DEF 14A 1 d651551ddef14a.htm DEF 14A

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No. )

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

☐ |  | Preliminary Proxy Statement
☐ |  | Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
☒ |  | Definitive Proxy Statement
☐ |  | Definitive Additional Materials
☐ |  | Soliciting Material under §240.14a-12

INCYTE CORPORATION

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

☒ |  | No fee required.
☐ |  | Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
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☐ |  | Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.
|  | (1) |  | Amount Previously Paid:
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Dear Fellow Stockholders,

This past year was one of significant progress as we seek to build Incyte into a diversified, fast-growing and global biopharmaceutical company.

Before highlighting our achievements in 2018, an important, although disappointing, event was the result of ECHO-301, our Phase 3 trial together with Merck evaluating epacadostat in combination with pembrolizumab, Merck’s PD-1 antagonist, for the first-line treatment of patients with advanced or metastatic melanoma. The expectations internally and within the medical community were high, and we were disappointed that the combination did not show a benefit in progression-free survival (PFS) over pembrolizumab monotherapy. We continue to learn as much as we can from the results, but this event reinforced our belief in the importance of having a robust portfolio of development projects. I’d like to now move on to our 2018 achievements.

Sales of Jakafi® (ruxolitinib) continue to grow in both approved indications, myelofibrosis (MF)1 and polycythemia vera (PV)1. The stories of the patients we treat inspire us to do better, and we are committed to maintaining our leadership position in the treatment of patients with myeloproliferative neoplasms (MPNs). To that end, we are pursuing strategies that may improve patient outcomes in three ways: improved formulations of ruxolitinib, investigating ruxolitinib-based combination therapies, and discovering new targets beyond JAK inhibition.

With the ongoing U.S. Food and Drug Administration (FDA) review of ruxolitinib in steroid-refractory acute graft versus host disease (GVHD) and NDA submissions expected in the near-term for pemigatinib in patients with cholangiocarcinoma and itacitinib in treatment-naïve GVHD, we are confident in our potential to drive top-line growth in the years to come.

Our discovery and development teams have created multiple opportunities for growth. In the coming year, we plan to focus on six key late-stage product candidates outlined below that, together, we believe may drive significant revenue growth in the near future.

We also have two late-stage product candidates, baricitinib and capmatinib, which are out-licensed globally to Eli Lilly and Novartis, respectively. In June, we, along with Eli Lilly, announced the FDA approval of Olumiant® (baricitinib) for the treatment of certain patients with rheumatoid arthritis (RA)5. Lilly is also developing baricitinib in multiple other autoimmune disorders and recently announced that the first two Phase 3 trials of baricitinib in atopic dermatitis achieved their primary endpoints. Lilly expects the last three of the five Phase 3 trials needed to seek approval in patients with moderate to severe atopic dermatitis to readout later in 2019. Data from capmatinib were presented in non-small cell lung cancer patients with MET exon 14 skipping mutations at the European Society for Medical Oncology 2018 Congress (ESMO), and Novartis has stated that it plans to submit an NDA in this indication this year.

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It’s also important to note that should these goals come to fruition as we expect, five Incyte-invented molecules will have received FDA approval. We believe this remarkable achievement would be an excellent illustration of the quality of the work of our world class biologists and chemists.

On the financial front, total revenues reached $1.9B in 2018, an increase of over 20% versus 2017. Iclusig® (ponatinib)6 continues to grow, and royalties from Jakavi® (ruxolitinib)7 and Olumiant® (baricitinib) are contributing more to our top-line growth with each passing year. GAAP Net Income grew to $110M for 2018 as compared to a GAAP Net Loss of $313M in 2017.

We also had the opportunity to strengthen our executive management team with three new members in the last twelve months. First, we welcomed Maria Pasquale, J.D. as our General Counsel in April 2018. Ms. Pasquale has nearly 20 years of legal and compliance experience in the biopharmaceutical industry and most recently held the position of Global Chief Compliance Officer at Celgene Corporation. In December 2018, we were excited to welcome Dr. Dashyant Dhanak to the team as our Chief Scientific Officer. Dr. Dhanak joined us from Janssen Research & Development, where he most recently served as Global Head, Discovery Sciences. In February 2019, we welcomed Christiana Stamoulis as our new Chief Financial Officer. Ms. Stamoulis has over 20 years of experience in the biopharmaceutical industry, 15 of which was in investment banking and management consulting, and thereafter in executive positions at Vertex Pharmaceuticals and most recently serving as the President and CFO of Unum Therapeutics. We believe the collective experience of our new leadership team members will be a great asset for Incyte as we embark on our next stage of growth.

In October, we were proud to be recognized as the number two top employer in the biopharma industry by Science magazine. We believe that the collective experience and passion of our over 1,300 talented colleagues is foundational to our success, and as our organization continues to grow, we are committed to maintaining a culture that is driven by a passion for innovative science and where patients are at the forefront of everything we do.

Together, we strive to make a meaningful difference in the lives of those with cancer and other serious diseases, and in doing so, we aim to create long-term and sustainable value for you, our stockholders.

We thank you for your continued support and look forward to keeping you updated on our progress.

|  | Sincerely,
| Hervé Hoppenot Chairman of the Board of Directors

| 1. | Jakafi (ruxolitinib) is approved in intermediate or high-risk myelofibrosis (MF), including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis, and in patients with polycythemia vera (PV) who have had an inadequate response to or are intolerant of hydroxyurea. |

| 2. | Development of ruxolitinib in GVHD in collaboration with Novartis. |

| 3. | Inflammation and Autoimmunity. |

| 4. | All epidemiology data is for U.S., Europe and Japan except where noted for U.S. only; all incidence data for unresectable or metastatic disease, except prevalence for ruxolitinib cream. |

| 5. | Olumiant (baricitinib) is approved for the treatment of mild to moderate rheumatoid arthritis in patients with inadequate response to standard-of-care therapies. |

| 6. | Iclusig® is marketed by ARIAD Pharmaceuticals, Inc in the U.S. and by Incyte in the European Union and select countries. In the European Union, Iclusig is indicated for adult patients with CP-, AP-, or BP-CML who are resistant to dasatinib or nilotinib; who are intolerant to dasatinib or nilotinib and for whom subsequent treatment with imatinib is not clinically appropriate; or who have the T315I mutation, and adult patients with Ph+ ALL who are resistant to dasatinib; who are intolerant to dasatinib and for whom subsequent treatment with imatinib is not clinically appropriate; or who have the T315I mutation. |

| 7. | Ex-U.S. rights to ruxolitinib license to Novartis; commercialized by Novartis as Jakavi. |

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Company History of Success

Current Portfolio of Projects

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Incyte Corporation

1801 Augustine Cut-Off

Wilmington, Delaware 19803

Notice of Annual Meeting of Stockholders

Friday, April 26, 2019

1:00 PM Eastern Daylight Time

1815 Augustine Cut-Off, Wilmington, Delaware 19803

To the Stockholders of Incyte Corporation:

The Annual Meeting of Stockholders of Incyte Corporation, a Delaware corporation (the “Company”), will be held at the Company’s offices located at 1815 Augustine Cut-Off, Wilmington, Delaware 19803, on Friday, April 26, 2019, at 1:00 PM Eastern Daylight Time, for the following purposes:

Purposes:

1. | To elect eight directors to serve until the 2020 Annual Meeting of Stockholders and thereafter until their successors are duly elected and qualified;

2. | To approve, on a non-binding, advisory basis, the compensation of the Company’s named executive officers;

3. | To approve amendments to the Company’s Amended and Restated 2010 Stock Incentive Plan;

4. | To ratify the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for 2019;

5. | To vote on a stockholder proposal, if properly presented, described in more detail in the proxy statement; and

6. | To transact such other business as may properly come before the Annual Meeting of Stockholders and any postponement or adjournment of the Annual Meeting.

Record Date: |  | March 12, 2019—Stockholders of record as of the close of business on March 12, 2019 are entitled to notice of and to vote at the Annual Meeting and any postponement or adjournment thereof.

It is important that your shares be represented at this meeting. Even if you plan to attend the meeting, we hope that you will vote as soon as possible. Voting now will ensure your representation at the Annual Meeting regardless of whether you attend in person. You may vote over the internet, by telephone or by mailing the enclosed proxy card or voting instruction form. Please review the instructions on page 3 of the attached Proxy Statement and your proxy card or voting instruction form regarding each of these voting options.

By Order of the Board of Directors
Maria E. Pasquale
Secretary

March 21, 2019

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Table of Contents

1 |  | Proxy Statement Summary
|  | 2 |  | Frequently Asked Questions
6 |  | Stockholder Engagement
8 |  | Proposal 1 Election of Directors
14 |  | Board Committees
16 |  | Corporate Governance
24 |  | Compensation of Directors
27 |  | Executive Compensation
|  | 27 |  | Compensation Discussion and Analysis
|  | 46 |  | Compensation Committee Report
|  | 47 |  | Executive Compensation Tables
61 |  | Equity Compensation Plan Information
62 |  | Report of the Audit Committee of the Board
63 |  | Proposal 2 Advisory Vote to Approve Executive Compensation
64 |  | Proposal 3 Proposal to Amend the Amended and Restated 2010 Stock
|  | Incentive Plan
76 |  | Proposal 4 Ratification of Independent Registered Public Accounting Firm
78 |  | Proposal 5 Stockholder Proposal
83 |  | Security Ownership of Certain Beneficial Owners and Management
86 |  | Other Matters
A-1 |  | Appendix A: Note Regarding Forward-Looking Statements

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Proxy Statement Summary

Meeting Information

Time and Date: |  | 1:00 PM EDT, April 26, 2019 |  |
Place: |  | 1815 Augustine Cut-Off
|  | Wilmington, DE 19803
Record Date: |  | March 12, 2019
Admission: |  | Please follow the instructions
|  | contained in this Proxy
|  | Statement
Mail Date: |  | This Proxy Statement and the
|  | accompanying form of proxy
|  | are being mailed to
|  | stockholders on or about
|  | March 25, 2019

Voting Matters

PROPOSAL |  | BOARD’S VOTING RECOMMENDATION
1 |  | Election of Directors |  | FOR Each Nominee
2 |  | Advisory Vote to Approve Executive Compensation |  | FOR
3 |  | Amend the Amended and Restated 2010 Stock Incentive Plan |  | FOR
4 |  | Ratification of Independent Registered Public Accounting Firm |  | FOR
5 |  | Stockholder Proposal |  | AGAINST

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Proxy Statement Summary |  |

Frequently Asked Questions

Will there be any other items of business on the agenda?

We do not expect any other items of business because the deadline for stockholder proposals and nominations has already passed. Nonetheless, in case there is an unforeseen need, the accompanying proxy gives discretionary authority to the persons named on the proxy with respect to any other matters that might be brought before the meeting. Those persons intend to vote that proxy in accordance with their best judgment.

Who is entitled to vote?

Stockholders of record at the close of business on March 12, 2019, the Record Date, may vote at the Annual Meeting. Each stockholder is entitled to one vote for each share of our common stock held by such stockholder as of the Record Date.

How many shares must be present to hold the Annual Meeting?

The presence, in person or by proxy, of the holders of a majority of our outstanding common stock on the Record Date constitutes a quorum, which is required to hold and conduct business at the Annual Meeting. As of the close of business on the Record Date, there were 214,264,527 shares of our common stock outstanding. If you are a record holder and you submit your proxy, regardless of whether you abstain from voting on one or more matters, your shares will be counted as present at the Annual Meeting for purposes of determining a quorum. If your shares are held in street name, your shares are counted as present for purposes of determining a quorum if your broker, bank or other nominee submits a proxy covering your shares. Your broker, bank or other nominee is entitled to submit a proxy covering your shares as to certain “routine” matters, even if you have not instructed your broker, bank or other nominee on how to vote on those matters. Please see “How are votes counted?” below. If a quorum is not present, we expect that the Annual Meeting will be adjourned until we obtain a quorum.

What is the difference between holding shares as a stockholder of record and as a beneficial owner?

Stockholder of Record. If your shares are registered directly in your name with our transfer agent, Computershare, you are considered, with respect to those shares, the “stockholder of record.” This Proxy Statement, our Annual Report and the proxy card have been sent directly to you by Incyte.

Beneficial Owner. If your shares are held in a stock brokerage account or by a broker, bank or other nominee, you are considered the “beneficial owner” of shares held in street name. This Proxy Statement and our Annual Report have been forwarded to you by your broker, bank or other nominee who is considered, with respect to those shares, the stockholder of record. As the beneficial owner, you have the right to direct your broker, bank or other nominee how to vote your shares by using the voting instruction form provided by your broker, bank or other nominee.

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|  | Proxy Statement Summary

How do I vote?

You may vote using any of the following methods:

By Mail |  |  |  | By Telephone |  |  |  | By Internet |  |  |  | In Person at the Annual Meeting
Mail – Follow the instructions in your proxy materials. |  |  |  | Telephone – Stockholders of record may call toll-free 1-800-652–VOTE (8683) |  |  |  | By Internet – Stockholders of record may vote online at www.envisionreports.com/INCY |  |  |  | In Person at the Annual Meeting – You may obtain directions to the Annual Meeting by contacting our Company’s Investor Relations Department at (302) 498-6700.
|  |  |  | Most stockholders who hold shares beneficially in street name may provide voting instructions to their brokers, banks or other nominees by telephone by calling the number specified on the voting instruction form provided by their brokers, banks or other nominees. The telephone voting facilities will close at 11:59pm, Eastern Daylight Time, the day before the meeting date. |  |  |  | Most stockholders who hold shares beneficially in street name may provide voting instructions to their brokers, banks or other nominees by accessing the website specified on the voting instruction form provided by their brokers, banks or other nominees. The internet voting facilities will close at 11:59pm, Eastern Daylight Time, the day before the meeting date. |  |  |  | Even if you plan to attend the Annual Meeting, we recommend that you also submit your proxy or voting instructions or vote by telephone or the internet so that your vote will be counted if you later decide not to attend the meeting

Can I change my vote or revoke my proxy?

You may change your vote or revoke your proxy at any time prior to the vote at the Annual Meeting. If you submitted your proxy by mail, you must file with the Secretary of our Company a written notice of revocation or deliver, prior to the vote at the Annual Meeting, a valid, later dated proxy. If you submitted your proxy by telephone or the internet, you may change your vote or revoke your proxy with a later telephone or internet proxy, as the case may be. Attendance at the Annual Meeting will not have the effect of revoking a proxy unless you give written notice of revocation to the Secretary before the proxy is exercised or you vote by written ballot at the Annual Meeting. For shares you hold beneficially in street name, you may change your vote or revoke your proxy by submitting new voting instructions to or informing your broker, bank or other nominee in accordance that entity’s procedures for changing or revoking your voting instructions.

How are votes counted?

In the election of directors, you may vote “FOR,” “AGAINST” or “ABSTAIN” for each nominee. For each of Proposals 2, 3, 4 and 5, you may vote “FOR,” “AGAINST” or “ABSTAIN.”

If you provide specific instructions, your shares will be voted as you instruct. If you sign your proxy card or voting instruction form with no further instructions, your shares will be voted in accordance with the recommendations of the Board (“FOR” all of the nominees to the Board of Directors, “FOR” the approval of the compensation of our named executive officers, “FOR” the approval of the amendments to our Amended and Restated 2010 Stock Incentive Plan, “FOR” the ratification of the independent registered public accounting firm, “AGAINST” the stockholder proposal, if properly presented, and in the discretion of the proxy holders on any other matters that may properly come before the meeting).

If you hold shares beneficially in street name and do not provide your broker, bank or other nominee with voting instructions, your shares may constitute “broker non-votes.” Generally, broker non-votes occur on a matter when a broker, bank or other nominee is not permitted to vote on that matter without instructions from the beneficial owner and instructions are not given. If you hold shares beneficially in

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Proxy Statement Summary |  |

street name and do not vote your shares, your broker, bank or other nominee can vote your shares at its discretion only on Proposal 4, the ratification of the independent registered public accounting firm. In tabulating the voting result for any particular proposal, shares that constitute broker non-votes are not considered entitled to vote on that proposal. Thus, broker non-votes will not affect the outcome of any matter being voted on at the Annual Meeting, other than Proposal 4, assuming that a quorum is obtained.

What vote is required to approve each item?

We have a majority voting standard for the election of directors in an uncontested election, which is generally defined as an election in which the number of nominees does not exceed the number of directors to be elected at the meeting. Cumulative voting is not permitted, which means that each stockholder may vote no more than the number of shares he or she owns for a single director candidate. Under our majority voting standard, in uncontested elections of directors, such as this election, each director must be elected by the affirmative vote of a majority of the votes cast by the shares present in person or represented by proxy. A “majority of the votes cast” means that the number of votes cast “FOR” a director nominee exceeds the number of votes cast “AGAINST” the nominee. If a director nominee is an incumbent director and does not receive a majority of the votes cast in an uncontested election, that director will continue to serve on the Board as a “holdover” director, but will be subject to our director resignation policy. Additional information concerning our director resignation policy is set forth under the heading “Corporate Governance—Majority Voting Policy.”

The table below describes the proposals to be considered at the Annual Meeting and the vote required for each proposal:

Proposal |  | Vote Required |  | Effect of Abstentions(1) |  | Broker Discretionary Voting Allowed?(2)
1 |  | Election of Directors |  | A nominee for director will be elected if the votes cast “FOR” such nominee exceed the votes cast “AGAINST” such nominee. |  | No effect Not considered votes cast on this proposal |  | No Brokers without voting instructions will not be able to vote on this proposal
2 |  | Advisory Vote to Approve Executive Compensation |  | Non-binding, advisory proposal. We will consider the matter approved if it receives the affirmative vote of a majority of the shares of common stock present at the Annual Meeting in person or by proxy and entitled to vote. |  | Counted as vote Same effect as votes against |  | No Brokers without voting instructions will not be able to vote on this proposal
3 |  | Approval of Amendments to the Amended and Restated 2010 Stock Incentive Plan |  | The affirmative “FOR” vote of a majority of the shares present at the Annual Meeting in person or by proxy and entitled to vote. |  | Counted as vote Same effect as votes against |  | No Brokers without voting instructions will not be able to vote on this proposal
4 |  | Ratification of the Appointment of Ernst & Young LLP |  | The affirmative “FOR” vote of a majority of the shares present at the Annual Meeting in person or by proxy and entitled to vote. |  | Counted as vote Same effect as votes against |  | Yes Brokers without voting instructions will have discretionary authority to vote
5 |  | Stockholder Proposal |  | Non-binding, advisory proposal. We will consider the matter approved if it receives the affirmative vote of a majority of the shares of common stock present at the Annual Meeting in person or by proxy and entitled to vote. |  | Counted as vote Same effect as votes against |  | No Brokers without voting instructions will not be able to vote on this proposal

(1) | As noted above, abstentions will be counted as present for purposes of establishing a quorum at the Annual Meeting.

(2) | Only relevant if you are the beneficial owner of shares held in street name. If you are a stockholder of record and you do not cast your vote, no votes will be cast on your behalf on any of the items of business at the Annual Meeting.

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|  | Proxy Statement Summary

If any other matter is properly brought before the Annual Meeting, such matter also will be determined by the affirmative vote of a majority of the shares of common stock present at the Annual Meeting in person or by proxy and entitled to vote at the Annual Meeting.

What is “householding” and how does it affect me?

We have adopted a process for mailing our Annual Report and this Proxy Statement called “householding,” which has been approved by the Securities and Exchange Commission. Householding means that stockholders who share the same last name and address will receive only one copy of our Annual Report and this Proxy Statement, unless we receive contrary instructions from any stockholder at that address. We will continue to mail a proxy card to each stockholder of record.

If you prefer to receive multiple copies of our Annual Report and this Proxy Statement at the same address, additional copies will be provided to you upon request. If you are a stockholder of record, you may contact us by writing to Investor Relations Department, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803 or by calling (302) 498-6700 and asking for Investor Relations. Eligible stockholders of record receiving multiple copies of our Annual Report and this Proxy Statement can request householding by contacting us in the same manner. We have undertaken householding to reduce printing costs and postage fees, and we encourage you to participate.

If you are a beneficial owner, you may request additional copies of our Annual Report and this Proxy Statement or you may request householding by notifying your broker, bank or other nominee.

How are proxies solicited?

Our employees, officers and directors may solicit proxies. We will pay the cost of printing and mailing proxy materials, and will reimburse brokerage houses and other custodians, nominees and fiduciaries for their reasonable out-of-pocket expenses for forwarding proxy and solicitation material to the owners of our common stock. In addition, we have engaged D.F. King & Co., Inc. to assist us in soliciting proxies for a fee of $12,500, plus out-of-pocket expenses.

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Stockholder Engagement

Throughout the year, we maintain an ongoing stockholder outreach program to garner feedback as well as to answer any questions stockholders may have both during and outside of proxy season. Our goal is to ensure that our corporate governance practices, our compensation program and our stockholder communications align with best practices.

Each year, we proactively reach out to our stockholders to determine how our corporate governance, compensation practices and stockholder communications might improve. In 2018 and 2017, we contacted stockholders representing over 80% and 60% of our shares outstanding, respectively. Our CEO, our Lead Independent Director and the rest of our Board – along with the rest of our executive management – regularly discuss the learnings from these thorough and informative conversations. As a result of this ongoing stockholder engagement over the last four years, we have implemented several significant enhancements in our corporate governance and compensation policies and in our stockholder communication practices, including most recently in 2019. We believe these changes help us to further align the Company’s interests with the best interests of our stockholders.

What We Heard |  | What We Did
|  | 2018 Say-on-pay stockholder discussions made clear that ad hoc retention equity grants to CEO were out of favor |  |  |  | Compensation Committee eliminated special option grants to CEO in 2019
|  | Compensation to Board of Directors should be better aligned with best practices |  |  |  | Restructured director compensation to eliminate fixed share grants and instead use target dollar value equity awards
|  | Need for enhanced disclosure about our Corporate Responsibility efforts |  |  |  | New disclosure detailing our commitment to patients, employees, the community and the environment
|  | Not enough performance-based compensation for executive officers |  |  |  | Commencing in July 2018, executive officers receive 25% of target equity award value in the form of performance shares tied to pre-specified performance goals
|  | “Plurality-plus” voting for directors in uncontested elections not preferred |  |  |  | Our Bylaws now require majority voting for directors in uncontested elections
|  | No clawback policy for executives |  |  |  | Adopted a 3 year cash clawback for executives
|  | No minimum vesting period for employee equity awards |  |  |  | Implemented a minimum vesting period of 12 months generally for employees
|  | Need for further diversification of expertise on Board and executive team |  |  |  | Increased gender diversity on our Board and our executive team

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|  | Stockholder Engagement

What We Heard |  | What We Did
|  | Insufficient rationale on why CEO also serves as the Chairman of the Board |  |  |  | Provided more insight into the Board’s rationale behind our current leadership structure, as well as enhanced detail on the function of our Lead Independent Director
|  | Limited detail on corporate goals |  |  |  | Provided a more detailed retrospective analysis of our 2017 and 2018 corporate goals, and also general prospective overview of current year goals
|  | No official stock ownership guidelines for Board and executives |  |  |  | Implemented robust stock ownership guidelines for our Board, our CEO and all other executive officers
|  | Excise tax gross-ups are not in line with best practices |  |  |  | Eliminated excise tax gross-ups
|  | Insider trading policy unclear to stockholders |  |  |  | Enhanced disclosure to make clear that robust anti-hedging and anti-speculation policies are in place

We continually seek to engage with stockholders throughout the year, and we invite you to reach out with any comments or questions at any time. Please see the Investor section of our website for the appropriate contact information.

