Receivable | Credit Concentration Risk | Collaboration Partner A, B and C
Concentration of risk
Percentage of concentration risk			27.00%
Accounts Receivable | Credit Concentration Risk | Customer A, B, C and D
Concentration of risk
Percentage of concentration risk			36.00%		30.00%

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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