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License agreements - Lilly (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 118 Months Ended
--- | --- | --- | --- | --- | ---
May 31, 2019 USD ($) | Mar. 31, 2016 USD ($) | Dec. 31, 2009 USD ($) item | Sep. 30, 2019 USD ($) | Sep. 30, 2018 USD ($) | Sep. 30, 2019 USD ($) | Sep. 30, 2018 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2012 USD ($) | Dec. 31, 2010 USD ($) | Sep. 30, 2019 USD ($)
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Expense |  |  |  | $ 281,336 | $ 292,527 | $ 841,244 | $ 893,719 |  |  |  |  |  |
Revenues |  |  |  | 551,581 | 449,683 | 1,579,370 | 1,353,481 |  |  |  |  |  |
Product royalty revenues |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  | 80,083 | 61,923 | 217,726 | 165,592 |  |  |  |  |  |
Eli Lilly |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received under license agreement |  |  | $ 90,000 |  |  |  |  |  |  |  |  |  |
Number of deliverables under license agreement | item |  |  | 2 |  |  |  |  |  |  |  |  |  |
Product royalties in accounts receivable |  |  |  | $ 21,700 |  | $ 21,700 |  | $ 14,000 |  |  |  |  | $ 21,700
Eli Lilly | Phase IIB |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Funding of future development costs (as a percent) |  |  |  | 30.00% |  | 30.00% |  |  |  |  |  |  |
Research and Development Expense |  |  |  |  | 18,900 |  | 45,600 |  |  |  |  |  |
Accrued and other liabilities |  |  |  |  |  |  |  | 23,100 |  |  |  |  |
Eli Lilly | Pre-specified Events | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | $ 665,000 |  |  |  |  |  |  |  |  |  |
Eli Lilly | Development Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | 20,000 | $ 30,000 |  |  |  | 149,000
Eli Lilly | Development Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | 150,000 |  |  |  |  |  |  |  |  |  |
Eli Lilly | Development Milestones | Phase III |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  | $ 50,000 |  |
Eli Lilly | Development Milestones | Phase IIA |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  | $ 30,000 |
Eli Lilly | Development Milestones | Phase IIB |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  |  |  | $ 19,000 |
Eli Lilly | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  | $ 235,000
Eli Lilly | Regulatory Milestones | JAPAN |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  | 15,000 |  |  |  |
Eli Lilly | Regulatory Milestones | U.S. |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  |  | $ 35,000 |  |  |
Eli Lilly | Regulatory Milestones | Europe |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Amount recognized and received for the achievement of a predefined milestone |  |  |  |  |  |  |  |  | $ 65,000 | $ 20,000 |  |  |
Eli Lilly | Regulatory Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | 365,000 |  |  |  |  |  |  |  |  |  |
Eli Lilly | Commercialization Milestones | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and immediate milestone payment to be received under license agreement |  |  | $ 150,000 |  |  |  |  |  |  |  |  |  |
Eli Lilly | GVHD |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment under license agreement |  | $ 35,000 |  |  |  |  |  |  |  |  |  |  |
Additional milestone payments under the license agreement |  | $ 40,000 |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | GVHD | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment made under license agreement | $ 20,000 |  |  |  |  |  |  |  |  |  |  |  |
Eli Lilly | Product royalty revenues |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  | $ 21,600 | 11,000 | $ 56,800 | 26,200 |  |  |  |  |  |
Eli Lilly | Milestone revenues |  |  |  |  |  |  |  |  |  |  |  |  |
License agreements |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  | $ 0 | $ 20,000 | $ 0 | $ 120,000 |  |  |  |  |  |

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