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Proposal 1

Election of Directors

The Board proposes the election of eight directors of our Company to serve until the next annual meeting of stockholders, or thereafter until their successors are duly elected and qualified. If any nominee is unable or declines to serve as director at the time of the Annual Meeting, an event that we do not currently anticipate, proxies will be voted for any nominee designated by the Board to fill the vacancy.

|  |  |  |  |  |  |  |  |  | Committee Membership
Name and Primary Occupation |  | Director Since |  | Age |  | Independent |  |  | Compensation |  | Audit |  | Nominating and Corporate Governance |  |  | Finance
Hervé Hoppenot—Chairman of the Board |  | 2014 |  | 59 |  |  |  |  |  |  |  |  |  |  |  |  |  | ●
President and Chief Executive Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Incyte Corporation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Julian C. Baker—Lead Independent Director |  | 2001 |  | 52 |  |  | ● |  |  | ● |  |  |  |  |  |  |  | ●
Managing Partner |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Baker Brothers Investments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Jean-Jacques Bienaimé |  | 2015 |  | 65 |  |  | ● |  |  | ● |  |  |  |  |  |  |  |
Chief Executive Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
BioMarin Pharmaceutical Inc. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Paul A. Brooke |  | 2001 |  | 73 |  |  | ● |  |  |  |  |  |  |  | ● |  |  |
Former Founder and Managing Partner venBio, LLC |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Paul J. Clancy |  | 2015 |  | 57 |  |  | ● |  |  |  |  |  |  |  |  |  |  |
Executive Vice President and Chief Financial Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Alexion Pharmaceuticals, Inc. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Wendy L. Dixon, Ph.D. |  | 2010 |  | 63 |  |  | ● |  |  |  |  | ● |  |  | ● |  |  |
Former Chief Marketing Officer and |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
President, Global Marketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Bristol-Myers Squibb Company |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Jacqualyn A. Fouse, Ph.D. |  | 2017 |  | 57 |  |  | ● |  |  |  |  |  |  |  |  |  |  |
Chief Executive Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Agios Pharmaceuticals, Inc. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Paul A. Friedman, M.D. |  | 2001 |  | 76 |  |  | ● |  |  |  |  |  |  |  |  |  |  |
Chief Executive Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Madrigal Pharmaceuticals, Inc. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Committee Chair |  | Financial Expert |  | ● Member

8 | Proxy Statement 2019 |  |

##### Table of Contents

|  | Proposal 1 Election of Directors

Director Nominees

Names of the nominees and certain biographical information about them are set forth below:

Hervé Hoppenot |  |  |  |
Age 59 Director since 2014 Chairman of the Board Committees • Finance |  | BACKGROUND
| Mr. Hoppenot joined Incyte as President and Chief Executive Officer and a Director in January 2014, and was appointed Chairman of the Board in May 2015. Mr. Hoppenot served as the President of Novartis Oncology, Novartis Pharmaceuticals Corporation, the U.S. subsidiary of Novartis AG, a pharmaceutical company, from January 2010 to January 2014. Prior to that, Mr. Hoppenot served in other executive positions at Novartis Pharmaceuticals Corporation, serving from September 2006 to January 2010 as Executive Vice President, Chief Commercial Officer of Novartis Oncology and Head of Global Product Strategy & Scientific Development of Novartis Pharmaceuticals Corporation and from 2003 to September 2006 as Senior Vice President, Head of Global Marketing of Novartis Oncology. Prior to joining Novartis, Mr. Hoppenot served in various increasingly senior roles at Aventis S.A. (formerly Rhône Poulenc S.A.), a pharmaceutical company, including as Vice President Oncology US of Aventis Pharmaceuticals, Inc. from 2000 to 2003 and Vice President US Oncology Operations of Rhone Poulenc Rorer Pharmaceuticals, Inc. from 1998 to 2000.
|  | QUALIFICATIONS
|  | The Board has concluded that Hervé Hoppenot should serve on the Board because he has significant leadership and senior management experience from his various executive positions in the healthcare industry, including as the President of Novartis Oncology, Novartis Pharmaceuticals Corporation. His past experiences and his current role as our CEO give him strong knowledge of our strategy, markets, competitors, financials and operations.
|  | OTHER PUBLIC COMPANY BOARDS
|  | Current |  | Past 5 Years
|  | Cellectis S.A. |  | None

Julian C. Baker |  |  |  |
Age 52 Director since 2001 Lead Independent Director Committees • Compensation • Finance • Nominating & Corporate Governance (Chair) |  | BACKGROUND
| Mr. Baker is a Managing Partner of Baker Brothers Investments, which he and his brother, Felix Baker, Ph.D., founded in 2000. Baker Brothers Investments is an investment advisor focused on long term investments in life sciences companies. Mr. Baker’s career as a fund manager began in 1994 when he co-founded a biotechnology investing partnership with the Tisch family. Previously, Mr. Baker was employed from 1988 to 1993 by the private equity investment arm of Credit Suisse First Boston Corporation.
| QUALIFICATIONS
| The Board has concluded that Julian C. Baker should serve on the Board because he is an experienced investor in many life sciences companies. He brings to the Board significant strategic and financial expertise and extensive knowledge of the life sciences and biopharmaceuticals industries as a result of his investments in and service as a director of other publicly and privately held life sciences companies.
|  | OTHER PUBLIC COMPANY BOARDS
|  | Current |  | Past 5 Years
|  | Acadia Pharmaceuticals, Inc. |  | Idera Pharmaceuticals, Inc. (2014-2018)
|  | Genomic Health, Inc. |  |

|  | Proxy Statement 2019 | 9

##### Table of Contents

Proposal 1 Election of Directors |  |

Jean-Jacques Bienaimé |  |  |  |
Age 65 Director since 2015 Independent Director Committees • Compensation |  | BACKGROUND
| Mr. Bienaimé has served as Chief Executive Officer and a member of the board of directors of BioMarin Pharmaceutical Inc., a biopharmaceutical company, since May 2005. Mr. Bienaimé has also served as Chairman of BioMarin since June 2015. From November 2002 to April 2005, Mr. Bienaimé served as Chairman, Chief Executive Officer and President of Genencor, a biotechnology company focused on industrial bioproducts and targeted cancer biotherapeutics. Prior to joining Genencor, Mr. Bienaimé was Chairman, President and Chief Executive Officer of SangStat Medical Corporation, an immunology focused biotechnology company that was later acquired by Genzyme Corporation. He became President of SangStat in 1998 and Chief Executive Officer in 1999. Prior to joining SangStat, Mr. Bienaimé held various management positions from 1992 to 1998 with Rhône Poulenc Rorer Pharmaceuticals (now known as Sanofi Aventis), including Senior Vice President of Corporate Marketing and Business Development, and Vice President and General Manager of the advanced therapeutic and oncology division. Mr. Bienaimé is a director of the Biotechnology Innovation Organization and the Pharmaceutical Research and Manufacturers of America® (PhRMA).
|  | QUALIFICATIONS
|  | The Board has concluded that Jean-Jacques Bienaimé should serve on the Board because he has significant leadership experience in the management of biotechnology organizations, business development, and sales and marketing of both biotechnology and pharmaceutical products. He also brings significant experience as a director of other publicly held life sciences companies.
|  | OTHER PUBLIC COMPANY BOARDS
|  | Current |  | Past 5 Years
|  | BioMarin Pharmaceutical Inc. |  | InterMune, Inc. (2012-2014) Portola Pharmaceuticals, Inc. (2010-2014) Vital Therapies, Inc. (2013–2018)

Paul A. Brooke |  |  |  |
Age 73 Director since 2001 Independent Director Committees • Audit • Compensation (Chair) • Finance (Chair) • Nominating & Corporate Governance |  | BACKGROUND
| Mr. Brooke was a founder and managing partner of venBio, LLC, a pharmaceutical investment company, from which he retired at the end of 2016. Mr. Brooke was Chairman of the Board of Directors of Alsius Corporation, a medical device company, from June 2007 through its sale in May 2009, and was the Chairman and Chief Executive Officer of a predecessor company from April 2005 to June 2007. Mr. Brooke has been the Managing Member of PMSV Holdings, LLC, a private investment firm, since 1993. He also served as a Senior Advisor to Morgan Stanley & Co. Incorporated from April 2000 to December 2009, and was a Venture Partner at MPM Capital, a venture capital firm specializing in the healthcare industry, from 1997 through 2006. From April 1999 through May 2000, Mr. Brooke served as a Managing Director at Tiger Management LLC. He was a Managing Director and the Global Head of Healthcare Research and Strategy at Morgan Stanley & Co. from 1983 to April 1999. Mr. Brooke is also a director of several privately held companies.
| QUALIFICATIONS
| The Board has concluded that Paul A. Brooke should serve on the Board because he has leadership experience and insight into the operations, challenges and complex issues facing healthcare companies gained from his experience as head of healthcare research at a major investment bank and as an investor. He also has extensive financial and capital markets experience, which is critical to his role as Chair of the Finance Committee, and significant experience as a director of other publicly and privately held life sciences and healthcare companies.
|  | OTHER PUBLIC COMPANY BOARDS
|  | Current |  | Past 5 Years
|  | Manning & Napier Fund, Inc. |  | ViroPharma Incorporated (2001-2014)

10 | Proxy Statement 2019 |  |

##### Table of Contents

|  | Proposal 1 Election of Directors

Paul J. Clancy |  |  |  |
Age 57 Director since 2015 Independent Director Committees • Audit (Chair) |  | BACKGROUND
| Mr. Clancy has more than 30 years of experience in financial management and strategic business planning, and has served as the Executive Vice President and Chief Financial Officer of Alexion Pharmaceuticals, Inc., a biopharmaceutical company, since July 2017. Prior to joining Alexion, Mr. Clancy served as Executive Vice President, Finance and Chief Financial Officer of Biogen Inc. (formerly known as Biogen Idec Inc.), a biopharmaceutical company, from August 2007 until June 2017. He also served as Senior Vice President of Finance of Biogen, with responsibilities for leading the treasury, tax, investor relations and business planning groups. Prior to the 2003 merger of Biogen, Inc. and IDEC Pharmaceuticals Corporation to form Biogen, Mr. Clancy was the Vice President of Portfolio Management of Biogen. He joined Biogen in 2001 as Vice President of U.S. Marketing. Before Biogen, Mr. Clancy spent 13 years at PepsiCo Inc., a food and beverage company, serving in a variety of financial and general management positions, including Vice President and General Manager of their Great West Business Unit.
|  | QUALIFICATIONS
|  | The Board has concluded that Paul J. Clancy should serve on the Board because he has significant financial and executive leadership experience at large multi-national biopharmaceutical companies. Mr. Clancy also has experience as a director of a publicly held biotechnology company, and his breadth and depth of financial experience position him well to serve on the Audit Committee of the Board.
|  | OTHER PUBLIC COMPANY BOARDS
|  | Current |  | Past 5 Years
|  | Agios Pharmaceuticals, Inc. |  | None

Wendy L. Dixon, Ph.D. |  |  |  |
Age 63 Director since 2010 Independent Director Committees • Audit • Nominating & Corporate Governance |  | BACKGROUND
| Dr. Dixon served as Chief Marketing Officer and President, Global Marketing for Bristol Myers Squibb Company from December 2001 until May 2009 and served on the Chief Executive Officer’s Executive Committee. From 1996 to 2001 she was Senior Vice President, Marketing—USHH at Merck & Co., Inc., and prior to that she held executive management positions at West Pharmaceuticals, Osteotech, Inc. and Centocor, Inc. and various positions at SmithKline & French Pharmaceuticals in marketing, regulatory affairs, project management and as a biochemist.
| QUALIFICATIONS
| The Board has concluded that Wendy L. Dixon should serve on the Board because she has significant leadership experience in the pharmaceutical and biotechnology industry, including experience in drug development and regulatory affairs. Dr. Dixon has extensive experience in building successful marketing and sales teams and launching multiple pharmaceutical products across a broad range of therapeutic areas. Dr. Dixon also has significant experience serving as a director of other publicly held life sciences companies, including as a member of certain audit committees.
|  | OTHER PUBLIC COMPANY BOARDS
|  | Current |  | Past 5 Years
|  | Alkermes plc |  | Furiex Pharmaceuticals, Inc. (2010-2014)
|  | bluebird bio, Inc. |  | Orexigen Therapeutics, Inc. (2010-2016)
|  | Sesen Bio, Inc. |  |
|  | Voyager Therapeutics, Inc. |  |

|  | Proxy Statement 2019 | 11

##### Table of Contents

Proposal 1 Election of Directors |  |

Jacqualyn A. Fouse, Ph.D. |  |  |  |
Age 57 Director since 2017 Independent Director Committees • None |  | BACKGROUND
| Dr. Fouse has served as Chief Executive Officer of Agios Pharmaceuticals, Inc., a biopharmaceutical company, since February 2019. Prior to Agios, she served as Executive Chair of Dermavant Sciences, a biopharmaceutical company from July 2017 to September 2018. From September 2010 until June 2017, Dr. Fouse served in various capacities at Celgene Corporation, a biopharmaceutical company, serving as Strategic Advisor to the Management Executive Committee from April 2017 to June 2017, President and Chief Operating Officer from March 2016 to March 2017, President, Hematology and Oncology from August 2014 to February 2016, Executive Vice President and Chief Financial Officer from February 2012 to July 2014, and Senior Vice President and Chief Financial Officer from September 2010 to February 2012. Prior to joining Celgene, Dr. Fouse served as Chief Financial Officer of Bunge Limited, a global agribusiness and food company, from July 2007 to September 2010. Prior to joining Bunge, Dr. Fouse served as Senior Vice President, Chief Financial Officer and Corporate Strategy at Alcon Laboratories, Inc. since 2006, and as its Senior Vice President and Chief Financial Officer since 2002. Prior to her time with Alcon she held a variety of senior leadership roles with international companies.
|  | QUALIFICATIONS
|  | The Board has concluded that Jacqualyn A. Fouse should serve on the Board because she has significant corporate finance, financial reporting and accounting expertise as a result of her executive roles at Agios and previously at Dermavant Sciences and Celgene, as well as her prior positions with other companies. Additionally, Dr. Fouse is able to provide diverse and valuable corporate governance, management, operational and strategic expertise to the Board through her experience as an executive officer and a public company board member.
|  | OTHER PUBLIC COMPANY BOARDS
|  | Current |  | Past 5 Years
|  | Agios Pharmaceuticals, Inc. |  | Perrigo Company (2012-2016)
|  | Dick’s Sporting Goods, Inc. |  | Celgene Corporation (2016-2017)

12 | Proxy Statement 2019 |  |

##### Table of Contents

|  | Proposal 1 Election of Directors

Paul A. Friedman, M.D. |  |  |  |
Age 76 Director since 2001 Independent Director Committees • None |  | BACKGROUND
| Dr. Friedman has served as Chief Executive Officer and Chairman of the Board of Directors of Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, since July 2016. Dr. Friedman served as our Chief Executive Officer from November 2001 to January 2014 and was our President from May 2004 to January 2014. From 1998 until October 2001, Dr. Friedman served as President of DuPont Pharmaceuticals Research Laboratories, a wholly owned subsidiary of DuPont Pharmaceuticals Company (formerly The DuPont Merck Pharmaceutical Company), from 1994 to 1998 he served as President of Research and Development of The DuPont Merck Pharmaceutical Company, and from 1991 to 1994 he served as Senior Vice President at Merck Research Laboratories. Prior to his work at Merck and DuPont, Dr. Friedman was an Associate Professor of Medicine and Pharmacology at Harvard Medical School. Dr. Friedman is a Diplomate of the American Board of Internal Medicine and a Member of the American Society of Clinical Investigation. Dr. Friedman is a director of two privately held companies.
|  | QUALIFICATIONS
|  | The Board has concluded that Paul A. Friedman should serve on the Board because he has extensive expertise in our business and in the drug development and discovery industry. His past experiences, including as our former CEO, give him strong knowledge of our strategy, markets, competitors, financials and operations. He also has experience as a director of publicly held life sciences and healthcare companies.
|  | OTHER PUBLIC COMPANY BOARDS
|  | Current |  | Past 5 Years
|  | Alexion Pharmaceuticals, Inc. |  | Auxilium Pharmaceuticals, Inc. (2010-2015)
|  | Madrigal Pharmaceuticals, Inc. |  | Cerulean Pharma Inc. (2014-2017)
|  |  |  | Durata Therapeutics, Inc. (2013-2014)
|  |  |  | Verastem, Inc. (2014-2017)

|  | The Board recommends a vote “FOR” election as director of each of the nominees set forth above.

|  | Proxy Statement 2019 | 13

##### Table of Contents

Board Committees

The Board has appointed an Audit Committee, a Compensation Committee and a Nominating and Corporate Governance Committee. The Board has determined that each director who serves on these committees is “independent,” as that term is defined by applicable listing standards of The Nasdaq Stock Market and Securities and Exchange Commission rules. The Board has approved a charter for each of these committees, a current copy of each committee’s charter can be found on our website at http://www.incyte.com under the “Corporate Governance” heading in the “For Investors” portion of our website. The Board has also appointed a Finance Committee and a Non-Management Stock Option Committee.

Audit Committee |  | COMMITTEE MEMBERS
The Audit Committee’s responsibilities include: |  | Paul J. Clancy (Chair) Paul A. Brooke Wendy L. Dixon Met 8 times in 2018
Øassisting the Board in fulfilling its oversight responsibilities relating to the Company’s financial statements, systems of internal control over financial reporting, auditing, accounting and financial reporting processes, and compliance with legal and regulatory requirements;
Øappointing, compensating, evaluating and, when appropriate, replacing our independent registered public accounting firm;
Øreviewing and pre-approving audit and permissible non-audit services;
Øreviewing the scope of the annual audit; |  |
Ømonitoring the independent registered public accounting firm’s relationship with the Company; |  |
Ømeeting with the independent registered public accounting firm and management to discuss and review our financial statements, internal control over financial reporting, and auditing, accounting and financial reporting processes; |  |
Øreviewing the results of management’s efforts to monitor compliance with the Company’s programs and policies designed to promote adherence to applicable laws and regulations; and |  |
Øoverseeing the management of risks associated with financial and accounting systems, accounting policies, public reporting, investment strategies and cybersecurity, including the periodic review of management’s efforts to identify and mitigate such risks. |  |
The Board has determined that Mr. Clancy and Mr. Brooke are each qualified as an Audit Committee Financial Expert under the definition outlined by the Securities and Exchange Commission; |  |
No members of our Audit Committee sit on more than three public company audit committees, including ours. |  |

14 | Proxy Statement 2019 |  |

##### Table of Contents

|  | Board Committees

Compensation Committee |  | COMMITTEE MEMBERS
The Compensation Committee’s responsibilities include: |  | Paul A. Brooke (Chair) Julian C. Baker Jean-Jacques Bienaimé Met 8 times in 2018
Øassisting the Board in meeting its responsibilities with regard to oversight and determination of executive compensation;
Øreviewing and making recommendations with respect to major compensation plans, policies and programs of the Company;
Ødeveloping and monitoring compensation arrangements for our executive officers;
Ødetermining compensation for our CEO and other executive officers; |  |
Ødetermining stock-based compensation awards for our executive officers; |  |
Øadministering performance-based compensation plans such as our Amended and Restated 2010 Stock Incentive Plan (the “2010 Stock Incentive Plan”); |  |
Øreviewing and recommending directors’ compensation to the full Board; and |  |
Øpossessing sole authority to select, retain, terminate and approve the fees and other retention terms of consultants as it deems appropriate to perform its duties. |  |
Nominating and Corporate Governance Committee |  | COMMITTEE MEMBERS
The Nominating and Corporate Governance Committee’s responsibilities include: |  | Julian C. Baker (Chair) Paul A. Brooke Wendy L. Dixon Met 1 time in 2018
Øidentifying qualified individuals to become members of the Board;
Ødetermining the composition of the Board and its committees;
Ømonitoring a process to assess Board effectiveness;
Ørecommending nominees to fill vacancies on the Board;
Øreviewing and making recommendations to the Board with respect to candidates for director proposed by stockholders; |  |
Øreviewing the composition, functioning and effectiveness of the Board and its committees; |  |
Ødeveloping and recommending to the Board codes of conduct applicable to officers, directors and employees and charters for the various committees of the Board; and |  |
Øreviewing and making recommendations to the Board regarding the succession plan relating to our CEO and other executive officers. |  |
Finance Committee |  | COMMITTEE MEMBERS
The Finance Committee’s responsibilities include: |  | Paul A. Brooke (Chair) Julian C. Baker Hervé Hoppenot Did Not Meet in 2018
Øassisting the Board in its oversight of the Company’s strategic financing matters;
Øreviewing and recommending matters related to the capital structure of the Company; and
Øexercising the powers of the Board that may be lawfully delegated to the Finance Committee in connection with the authorization, issuance and sale of debt or equity securities of the Company.

|  | Proxy Statement 2019 | 15

##### Table of Contents

Corporate Governance

What We Do
|  | Majority voting for directors in uncontested elections |  |  |  | Audit Committee receives semiannual updates by our Chief Compliance Officer
|  | Strong and active Lead Independent Director, representing our largest stockholder |  |  |  | Maintain robust Code of Business Conduct and Ethics, Senior Financial Officers’ Code of Ethics and Board of Directors Code of Conduct and Ethics
|  | Audit Committee, Nominating and Corporate Governance Committee and Compensation Committee comprised solely of independent directors |  |  |  | Pre-clearance by our General Counsel required for trading in our stock by any director or executive officer
|  | Audit Committee regularly meets in executive session with Ernst & Young, our independent registered public accounting firm, as well as our internal controls team – without members of executive management present |  |  |  | Board members have complete access to management and employees in their discretion
|  | An independent compensation consultant is engaged by and reports directly to our Compensation Committee |  |  |  | Board and the committees may seek advice from outside advisors
|  | Annual election of directors |  |  |  | Review corporate strategic plan at least annually
|  | High Board and committee attendance |  |  |  | Review and approve Company budget annually
|  | Limits on outside Board and audit committee service |  |  |  | Robust commitment to corporate, environmental and social responsibility

What We Don’t Do
|  | No staggered or classified Board |  |  |  | No hedging or speculative trading in our stock by directors, executives or other employees
|  | No plurality voting in uncontested Board elections |  |  |  | Board members may not be “overboarded”

16 | Proxy Statement 2019 |  |

##### Table of Contents

|  | Corporate Governance

Corporate Responsibility

At Incyte, in addition to our commitment to innovation and the rigorous pursuit of research and development excellence, we are also committed to enhancing the communities in which we operate, improving the treatment and experience of patients, supporting our colleagues and operating our business in a way that protects the environment. For more information, please see “Our Commitment” in the “Our Company” portion of our website at http://www.incyte.com; however, the information on our website is not part of this proxy statement.

|  | PATIENTS At Incyte, we believe in the power of research to advance scientific innovation and improve patient health and outcomes. Every day we |  |  |  |  |  | EMPLOYEES Incyte is committed to promoting a collaborative, safe and innovative work environment at which everyone can contribute to their fullest potential.
are driven to discover and deliver medicines that will positively impact the lives of patients with cancer and other serious diseases. We support our patients through commitments in four key areas: •  Patient Safety •  Scientific Excellence •  Access to Medicine •  Patient Education and Awareness |  |  |  | We appreciate, celebrate, and thrive on one another’s differences and strengths. A strong safety culture is a fundamental part of how we work. Our philosophy is that everyone at Incyte has a responsibility to create and maintain a safe and healthy workplace with a goal to reduce risk and prevent injuries. •  Recognized as the number two employer in the biopharma industry by Science magazine. •  Specifically recognized by team members for its innovation, work culture and respect for employees.
|  | COMMUNITY Incyte is committed to being an active participant in improving the communities where we live and work. |  |  |  |  |  | ENVIRONMENT At Incyte, we seek to operate in a way that reduces our environmental impact. This includes programs for data collection and
Incyte Involved is comprised of three initiatives focused on philanthropy as well as employee and community engagement. The Incyte Charitable Giving Foundation •  Includes the Incyte Cancer Care Assistance Fund for Delaware, which provides emergency financial assistance for cancer patients, their caregivers, and family members living in Delaware. The Community Service Program •  Incyte colleagues donated over 1,200 hours to working with organizations, including the Food Bank of Delaware and the Salvation Army in 2018. The Matching Gifts Program •  In 2018, Incyte matched more than $120,000 donated by our colleagues. |  |  |  | analysis in order to measure and reduce hazardous air emissions, greenhouse gases and water use. In 2019, Incyte launched Greencyte, which is a cross-functional and global team dedicated to seeking ways to minimize our impact on the environment. United States: •  All hazardous waste is recycled, reused, fuel-blended or disposed of at an EPA approved facility. •  Incyte’s Environmental, Health and Safety team works to identify waste minimization and pollution prevention. Ex-U.S.: •  Construction of two sites in Switzerland follow strict Swiss regulations regarding environmental protection and energy consumption. •  Solar panels are being used on both buildings.

