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License agreements - Calithera (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Jan. 01, 2018 | Jan. 30, 2017 | Mar. 31, 2017 | Jan. 31, 2017 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Sep. 30, 2019 | Sep. 30, 2018 | Dec. 31, 2017 | Dec. 31, 2018 | Jan. 01, 2017
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  | $ 117,902 |  |  |  |  |  | $ 117,902 |  |  | $ 99,199 |
Research and development expense |  |  |  |  | 281,336 |  |  | $ 292,527 |  |  | 841,244 | $ 893,719 |  |  |
Net income |  |  |  |  | 128,271 | $ 105,318 | $ 102,312 | 29,176 | $ 52,394 | $ (41,140) | 335,901 | 40,430 |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  | 2,339 |  |  | (9,949) |  |  | 18,703 | (21,911) |  |  |
Calithera |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  |  | 70.00% |  |  |  |  |  |  |  |  |  |  |
Upfront payment made under license agreement |  |  |  | $ 45,000 |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments to be made with profit sharing in effect |  |  |  | 430,000 |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments to be made with profit sharing terminated |  |  |  | $ 750,000 |  |  |  |  |  |  |  |  |  |  |
Milestone payment made under license agreement |  |  | $ 12,000 |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  | 4,700 |  |  | 2,400 |  |  | 14,700 | 8,200 |  |  |
Calithera | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  | 3,400 |  |  |  |  |  | 3,400 |  |  |  |
Calithera | U.S. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of profit (losses) |  |  |  | 60.00% |  |  |  |  |  |  |  |  |  |  |
Calithera |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total consideration paid |  | $ 53,000 |  | $ 53,000 |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  | $ 5,300 |  |  |  |  |  | $ 5,300 |  |  | 6,900 |
Ownership percentage (as a percent) |  |  |  |  | 3.00% |  |  |  |  |  | 3.00% |  |  |  |
Calithera | Other Comprehensive Income |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gain (loss) on long term investments |  |  |  |  | $ (1,400) |  |  | $ 400 |  |  | $ (1,600) | $ (5,300) |  |  |
Calithera | Calithera | Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,600 |
Calithera | Stock purchase agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase of common stock under Stock Purchase Agreement (in shares ) |  |  |  | 1.7 |  |  |  |  |  |  |  |  |  |  |
Purchase price of common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,000
Per share price |  | $ 6.75 |  |  |  |  |  |  |  |  |  |  |  |  | $ 4.65
Fair market value of our long term investments |  | $ 11,600 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock purchase price |  |  |  | $ 8,000 |  |  |  |  |  |  |  |  |  |  |
Long term investment |  |  |  |  |  |  |  |  |  |  |  |  | $ 11,600 |  |
Research and development expense |  |  |  |  |  |  |  |  |  |  |  |  | $ 41,400 |  |
Calithera | Collaboration and license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront license fees |  |  |  | $ 45,000 |  |  |  |  |  |  |  |  |  |  |
Calithera | ASU 2016-01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net income | $ 2,800 |  |  |  |  |  |  |  |  |  |  |  |  |  |

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