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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Revenues:        
Total revenues $ 551,581 $ 449,683 $ 1,579,370 $ 1,353,481
Costs and expenses:        
Cost of product revenues (including definite-lived intangible amortization) 30,040 24,795 82,034 67,757
Research and development 281,336 292,527 841,244 893,719
Selling, general and administrative 102,608 96,522 332,534 326,049
Change in fair value of acquisition-related contingent consideration 3,281 4,720 16,560 18,708
Total costs and expenses 417,265 418,564 1,272,372 1,306,233
Income from operations 134,316 31,119 306,998 47,248
Other income (expense), net 11,961 10,211 36,334 20,481
Interest expense (597) (405) (1,248) (1,188)
Unrealized gain (loss) on long term investments 2,339 (9,949) 18,703 (21,911)
Income before provision for income taxes 148,019 30,976 360,787 44,630
Provision for income taxes 19,748 1,800 24,886 4,200
Net income $ 128,271 $ 29,176 $ 335,901 $ 40,430
Net income per share:        
Basic $ 0.60 $ 0.14 $ 1.57 $ 0.19
Diluted $ 0.59 $ 0.14 $ 1.55 $ 0.19
Shares used in computing net income per share:        
Basic 215,199 212,627 214,628 212,172
Diluted 217,791 215,964 217,393 215,516
Product revenues, net        
Revenues:        
Total revenues $ 453,998 $ 367,715 $ 1,284,144 $ 1,067,744
Product royalty revenues        
Revenues:        
Total revenues 80,083 61,923 217,726 165,592
Other revenues        
Revenues:        
Total revenues   45   145
Milestone revenues        
Revenues:        
Total revenues $ 17,500 $ 20,000 $ 77,500 $ 120,000