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Stock compensation (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Stock compensation
Stock compensation expense	$ 43.4	$ 38.0	$ 124.6	$ 110.8
Stock Compensation Expense Capitalized	0.1		$ 0.3
Weighted-average fair value assumptions
Valuation method			Black-Scholes valuation model
Dividend yield (as a percent)			0.00%
Research and Development Expense [Member]
Stock compensation
Stock compensation expense	30.5	26.3	$ 85.5	75.3
Selling, General and Administrative Expenses [Member]
Stock compensation
Stock compensation expense	12.8	$ 11.7	38.6	$ 35.5
Cost of product revenues
Stock compensation
Stock compensation expense	$ 0.1		$ 0.5
Stock Options
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	1.74%	2.72%	2.29%	2.60%
Average expected life (in years)	5 years 1 month 2 days	5 years 10 days	5 years 3 months 10 days	5 years 3 months 7 days
Volatility (as a percent)	45.00%	45.00%	45.00%	45.00%
Weighted-average fair value (in dollars per share)	$ 34.83	$ 29.32	$ 32.38	$ 34.41
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 114.4		$ 114.4
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 7 months 6 days
Restricted Stock Units (RSUs)
Weighted-average fair value assumptions
Average risk-free interest rates (as a percent)	1.63%	2.81%	1.94%	2.63%
Average expected life (in years)	6 months	6 months	6 months	6 months
Volatility (as a percent)	34.00%	27.00%	34.00%	45.00%
Weighted-average fair value (in dollars per share)	$ 15.04	$ 13.56	$ 14.53	$ 15.91
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 102.0		$ 102.0
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			1 year 10 months 24 days
Performance Stock Units (PSUs)
Unrecognized compensation
Unrecognized compensation cost for nonvested option (in dollars)	$ 34.4		$ 34.4
Vesting period of recognition of the unrecognized compensation cost of nonvested awards			2 years 4 months 24 days

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