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License agreements - MacroGenics (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Nov. 30, 2018
Sep. 30, 2018
Dec. 31, 2017
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
License agreements                
Research and development       $ 281,336 $ 292,527 $ 841,244 $ 893,719  
MacroGenics                
License agreements                
Upfront payment under license agreement     $ 150,000          
Research and development $ 5,000 $ 10,000   14,100 $ 6,300 33,300 $ 23,700  
MacroGenics | Accrued and other liabilities                
License agreements                
Accrued and other liabilities       $ 2,400   $ 2,400   $ 3,200
Minimum | MacroGenics                
License agreements                
Royalty payments on future global net sales (as a percent)     15.00%          
Maximum | MacroGenics                
License agreements                
Royalty payments on future global net sales (as a percent)     24.00%          
Development and Regulatory Milestones | Maximum | MacroGenics                
License agreements                
Additional milestone payments under the license agreement     $ 420,000          
Commercialization Milestones | Minimum | MacroGenics                
License agreements                
Additional milestone payments under the license agreement     $ 330,000