Majority Voting Policy

Our Bylaws include a majority voting standard for the election of directors. In order to receive a majority of the votes cast, the number of shares voted “FOR” must exceed the number of votes “AGAINST”; abstentions and broker non-votes do not count as votes cast. Our Bylaws provide that, in an uncontested election, director nominees must receive a majority of the votes cast to be elected to

|  | Proxy Statement 2019 | 17

##### Table of Contents

Corporate Governance |  |

the Board. Our Corporate Governance Guidelines state that if a nominee for director in an uncontested election does not receive a majority of the votes cast, the director should submit a resignation for consideration by the Board. The Nominating and Corporate Governance Committee will evaluate and make a recommendation to the Board with respect to the proffered resignation. The Board must take action on the recommendation within 90 days following certification of the stockholder vote. The director whose resignation is under consideration cannot participate in any decision regarding his or her resignation. The Nominating and Corporate Governance Committee and the Board may consider any factors they deem relevant in deciding whether to accept a director’s resignation.

Board Leadership Structure and Role in Risk Oversight

Our current leadership structure and governing documents permit the roles of Chairman and CEO to be filled by the same or different individuals. Where the Chairman and CEO roles are filled by the same individual, our Corporate Governance Guidelines require the independent directors on our Board to appoint a Lead Independent Director. The Board has currently determined that it is in the best interests of our stockholders to have Hervé Hoppenot, our President and CEO, serve as Chairman, coupled with an active Lead Independent Director. As such, Mr. Hoppenot holds the position of Chairman, President and CEO, and Julian C. Baker serves as our Lead Independent Director. Mr. Baker is a managing member of the general partner of our largest stockholder—namely, Baker Bros. Advisors LP and affiliated entities—who collectively holds 16.1% of our common stock as of March 12, 2019. The Board retains the authority to modify this structure as it deems appropriate.

Focus on Independence. The Board maintains a strong commitment to ensuring Board independence so that it is able to maintain effective oversight of management. The Board’s commitment to independence includes:

| ✓ | Annual appointment of a strong Lead Independent Director, who also represents our largest stockholder, thereby ensuring strong representation of stockholder interests

| ✓ | Robust duties of the Lead Independent Director:

| • |  | presiding at all meetings of the Board at which the Chairman is not present, including executive sessions of the independent directors

| • |  | serving as liaison between the Chairman and the independent directors

| • |  | approving information sent to the Board

| • |  | approving meeting agendas for the Board

| • |  | approving meeting schedules to assure that there is sufficient time for discussion of all agenda items

| • |  | authority to call meetings of the independent directors

| • |  | being available for consultation with stockholders, when appropriate.

| ✓ | Review, at least annually, of the Company’s strategic plan and the following year’s capital and operating budgets

| ✓ | Annual election of all directors, ensuring accountability to stockholders

| ✓ | Regular executive sessions of the independent, non-management directors—without Mr. Hoppenot—to review Company performance, management effectiveness, proposed programs and transactions and the Board meeting agenda item

18 | Proxy Statement 2019 |  |

##### Table of Contents

|  | Corporate Governance

| ✓ | Requirement that only independent directors serve on the Audit Committee, the Compensation Committee and the Nominating and Corporate Governance Committee

| ✓ | Requirement that a majority of the Board be comprised of independent directors, with 87.5% of the current Board being independent

| ✓ | Corporate Governance Guidelines providing that the Board may have access to Company management and employees and its own advisors, at the Board’s discretion.

Benefits of Combined Leadership Structure. The Board believes that the Company and our stockholders have been best served by having Mr. Hoppenot in the role of Chairman and CEO for the following reasons:

| • |  | Mr. Hoppenot is most familiar with our business and the unique challenges we face. As such, Mr. Hoppenot is the director best suited to identify strategic opportunities and focus the activities of the Board. Mr. Hoppenot’s day-to-day insight into our challenges facilitates a timely deliberation by the Board of important matters.

| • |  | Mr. Hoppenot has and will continue to identify agenda items and lead effective discussions on the important matters affecting us. Mr. Hoppenot’s knowledge and extensive experience regarding our operations and the highly-regulated industries and markets in which we compete position him to identify and prioritize matters for Board review and deliberation.

| • |  | As Chairman and CEO, Mr. Hoppenot serves as an important bridge between the Board and management and provides critical leadership for carrying out our strategic initiatives and confronting our challenges. The Board believes that Mr. Hoppenot brings a unique, stockholder-focused insight to assist the Company to most effectively execute its strategy and business plans to maximize stockholder value.

| • |  | The strength and effectiveness of the communications between Mr. Hoppenot as our Chairman and Mr. Baker as our Lead Independent Director result in effective Board oversight of the issues, plans and prospects of our Company.

| • |  | This leadership structure provides the Board with more complete and timely information about the Company, a unified structure and consistent leadership direction internally and externally and provides a collaborative and collegial environment for Board decision-making.

Flexibility of the Leadership Structure. The Board is committed to high standards of corporate governance. The Board values its flexibility to select, from time to time, a leadership structure that is most able to serve the Company’s and stockholders’ best interests based on the qualifications of individuals available and circumstances existing at the time. As such, the Board periodically evaluates whether combining or separating the roles of Chairman and CEO is in the best interests of the Company and our stockholders. The Board believes that a policy limiting its flexibility to choose, consistent with its fiduciary duties, a leadership structure that will enable the Company to most effectively execute its strategy and business plans to maximize stockholder value would be detrimental to the Company and our stockholders.

Board’s Role in Risk Oversight. Our Board is responsible for overseeing the overall risk management process at the Company directly and through its committees. The responsibility for managing risk rests with executive management while the committees of the Board and the Board as a whole participate in the oversight process. The Board’s risk oversight process builds upon management’s

|  | Proxy Statement 2019 | 19

##### Table of Contents

Corporate Governance |  |

risk assessment and mitigation processes, which include reviews of long term strategic and operational planning, executive development and evaluation, regulatory and legal compliance, and financial reporting and internal controls. The Board considers strategic and operational risks and opportunities and regularly receives reports from executive management regarding specific aspects of risk management. The Audit Committee receives periodic reports from executive management with respect to, and reviews such risks associated with, our financial and accounting systems, accounting policies, investment strategies, regulatory compliance and our information systems and technology, including cybersecurity risks and readiness. The Audit Committee also meets regularly with our Chief Compliance Officer, our internal controls team and our independent registered public accounting firm in executive session without the presence of other members of management. The Compensation Committee evaluates our compensation policies and practices to help ensure that these policies and practices do not incentivize employees to take unnecessary or excessive risks that are reasonably likely to have a material adverse effect on our Company and provide appropriate incentives for meeting both short-term and long-term objectives and increasing stockholder value over time. The Nominating and Corporate Governance Committee reviews our risks associated with governance matters and non-compensation related human resources matters.

Director Independence

In 2018, our Board determined that each individual who served as a member of the Board in 2018, except for Mr. Hoppenot, was an “independent director” within the meaning of Rule 5605 of The Nasdaq Stock Market.

Mr. Hoppenot is not considered independent as he is currently employed as our CEO. For Mr. Bienaimé, Mr. Baker, Mr. Brooke, Mr. Clancy, Dr. Dixon, Dr. Fouse and Dr. Friedman, the Board considered their relationship and transactions with our Company as directors and security holders of our Company.

All of the nominees are current members of the Board.

Director Nominations

The Board nominates directors for election at each annual meeting of stockholders and elects new directors to fill vacancies when they arise. The Board has as an objective, set forth in our Corporate Governance Guidelines, that its membership be composed of experienced and dedicated individuals with diversity of backgrounds, perspectives and skills. The Nominating and Corporate Governance Committee has the responsibility to identify, evaluate, recruit and recommend qualified candidates to the Board for nomination or election.

The Nominating and Corporate Governance Committee will select candidates for director based on their character, judgment, diversity of experience, business acumen, and ability to act on behalf of all stockholders. The Nominating and Corporate Governance Committee believes that nominees for director should have experience, such as experience in management, accounting, finance, drug discovery and development, or marketing, or industry and technology knowledge, that may be useful to the Company and the Board; high personal and professional ethics and the willingness and ability to devote sufficient time to effectively carry out his or her duties as a director. Although the Company has no formal diversity policy for board members, the Board and the Nominating and Corporate Governance Committee consider diversity of backgrounds and experiences and other forms of diversity when selecting nominees.

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|  | Corporate Governance

The Nominating and Corporate Governance Committee believes it appropriate for at least one, and, preferably, multiple, members of the Board to meet the criteria for an “audit committee financial expert” as defined by Securities and Exchange Commission rules, and our Corporate Governance Guidelines require that a majority of the members of the Board meet the definition of “independent director” under the rules of The Nasdaq Stock Market. The Nominating and Corporate Governance Committee believes it appropriate for certain key members of our management — currently, our CEO — to participate as members of the Board.

Prior to each annual meeting of stockholders, the Nominating and Corporate Governance Committee identifies nominees first by evaluating the current directors whose term will expire at the annual meeting and who are willing to continue in service. These candidates are evaluated based on the criteria described above, including as demonstrated by the candidate’s prior service as a director, and the needs of the Board with respect to the particular talents and experience of its directors. In the event that a director does not wish to continue in service, the Nominating and Corporate Governance Committee determines not to re-nominate the director, or if a vacancy is created on the Board as a result of a resignation, an increase in the size of the Board or other event, then the Committee will consider various candidates for Board membership, including those suggested by the Committee members, by other Board members, by any search firm engaged by the Committee and by stockholders. The Committee may only recommend, and the Board may only nominate, candidates for director who agree to tender, promptly following their election or re-election as a director, irrevocable resignations that would be effective if the director fails to receive a sufficient number of votes for re-election at the next annual meeting of stockholders at which he or she faces re-election and if the Board accepts the resignation. The Committee recommended all of the nominees for election included in this Proxy Statement. All of the nominees are current members of the Board.

A stockholder who wishes to suggest a prospective nominee for the Board should notify the Secretary of the Company or any member of the Nominating and Corporate Governance Committee in writing with any supporting material the stockholder considers appropriate. In addition, our Bylaws contain provisions that address the process by which a stockholder may nominate an individual to stand for election to the Board at our annual meeting of stockholders. In order to nominate a candidate for director, a stockholder must give timely notice in writing to the Secretary of the Company and otherwise comply with the provisions of our Bylaws. To be timely, our Bylaws provide that our Secretary must have received the stockholder’s notice not less than 90 days nor more than 120 days prior to the first anniversary of the preceding year’s annual meeting of stockholders. However, in the event that no annual meeting was held in the preceding year or the annual meeting is called for a date that is more than 30 days before or more than 60 days after the first anniversary date of the preceding year’s annual meeting of stockholders, notice by the stockholder to be timely must be so received by the Secretary of the Company not later than the close of business on the later of (1) the 90th day prior to the date of the meeting and (2) the 10th day following the first public announcement or disclosure of the meeting date. Information required by the Bylaws to be in the notice include the name and contact information for the candidate and the person making the nomination and other information about the nominee that must be disclosed in proxy solicitations under Section 14 of the Securities Exchange Act of 1934 and the related rules and regulations under that Section.

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Corporate Governance |  |

Stockholder nominations must be made in accordance with the procedures outlined in, and include the information required by, our Bylaws and must be addressed to:

Secretary

Incyte Corporation

1801 Augustine Cut-Off

Wilmington, DE 19803

You can obtain a copy of the full text of the Bylaw provision by writing to the Company’s Secretary at the above address.

Board Meetings

The Board held five meetings during 2018. All directors attended all meetings held by the Board and of the committees on which such director served during his or her tenure in 2018.

The independent directors meet in executive sessions at regularly scheduled meetings of the Board without the participation of our CEO or other members of management. There were four regularly scheduled meetings of the Board in 2018.

In 2018, we did not, and for 2019, we do not, have a policy that requires the attendance of directors at the Annual Meeting.

Corporate Governance Guidelines

The Board is committed to sound and effective corporate governance practices. Accordingly, the Board has adopted Corporate Governance Guidelines, which are intended to describe the governance principles and procedures by which the Board functions. The guidelines are subject to periodic review and update by the Nominating and Corporate Governance Committee and the Board, and were most recently amended in November 2017. These Guidelines can be found on our website at http://www.incyte.com under the “Corporate Governance” heading in the “For Investors” portion of our website.

The Corporate Governance Guidelines provide, among other things, that:

| • |  | a majority of the directors must be independent;

| • |  | if the Chairman of the Board is not an independent director, the independent directors will appoint a Lead Independent Director, whose duties would include presiding at all meetings of the Board at which the Chairman is not present, presiding at executive sessions of the independent directors, serving as liaison between the Chairman and the independent directors, approving information sent to the board, approving meeting agendas for the Board, approving meeting schedules to assure that there is sufficient discussion time for all agenda items, and being available for consultation with stockholders (when appropriate);

| • |  | directors should offer to resign from the Board if they experience a change in their principal occupation;

| • |  | directors should submit their resignations from the Board if they do not receive the votes of a majority of the votes cast in an uncontested election;

| • |  | directors should advise the chair of the Nominating and Corporate Governance Committee before accepting an invitation to serve on more than four other public company boards (or, if a director is a chief executive officer of a public company, more than two other public company boards);

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|  | Corporate Governance

| • |  | the Audit, Compensation, and Nominating and Corporate Governance Committees must consist solely of independent directors;

| • |  | the Board and its committees may seek advice from outside advisors as appropriate;

| • |  | the independent directors regularly meet in executive sessions without the presence of the non-independent directors or members of our management; and

| • |  | the Nominating and Corporate Governance Committee periodically reviews the composition, functioning and effectiveness of the Board and its committees, and oversees the self-assessment of the Board and its committees.

Communications with the Board

If you wish to communicate with the Board, you may send your communication in writing to:

Secretary

Incyte Corporation

1801 Augustine Cut-Off

Wilmington, DE 19803

You must include your name and address in the written communication and indicate whether you are a stockholder of the Company.

The Secretary will review any communications received from a stockholder and all material communications from stockholders will be forwarded to the appropriate director or directors or Committee of the Board based on the subject matter.

Certain Relationships and Related Transactions

Our policy is that all employees, officers and directors must avoid any activity that is or has the appearance of conflicting with the interests of the Company. This policy is included in our Code of Business Conduct, Ethics and Board Code of Conduct and Ethics. We conduct a review of all related party transactions for potential conflict of interest situations on an ongoing basis and all such transactions must be approved by the Audit Committee or another independent body of the Board.

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Compensation of Directors

Our director compensation program is designed to enable continued attraction and retention of highly qualified non-employee directors by ensuring that our director compensation is in line with compensation offered by our peer companies that compete with us for director talent. The program is designed to address the time, effort, expertise, and accountability required of active board membership. Directors who are employees of the Company do not receive any fees for their service on the Board or any committee. Mr. Hoppenot is the Company’s only employee director. The Compensation Committee, with the assistance of its independent compensation consultant, periodically reviews the compensation for our non-employee directors in relation to the peer group used for compensation purposes (as described below under “Compensation Discussion and Analysis”).

In the course of our stockholder engagement during 2018, it became clear that it was time to re-evaluate our director compensation practices. Existing director compensation practices included an equity grant of a fixed number of options. A consensus was forming among several of our stockholders that the equity component of director compensation should, instead, aim to deliver a fixed value. The goal of fixed-value equity compensation is to ensure that overall compensation amounts are generally consistent over time, thus avoiding the up-and-down values that occur when equity compensation grants are fixed to a particular number of stock options. Accordingly, based on the Compensation Committee’s most recent review in September 2018, the Compensation Committee recommended, and, in March 2019, the Board of Directors approved the changes in non-employee director compensation described below, noting the continued heavy weighting of compensation toward equity and stock options. These changes will take effect upon the approval of amendments to our Amended and Restated 2010 Stock Incentive Plan (the “2010 Stock Incentive Plan”), as described below under “Proposal 3.”

Cash Compensation

Effective as of the date of stockholder approval of Proposal 3, the amendments to the 2010 Stock Incentive Plan, each non-employee director, other than the Lead Independent Director, will receive a $60,000 annual retainer, payable quarterly, and prorated for such portion of the year that the director serves on the Board. The Lead Independent Director will receive a $90,000 annual retainer. The chair of the Audit Committee will receive an additional $25,000 annual retainer, and each other member of the Audit Committee will receive an additional $12,000 annual retainer. The chair of the Compensation Committee will receive an additional $25,000 annual retainer, and each other member of the Compensation Committee will receive an additional $10,000 annual retainer. The chair of the Nominating and Corporate Governance Committee will receive an additional $16,000 annual retainer, and each other member of the Nominating and Corporate Governance Committee will receive an additional $8,000 annual retainer. The chair of the Finance Committee receives an additional $15,000 annual retainer, and each other member of the Finance Committee receives an additional $8,000 annual retainer. All retainers will be prorated for such portion of the year that the director serves on the Board.

Non-employee directors have the option to elect to receive their retainers and committee fees in the form of restricted stock that vests immediately when the associated quarterly retainer amount is paid. All directors are reimbursed for their travel and out-of-pocket expenses in accordance with our travel policy for each in-person Board or committee meeting that they attend.

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|  | Compensation of Directors

Equity Compensation

In addition to cash compensation for services as a member of the Board, non-employee directors also receive equity awards. If our stockholders approve Proposal 3, the 2010 Stock Incentive Plan will be amended to provide that following the conclusion of the Annual Meeting and each future annual meeting of our stockholders, each non-employee director who continues to serve as a member of the Board will receive awards with a grant date value of $500,000, of which 75% would be in the form of stock options and 25% would be in the form of restricted stock unit (RSU) awards, determined in the same manner as with awards to our executive officers, as described below under “Compensation Discussion and Analysis.” The exercise price of the options will be equal to the fair market value on the date of grant, and the options will have a term of ten years. Each of these options and RSUs will vest in full on the first anniversary of the date of the grant or, if earlier, the date of the next annual meeting of stockholders or upon a change in control. The initial stock option grants described in the next paragraph will be eliminated.

Prior to the date of stockholder approval of Proposal 3, each new non-employee director appointed to the Board will receive an initial stock option to purchase 25,000 shares of our common stock at an exercise price equal to the fair market value of our common stock on the date of grant. The initial stock option vests and becomes exercisable as to 25% of those shares on the first anniversary of the date of the grant, and the remaining shares vest and become exercisable monthly over the following three years. In addition, on the date of each annual meeting of stockholders, each non-employee director who continues to serve as a member of the Board will receive an option to purchase 15,000 shares of our common stock at an exercise price equal to the fair market value of our common stock on the date of grant. Each of these annually granted options will vest in full on the first anniversary of the date of the grant or, if earlier, the date of the next annual meeting of stockholders or upon a change in control.

Under the 2010 Stock Incentive Plan, when a new non-employee director is appointed to the Board at a time other than at an annual meeting, the director receives a pro rata portion of the automatic annual grants. On May 1, 2018, the date of our 2018 Annual Meeting of Stockholders, each then continuing non-employee director received his or her annual grant of an option to purchase 15,000 shares of our common stock at an exercise price equal to the fair market value of our common stock on the date of grant.

