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Fair value of financial instruments - Fair value on a recurring basis (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2019
Jun. 30, 2019
Dec. 31, 2018
Sep. 30, 2018
Sep. 30, 2019
Dec. 31, 2018
Fair value of financial instruments            
Assets transfers from Level 1 to Level 2 $ 0       $ 0  
Assets transfers from Level 2 to Level 1 0       0  
Assets transfers into Level 3         0  
Assets transfers out of Level 3         0  
Liabilities transfers from Level 1 to Level 2 0       0  
Liabilities transfers from Level 2 to Level 1 0       0  
Liabilities transfers into Level 3         0  
Liabilities transfers out of Level 3         0  
Long term investments 117,902   $ 99,199   117,902 $ 99,199
ARIAD            
Roll forward of Level 3 liabilities            
Contingent consideration earned during the period but not yet paid (14,900)         (13,200)
ARIAD | Account payable            
Roll forward of Level 3 liabilities            
Contingent consideration earned during the period but not yet paid       $ (6,700)    
ARIAD | Accrued and other current liabilities            
Roll forward of Level 3 liabilities            
Contingent consideration earned during the period but not yet paid (7,300) $ (7,600) (6,500)      
Level 3 | Fair Value            
Roll forward of Level 3 liabilities            
Balance at the beginning of the period         287,001  
Contingent consideration earned during the period but not yet paid         (14,889)  
Payments made during the period         (6,672)  
Change in fair value of contingent consideration         16,560  
Balance at the end of the period 282,000   287,001   282,000 287,001
Recurring | Fair Value            
Fair value of financial instruments            
Cash and cash equivalents 1,702,023   1,163,980   1,702,023 1,163,980
Debt securities (corporate and government) 284,195   274,343   284,195 274,343
Long term investments 117,902   99,199   117,902 99,199
Total assets 2,104,120   1,537,522   2,104,120 1,537,522
Acquisition-related contingent consideration 282,000   287,001   282,000 287,001
Total liabilities 282,000   287,001   282,000 287,001
Recurring | Level 1            
Fair value of financial instruments            
Cash and cash equivalents 1,702,023   1,163,980   1,702,023 1,163,980
Long term investments 117,902   99,199   117,902 99,199
Total assets 1,819,925   1,263,179   1,819,925 1,263,179
Recurring | Level 2            
Fair value of financial instruments            
Debt securities (corporate and government) 284,195   274,343   284,195 274,343
Total assets 284,195   274,343   284,195 274,343
Recurring | Level 3            
Fair value of financial instruments            
Acquisition-related contingent consideration 282,000   287,001   282,000 287,001
Total liabilities $ 282,000   $ 287,001   $ 282,000 $ 287,001