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Compensation of Directors |  |

The table below shows the compensation paid to each non-employee director for his or her service in 2018:

2018 Director Compensation Table

Name |  | Fees Earned or Paid in Cash ($) |  |  | Stock Awards ($)(1) |  |  | Option Awards ($)(2)(3) |  |  | Total ($) |
Julian C. Baker |  |  | — |  |  |  | 76,000 |  |  |  | 427,371 |  |  |  | 503,371 |
Jean-Jacques Bienaimé |  |  | — |  |  |  | 58,000 |  |  |  | 427,371 |  |  |  | 485,371 |
Paul A. Brooke |  |  | — |  |  |  | 95,000 |  |  |  | 427,371 |  |  |  | 522,371 |
Paul J. Clancy |  |  | 70,000 |  |  |  | — |  |  |  | 427,371 |  |  |  | 497,371 |
Wendy L. Dixon |  |  | — |  |  |  | 65,000 |  |  |  | 427,371 |  |  |  | 492,371 |
Jacqualyn A. Fouse |  |  | — |  |  |  | 50,000 |  |  |  | 427,371 |  |  |  | 477,371 |
Paul A. Friedman |  |  | 50,000 |  |  |  | — |  |  |  | 427,371 |  |  |  | 477,371 |

(1) | Value of restricted stock awards issued at the election of the director in lieu of some of his or her annual retainer and committee fees.

(2) | Amounts listed in this column represent the aggregate grant date fair value of option awards granted in 2018 determined in accordance with the Financial Accounting Standards Board Accounting Standards Codification Topic 718 (ASC 718) for financial reporting purposes. See Note 13 of the Notes to Consolidated Financial Statements in our Annual Report on Form 10-K for the year ended December 31, 2018 for a discussion of our assumptions in determining the ASC 718 values of our stock awards.

(3) | The following table provides the number of shares of common stock subject to outstanding options held at December 31, 2018 for each director. The number of shares shown for Dr. Friedman includes 107,500 shares underlying options received while he served as our CEO.

Name |  | Number of Shares Underlying Unexercised Options |
Julian C. Baker |  |  | 175,000 |
Jean-Jacques Bienaimé |  |  | 90,000 |
Paul A. Brooke |  |  | 155,000 |
Paul J. Clancy |  |  | 90,000 |
Wendy L. Dixon |  |  | 188,334 |
Jacqualyn A. Fouse |  |  | 48,750 |
Paul A. Friedman |  |  | 182,500 |

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Executive Compensation

Compensation Discussion and Analysis

What We Do
|  | We pay for performance |  |  |  | We have adopted a compensation clawback policy
|  | 25% of executives’ target equity award value is in the form of performance shares |  |  |  | Our Compensation Committee uses an independent compensation consultant, Compensia
|  | We consider peer groups in establishing executive compensation |  |  |  | We have robust anti-hedging and anti-speculation policies in place
|  | We have implemented robust stock ownership guidelines for our CEO, executive officers and our directors |  |  |  | We conduct an annual say-on-pay vote
|  | We have double-trigger equity vesting in the event of a change-in-control |  |  |  | Our Compensation Committee is comprised of all independent directors
|  | Equity awards have a minimum vesting period of 12 months. |  |  |  | We engage proactively with our stockholders throughout the year

What We Don’t Do
|  | We do not reprice stock options without stockholder approval |  |  |  | We do not provide golden parachute excise tax gross-ups
|  | We do not provide single-trigger equity vesting in the event of a change-in-control |  |  |  | We do not provide executive perquisites beyond financial and tax planning

Compensation Program Strategy and Objectives

The Compensation Committee of our Board believes that the compensation of our executive officers should:

| • |  | Pay for performance;

| • |  | Encourage both creation of stockholder value and achievement of strategic corporate objectives;

| • |  | Integrate compensation with our annual and long-term corporate objectives and strategy, and focus executive behavior on the fulfillment of both of those objectives;

| • |  | Provide a competitive total compensation package that enables us to attract and retain, on a long-term basis, qualified personnel; and

| • |  | Provide fair compensation consistent with internal compensation programs.

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Executive Compensation |  |

Our executive officers’ compensation currently includes three primary components: base salary, cash bonus, and equity-based incentive awards. Equity-based incentive awards can be made up of restricted stock units, performance shares or stock options. Salary is a fixed amount and does not vary with our performance. All other components of our executives’ compensation are closely tied to our Company’s performance – either through the amounts (if any) of each component actually received or the value of each component over time, or both – and each contributes toward our goal of delivering long-term stockholder value. Each of the equity-based components – including the performance shares that only become earned upon achievement of pre-determined goals – are also subject to time-based vesting, which the Compensation Committee believes incentivizes executive retention. The performance-based components and time-based components of our equity compensation program are designed to encourage both an appropriate level of risk-taking and a focus on sound long-term decision-making, thus aligning executive interests with the long-term best interests of our Company and our stockholders. The chart below sets out each of these components.

Fixed Compensation Performance-Based Compensation Short Term Cash Compensation Program Long Term Equity Compensation Program Partially At-Risk Wholly At-Risk Salary Incentive Compensation Program Restricted Stock Units1 Performance Shares Stock Options2 Form and Key Features Provides base compensation that is predictable and competitive with our peer group Reflects the scope and complexity of executives' roles and responsibilities Reviewed and approved annually by the Compensation Committee Annual cash bonus opportunity Percentage of base salary awarded is determined by level of achievement of commercial, R&D and strategic goals Goals approved at the start of each year by the Compensation Committee Achievement percentage determined at the end of each year by the Compensation Committee 25% of target equity value Value is tied to the stock price Vests over four years 25% of target equity value Goals approved at the start of each year by the Compensation Committee Performance goals align with stockholder interests Only earned if we meet pre-determined performance goals If achieved, value is directly tied to the stock priceVests over four years50% of target equity value Value is directly tied to the stock price Vests over four years Purpose Rewards current contributions to the CompanyAttracts and retains high-level talentProvides opportunity for near-term cash bonus based on the achievement of short-term strategic corporate objectives, which are intended to drive long-term growthSets the stage for potential continued growthProvides opportunity for compensation when stock price is volatileProvides long-term retention of key talentEncourages long-term decision making Aligns management objectives with stockholder interest Provides incentive to achieve key objectives intended to maximize stockholder valueProvides long-term retention of key talentEncourages long-term decision making Aligns management objectives with stockholder interestProvides incentives for strategic risk-taking to maximize value, which correlates to our longer-term R&D plans, and aligns with longer-term stockholder valueProvides long-term retention of key talentEncourages long-term decision makingAligns management objectives with stockholder interest Equity Ownership Guidelines for Executives Help Ensure Continued Alignment with Stockholder Interests Year After Year

1. | Restricted Stock Units were not used as part of the 2018 equity compensation program, but comprise 25% of target equity compensation for 2019. For a further description of the evolution of the equity compensation program from 2018 through 2019, see “-Recent Evaluation of Our Equity Grant Practices”, starting on page 33.

2. | Stock options comprised 75% of target equity compensation for 2018, and now comprise 50% for 2019. For a further description of the evolution of the equity compensation program from 2018 through 2019, see “-Recent Evaluation of Our Equity Grant Practices”, starting on page 33.

As the design of our executive compensation program shows, the Compensation Committee believes that executive compensation should be designed to pay for performance. Our Company has been very successful in recent years, and executive compensation has reflected that performance. While 2018 was also successful in many respects, we did miss a very important development goal

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|  | Executive Compensation

when our ECHO-301 trial failed, resulting in a lower cash bonus of 81% of target as well as decreased value of equity holdings. In addition, in the case of performance shares which were tied to pre-determined, internal, stretch revenue targets, the shares earned amounted to only 83% of target shares. The charts below illustrate how our CEO’s compensation is closely tied to our Company’s performance goals over the last three years and how the percentage of our CEO’s compensation that is tied to performance compares with those of our peer group of companies. The chart below illustrates this evolution with respect to our CEO’s compensation, demonstrating that our CEO’s total compensation tracks our achievement of Board-approved corporate goals:

CEO Total Compensation is Linked to Performance

Total CEO Compensation

Incentive Compensation Program Achievement |  | Performance Share Achievement

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Executive Compensation |  |

CEO At-Risk Compensation is In-Line with 2019 Peer Group

Implementing Our Objectives – Role of Compensation Committee and Our Chief Executive Officer

The Compensation Committee approves, administers and interprets our executive compensation and benefits policies, including our 2010 Stock Incentive Plan. The Compensation Committee evaluates the performance of our CEO and determines his compensation in light of the goals and objectives of our compensation program. Our CEO and the Compensation Committee together assess the performance of our other executive officers and determine their compensation, based on initial recommendations from our CEO.

Role of the Independent Compensation Consultant

Under its charter, the Compensation Committee has the sole authority to retain any independent compensation consultant or other advisor as the Committee may deem appropriate. Pursuant to this authority, the Compensation Committee has engaged Compensia, a national compensation consulting firm, for support on matters related to the compensation of our executive officers. Compensia does not provide any other services to our Company.

Compensia was retained by the Compensation Committee to prepare compensation analyses for our executive officers and the non-employee members of our Board of Directors. Specifically, Compensia was directed to provide a competitive market analysis of the base salary, annual cash incentive awards, and long-term incentive equity compensation of our executive officers compared against our compensation peer groups and to review other market practices and trends. This market analysis was reviewed with the Compensation Committee in connection with its January 2018 compensation decisions, and was used to guide decisions regarding base salary adjustments and target annual cash and equity incentive award opportunities. Updated data prepared by Compensia were used to inform the July 2018 equity award decisions made by the Compensation Committee.

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Market Reference Data

While the Compensation Committee reviews market benchmarks, it does not necessarily target a specific percentile within our peer group but rather utilizes market reference data to evaluate the competitiveness of our executive officers’ compensation and to determine whether the total compensation paid to each of our named executive officers was reasonable in the aggregate.

In connection with its analysis for purposes of 2018 compensation decisions, the Compensation Committee reviewed information prepared by Compensia comparing the compensation for our executive officers with data from SEC filings and the Radford Life Sciences Survey for a peer group comprised of 16 publicly-traded biopharmaceutical companies. Where peer data was unavailable, Compensia used survey data from the Mercer SIRS Survey. We collectively refer to this data as the competitive compensation data.

The peer group for 2018 compensation decisions, referred to as the 2018 peer group, was chosen based on the following characteristics: major labor and capital market competitors, broadly similar size in revenue, market capitalization and headcount, and similar product and business models.

In September 2018, the peer group was changed because one company, Bioverativ, had been acquired and another company, Tesaro, no longer met our revenue and market capitalization criteria. Two new companies that did meet our criteria, Jazz Pharmaceuticals and Neurocrine Biosciences, were added to our peer group to replace the dropped companies. This updated peer group was used for 2019 compensation decisions and is referred to as the 2019 peer group.

The following table sets forth our peer group criteria and a comprehensive list of the peer group companies used for 2018 and 2019 compensation decisions:

How We Establish Our Peer Group

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Executive Compensation |  |

Using recent data as of December 31, 2018, the following tables illustrate Incyte’s twelve trailing months of revenue performance relative to the 2019 peer group and also illustrate our relative headcount and revenue-to-employee ratio compared to the 2019 peer group. We believe this data helps underscore the efficiency of our operations.

2018 Revenue vs. Peers

Revenue to Employee Ratio vs. Peers

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Recent Evaluation of Our Equity Grant Practices

In July 2016, the Compensation Committee, after consulting with Compensia with respect to peer group practices, revised our equity grant guidelines. In 2016 and 2017, 75% of the value of an executive officer’s annual equity-based incentive awards were in the form of stock options while the remaining 25% were in the form of restricted stock units (RSUs).

In response to stockholder feedback, in 2018, the Compensation Committee changed the RSU portion to performance share awards, which combine the time-based vesting aspects of RSUs with a performance-based vesting requirement, resulting in 75% of the value being in the form of stock options and 25% in performance share awards.

In 2019, the Compensation Committee noted Compensia’s observation that our mix for executives of 75% stock options and 25% performance shares put our executives’ equity-based compensation more at-risk than our peer group and the broader market norm and that, on average, our peers deliver approximately 25% of executive equity compensation value in the form of time-based vesting RSUs, with approximately 50% being delivered in the form of stock options and approximately 25% being delivered in the form of performance-based shares or options. The Committee also noted that, due to our stock price decline and limited use of RSUs, realizable compensation for our executives for 2016 through 2018 fell well below target compensation values. Accordingly, to enhance executive retention and bring our executive equity compensation practices in line with our peers, the Committee determined that, for 2019, our executives will receive 50% of their grant date target value in the form of stock options, 25% in the form of performance shares, and 25% in the form of RSUs.

While the equity awards are actually granted in July of each year, the Compensation Committee determines the overall equity grant target value for our executive officers in the early portion of the year, in conjunction with the determination of base salary adjustments and the establishment of the annual incentive compensation plan described in greater detail below. Based on those target values, the share numbers of our annual stock option grants are determined in the middle of each calendar year, with one-half of the grants made at that time and one-half made at the beginning of the following calendar year, with a view toward countering some of the effects of the volatile trading price of our common stock. Our annual stock option grants have a ten-year term with four-year service-based vesting with one-quarter vesting after one year and the remainder vesting in 36 equal monthly installments. Our annual executive performance share and RSU awards are made in the middle of each calendar year. The performance share awards vest, assuming performance goals are achieved at specified levels, in equal annual installments over four years and are described further below. The RSU awards vest in equal installments on each of the first four anniversaries of the grant date.

The Compensation Committee also has the discretion to make outstanding merit stock option awards, which have a ten-year term and vest in a single installment after four years. Those awards, if granted, can be made to executives other than our CEO as well as other key employees throughout our Company and are typically made in connection with salary adjustments at the beginning of each year as the awards are intended to relate to prior year performance and to incentivize and retain the recipients. Our CEO championed the creation of the outstanding merit grant program to recognize important contributions – both within a function and the Company as a whole - by leaders throughout our organization. Previously, our CEO received these grants too, but, starting in 2019, in response to stockholder feedback, the Compensation Committee eliminated awards of outstanding merit grants to our CEO.

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Executive Compensation |  |

In addition, as described below, in June 2018, the Compensation Committee made retention plan awards to certain key R&D and salesforce employees, including the grant of performance share awards to certain executive officers (not including our CEO).

The exercise price of each stock option awarded under our 2010 Stock Incentive Plan is the closing price of our common stock on the date of grant, which for our annual stock option grants are the dates of the regularly scheduled Compensation Committee meetings or actions without meetings, which are taken following decisions at meetings, in the middle of the year at which equity awards for senior executives are formally determined and at the beginning of the year at which salary adjustments and cash bonuses under our incentive compensation plan are determined. These meetings are scheduled in advance, and we do not coordinate the timing of equity award grants with the release of financial results or other material announcements by our Company. Under our 2010 Stock Incentive Plan, we may not reprice or replace options at lower exercise prices without stockholder approval.

Compensation Practices and Policies

Equity Ownership Guidelines. Effective January 1, 2016, our Board adopted robust equity ownership guidelines for members of senior management, including our executive officers, and members of the Board. Under these guidelines, the covered individuals are expected to meet the following equity ownership requirements:

Equity Ownership Requirements
CEO |  | 6x Annual Base Salary
All Other Executive Officers |  | 3x Annual Base Salary
Non-Employee Members of the Board |  | 6x Annual Cash Retainer

All directors and executive officers have either met their respective equity ownership targets or are within the five-year period for achieving compliance.

Covered individuals as of January 1, 2016 must satisfy these guidelines by December 31, 2020, and individuals who subsequently become subject to the guidelines will have five years to reach their ownership requirements. Shares held directly, shares held indirectly, such as by a trust or a 401(k) plan, unvested restricted shares and RSUs, and shares underlying vested stock options are included in determining an individual’s equity ownership. Unvested stock options and unearned performance shares are not counted toward meeting these guidelines.

Compensation Recovery Policy. In late 2017, in response to our 2017 stockholder engagement campaign (described more fully under “Stockholder Engagement” on page 6), our Compensation Committee adopted a compensation recovery (“clawback”) policy which provides that, in the event that, on account of fraud or other intentional misconduct, we are required to prepare an accounting restatement, we may recover from any executive officer any incentive compensation erroneously paid or awarded in excess of what would have been paid under the accounting restatement. This policy applies prospectively to certain incentive compensation paid or awarded after January 1, 2018, its effective date, and covers the three-year period preceding the date on which we are required to prepare the accounting restatement. The incentive compensation to which it applies is cash bonuses or other cash awards to the extent those bonuses or awards are earned based on the attainment of a financial reporting measure presented in our financial statements or derived from our accounting

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records. In addition, we are subject to the provisions of Section 304 of the Sarbanes-Oxley Act of 2002, which provides that if we are required as a result of misconduct to restate our financial results due to our material noncompliance with any financial reporting requirements under the federal securities laws, our CEO and Chief Financial Officer may be legally required to reimburse us for any bonus or other incentive-based or equity-based compensation they receive. To the extent our policy is inconsistent with any final regulations adopted by the SEC to implement the requirements of the Dodd-Frank Wall Street Reform and Consumer Protection Act, we intend to revise our policy to comply with those regulations.

Limitations on Hedging and Pledging. Under our insider trading policy, our employees, including our executive officers, and Board members are prohibited from trading in our securities on a short-term basis, purchasing our securities on margin, making short sales in our securities, buying or selling put or call options on our stock, pledging our securities as collateral for a loan, and engaging in other hedging or monetization transactions such as prepaid variable forwards, equity swaps, collars and exchange funds, that permit a holder to continue to own our securities but, without the full risks and rewards of ownership.

Effects of Stockholder Advisory Vote on Executive Compensation, Stockholder Engagement

Approximately 72% of the votes cast in the stockholder advisory “say on pay” vote on executive compensation in 2018 approved our executive compensation described in last year’s proxy statement. Throughout the 2018 proxy season, we engaged directly or indirectly through our proxy solicitor, D. F. King & Co., with investors across the vast majority of our stockholder base, representing over 80% of our outstanding shares at that time, including our top ten stockholders. The Compensation Committee considered the result of the stockholder advisory vote as generally strong support for its overall compensation policies, practices and philosophy for our executive officers while also clearly understanding the perspective from several of our stockholders that some change was needed. Accordingly, as a result of this valuable stockholder feedback, the Compensation Committee eliminated the practice of granting special option grants (now called outstanding merit option grants) to our CEO on an ad hoc basis.

While say-on-pay votes are a key indicator of stockholder feedback, we are committed to keeping an open dialogue with our stockholders, including our institutional investors, throughout the year, not just during proxy season. We regularly and frequently engage with our stockholders to discuss business topics, seek feedback on our performance and address other matters of importance to our stockholders, such as executive compensation and corporate governance. Even though our 2017 say-on-pay vote resulted in nearly unanimous approval of our compensation practices, our 2017 stockholder engagement campaign (described more fully under “Stockholder Engagement” on page 6) made clear that a persistent stockholder concern was that our executive compensation program did not include any performance-based shares tied to financial metrics. As a result, and as described elsewhere in this proxy statement, the Compensation Committee included performance shares tied to pre-specified performance goals (which were revenue-based for 2018) starting with the equity grant cycle in July 2018. These performance share awards comprised 25% of each executive officer’s target equity award value for 2018 and 2019.

The Compensation Committee intends to continue to regularly review, assess and, when appropriate, adjust our compensation practices based on feedback from our stockholders or other determinations informed by best practices and trends.

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Tax Deductibility of Compensation

Section 162(m) of the Internal Revenue Code places a limit of $1,000,000 on the amount of compensation that we may deduct in any one year with respect to our CEO and each of the next three most highly compensated executive officers (excluding the chief financial officer for taxable years prior to 2018). Section 162(m) historically permitted deductions in excess of $1,000,000 for “performance-based compensation,” which included stock options meeting certain requirements, but the exception for “performance-based compensation” has been repealed effective for taxable years beginning after December 31, 2017.

Stock options that we granted in 2017 and prior years should still qualify for full deductibility under a transition rule for amounts payable pursuant to written binding contracts in effect on November 2, 2017. To maintain flexibility in compensating our executive officers, the Compensation Committee has not adopted a policy requiring all executive compensation to be deductible.

Key Elements of Executive Compensation

Our executive officers’ compensation currently includes three primary components: base salary, cash bonus, and long-term equity-based incentive awards. Of these components, only base salary is not tied directly and meaningfully to our Company’s performance because base salary is intended to attract and retain key talent by providing a stable source of income. In addition, we provide our executive officers a variety of benefits that are available generally to all salaried employees. Each of these components is described in more detail below.

Base Salary

Base salaries are designed to attract and retain qualified personnel by providing a consistent cash flow throughout the year as compensation for acceptable levels of performance of day-to-day responsibilities. Base salaries for our executive officers are established based on the scope of their responsibilities, their performance, and their prior relevant background, training and experience, taking into account competitive market compensation paid by the companies represented in the compensation data we review for similar positions and the overall market demand for those executive officers at the time of hire. The Compensation Committee reviews salaries on an annual basis. At such time, the Compensation Committee may change each executive officer’s salary based on the individual’s contributions and responsibilities over the prior twelve months and any change in competitive market pay levels.

In January 2018, the Compensation Committee set the 2018 base salaries for our executive officers. The Committee considered our Company’s performance in 2017, including our commercial operations, clinical trial progress of our other drug candidates, job performance, internal pay alignment and equity, marketplace competitiveness and the 2018 peer group data in determining the base salaries for 2018.

In January 2019, the Compensation Committee set the 2019 base salaries for our executive officers. The Committee considered our Company’s performance in 2018, including our commercial operations, clinical trial progress of our other drug candidates, job performance, internal pay alignment and equity, marketplace competitiveness and the 2019 peer group data in determining the base

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salaries for 2019. The following table sets forth the salary history of our named executive officers listed in the Summary Compensation Table and for Christiana Stamoulis, our new Chief Financial Officer.

Name |  | 2016 Base Salary |  |  | 2017 Increase |  |  | 2017 Base Salary |  |  | 2018 Increase |  |  | 2018 Base Salary |  |  | 2019 Increase |  |  | 2019 Base Salary |
Hervé Hoppenot |  | $ | 940,000 |  |  |  | 3.0 | % |  | $ | 968,200 |  |  |  | 3.0 | % |  | $ | 997,246 |  |  |  | 5.0 | % |  | $ | 1,047,108 |
Christiana Stamoulis (1) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  | $ | 560,000 |
David Gryska (2) |  | $ | 553,805 |  |  |  | 3.0 | % |  | $ | 570,419 |  |  |  | 3.0 | % |  | $ | 587,532 |  |  |  | — |  |  |  | — |
Reid Huber (3) |  | $ | 480,000 |  |  |  | 3.0 | % |  | $ | 494,400 |  |  |  | 3.0 | % |  | $ | 509,232 |  |  |  | — |  |  |  | — |
Steven Stein |  | $ | 442,900 |  |  |  | 7.3 | % |  | $ | 475,000 |  |  |  | 10.5 | % |  | $ | 525,000 |  |  |  | 5.0 | % |  | $ | 551,250 |
Wenqing Yao |  | $ | 430,000 |  |  |  | 4.7 | % |  | $ | 450,000 |  |  |  | 3.0 | % |  | $ | 463,500 |  |  |  | 5.0 | % |  | $ | 486,675 |
Maria Pasquale (4) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  | $ | 500,000 |  |  |  | 3.0 | % |  | $ | 515,000 |

(1) | Ms. Stamoulis joined us as our Executive Vice President and Chief Financial Officer effective February 2019.

(2) | Mr. Gryska resigned as Executive Vice President and Chief Financial Officer effective December 2018.

(3) | Dr. Huber resigned as Executive Vice President and Chief Scientific Officer effective November 2018.

(4) | Ms. Pasquale was appointed Executive Vice President and General Counsel effective April 2018.

For each of 2018 and 2019, 3.0% was the average base salary increase for all of our non-executive employees.

Annual Incentive Compensation Plan

Each year, we have established an incentive compensation plan that provides for cash incentive awards for all of our eligible employees. The plans have been designed to pay for performance by aligning incentive awards for each participant with an evaluation of our achievement of corporate objectives. These corporate objectives are approved by the independent members of our Board based on the recommendations of the Compensation Committee, as well as, in the case of individuals other than our CEO, the achievement of individual business objectives for a particular year. Eligibility to participate in the plans and actual award amounts are not guaranteed and are determined, in the case of our executive officers, at the discretion of the Compensation Committee. After the completion of each year, the Compensation Committee reviews with our CEO the level of achievement of the corporate objectives under the plan and determines the size of the overall bonus pool to be used for awards. The Compensation Committee, with input from our CEO with respect to our other executive officers, may use discretion in determining for each executive officer his or her bonus amount.

Incentive awards for our executive officers were approved by the Compensation Committee and paid in 2019 pursuant to our 2018 incentive compensation plan. Each of our executive officers who was with us for all of 2018, other than our CEO, had a funding target under the plan of 50% of his or her annual base salary for 2018, with the potential for actual awards under the plan to either exceed or be less than the funding target depending upon corporate performance, as well as the executive officer’s achievement of certain individual goals that are predetermined by our CEO. Our CEO had a funding target under the plan of 100% of his annual base salary for 2018, with the potential for actual awards under the plan to either exceed or be less than such funding target depending upon corporate performance. Target incentive award amounts for each participant were based on the participant’s potential impact on our operating and financial results and on market competitive pay practices. Individual performance goals were also established for eligible employees other than our CEO, and evaluations were based upon whether the employee met, exceeded or did not meet each established goal. The Committee believes that it is appropriate to align a higher percentage of our executive officers’ total cash compensation with the achievement of our Board-approved corporate objectives because those objectives are determined with a view toward progressing our Company’s business and

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maximizing stockholder value. Linking a significant percentage of executive officer cash incentive awards to achievement of Committee-approved corporate objectives puts a substantial portion of our CEO’s and executive officers’ cash compensation at risk, and is another way the Committee has designed executive compensation to pay for performance.

While executive officers other than our CEO have individual performance objectives that are evaluated by our CEO, the outcome of those objectives did not affect awards under our 2018 incentive compensation plan to those officers, and the award amounts were based solely on achievement of the corporate performance objectives.

Annual Incentive Compensation Plan

2018 Corporate Performance Objectives

Corporate performance objectives for 2018 were based on achievement of drug discovery objectives, drug development objectives, commercial objectives, finance objectives, and technical operations objectives.

Threshold, target and outperform achievement levels are defined for each corporate objective and, depending on the achievement of those performance levels, a payout ranging from 0% to 150% may be made for each objective. The ECHO-301 component of our drug development objectives was only achievable at the outperform level and related to achieving data sufficient for a regulatory submission. Bonus objectives included an extra 5% for drug discovery, an extra 25% for drug development, and an extra 5% for business development. Collectively, the bonus opportunities enabled the payout of up to an additional 35 percentage points for extraordinary achievements beyond core objectives.

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At the time the corporate performance objectives for 2018 were set, the Committee and management believed that achievement of the target levels of performance for the non-ECHO-301 objectives would be difficult and challenging, but achievable with significant effort and skill, favorable preclinical study and clinical trial results and continued strong commercial performance. As noted above, achievement of the ECHO-301 component of our drug development objectives were dependent on clinical trial results.

In January 2019, the Compensation Committee evaluated the achievement of the 2018 corporate performance objectives and determined that incentive awards under our 2018 incentive compensation plan should be based upon achievement of 81% of the target level of corporate performance objectives. While the Committee noted that the business development bonus opportunity relating to the establishment of a strategic relationship that provides near-term sales revenues was not met, the Committee determined that our establishment of our strategic collaboration in China with Innovent warranted the award of two percentage points. The various objective categories, target payouts and actual payouts, are listed in the table below.

Objectives |  |  | Target % |  |  |  | Payout % |
Drug Discovery |  |  | 15 |  |  |  | 22.5 |
|  | Achieved IND filings for INCAGN2385, INCAGN2390, and INCB86550 |  |  |  |  |  |  |  |
|  | Achieved pre-clinical objectives relating to certain programs |  |  |  |  |  |  |  |
Bonus Achieved |  |  | — |  |  |  | 5 |
|  | Achieved four objectives, including filing an IND for INCB86550 |  |  |  |  |  |  |  |
Drug Development |  |  | 60 |  |  |  | 30 |
JAK Programs |  |  | 5 |  |  |  | 5 |
|  | Submitted sNDA for ruxolitinib in steroid-refractory acute GVHD |  |  |  |  |  |  |  |
|  | Completed enrollment targets for pre-specified trials, including GRAVITAS-301 |  |  |  |  |  |  |  |
Immune Therapies – Large Molecule |  |  | 5 |  |  |  | 7.5 |
|  | Achieved five of six objectives, including initiating three monotherapy clinical trials with registrational intent for INCMGA0012 |  |  |  |  |  |  |  |
Immune Therapies – Small Molecule |  |  | 5 |  |  |  | 5 |
|  | Achieved three of five objectives, including opening enrollment for the first clinical trial of INCB86550 |  |  |  |  |  |  |  |
Epacadostat |  |  | 35 |  |  |  | — |
|  | Did not achieve sufficient pivotal data from ECHO-301 to trigger a decision to submit to regulatory authorities |  |  |  |  |  |  |  |
|  | Did not complete enrollment in other pivotal epacadostat trials |  |  |  |  |  |  |  |
Targeted Therapies |  |  | 5 |  |  |  | — |
|  | Only achieved four of eleven objectives, including opening enrollment for the Phase III study of pemigatinib in first-line cholangiocarcinoma |  |  |  |  |  |  |  |
Bonus Achieved |  |  | — |  |  |  | 5 |
|  | Reported preliminary data for pemigatinib in second-line FGFR2 translocated cholangiocarcinoma which, if confirmed in the full cohort, would support an NDA submission |  |  |  |  |  |  |  |
Inflammation/Autoimmunity |  |  | 5 |  |  |  | 7.5 |
|  | Achieved four out of five objectives, including the initiation of the Phase III trial of ruxolitinib cream in atopic dermatitis as well as trials with INCB54707 and parsaclisib in pre-specified indications |  |  |  |  |  |  |  |
Commercial |  |  | 25 |  |  |  | 21 |
|  | Achieved pre-specified level of revenue for Jakafi and Iclusig |  |  |  |  |  |  |  |
Business Development Bonus Achieved |  |  | — |  |  |  | 2 |
|  | Achieved out-licensing collaboration that provides potential for royalties by 2021 |  |  |  |  |  |  |  |

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The table below sets forth the incentive awards under our 2018 incentive compensation plan for our named executive officers:

Name |  | Year-End Salary (A) x |  |  | Target Bonus % (B) x |  |  | Overall Multiplier (C) = |  |  | Bonus Award (D) |
Hervé Hoppenot |  | $ | 997,246 |  |  |  | 100 | % |  |  | 81.0 | % |  | $ | 807,769 |
David W. Gryska (1) |  | $ | 587,532 |  |  |  | 50 | % |  |  | 81.0 | % |  | $ | 237,551 |
Reid M. Huber (2) |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Steven H. Stein |  | $ | 525,000 |  |  |  | 50 | % |  |  | 81.0 | % |  | $ | 212,625 |
Wenqing Yao |  | $ | 463,500 |  |  |  | 50 | % |  |  | 81.0 | % |  | $ | 187,718 |
Maria E. Pasquale (3) |  | $ | 500,000 |  |  |  | — |  |  |  | — |  |  | $ | 250,000 |

(1) | Mr. Gryska resigned as Executive Vice President and Chief Financial Officer effective December 2018.

(2) | Dr. Huber resigned as Executive Vice President and Chief Scientific Officer effective November 2018.

(3) | Ms. Pasquale was appointed Executive Vice President and General Counsel effective April 2018. Her bonus award for 2018 was contractually agreed, independent of our corporate achievement factor.

Our incentive compensation program is designed to incentivize employees, including our executive officers, in every area of our Company, which we believe helps lead to significant achievement across all areas. Our Compensation Committee believes that measuring and rewarding achievements from all functions — including functions such as discovery, development, technical operations and business development, whose efforts take a much longer time to make an impact on our top-line revenue or on our stock price — helps ensure that we are properly incentivizing the collective efforts that lead not only to successful current commercial performance but also critically set the stage for potential continued growth and potential long-term sustained success in the years ahead. Our Compensation Committee also believes that linking incentive compensation to corporate goals aligns employees’ incentives with strategic imperatives, thus paying for performance.

The chart below illustrates the achievement levels under our incentive compensation program over the last three years, and illustrates how the annual incentive compensation plan serves to execute on the Compensation Committee’s goal of paying for performance:

Incentive Compensation Plan Achievement — 2016-2018

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Annual Incentive Compensation Plan

2019 Corporate Performance Objectives

In January 2019, our Board, based on the recommendations of the Compensation Committee, approved corporate objectives for our 2019 incentive compensation plan. Under this plan, the funding targets for our executive officers remain the same as for 2018. Corporate performance objectives for 2019 are based on achievement of drug discovery objectives, drug development objectives and commercial objectives.

Threshold, target and outperform achievement levels are defined for each corporate objective and, depending on the achievement of those performance levels, a payout ranging from 0% to 150% may be made for each objective. Bonus objectives include an extra 5% for Drug Discovery, an extra 20% for Drug Development, and an extra 10% for Business Development. Collectively, the bonus opportunities enable the payout of up to an additional 35 percentage points for extraordinary achievements beyond core objectives.

The Committee and management believe that achievement of the target levels of performance will be difficult and challenging, but achievable with significant effort and skill, favorable preclinical study and clinical trial results and continued strong commercial performance.

Equity-Based Incentive Awards

The Compensation Committee administers equity-based incentive awards, such as stock option grants, RSUs and performance shares that are made to our executive officers under our 2010 Stock Incentive Plan. The Compensation Committee believes that by providing those persons who have substantial responsibility for our management and growth with an opportunity to increase their ownership of our stock, the best interests of our stockholders and executive officers will be closely aligned. Therefore, executive officers are eligible to receive equity-based incentive awards when the Compensation Committee performs its annual review, although these awards may be granted at other times in recognition of exceptional achievements. As is the case when the amounts of base salary and initial equity awards are determined, the Compensation Committee conducts a review of all components

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of an executive officer’s compensation when determining annual equity awards to ensure that the executive’s total compensation conforms to our overall philosophy and objectives.

Under our 2010 Stock Incentive Plan, we may grant restricted shares, performance shares, RSUs or stock appreciation rights.

In 2018, our executive officers received stock options and performance shares and, for 2019, our executive officers will receive stock options, performance shares, and RSUs. The value of all of these awards are inherently performance-based.

| • |  | Stock options are performance based because they pay nothing to our executive officers unless stockholders benefit by stock price appreciation. In addition, with a ten-year life and a four-year vesting period, stock options are in sync with the time required for discovery, development and commercialization of new medicines. Our Compensation Committee believes that stock options help align executives’ interests with the long-term interests of our Company and our stockholders. Stock options reinforce our belief that future potential growth of Incyte will be generated by innovation, our discovery and development pipeline, demand for our products and our commercial execution.

| • |  | Performance shares do not become earned unless pre-determined performance goals are met.

| • |  | RSU awards grow or decline in value based on stock price, also linking executive officers’ compensation to the value delivered to stockholders.

In addition to the performance-based aspects of stock options, performance shares and RSUs, the four-year vesting periods of all of these awards also serves a critical retention function. Time-based vesting helps ensure the long-term retention of highly valuable executive officers, in whom we have invested considerable time and money, and the intellectual capital they create as well as continuity of their respective teams. The performance-based components and time-based components of our equity compensation program are designed to encourage both an appropriate level of risk-taking and a focus on sound long-term decision making, thus aligning executive interests with the long-term best interests of our Company and our stockholders.

For our 2018 annual equity grants, stock options comprised 75% of an executive officer’s target equity compensation and performance shares comprised 25%. As described above under “—Equity Grant Practices,” for 2019 the Compensation Committee has determined that our executive officers’ annual equity award mix should be 50% stock options, 25% performance shares and 25% RSUs to bring our practices in line with our peer group and the broader market norm and to provide greater retentive value from our equity awards.

Performance shares granted in July 2018 had revenue triggers that were determined by the Compensation Committee in February 2018. Depending on revenue actually achieved, the payout on these performance shares could have varied from 0% to 150% of target. These performance shares comprise 25% of an executive officer’s target equity compensation awarded in connection with our annual equity grants. The Compensation Committee believes that these performance shares align our executive officers’ interest even more closely with the financial performance of our Company and the eventual value delivered to stockholders. For 2018, the revenue target for the performance shares that would have yielded a 100% payout was an aspirational, internal, stretch target. The Compensation Committee believes such stretch revenue targets help incentivize executives to achieve maximum performance and are a key element of the pay-for-performance strategy. While we achieved record revenue in 2018, we nevertheless did not achieve the internal, stretch target. Accordingly, in February 2019, the Compensation Committee determined that the performance shares earned were only 83% of the target payout.

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Performance Share Achievement 2018

Target Value of 2018 Equity Grants

For the 2018 annual equity grants, our CEO received awards with a grant date target value of $7,000,000 and each of our executive vice presidents received awards with a grant date target value of $1,800,000, in each case, unchanged from the values awarded in July 2017.

While, for our CEO, the Compensation Committee did not target a particular peer group percentile in setting the 2018 equity award values, in July 2018 when the Compensation Committee was actually granting these awards, it noted that then current peer group data indicated that the value of peer group long-term incentive awards had increased. Accordingly, the Compensation Committee noted that our CEO’s 2018 equity awards would result in target total direct compensation (target total cash compensation plus long-term incentive value of equity awards) approximating only the 30th percentile of our peer group. The Compensation Committee further noted that, for calendar year 2018, when including the outstanding merit stock option grant made to our CEO in January 2018 that was intended to relate to 2017 performance, our CEO’s target total direct compensation would approximate the peer group 40th percentile.

Similarly, for executive officers other than our CEO, the Compensation Committee noted in July 2018 that, because the value of peer group long-term incentive awards had increased since January 2018 when our equity target values were established, target award values likely no longer approximated the peer group 60th percentile.

Nevertheless, despite these target equity award values being lower relative to our then current peer group than initially designed to be, the Compensation Committee decided - in keeping with its pay-for-performance philosophy - that no changes would be made at that time.

For a discussion of updates to the equity grant target values undertaken by the Compensation Committee in 2019, see “—Target Value of 2019 Equity Grants” on page 45.

Outstanding Merit Grants

In January 2018, certain of our named executive officers received outstanding merit option grants intended to incentivize and retain those individuals. Our CEO received a grant with a grant date target

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value of $1,200,000 and certain other named executive officers - Drs. Huber, Stein and Yao - received grants with a grant date target value of $1,000,000. These outstanding merit option grants are subject to four-year cliff vesting. As noted above under “—Compensation Practices and Policies—Effects of Stockholder Advisory Vote on Executive Compensation,” the Compensation Committee has now eliminated the practice of awarding outstanding merit option grants (formerly named special option grants) to our CEO and no such grant was made in 2019.

2018 Retention Plans

With the failure of our ECHO-301 program in April 2018 and the significant stock price decline which accompanied it, the Compensation Committee believed it was vital to act to preserve the two key engines of growth within Incyte – namely, the salesforce which generates the revenue to fund our day-to-day operations and the R&D effort which aims to produce the compounds that will potentially lead to future growth. Accordingly, in June 2018, the Compensation Committee adopted retention plans utilizing performance share awards for certain groups of employees of our Company, namely key R&D employees and our salesforce. The R&D retention plan participants included three of our named executive officers, Drs. Huber, Stein and Yao, who each received performance share awards potentially representing 50,000 shares of common stock, which would be earned based on a specific number of investigational new drug (IND) filings made by our Company during a specified time frame and, if earned, would vest on the third anniversary of the initial grant date.

Full Value Share Issuance Limits

While the Compensation Committee, in its discretion, may elect to make grants of restricted shares, performance shares, RSUs or stock appreciation rights if it deems it advisable, the 2010 Stock Incentive Plan contains a limit on the total amount of shares that may be issued other than upon the exercise of stock options or stock appreciation rights or pursuant to sales of restricted shares at purchase prices at least equal to the fair market value of the shares sold. That limit is currently 3,500,000 shares and is proposed to be eliminated in connection with the amendments to the 2010 Stock Incentive Plan described under Proposal 3.

Termination Based Compensation Under Employment Agreements and Offer Letters

Our executive officers are parties to employment agreements and offer letters, as described below under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements.”

These employment agreements and offer letters provide for severance payments and acceleration of vesting of equity-based awards upon termination of employment under the circumstances described below under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements.” In general, the employment agreements provide for severance benefits if an officer’s employment is terminated within 24 months following a change in control. These agreements are designed both to attract executives, as we compete for talented employees in a marketplace where such protections are routinely offered, and to retain executives and provide continuity of management in the event of an actual or threatened change in control.

Other Compensation

All of our full-time employees, including our executive officers, may participate in our health programs, such as medical, dental and vision care coverage, and our 401(k) and life and disability insurance programs. These benefits are designed to provide our executive officers and eligible employees a competitive total compensation package that enables us to attract and retain qualified

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personnel. Under our employment agreement with our CEO, we paid the premiums with respect to a six-year insurance policy that becomes payable to the CEO or his estate upon his disability or death, although at his suggestion we recently amended his employment agreement to eliminate our obligation to pay the last year’s premium on that insurance policy, as described below under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements.”

Target Value of 2019 Equity Grants

In February 2019, the Compensation Committee established grant date target values for the 2019 annual equity grants for our CEO and other executive officers. In determining to establish a grant date target value of $12,900,000 for our CEO, the Committee noted that the 2019 peer group data presented to the Committee in November 2018 indicated that our CEO’s target total direct compensation (target total cash compensation plus long-term incentive value) for 2018 approximated the peer 25th percentile despite his target total cash compensation (base salary plus target bonus) approximating the peer 50th percentile. The Committee noted our Company’s overall performance in 2018 despite the ECHO-301 disappointment and the CEO’s strong leadership following that development as our Company continued to increase product revenues and continued to advance product candidates through our clinical pipeline, with a number of late-stage candidates that can accelerate near-term growth. Our CEO’s 2019 equity grant date target value approximates the 2019 peer group 68th percentile for long-term incentive value and places him at approximately the peer 67th percentile for target total direct compensation. The Committee established grant date target values of $2,200,000 for each of our other executive officers who is eligible to receive annual equity grants in 2019, intended generally to approximate the peer 60th percentile for long-term incentive value. Ms. Stamoulis joined us in February 2019, received initial equity awards with an aggregate grant date target value of $3,300,000 on joining us, and will not receive a 2019 annual equity award but instead will be entitled to receive, on the first anniversary of the commencement of her employment and in July 2020, equity awards with an aggregate grant date target value of $1,300,000 and $2,200,000, respectively.

CEO Pay Ratio

As required by Section 953(b) of the Dodd-Frank Wall Street Reform and Consumer Protection Act and Item 402(u) of Regulation S-K we are providing the following information about the relationship of the annual total compensation of our employees and the annual total compensation of Mr. Hoppenot, our CEO. The pay ratio included in this information is a reasonable estimate calculated in a manner consistent with Item 402(u) of Regulation S-K.

For 2018, our last completed fiscal year:

| • |  | the median of the annual total compensation of all employees of our Company (other than our CEO), was $228,006; and

| • |  | the annual total compensation of our CEO, as reported in the Summary Compensation Table presented elsewhere in this Proxy Statement, was $9,314,189.

Based on this information, for 2018 the ratio of the annual total compensation of Mr. Hoppenot, our CEO, to the median of the annual total compensation of all employees was 41 to 1.

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To identify the median of the annual total compensation of all our employees, as well as to determine the annual total compensation of the “median employee,” the methodology and the material assumptions, adjustments, and estimates that we used were as follows:

| • |  | We determined that, as of December 31, 2018, our employee population consisted of 1,367 employees, with 1,106 based in the United States and 261 based in Europe and Japan.

| • |  | We selected December 31, 2018, which is within the last three months of 2018, as the date upon which we would identify the “median employee.”

| • |  | For all employees, we examined total compensation, which included: base salary, incentive compensation plan payments for non-sales employees, sales incentive compensation plan payments for sales employees, equity awards consisting of stock options and restricted stock units, and other compensation such as 401(k) matching contributions and Company-paid life insurance premiums.

| • |  | We included all employees, whether employed on a full-time or part-time basis, and we annualized the compensation of all permanent employees who were not employed by us for all of 2018.

| • |  | We did not make any cost-of-living adjustments in identifying the “median employee.”

| • |  | For employees outside the United States, we converted their compensation to U.S. dollars using the average exchange rate for 2018.

Compensation Committee Report

This report shall not deemed to be “soliciting material” or “filed” with the Securities and Exchange Commission or be deemed incorporated by reference into any filing under the Securities Act of 1933 or under the Securities Exchange Act of 1934, except to the extent the Company specifically incorporates it by reference into a document filed under such Acts.

The Compensation Committee has reviewed and discussed the Compensation Discussion and Analysis set forth in this Proxy Statement with our management. Based on such review and discussions, the Compensation Committee recommended to the Board that the Compensation Discussion and Analysis be included in this Proxy Statement and incorporated by reference into the Company’s Annual Report on Form 10-K for the year ended December 31, 2018.

Compensation Committee

Paul A. Brooke (Chair)

Julian C. Baker

Jean-Jacques Bienaimé

Named Executive Officers

The Summary Compensation Table, Grants of Plan-Based Awards Table and the tables that follow provide compensation information for our named executive officers, including Hervé Hoppenot, our President and CEO, David W. Gryska, our Executive Vice President and Chief Financial Officer until December 31, 2018, and Reid M. Huber, Steven H. Stein, Wenqing Yao and Maria E. Pasquale.

46 | Proxy Statement 2019 |  |

##### Table of Contents

|  | Executive Compensation

Our named executive officers’ total compensation for 2018 as determined under the rules of the Securities and Exchange Commission, or SEC, is set forth in the following table under the caption “Total.”

SUMMARY COMPENSATION TABLE

Name and Principal Position |  | Year |  |  | Salary ($) |  |  | Bonus ($) |  |  | Stock Awards ($)(1) |  |  | Option Awards ($)(1) |  |  | Non-Equity Incentive Plan Compensation ($)(2) |  |  | All Other Compensation ($)(3) |  |  | Total ($) |
Hervé Hoppenot |  |  | 2018 |  |  |  | 995,575 |  |  |  | — |  |  |  | 1,733,822 |  |  |  | 5,564,508 |  |  |  | 807,769 |  |  |  | 212,515 |  |  |  | 9,314,189 |
President and Chief |  |  | 2017 |  |  |  | 966,505 |  |  |  | — |  |  |  | 1,755,563 |  |  |  | 11,677,844 |  |  |  | 1,476,505 |  |  |  | 210,614 |  |  |  | 16,087,031 |
Executive Officer |  |  | 2016 |  |  |  | 937,738 |  |  |  | — |  |  |  | 2,810,905 |  |  |  | 6,720,183 |  |  |  | 1,129,880 |  |  |  | 208,407 |  |  |  | 11,807,113 |
David W. Gryska |  |  | 2018 |  |  |  | 586,547 |  |  |  | — |  |  |  | 445,824 |  |  |  | 1,123,701 |  |  |  | 237,551 |  |  |  | 38,875 |  |  |  | 2,432,498 |
Executive Vice President and |  |  | 2017 |  |  |  | 569,421 |  |  |  | — |  |  |  | 451,372 |  |  |  | 1,588,433 |  |  |  | 434,945 |  |  |  | 35,519 |  |  |  | 3,079,690 |
Chief Financial Officer (4) |  |  | 2016 |  |  |  | 552,792 |  |  |  | — |  |  |  | 715,609 |  |  |  | 1,649,443 |  |  |  | 332,837 |  |  |  | 17,485 |  |  |  | 3,268,166 |
Steven H. Stein |  |  | 2018 |  |  |  | 522,123 |  |  |  | — |  |  |  | 3,733,824 |  |  |  | 2,119,070 |  |  |  | 212,625 |  |  |  | 23,874 |  |  |  | 6,611,516 |
Executive Vice President and |  |  | 2017 |  |  |  | 473,070 |  |  |  | 100,000 | (6) |  |  | 451,372 |  |  |  | 2,688,504 |  |  |  | 362,188 |  |  |  | 24,121 |  |  |  | 4,099,255 |
Chief Medical Officer (5) |  |  | 2016 |  |  |  | 442,089 |  |  |  | — |  |  |  | 715,609 |  |  |  | 1,649,441 |  |  |  | 266,183 |  |  |  | 16,338 |  |  |  | 3,089,660 |
Reid M. Huber |  |  | 2018 |  |  |  | 465,129 |  |  |  | — |  |  |  | 3,733,824 |  |  |  | 2,119,070 |  |  |  | — |  |  |  | 34,578 |  |  |  | 6,352,601 |
Executive Vice President and |  |  | 2017 |  |  |  | 493,534 |  |  |  | — |  |  |  | 451,372 |  |  |  | 2,688,504 |  |  |  | 376,980 |  |  |  | 40,680 |  |  |  | 4,051,070 |
Chief Scientific Officer (7) |  |  | 2016 |  |  |  | 474,973 |  |  |  | — |  |  |  | 715,609 |  |  |  | 2,549,416 |  |  |  | 288,480 |  |  |  | 34,866 |  |  |  | 4,063,344 |
Wenqing Yao |  |  | 2018 |  |  |  | 462,723 |  |  |  | — |  |  |  | 3,733,824 |  |  |  | 2,119,070 |  |  |  | 187,718 |  |  |  | 36,716 |  |  |  | 6,540,051 |
Executive Vice President, |  |  | 2017 |  |  |  | 448,798 |  |  |  | — |  |  |  | 451,372 |  |  |  | 2,688,504 |  |  |  | 343,125 |  |  |  | 41,374 |  |  |  | 3,973,173 |
Head of Discovery Chemistry |  |  | 2016 |  |  |  | 426,858 |  |  |  | — |  |  |  | 715,609 |  |  |  | 2,124,411 |  |  |  | 258,430 |  |  |  | 34,299 |  |  |  | 3,559,607 |
Maria E. Pasquale |  |  | 2018 |  |  |  | 365,753 |  |  |  | 250,000 | (9) |  |  | 833,278 |  |  |  | 1,830,477 |  |  |  | 250,000 |  |  |  | 93,960 |  |  |  | 3,623,468 |
Executive Vice President |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
and General Counsel (8) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

(1) | Amounts shown do not reflect compensation actually received by the named executive officer. Instead, the amounts reported above in the “Stock Awards” and “Option Awards” columns represent the aggregate grant date fair value of stock awards and options awards granted in the respective fiscal years, as determined in accordance with ASC 718. The reported amounts for 2018 include the grant date fair value of awards of performance shares, restricted stock units (“RSUs”) and option awards. Additional information with respect to 2018 performance share, RSU and option awards is set forth in the “2018 Grants of Plan Based Awards” table below.

(2) | Amounts listed in this column represent bonuses paid under the annual incentive compensation plan for each of the respective years. These amounts are not reported in a separately identified Bonus column because the awards are tied to corporate performance objectives.

|  | Proxy Statement 2019 | 47

##### Table of Contents

Executive Compensation |  |

(3) | Amounts listed in this column for each year represent payments made for group term life insurance and matching contributions under our 401(k) plan and also the following payments:

Name |  | Year |  |  | Life Insurance Premiums ($)(1) |  |  | Financial Planning Services ($)(2) |  |  | Statutory Fee for Serving as Director of EU Subsidiary ($) |  |  | Relocation Fees ($)(3) |
Hervé Hoppenot |  |  | 2018 |  |  |  | 160,207 |  |  |  | 27,649 (12,649) |  |  |  | 4,400 |  |  |  | — |
|  |  | 2017 |  |  |  | 160,207 |  |  |  | 26,131 (12,631) |  |  |  | 4,400 |  |  |  | — |
|  |  | 2016 |  |  |  | 160,207 |  |  |  | 24,118 (11,118) |  |  |  | 4,400 |  |  |  | — |
David Gryska |  |  | 2018 |  |  |  | — |  |  |  | 18,132 (6,270) |  |  |  | — |  |  |  | — |
|  |  | 2017 |  |  |  | — |  |  |  | 15,211 (7,937) |  |  |  | — |  |  |  | — |
|  |  | 2016 |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Reid Huber |  |  | 2018 |  |  |  | — |  |  |  | 17,617 (5,617) |  |  |  | — |  |  |  | — |
|  |  | 2017 |  |  |  | — |  |  |  | 23,683 (11,683) |  |  |  | — |  |  |  | — |
|  |  | 2016 |  |  |  | — |  |  |  | 23,794 (11,794) |  |  |  | — |  |  |  | — |
Steven Stein |  |  | 2018 |  |  |  | — |  |  |  | 1,674 (479) |  |  |  | 4,400 |  |  |  | — |
|  |  | 2017 |  |  |  | — |  |  |  | 2,358 (1,098) |  |  |  | 4,400 |  |  |  | — |
|  |  | 2016 |  |  |  | — |  |  |  | — |  |  |  | 4,400 |  |  |  | — |
Wenqing Yao |  |  | 2018 |  |  |  | — |  |  |  | 18,390 (5,640) |  |  |  | — |  |  |  | — |
|  |  | 2017 |  |  |  | — |  |  |  | 23,123 (11,123) |  |  |  | — |  |  |  | — |
|  |  | 2016 |  |  |  | — |  |  |  | 18,090 (6,090) |  |  |  | — |  |  |  | — |
Maria Pasquale |  |  | 2018 |  |  |  | — |  |  |  | 588 (176) |  |  |  | — |  |  |  | 92,464 (28,639) |

| (1) | Payment of life insurance premiums for Mr. Hoppenot is designed to compensate him for certain components of equity awards from his previous employer that he forfeited when joining Incyte. Our obligation to make these payments expired in 2019. For a more detailed explanation, please see “Employment Contracts, Termination of Employment and Change-in-Control Arrangements—President and CEO—Life Insurance and Disability Insurance Coverage” below.

| (2) | Amounts in this column are inclusive of tax gross-up payments. The amount of the specific tax gross-ups are detailed in the parentheses next to the total amount.

| (3) | Amounts in this column are inclusive of tax gross-up payments. The amount of the specific tax gross-ups are detailed in the parentheses next to the total amount.

(4) | Mr. Gryska resigned as Executive Vice President and Chief Financial Officer effective December 2018.

(5) | Dr. Stein was appointed Executive Vice President, Chief Medical Officer effective May 2016.

(6) | This amount represents a portion of Dr. Stein’s signing bonus in connection with the commencement of his employment and intended to compensate Dr. Stein for compensation forfeited by leaving his previous employer; payment of this portion was deferred until the second anniversary of the date of his employment.

(7) | Dr. Huber resigned as Executive Vice President and Chief Scientific Officer effective November 2018.

(8) | Ms. Pasquale was appointed Executive Vice President and General Counsel effective April 2018.

(9) | This amount represents Ms. Pasquale’s signing bonus in connection with the commencement of her employment.

48 | Proxy Statement 2019 |  |

##### Table of Contents

|  | Executive Compensation

2018 Grants of Plan-Based Awards

|  |  |  |  |  |  | Estimated Future Payouts Under Non-Equity Incentive Plan Awards(1)(2) |  |  |  |  |  |  |  | Estimated Future Payouts Equity Incentive Plan Awards Shares (3) |  |  |  | All Other Stock Awards: Number of Shares of Stocks or Units (#) (4) |  |  |  | All Other Option Awards: Number of Securities Underlying Options (#) |  |  |  | Exercise or Base Price of Option Awards ($/Sh) |  |  |  | Grant Date Fair Value of Stock and Option Awards ($)(5) |
Name |  | Grant Date |  |  | Threshold ($) |  |  | Target ($) |  |  | Maximum ($) |  |  |  |  |  | Threshold (#) |  |  | Target (#) |  |  | Maximum (#) |
Hervé Hoppenot |  |  |  |  |  |  | 747,935 |  |  |  | 997,246 |  |  |  | 1,495,869 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/23/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 47,168 (6) |  |  |  | 94.63 |  |  |  | 1,766,502 |
|  |  | 01/24/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,401 (7) |  |  |  | 95.34 |  |  |  | 1,194,472 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 88,557 (8) |  |  |  | 68.62 |  |  |  | 2,603,534 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,633 |  |  |  | 25,267 |  |  |  | 37,900 |  |  |  |  |  |  |  |  |  |  |  | 68.62 |  |  |  | 1,733,822 |
David W. Gryska (9) |  |  |  |  |  |  | 220,325 |  |  |  | 293,766 |  |  |  | 440,649 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/23/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,128 (6) |  |  |  | 94.63 |  |  |  | 454,212 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 22,772 (8) |  |  |  | 68.62 |  |  |  | 669,489 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,248 |  |  |  | 6,497 |  |  |  | 9,745 |  |  |  |  |  |  |  |  |  |  |  | 68.62 |  |  |  | 445,824 |
Steven H. Stein |  |  |  |  |  |  | 196,875 |  |  |  | 262,500 |  |  |  | 393,750 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/23/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,128 (6) |  |  |  | 94.63 |  |  |  | 454,212 |
|  |  | 01/24/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 21,167 (7) |  |  |  | 95.34 |  |  |  | 995,370 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 22,772 (8) |  |  |  | 68.62 |  |  |  | 669,489 |
|  |  | 06/28/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 65.76 |  |  |  | 3,288,000 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,248 |  |  |  | 6,497 |  |  |  | 9,745 |  |  |  |  |  |  |  |  |  |  |  | 68.62 |  |  |  | 445,824 |
Reid Huber (10) |  |  |  |  |  |  | 190,962 |  |  |  | 254,616 |  |  |  | 381,924 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/23/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,128 (6) |  |  |  | 94.63 |  |  |  | 454,212 |
|  |  | 01/24/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 21,167 (7) |  |  |  | 95.34 |  |  |  | 995,370 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 22,772 (8) |  |  |  | 68.62 |  |  |  | 669,489 |
|  |  | 06/28/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 65.76 |  |  |  | 3,288,000 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,248 |  |  |  | 6,497 |  |  |  | 9,745 |  |  |  |  |  |  |  |  |  |  |  | 68.62 |  |  |  | 445,824 |
Wenqing Yao |  |  |  |  |  |  | 173,813 |  |  |  | 231,750 |  |  |  | 347,625 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/23/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,128 (6) |  |  |  | 94.63 |  |  |  | 454,212 |
|  |  | 01/24/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 21,167 (7) |  |  |  | 95.34 |  |  |  | 995,370 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 22,772 (8) |  |  |  | 68.62 |  |  |  | 669,489 |
|  |  | 06/28/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 65.76 |  |  |  | 3,288,000 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,248 |  |  |  | 6,497 |  |  |  | 9,745 |  |  |  |  |  |  |  |  |  |  |  | 68.62 |  |  |  | 445,824 |
Maria E. Pasquale (11) |  |  |  |  |  |  | 187,500 |  |  |  | 250,000 |  |  |  | 375,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 04/09/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 41,193 (8) |  |  |  | 65.36 |  |  |  | 1,160,988 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 22,772 (8) |  |  |  | 68.62 |  |  |  | 669,489 |
|  |  | 04/09/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,928 |  |  |  |  |  |  |  | 65.36 |  |  |  | 387,454 |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,248 |  |  |  | 6,497 |  |  |  | 9,745 |  |  |  |  |  |  |  |  |  |  |  | 68.62 |  |  |  | 445,824 |

(1) | The target amounts shown reflect our annual incentive plan awards originally provided under the 2018 incentive compensation plan and represent the pre-established target awards as a percentage of base salary for the 2018 fiscal year, with the potential for actual awards under the plan to either exceed or be less than such funding target depending upon corporate performance. Actual award amounts are not guaranteed and are determined at the discretion of the Compensation Committee, which may consider an individual’s performance during the period. For additional information, please refer to the section titled “Executive Compensation—Compensation Discussion and Analysis—Key Elements of Executive Compensation—Annual Incentive Compensation Plan.” Actual 2018 incentive compensation plan payouts are reflected in the Non-Equity Incentive Plan Compensation column of the Summary Compensation Table.

(2) | The threshold amounts shown illustrate the smallest payout that can be made under the 2018 incentive compensation plan if all of the pre-established performance objectives are achieved at the minimum achievement level. The target amounts shown are the payouts that can be made if all of the pre-established performance objectives have been achieved at the target achievement level and, as noted in footnote (1), correlate to the pre-established target awards as a percentage of base salary. The maximum amounts shown are the greatest payout that can be made if all of the pre-established maximum performance objectives are achieved or exceeded at the outperform achievement levels and all potential bonus points under the 2018 incentive compensation plan were earned. Actual awards may be more or less than these amounts and, as

|  | Proxy Statement 2019 | 49

##### Table of Contents

Executive Compensation |  |

| noted in footnote (1), are at the discretion of the Compensation Committee. For additional information, please refer to the section titled “Executive Compensation—Compensation Discussion and Analysis—Key Elements of Executive Compensation—Annual Incentive Compensation Plan.”

(3) | Awards under these columns represent performance shares. For the awards made on June 28, 2018, the performance shares become earned only if a specified number of investigational new drug (IND) filings are made during a specified time frame and, if earned, would vest on the third anniversary of the initial grant date. For the awards made on July 2, 2018, the actual number of number of shares of common stock into which each performance share award may convert will be calculated by multiplying the target number of performance shares allocated to that award by performance percentage multipliers ranging from 0% to 150% based on the actual level at which the applicable revenue-based performance goal is achieved, as certified by the Compensation Committee. The performance period was the year ended December 31, 2018 and achievement of maximum, target and threshold levels will result in percentage multipliers of 150%, 100% and 50%, respectively, with achievement below the threshold level resulting in a percentage multiplier of 0%. In February 2019, the Compensation Committee of the Board of Directors determined that the performance shares were earned at the 83% level, resulting in 20,571 shares being earned by Mr. Hoppenot and 5,389 shares earned by the other executive officers who received performance shares, and the earned shares will vest in equal installments on each of the first four anniversaries of the grant date of July 2, 2018. For additional information, please refer to the section titled “Executive Compensation—Compensation Discussion and Analysis—Key Elements of Executive Compensation—Equity Based Incentive Awards.”

(4) | Represents RSUs that will vest in equal installments on each of the first four anniversaries of the grant date. Vesting of the RSUs is subject to acceleration under the circumstances described under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements” below. The RSUs were granted in connection with the commencement of Ms. Pasquale’s employment.

(5) | Represents the aggregate fair value of stock and option awards computed as of the grant date of each performance share, RSU or option award in accordance with ASC 718, rather than amounts paid to or realized by the named individual. There can be no assurance that options will be exercised (in which case no value will be realized by the individual), that the value on exercise of options will approximate the compensation expense we recognized, or that the price of our common stock when RSUs vest and if and when performance shares vest will equal or exceed the price of our common stock on the date of the applicable RSU or performance share award. The grant date fair values of performance shares were calculated by multiplying the closing price of our common stock on the grant date by the target number of shares payable if the performance targets for those shares are achieved at the target level of 100%.

(6) | Options become exercisable as to one-fourth of the shares on July 5, 2018, with the remaining shares vesting ratably each month thereafter over the following three years, and have a term of ten years, subject to earlier termination in certain events relating to termination of employment. Vesting of the options is subject to acceleration under the circumstances described under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements” below.

(7) | Options become exercisable as to all of the shares on the fourth anniversary of the grant date, and have a term of ten years, subject to earlier termination in certain events relating to termination of employment. Vesting of the options is subject to acceleration under the circumstances described under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements” below.

(8) | Options become exercisable as to one-fourth of the shares on the first anniversary of the grant date, with the remaining shares vesting ratably each month thereafter over the following three years, and have a term of ten years, subject to earlier termination in certain events relating to termination of employment. Vesting of the options is subject to acceleration under the circumstances described under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements” below.

(9) | Mr. Gryska resigned as Executive Vice President and Chief Financial Officer effective December 2018.

(10) | Dr. Huber resigned as Executive Vice President and Chief Scientific Officer effective November 2018.

(11) | Ms. Pasquale was appointed Executive Vice President and General Counsel effective April 2018.

Salary

The annual salaries of the named executive officers are reflected under the Salary column of the Summary Compensation Table. The Compensation Committee reviews salaries on an annual basis, and may change each executive officer’s salary based on the individual’s contributions and responsibilities over the prior twelve months and any change in comparable company pay levels. In

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January 2018, the Compensation Committee set the 2018 base salaries for our executive officers. Salary compensation is discussed in greater detail under the heading “Executive Compensation—Compensation Discussion and Analysis.”

Incentive Compensation

All named executive officers who continued to be employed by us at the time of the January 2019 Compensation Committee determination with respect to achievement under our discretionary 2018 incentive compensation plan received a bonus for the 2018 fiscal year under that plan, although the bonus for Ms. Pasquale was the negotiated amount determined in connection with the commencement of her employment in April 2018. This bonus is reflected under the Non-Equity Incentive Plan Compensation column of the Summary Compensation Table because the bonus is tied to the corporate performance of the Company. The plan established cash incentive awards for all of our eligible employees for 2018, and was designed to align incentive awards for each participant’s individual performance with our corporate goals. Incentive awards for our executive officers were approved by the Compensation Committee in January 2019 and paid in February 2019 pursuant to this plan. Our executive officers each had a funding target under the plan, with the potential for actual awards under the plan to either exceed or be less than such funding target depending upon corporate performance, as well as each executive officer’s individual performance. The range of the 2018 awards at the time of establishment of the plan is set forth under the Estimated Future Payouts Under Non-Equity Incentive Plan Awards column to the Grants of Plan-Based Awards Table. Actual incentive award amounts paid to named executive officers for 2018 pursuant to this plan were based on the achievement of corporate goals that were predetermined by the Compensation Committee, as described in greater detail under the heading “Executive Compensation—Compensation Discussion and Analysis,” and is disclosed in the Non-Equity Incentive Plan Compensation column of the Summary Compensation Table.

In January 2018, all named executive officers who were then employed by us received grants of options to purchase common stock in connection with our annual equity award cycle and certain named executive officers also received outstanding merit option grants, and in July 2018, in connection with our annual equity award cycle, all named executive officers received grants of options to purchase common stock and performance shares. As described in greater detail under the heading “Executive Compensation—Compensation Discussion and Analysis,” the outstanding merit option grants were intended to incentivize and retain the recipients of those grants and the performance shares were tied to a corporate-based performance goal. The numbers and grant date fair values of these awards under ASC 718 are set forth in the Grants of Plan-Based Awards Table. The exercise price for options awarded in 2018 was the fair market value of our common stock on the grant date. The options awarded in January 2018 under our equity grant guidelines will generally vest and become exercisable as to one-fourth of the shares on the first anniversary of the July 2017 grant date, with the remaining shares vesting ratably each month thereafter over the following three years. The options awarded in July 2018 will generally vest and become exercisable as to one-fourth of the shares on the first anniversary of the grant date, with the remaining shares vesting ratably each month thereafter over the following three years. The outstanding merit option grants awarded in January 2018 will vest and become exercisable as to all of the shares on the fourth anniversary of the grant date. The options awarded in January 2018 and in July 2018, and outstanding merit option grants, have a term of ten years from the grant date. The performance shares, if earned, will vest in equal installments on each of the first four anniversaries of the grant date.

In April 2018, Ms. Pasquale received options and RSUs in connection with her employment with us; the options will vest and become exercisable as to one-fourth of the shares on the first anniversary

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of the grant date, with the remaining shares vesting ratably each month thereafter over the following three years, and the RSUs will vest in equal installments on each of the first four anniversaries of the grant date.

In June 2018, certain of our named executive officers were participants in our R&D retention plan and received performance share awards that are described in greater detail under the heading “Executive Compensation—Compensation Discussion and Analysis.”

The amounts, if any, actually realized by the named executive officers for the 2018 awards will vary depending on the vesting of the award and the price of our common stock in relation to the exercise price at the time of exercise. Detail regarding the number of exercisable and unexercisable options held by each named executive officer at year-end is set forth in the Outstanding Equity Awards at Fiscal Year-End Table.

Compensation Risk Assessment

The Compensation Committee, in consultation with the Company’s executive management, reviewed the Company’s compensation policies and practices for its employees and concluded that risks arising from those policies and practices are not reasonably likely to have a material adverse effect on the Company.

Employment Contracts, Termination of Employment and Change-in-Control Arrangements

In April 2014, the Compensation Committee and Management Stock Option Committee approved amendments to outstanding employee stock option and RSU agreements and to the forms of agreements for future employee stock option and RSU agreement to provide that, in the event of a change in control of the Company, (i) if the successor corporation does not assume or substitute comparable awards for all outstanding employee options and RSUs, then as of the date of completion of the change in control transaction, the vesting of such options and RSUs shall be accelerated in full, and (ii) if outstanding options and RSUs are assumed or replaced by comparable awards by the successor corporation and within one year after the change in control, an equity awardee’s service as an employee is terminated without cause or due to constructive termination, then the vesting of such person’s assumed or substituted options and RSUs shall be accelerated in full. The value of such acceleration in full for each Named Executive Officer, assuming such termination or event was effective as of December 31, 2018, is set forth in the table below under the heading “Potential Payments Upon Termination in Connection with a Change in Control.”

President and CEO

In connection with his appointment as President and CEO in January 2014, Mr. Hoppenot and the Company entered into an offer of employment letter and an employment agreement.

Pursuant to the offer letter, Mr. Hoppenot was entitled to an initial base salary of $800,000 and participated in the Company’s annual incentive compensation plan with a funding target for a cash bonus under such plan of 100% of his annual base salary and a minimum bonus for 2014 of $800,000. Mr. Hoppenot’s base salary is reviewed annually by the Compensation Committee. Future bonuses under the incentive compensation plan will be determined by the Compensation Committee in its discretion based on the achievement of performance goals to be determined annually by the Board or, as applicable, the Committee. Pursuant to the offer letter, Mr. Hoppenot also received a signing bonus of $2,200,000, one quarter of which was paid upon commencement of employment and the remainder of which was paid in equal installments on the first day of each of the second, third and fourth calendar

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quarters of 2014. Except as otherwise provided in his employment agreement, Mr. Hoppenot must have remained employed by the Company through the first calendar day of each such quarter in order to receive the respective quarterly portion of the signing bonus.

Mr. Hoppenot received an initial award in January 2014 of options to purchase 124,148 shares of common stock and 17,428 performance shares under the Company’s 2010 Stock Incentive Plan with an aggregate value as of the grant date equal to $4,500,000, determined under generally accepted accounting principles consistent with the valuation of the Company’s equity incentives. Mr. Hoppenot will be eligible to receive future annual equity awards as determined by the Compensation Committee, and all such equity awards, including the initial award, will be subject to vesting or attainment of performance criteria, as applicable, at the same levels as apply to awards of the same type granted to the Company’s other senior executives for the same fiscal year. Mr. Hoppenot also received in January 2014 a one-time grant of 400,000 RSUs, designed to make him whole for equity he forfeited at his previous employer and also to further incentivize retention over a six-year period. Each RSU represents the right to acquire one share of the Company’s common stock. Vesting of the RSUs will be subject to Mr. Hoppenot’s continued employment on the applicable vesting dates, with one-sixth of the RSUs vesting at the end of each of the calendar years 2014 through 2019, subject to earlier acceleration of vesting upon the occurrence of certain events in accordance with the terms of his employment agreement.

Termination Without Good Reason Prior to a Change in Control. If Mr. Hoppenot voluntarily terminates his employment with the Company other than for good reason and other than in the 24-month period following a change in control (the “Change in Control Employment Period”), the Company will pay Mr. Hoppenot, to the extent not already paid, his annual base salary through the date of termination, any deferred compensation and any accrued vacation pay.

Termination Without Good Reason in Connection with a Change in Control. If Mr. Hoppenot terminates his employment with the Company without good reason during the Change in Control Employment Period, the Company will pay Mr. Hoppenot, to the extent not already paid, his annual base salary through the date of termination, any deferred compensation, any accrued vacation pay, and an amount equal to a pro rata portion of his target bonus calculated according to the number of days he worked through the date of termination in the current fiscal year.

Termination Without Cause or for Good Reason Not in Connection with a Change in Control. If, at any time other than during the Change in Control Employment Period, Mr. Hoppenot’s employment is terminated by the Company without cause or by Mr. Hoppenot for good reason, the Company will pay Mr. Hoppenot, to the extent not already paid, his annual base salary through the date of termination, his signing bonus, any deferred compensation, any accrued vacation pay, and an amount equal to a pro rata portion of his target bonus calculated according to the number of days he worked through the date of termination in the current fiscal year. In addition, the Company will pay him an amount equal to the sum of 1.5 times his annual base salary and the greater of his current target bonus or his bonus amount for the preceding fiscal year. The agreement also provides that Mr. Hoppenot’s stock options and RSUs (other than his one-time grant of 400,000 RSUs) will vest as to the amount that would have vested had he continued to work for the Company for an additional 18 months. All options would continue to be exercisable for 180 days following the date of termination. In addition, the agreement provides that the 400,000 RSUs granted in connection with joining the Company will vest as to 100% of the amount that would have vested had he continued to work for the Company for an additional 12 months and vest as to 50% of the amount that would have vested had he continued to work for the Company for an additional 12 months subsequent to the initial 12 months after the date of termination. The agreement also provides for the payment of COBRA premiums by the

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Company, or the cash equivalent thereof, for Mr. Hoppenot and his family for up to 12 months, outplacement services for up 12 months, as well as payment with respect to any other accrued amounts under other of the Company’s benefits arrangements.

Termination in Connection with a Change in Control Without Cause or for Good Reason. If during the Change in Control Employment Period Mr. Hoppenot’s employment is terminated by the Company without cause or by Mr. Hoppenot for good reason, the Company will pay Mr. Hoppenot, to the extent not already paid, his annual base salary through the date of termination, his signing bonus, any deferred compensation, any accrued vacation pay, and an amount equal to a pro rata portion of his target bonus calculated according to the number of days he worked through the date of termination in the current fiscal year. In addition, the Company will pay him an amount equal to three times the sum of his current annual base salary and the greater of his current target bonus or his bonus amount for the preceding fiscal year. The agreement also provides that in the event of such a termination, all of Mr. Hoppenot’s unvested RSUs and unvested stock options will vest in full, and all stock options will remain exercisable for 12 months following his termination. In addition, all performance shares will vest in full and be settled assuming the target level of performance has been achieved. The agreement also provides for the continuation of benefits for Mr. Hoppenot and his family for up to 36 months, outplacement services for up 12 months, as well as payment with respect to any other accrued amounts under other of the Company’s benefits arrangements.

Life Insurance and Disability Insurance Coverage. When Mr. Hoppenot became our CEO in January 2014, after being recruited by our Board, he forfeited certain equity based awards with his previous employer that had provided for an acceleration of vesting of a majority of the awards in the event of his death or permanent disability. Our one-time grant of 400,000 RSUs to Mr. Hoppenot, described above, does not contain a similar provision. To provide Mr. Hoppenot with similar economic value commensurate with the equity based awards he had forfeited in order to join us, we agreed in Mr. Hoppenot’s employment agreement to pay the premiums for an insurance policy that will remain in place for the six-year period that commenced on the first day of his employment that will pay $15 million to Mr. Hoppenot upon termination of his employment for disability or his estate on his death. The six-year period for the life and disability insurance is the same vesting period for the 400,000 RSUs. Mr. Hoppenot’s initial employment agreement also required us to gross-up each premium amount so that the total payment made by us was sufficient to cover the premiums and all federal, state and local income taxes incurred by Mr. Hoppenot. In April 2015, we amended Mr. Hoppenot’s employment agreement so that we would no longer be required to gross-up each premium amount to cover taxes incurred by Mr. Hoppenot. In 2019, at Mr. Hoppenot’s suggestion, we amended Mr. Hoppenot’s employment agreement so that we would no longer be required to pay the premiums for the life and disability insurance coverage for 2019, the last year of vesting of Mr. Hoppenot’s initial RSU grant.

Other Covenants. Under the agreement, Mr. Hoppenot is subject to non-solicitation/non-hiring and non-disparagement covenants that extend two years from termination of employment. Upon certain breaches of those covenants after termination of employment, Mr. Hoppenot must forfeit all of his unvested stock options, stock appreciation rights, restricted stock units, performance shares, and the gain or income realized from the exercise, vesting or settlement of the same within 24 months prior to the breach.

Agreements with Other Named Executive Officers

In November 2003, our Board approved a form of employment agreement for Executive Vice Presidents and certain other senior employees. The form of employment agreement for the Executive Vice Presidents and certain other senior employees was amended in December 2008 to comply with

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Section 409A of the Internal Revenue Code of 1986, as amended. In April 2012, the employment agreements with our Executive Vice Presidents and certain other senior employees were amended to increase the amount payable upon an “involuntary termination” of the executive’s employment within 24 months following a change in control. The Company entered into an employment agreement with Reid M. Huber in May 2011, Steven H. Stein in March 2015 and Wenqing Yao in November 2003 while each served as one of our senior employees. The Company entered into an employment agreements with David W. Gryska in October 2014 upon his employment as Executive Vice President and Chief Financial Officer and with Maria E. Pasquale in April 2018 upon her employment as Executive Vice President and General Counsel.

The employment agreements with our Executive Vice Presidents provide that in the event of an “involuntary termination” of the executive’s employment within 24 months following a change in control (which includes actual termination without cause and constructive termination by way of the assignment of duties substantially and materially inconsistent with the executive’s position or other diminishment in position, requiring the executive to be based at any location outside more than 35 miles from the office or location where he or she was based prior to a change in control, a reduction in salary, bonus or adverse change in benefits, or a breach by the Company of the terms of the executive’s employment arrangement), we will pay the executive an amount equal to two times the sum of the executive’s current annual base salary and the greater of (1) the executive’s current target bonus or (2) the executive’s bonus amount for the preceding fiscal year. A “change in control” generally includes a significant change in the composition of the Board, the acquisition by any person or entity of greater than 50% of the combined voting power of the Company’s outstanding securities, the approval of a liquidation or dissolution of the Company, or the sale or disposition of all or substantially all of the Company’s assets or similar transaction. We will also pay the executive a pro rata portion of the executive’s target bonus calculated according to the number of days the executive worked through the termination date in the current fiscal year. The cash payment would be paid in a lump sum payment following the executive’s termination. The agreement also provides that in the event of such a termination, all of the executive’s unvested stock options will vest in full, and all stock options will be exercisable for 12 months following the executive’s termination. In addition, the agreement provides for the reimbursement of COBRA premiums by the Company for the executive and eligible dependents for up to 12 months, reimbursement (or payment) by the Company for the cost of continued life and disability insurance for the executive for 12 months at the same levels in effect on the termination date, as well as payment with respect to any other accrued amounts under other of the Company’s benefits arrangements.

Potential Payments Upon Termination Without a Change in Control

The following table describes the potential payments and benefits triggered by a termination of employment of a named executive officer by the Company without cause, or by the executive for good reason, in each case prior to a change in control and assuming the employment of the named executive officer was terminated on December 31, 2018.

Termination |  | Cash Payment ($) |  |  | Medical/ Insurance Benefits ($) |  |  | Acceleration of Equity Awards ($)(1) |  |  | Other ($)(2) |  |  | Total ($) |
Hervé Hoppenot |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Termination without cause |  |  | 4,707,873 |  |  |  | 30,502 |  |  |  | 6,624,425 |  |  |  | 236,025 |  |  |  | 11,598,825 |

(1) | Represents the amount by which the $63.59 closing price of our common stock on December 31, 2018 exceeded the exercise price for equity awards for which vesting would have accelerated as a result of termination of employment.

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(2) | Includes accrued amounts under other of the Company’s benefits arrangements, including accrued vacation and other vested benefits the named executive officer is entitled to receive that are generally available to all salaried employees.

Potential Payments Upon Termination in Connection with a Change in Control

The following table describes the potential payments and benefits triggered by a termination of employment of a named executive officer in connection with a change in control, by the Company without cause or by the executive for good reason, in each case assuming the employment of the named executive officer was terminated on December 31, 2018.

Termination |  | Cash Payment ($) |  |  | Medical/ Insurance Benefits ($) |  |  | Acceleration of Equity Awards ($)(1) |  |  | Other ($)(2) |  |  | Total ($) |
Hervé Hoppenot |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Termination without cause or for good reason(3) |  |  | 8,418,499 |  |  |  | 100,930 |  |  |  | 7,849,359 |  |  |  | 236,025 |  |  |  | 16,604,813 |
Steven H. Stein |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Termination without cause or for good reason(3) |  |  | 2,036,876 |  |  |  | 6,838 |  |  |  | 4,103,018 |  |  |  | 40,385 |  |  |  | 6,187,117 |
Wenqing Yao |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Termination without cause or for good reason(3) |  |  | 1,845,000 |  |  |  | 32,447 |  |  |  | 4,103,018 |  |  |  | 53,481 |  |  |  | 6,033,946 |
Maria E. Pasquale |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Termination without cause or for good reason(3) |  |  | 1,750,000 |  |  |  | 33,734 |  |  |  | 790,106 |  |  |  | — |  |  |  | 2,573,840 |

(1) | Represents the amount by which the $63.59 closing price of our common stock on December 31, 2018 exceeded the exercise price for stock options for which vesting would have accelerated as a result of termination of employment and $63.59 multiplied by the number of RSUs for which vesting would have accelerated as a result of termination of employment.

(2) | Includes accrued amounts under other of the Company’s benefits arrangements, including accrued vacation and other vested benefits the named executive officer is entitled to receive that are generally available to all salaried employees.

(3) | Includes constructive termination following a change in control. See the section entitled “Employment Contracts, Termination of Employment and Change-in-Control Arrangements—Agreements with Other Named Executive Officers” above.

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2018 Outstanding Equity Awards at Fiscal Year-End

|  |  |  |  |  |  | Option Awards |  |  |  |  |  |  |  | Stock Awards |
Name |  | Grant Date |  |  | Number of Securities Underlying Unexercised Options (#) Exercisable (1) |  |  | Number of Securities Underlying Unexercised Options (#) Un-Exercisable |  |  | Option Exercise Price ($) |  |  | Option Expiration Date |  |  |  |  |  | Number of Shares or Units of Stock That Have Not Vested (#) |  |  |  |  |  | Market Value of Shares or Units of Stock That Have Not Vested ($)(2) |  |  | Equity Incentive Plan Awards: Number of Unearned Shares, Units or Other Rights That Have Not Vested (#) |  |  | Equity Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Vested ($) |
Hervé Hoppenot |  |  | 01/13/2014 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 66,666 | (3) |  |  |  |  |  |  | 4,239,291 |  |  |  |  |  |  |  |  |
|  | 01/21/2014 |  |  |  | 124,148 |  |  |  | — |  |  |  | 64.55 |  |  |  | 01/20/2021 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/08/2015 |  |  |  | 89,771 |  |  |  | — |  |  |  | 73.21 |  |  |  | 01/07/2022 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | **01/07/2016 |  |  |  | — |  |  |  | 20,195 |  |  |  | 95.76 |  |  |  | 01/06/2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/07/2016 |  |  |  | 73,050 |  |  |  | 2,088 |  |  |  | 95.76 |  |  |  | 01/06/2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/07/2016 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10,442 | (4) |  |  |  |  |  |  | 664,007 |  |  |  |  |  |  |  |  |
|  |  | *07/15/2016 |  |  |  | 44,856 |  |  |  | 29,389 |  |  |  | 83.83 |  |  |  | 07/14/2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/15/2016 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10,802 | (5) |  |  |  |  |  |  | 686,899 |  |  |  |  |  |  |  |  |
|  |  | ***01/17/2017 |  |  |  | 44,856 |  |  |  | 29,389 |  |  |  | 113.64 |  |  |  | 01/16/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | **01/17/2017 |  |  |  | — |  |  |  | 94,325 |  |  |  | 113.64 |  |  |  | 01/16/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/05/2017 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10,260 | (5) |  |  |  |  |  |  | 652,433 |  |  |  |  |  |  |  |  |
|  |  | *07/05/2017 |  |  |  | 16,705 |  |  |  | 30,463 |  |  |  | 128.34 |  |  |  | 07/04/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | ***01/23/2018 |  |  |  | 16,705 |  |  |  | 30,463 |  |  |  | 94.63 |  |  |  | 01/22/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | **01/24/2018 |  |  |  | — |  |  |  | 25,401 |  |  |  | 95.34 |  |  |  | 01/23/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | *07/02/2018 |  |  |  | — |  |  |  | 88,557 |  |  |  | 68.62 |  |  |  | 07/01/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,267 | (6) |  |  | 1,606,729 | (7)
|  |  |  |  |  |  | 410,091 |  |  |  | 350,270 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 98,171 |  |  |  |  |  |  |  | 6,242,630 |  |  |  | 25,267 |  |  |  | 1,606,729 |
David W. Gryska(8) |  |  | 10/31/2014 |  |  |  | 12,459 |  |  |  | — |  |  |  | 67.06 |  |  |  | 03/31/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | 01/08/2015 |  |  |  | 4,190 |  |  |  | — |  |  |  | 73.21 |  |  |  | 03/31/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/07/2016 |  |  |  | 18,262 |  |  |  | — |  |  |  | 95.76 |  |  |  | 03/31/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | *07/15/2016 |  |  |  | 4,773 |  |  |  | — |  |  |  | 83.83 |  |  |  | 03/31/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | ***01/17/2017 |  |  |  | 11,533 |  |  |  | — |  |  |  | 113.64 |  |  |  | 03/31/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | *07/05/2017 |  |  |  | 4,295 |  |  |  | — |  |  |  | 128.34 |  |  |  | 03/31/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | ***01/23/2018 |  |  |  | 4,295 |  |  |  | — |  |  |  | 94.63 |  |  |  | 03/31/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  |  |  |  |  | 59,807 |  |  |  | — |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Steven H. Stein |  |  | 03/02/2015 |  |  |  | 10,876 |  |  |  | — |  |  |  | 88.68 |  |  |  | 03/01/2022 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | 01/07/2016 |  |  |  | 8,348 |  |  |  | 522 |  |  |  | 95.76 |  |  |  | 01/06/2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | **01/07/2016 |  |  |  | — |  |  |  | 4,039 |  |  |  | 95.76 |  |  |  | 01/06/2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/07/2016 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,610 | (4) |  |  |  |  |  |  | 165,970 |  |  |  |  |  |  |  |  |
|  |  | *07/15/2016 |  |  |  | 6,364 |  |  |  | 7,558 |  |  |  | 83.83 |  |  |  | 07/14/2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/15/2016 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,778 | (5) |  |  |  |  |  |  | 176,653 |  |  |  |  |  |  |  |  |
|  |  | ***01/17/2017 |  |  |  | 11,533 |  |  |  | 7,558 |  |  |  | 113.64 |  |  |  | 01/16/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | **01/17/2017 |  |  |  | — |  |  |  | 18,865 |  |  |  | 113.64 |  |  |  | 01/16/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/05/2017 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,638 | (5) |  |  |  |  |  |  | 167,750 |  |  |  |  |  |  |  |  |
|  |  | *07/05/2017 |  |  |  | 4,295 |  |  |  | 7,833 |  |  |  | 128.34 |  |  |  | 07/04/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | ***01/23/2018 |  |  |  | 4,295 |  |  |  | 7,833 |  |  |  | 94.63 |  |  |  | 01/22/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | **01/24/2018 |  |  |  | — |  |  |  | 21,167 |  |  |  | 95.34 |  |  |  | 01/23/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 06/28/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000 | (9) |  |  | 3,179,500 | (10)
|  |  | *07/02/2018 |  |  |  | — |  |  |  | 22,772 |  |  |  | 68.62 |  |  |  | 07/01/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,497 | (6) |  |  | 413,144 | (7)
|  |  |  |  |  |  | 45,711 |  |  |  | 98,147 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 8,026 |  |  |  |  |  |  |  | 510,373 |  |  |  | 56,497 |  |  |  | 3,592,644 |

|  | Proxy Statement 2019 | 57

##### Table of Contents

Executive Compensation |  |

|  |  |  |  |  |  | Option Awards |  |  |  |  |  |  |  | Stock Awards |
Name |  | Grant Date |  |  | Number of Securities Underlying Unexercised Options (#) Exercisable (1) |  |  | Number of Securities Underlying Unexercised Options (#) Un-Exercisable |  |  | Option Exercise Price ($) |  |  | Option Expiration Date |  |  |  |  |  | Number of Shares or Units of Stock That Have Not Vested (#) |  |  |  |  |  | Market Value of Shares or Units of Stock That Have Not Vested ($)(2) |  |  | Equity Incentive Plan Awards: Number of Unearned Shares, Units or Other Rights That Have Not Vested (#) |  |  | Equity Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Vested ($) |
Reid M. |  |  | 01/21/2014 |  |  |  | 22,070 |  |  |  | — |  |  |  | 64.55 |  |  |  | 11/30/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Huber(11) |  |  | 01/08/2015 |  |  |  | 21,545 |  |  |  | — |  |  |  | 73.21 |  |  |  | 11/30/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/07/2016 |  |  |  | 17,740 |  |  |  | — |  |  |  | 95.76 |  |  |  | 11/30/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | *07/15/2016 |  |  |  | 11,136 |  |  |  | — |  |  |  | 83.83 |  |  |  | 11/30/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | ***01/17/2017 |  |  |  | 11,136 |  |  |  | — |  |  |  | 113.64 |  |  |  | 11/30/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | *07/05/2017 |  |  |  | 4,042 |  |  |  | — |  |  |  | 128.34 |  |  |  | 11/30/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | ***01/23/2018 |  |  |  | 4,042 |  |  |  | — |  |  |  | 94.63 |  |  |  | 11/30/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  |  |  |  |  | 91,711 |  |  |  | — |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Wenqing Yao |  |  | 01/19/2012 |  |  |  | 25,354 |  |  |  | — |  |  |  | 17.79 |  |  |  | 01/18/2019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | 02/09/2013 |  |  |  | 62,542 |  |  |  | — |  |  |  | 18.32 |  |  |  | 02/08/2020 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/21/2014 |  |  |  | 16,553 |  |  |  | — |  |  |  | 64.55 |  |  |  | 01/20/2021 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/08/2015 |  |  |  | 21,545 |  |  |  | — |  |  |  | 73.21 |  |  |  | 01/07/2022 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | **01/08/2015 |  |  |  | — |  |  |  | 20,000 |  |  |  | 73.21 |  |  |  | 01/07/2022 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/07/2016 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,610 | (4) |  |  |  |  |  |  | 165,970 |  |  |  |  |  |  |  |  |
|  |  | **01/07/2016 |  |  |  | — |  |  |  | 13,631 |  |  |  | 95.76 |  |  |  | 01/06/2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 01/07/2016 |  |  |  | 18,262 |  |  |  | 522 |  |  |  | 95.76 |  |  |  | 01/06/2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | *07/15/2016 |  |  |  | 11,533 |  |  |  | 7,558 |  |  |  | 83.83 |  |  |  | 07/14/2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/15/2016 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,778 | (5) |  |  |  |  |  |  | 176,653 |  |  |  |  |  |  |  |  |
|  |  | ***01/17/2017 |  |  |  | 11,533 |  |  |  | 7,558 |  |  |  | 113.64 |  |  |  | 01/16/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | **01/17/2017 |  |  |  | — |  |  |  | 18,865 |  |  |  | 113.64 |  |  |  | 01/16/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/05/2017 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,638 | (5) |  |  |  |  |  |  | 167,750 |  |  |  |  |  |  |  |  |
|  |  | *07/05/2017 |  |  |  | 4,295 |  |  |  | 7,833 |  |  |  | 128.34 |  |  |  | 07/04/2027 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | ***01/23/2018 |  |  |  | 4,295 |  |  |  | 7,833 |  |  |  | 94.63 |  |  |  | 01/22/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | **01/24/2018 |  |  |  | — |  |  |  | 21,167 |  |  |  | 95.34 |  |  |  | 01/23/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 06/28/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000 | (9) |  |  | 3,179,500 | (10)
|  |  | *07/02/2018 |  |  |  | — |  |  |  | 22,772 |  |  |  | 68.62 |  |  |  | 07/01/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,497 | (6) |  |  | 413,144 | (7)
|  |  |  |  |  |  | 175,912 |  |  |  | 127,739 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 8,026 |  |  |  |  |  |  |  | 510,373 |  |  |  | 56,497 |  |  |  | 3,592,644 |
Maria E. Pasquale(12) |  |  | *04/09/2018 |  |  |  | — |  |  |  | 41,193 |  |  |  | 65.36 |  |  |  | 04/09/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | 04/09/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,928 | (6) |  |  |  |  |  |  | 376,962 |  |  |  |  |  |  |  |  |
|  |  | *07/02/2018 |  |  |  | — |  |  |  | 22,772 |  |  |  | 68.62 |  |  |  | 07/01/2028 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  | 07/02/2018 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,497 | (6) |  |  | 413,144 | (7)
|  |  |  |  |  |  | — |  |  |  | 63,965 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,928 |  |  |  |  |  |  |  | 376,962 |  |  |  | 6,497 |  |  |  | 413,144 |

(1) | All options listed in this table, other than those marked with an asterisk (*), a double asterisk (**) or a triple asterisk (***), become exercisable as to one-third of the shares on the first anniversary of the date of grant, with the remaining shares vesting ratably on a monthly basis thereafter over the following two years, and have a term of seven years, subject to earlier termination in certain events relating to termination of employment. Options marked with an asterisk become exercisable as to one-fourth of the shares on the first anniversary of the date of grant, with the remaining shares vesting ratably on a monthly basis thereafter over the following three years, and have a term of ten years, subject to earlier termination in certain events relating to termination of employment. Options marked with a double asterisk become exercisable as to all of the shares on the fourth anniversary of the date of grant, and have a term of ten years, subject to earlier termination in certain events relating to termination of employment. Options marked with a triple asterisk become exercisable as to one-fourth of the shares on the first anniversary of the grant date in July of the preceding year with the remaining shares vesting ratably on a monthly basis thereafter over the following three years, and have a term of ten years, subject to earlier termination in certain events relating to termination of employment. Vesting of all options listed in this table is subject to acceleration under the circumstances described under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements.”

58 | Proxy Statement 2019 |  |

##### Table of Contents

|  | Executive Compensation

(2) | The market value of unvested RSUs is calculated by multiplying the number of unvested RSUs held by the applicable named executive officer by $63.59, the closing price of our common stock on December 31, 2018.

(3) | In connection with the commencement of his employment as our CEO in January 2014, Mr. Hoppenot was awarded a one-time grant of 400,000 RSUs, with one-sixth vesting at the end of each of the calendar years 2014 through 2019 subject to Mr. Hoppenot’s continued employment and subject to acceleration of vesting upon certain events in accordance with the terms of his employment agreement, as described under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements.”

(4) | RSUs that vest in full on the third anniversary of the grant date, subject to the holder’s continued service through such date. Vesting of the RSUs is subject to acceleration under the circumstances described under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements.”

(5) | RSUs that vest in equal installments on each of the first four anniversaries of the grant date, subject to the holder’s continued service through such dates. Vesting of the RSUs is subject to acceleration under the circumstances described under “Employment Contracts, Termination of Employment and Change-in-Control Arrangements.”

(6) | Represents the target number of shares of common stock underlying performance shares that can be earned based upon the achievement of revenue based performance criteria. The actual number of number of shares of common stock into which each performance share award may convert will be calculated by multiplying the target number of performance shares allocated to that award by performance percentage multipliers ranging from 0% to 150% based on the actual level at which the applicable revenue-based performance goal is achieved, as certified by the Compensation Committee. The earned performance shares will vest in equal installments on each of the first four anniversaries of the grant date of July 2, 2018.

(7) | The market value of unearned and unvested performance shares assumes achievement of the performance goals at the target level of 100% and is calculated by multiplying the number of unearned and unvested target shares held by the applicable named executive officer by $63.59, the closing price of our common stock on December 31, 2018.

(8) | Mr. Gryska resigned as Executive Vice President and Chief Financial Officer effective December 2018.

(9) | Represents shares of common stock underlying performance shares that become earned only if a specified number of investigational new drug (IND) filings are made during a specified time frame. If earned, the shares would vest on the third anniversary of the initial grant date.

(10) | The market value of unearned and unvested performance shares is calculated by multiplying the number of unearned and unvested target shares held by the applicable named executive officer by $63.59, the closing price of our common stock on December 31, 2018.

(11) | Dr. Huber resigned as Executive Vice President and Chief Scientific Officer effective November 2018.

(12) | Ms. Pasquale was appointed Executive Vice President and General Counsel effective April 2018.

|  | Proxy Statement 2019 | 59

##### Table of Contents

Executive Compensation |  |

2018 Option Exercises and Stock Vested Table

|  | Option Awards |  |  |  | Stock Awards
Name |  | Number of Shares Acquired on Exercise (#) |  | Value Realized on Exercise ($)(1) |  |  |  | Number of Shares Acquired on Vesting (#) |  | Value Realized on Vesting ($)(2)
Hervé Hoppenot |  |  |  | — |  |  |  | $ | — |  |  |  |  |  |  |  |  |  | 88,079 | (3) |  |  | $ | 7,431,197 |
David W. Gryska(4) |  |  |  | 6,760 |  |  |  | $ | 101,696 |  |  |  |  |  |  |  |  |  | 5,290 | (5) |  |  | $ | 417,495 |
Steven H. Stein |  |  |  | — |  |  |  | $ | — |  |  |  |  |  |  |  |  |  | 8,751 | (6) |  |  | $ | 719,005 |
Reid M. Huber(7) |  |  |  | — |  |  |  | $ | — |  |  |  |  |  |  |  |  |  | 5,290 | (8) |  |  | $ | 417,495 |
Wenqing Yao |  |  |  | — |  |  |  | $ | — |  |  |  |  |  |  |  |  |  | 5,290 | (9) |  |  | $ | 417,495 |
Maria E. Pasquale(10) |  |  |  | — |  |  |  | $ | — |  |  |  |  |  |  |  |  |  | — |  |  |  | $ | — |

(1) | Value realized is based on the fair market value of our common stock on the date of exercise minus the exercise price and does not necessarily reflect proceeds actually received by the individual.

(2) | Value realized is based on the fair market value of our common stock on the vesting date and does not necessarily reflect proceeds actually received by the individual.

(3) | Represents 88,079 shares received upon vesting of RSUs, of which 41,205 shares were automatically withheld to cover tax withholding obligations.

(4) | Mr. Gryska resigned as Executive Vice President and Chief Financial Officer effective December 2018.

(5) | Represents 5,290 shares received upon vesting of RSUs, of which 1,805 shares were automatically withheld to cover tax withholding obligations.

(6) | Represents 8,751 shares received upon vesting of RSUs, of which 2,920 shares were automatically withheld to cover tax withholding obligations.

(7) | Dr. Huber resigned as Executive Vice President and Chief Scientific Officer effective November 2018.

(8) | Represents 5,290 shares received upon vesting of RSUs, of which 1,796 shares were automatically withheld to cover tax withholding obligations.

(9) | Represents 5,290 shares received upon vesting of RSUs, of which 1,729 shares were automatically withheld to cover tax withholding obligations.

(10) | Ms. Pasquale was appointed Executive Vice President and General Counsel effective April 2018.

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Equity Compensation Plan Information

The following table gives information about our common stock that may be issued upon the exercise of options, warrants and rights under all of our existing equity compensation plans as of December 31, 2018, including the 1993 Directors’ Stock Option Plan, the 1997 Employee Stock Purchase Plan and the 2010 Stock Incentive Plan.

|  | Number of securities to be issued upon exercise of outstanding options, warrants and rights |  |  |  | Weighted-average exercise price of outstanding options, warrants and rights ($) |  |  |  | Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a))
Plan Category |  | (a) |  |  |  | (b) |  |  |  | (c)
Equity compensation plans approved by security holders |  |  |  | 14,481,691 | (1) |  |  |  |  |  |  |  | $ | 74.39 | (2) |  |  |  |  |  |  |  |  | 7,563,654 | (3)
Equity compensation plans not approved by security holders |  |  |  | 133,333 | (4) |  |  |  |  |  |  |  |  | — |  |  |  |  |  |  |  |  |  | — |
Total |  |  |  | 14,615,024 |  |  |  |  |  |  |  |  | $ | 74.39 |  |  |  |  |  |  |  |  |  | 7,563,654 |

(1) | Includes 1,597,893 and 598,639 shares subject to RSUs and performance shares outstanding as of December 31, 2018 that were issued under the 2010 Stock Incentive Plan. The number of shares subject to such performance shares represents the maximum number of shares issuable pursuant to such performance shares as of such date.

(2) | RSUs and performance shares, which do not have an exercise price, are excluded in the calculation of weighted-average exercise price.

(3) | Includes 693,521 shares available for issuance under the 1997 Employee Stock Purchase Plan and 6,870,133 shares available for issuance under the 2010 Stock Incentive Plan. No shares remain available for future issuance under the 1993 Directors’ Stock Option Plan.

(4) | Represents shares subject to RSUs granted outside of the 2010 Stock Incentive Plan to Hervé Hoppenot, as described under “—Employment Contracts, Termination of Employment and Change in Control Arrangements—President and CEO.”

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Report of the Audit Committee of the Board

The Audit Committee of the Board is composed of three directors, each of whom qualifies as “independent” under the current listing requirements of The Nasdaq Stock Market. The current members of the Audit Committee are Paul J. Clancy, Paul A. Brooke and Wendy L. Dixon. The Audit Committee acts pursuant to a written charter that has been adopted by the Board. The charter is reviewed annually for changes, as appropriate.

In performing its functions, the Audit Committee acts in an oversight capacity and necessarily relies on the work and assurances of the Company’s management, which has the primary responsibility for financial statements and reports, and of the independent registered public accounting firm, who, in their report, express an opinion on the conformity of the Company’s annual financial statements with accounting principles generally accepted in the United States and the effectiveness of the Company’s internal control over financial reporting. It is not the duty of the Audit Committee to plan or conduct audits, to determine that the Company’s financial statements are complete and accurate and are in accordance with generally accepted accounting principles, or to assess or determine the effectiveness of the Company’s internal control over financial reporting.

Within this framework, the Audit Committee has reviewed and discussed with management the Company’s audited financial statements as of and for the year ended December 31, 2018 and the Company’s internal control over financial reporting. The Audit Committee has also discussed with the independent registered public accounting firm, Ernst & Young LLP, the matters required to be discussed by Auditing Standard No. 1301, “Communications with Audit Committees,” issued by the Public Company Accounting Oversight Board. In addition, the Audit Committee has received the written disclosures and the letter from the independent registered public accounting firm required by applicable requirements of the Public Company Accounting Oversight Board regarding the independent registered public accounting firm’s communications with the Audit Committee concerning independence, and has discussed with the independent registered public accounting firm the independent registered public accounting firm’s independence.

Based upon these reviews and discussions, the Audit Committee recommended to the Board that the audited financial statements be included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2018.

Audit Committee

Paul J. Clancy (Chair)

Paul A. Brooke

Wendy L. Dixon

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Proposal 2

Advisory Vote to Approve Executive Compensation

This Proposal 2, commonly known as a “say-on-pay” proposal, provides our stockholders with the opportunity to vote to approve, on a non-binding, advisory basis, the compensation of our named executive officers as disclosed in this Proxy Statement in accordance with the compensation disclosure rules of the Securities and Exchange Commission.

As described in detail under the heading “Executive Compensation—Compensation Discussion and Analysis,” our executive compensation programs are designed to attract and retain our named executive officers, who are critical to our success. Under these programs, our named executive officers are rewarded for the achievement of annual and long-term corporate objectives, and the creation of increased stockholder value. Please read the Compensation Discussion and Analysis for additional details about our executive compensation programs, including information about the 2018 compensation of our named executive officers.

Each year since 2011, we sought, and received, approval for our executive compensation program. In addition, in 2011, and again in 2017, we sought, and received, approval to hold a “say-on-pay” vote each year. Accordingly, we are again asking our stockholders to indicate their support for our named executive officer compensation as described in this Proxy Statement. This Proposal 2 gives our stockholders the opportunity to express their views on our named executive officers’ compensation. This vote is advisory, which means that the vote on executive compensation is not binding on the Company, our Board or the Compensation Committee of the Board. This vote is not intended to address any specific item of compensation, but rather the vote relates to the compensation of our named executive officers, as described in this Proxy Statement in accordance with the compensation disclosure rules of the Securities and Exchange Commission. Accordingly, we again will ask our stockholders to vote for the following resolution at the annual meeting:

“RESOLVED, that the Company’s stockholders approve, on a non-binding, advisory basis, the compensation of the named executive officers, as disclosed in the Company’s Proxy Statement for the 2019 Annual Meeting of Stockholders pursuant to the compensation disclosure rules of the Securities and Exchange Commission, including the Compensation Discussion and Analysis, the Summary Compensation Table and the other related tables and disclosure.”

|  | The Board recommends a vote “FOR” the Approval of Executive Compensation.

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Proposal 3

Proposal to Amend the Amended and Restated 2010

Stock Incentive Plan

In March 2019, the Board approved amendments to the Amended and Restated 2010 Stock Incentive Plan (referred to in this proposal description as the “2010 Plan”), subject to the approval of our stockholders at the Annual Meeting, to increase the number of shares available for issuance and make certain additional changes. Incyte has continued to grow at a significant rate. As our revenue and our discovery and development pipeline have substantially increased over the last several years, so too has our number of employees. Our 2016 expansion into Europe and our 2017 expansion into Japan has also contributed to our increasing employee headcount. Even though our employee headcount has risen substantially in the last several years, including in 2018, we have carefully managed the 2010 Plan to ensure that stockholders are subject to minimal dilution and that there is as little overhang as possible on our common stock. In fact, as the chart below shows, since the 2018 amendment to the 2010 Plan that added 6,000,000 shares, our overhang percentage remains low, at 9.1%, and our 3-year average burn rate is 2.26% (assuming that each full value award equates to 2.0 shares and each stock option award equates to 1.0 share), all while our employee headcount has grown by 98% over the past three years.

3-Year average burn rate for peer group 50th percentile is 2.8%

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Further detail of our year-end overhang percentage is set forth in the table below:

Overhang Detail

|  | 2015 |  |  | 2016 |  |  | 2017 |  |  | 2018 |
Overhang: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options and awards available for grant |  |  | 4,681,150 |  |  |  | 7,473,290 |  |  |  | 4,678,903 |  |  |  | 7,023,328 |
Options and awards outstanding |  |  | 11,617,846 |  |  |  | 12,751,142 |  |  |  | 12,385,213 |  |  |  | 14,328,496 |
Total overhang |  |  | 16,298,996 |  |  |  | 20,224,432 |  |  |  | 17,064,116 |  |  |  | 21,351,824 |
Common outstanding and overhang shares |  |  | 202,949,245 |  |  |  | 209,073,184 |  |  |  | 228,327,022 |  |  |  | 234,626,484 |
Overhang Percentage |  |  | 8.0% |  |  |  | 9.7% |  |  |  | 7.5% |  |  |  | 9.1% |

50th percentile peer group overhang is 14.1%

We believe that we have been careful stewards of the 2010 Plan and we now seek a new amendment to the 2010 Plan to add an additional 7,700,000 shares (as detailed further below) so that we will be in a position to continue our substantial growth as we seek to execute on our 2019 and longer-term strategic goals.

The following summary of the principal features of the 2010 Plan, as amended, is qualified by reference to the terms of the plan, a copy of which is available without charge upon stockholder request to Secretary, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803. The 2010 Plan, as amended, has also been filed electronically with the Securities and Exchange Commission together with this Proxy Statement, and can be accessed on the SEC’s web site at http://www.sec.gov.

Description of Amendments

The first amendment to the 2010 Plan approved by the Board and submitted for stockholder approval consists of an increase in the number of shares available for issuance thereunder by 7,700,000 shares, from 36,753,475 shares to 44,453,475 shares.

The proposed increase of 7,700,000 in the number of shares reserved for issuance under the 2010 Plan is needed to allow us to continue to provide effective and appropriate equity incentives to our growing number of employees and our directors. Our equity awards have historically consisted of stock options, RSUs and performance shares. Our Board and the Compensation Committee of the Board have believed that equity awards align compensation incentives with stockholder interests, provide at-risk compensation for management by providing them with a strong incentive to improve the Company’s performance, and provide employees with the opportunity to benefit significantly from the success of the Company. We offer equity awards to all new hires and have found that attractive and competitive initial equity awards are often an important inducement for the high-performing, entrepreneurial individuals who we believe are key to our success. We expect to continue to expand our workforce in support of our research and development and commercialization efforts as we execute on our long-term growth strategy. As we recruit to fill these new positions, the amount of shares required for initial awards to new hires, together with the amount required for annual awards to existing employees, in each case consistent with our historical practices, increases.

We do not believe the proposed 7,700,000 share increase will be unduly dilutive to stockholders. A common measure of potential dilution from outstanding equity awards is “overhang,” generally defined as equity awards outstanding but not exercised, plus equity awards available to be granted (together

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referred to as potential equity award shares), divided by the sum of total common shares outstanding plus potential equity award shares. As of March 12, 2019, our overhang was 9%, as compared with 7% as of February 28, 2018. We believe that our overhang has been reduced as a result of our equity award guidelines that were implemented in January 2014 and July 2016, pursuant to which the number of stock option awards was reduced through the use of RSUs and performance shares. For our annual awards and new employee awards beginning in July 2016, each U.S. recipient received a mix of stock options and RSUs, with the value as of the grant date of the options equal to 662/3% (75% for our executive officers), and the value of the shares underlying the RSU award equal to 331/3% (25% for our executive officers), of the aggregate value of such options and shares, in each case as determined under generally accepted accounting principles consistent with the valuation of our Company’s equity incentives. In 2018, we changed the 25% portion of our executive officer awards from RSUs to performance shares, which combine the time-based vesting aspects of RSUs with performance-based vesting requirements, and in 2019, our executive officers will receive for their annual awards a mix of 50% stock options, 25% performance shares and 25% RSUs. Non-U.S. recipients only receive RSUs.

The second amendment approved by the Board and submitted for stockholder approval would replace the current limitation of 3,500,000 shares that may be issued pursuant to so-called “full value” awards such as RSUs, restricted shares and performance shares (essentially any sales or awards of shares other than upon exercise of options or other than pursuant to sales at purchase prices at least equal to the fair market value of the shares) with a flexible or “fungible” share pool approach. Under this approach, each full value award will reduce the total share pool available under the 2010 Plan by 2.0 shares, and each stock option and any other non-full value award will reduce the total share pool by 1.0 share for each underlying award share granted. This amendment would provide us with more flexibility to use full value awards to compensate our employees and thus reduce the potential dilution of employee awards to our stockholders, while still recognizing the differences in value of each type of award.

In addition, the Board approved an amendment to the 2010 Plan to restructure the automatic grants of equity awards to our nonemployee “outside” directors. Such directors currently receive an initial grant of options to purchase 25,000 shares at the time of their initial election to the Board, and annual grants of nonstatutory options to purchase 15,000 shares at each regular annual meeting of our stockholders, in each case subject to time-based vesting requirements. If the proposed amendment is approved by our stockholders at the Annual Meeting, the initial grants of options to purchase 25,000 shares to new outside directors would be eliminated, and the annual grants made to outside directors following the conclusion of the Annual Meeting and each future annual meeting of our stockholders would be changed from a grant of options to purchase 15,000 shares to a grant having an aggregate grant date fair value of $500,000 and entitling the recipient to receive a mix of stock options and RSUs, with the value as of the grant date of the options equal to 75% and the value of the shares underlying the RSU award equal to 25% of the aggregate grant date fair value, in each case as determined under generally accepted accounting principles consistent with the valuation of our Company’s equity incentives. The number of shares subject to the options will be determined by dividing 75% of $500,000 (or $375,000) by the Black-Scholes value of one such option, based on the average closing sale price for our shares over the 30 consecutive trading days concluding with the last trading day prior to the grant date, rounded down to the nearest whole share. The number of shares subject to the RSUs will be determined by dividing 25% of $500,000 (or $125,000) by such 30 trading day average price, rounded down to the nearest whole share. The exercise price of the options will be equal to the fair market value on the date of grant, and the options will have a term of ten years. Each outside director who is not initially elected at a regular annual meeting of our stockholders will receive awards having an aggregate grant date fair value of a pro rata portion of $500,000, determined based on the

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number of full calendar months remaining from the date of election until the next regular annual meeting divided by 12. Such outside director’s awards will consist of 75% nonstatutory options and 25% RSUs determined in a manner similar to that used for the annual awards to outside directors following the conclusion of the regular annual meeting, except that the values of the awards to such outside director will be determined as of the grant date of such awards. Under the proposed amendment, all annual awards to outside directors will vest (and, in the case of options, become exercisable) on the earlier of the first anniversary of the date of grant or immediately prior to the next regular annual meeting of our stockholders, similar to the current vesting provisions for annual awards to outside directors under the 2010 Plan.

The last amendment approved by the Board and submitted for stockholder approval is an extension of the termination date of the 2010 Plan, from March 18, 2021 to June 30, 2021. This will allow us to continue using the 2010 Plan for equity awards through the date of our annual meeting of stockholders in 2021.

2010 Stock Incentive Plan

The 2010 Plan was initially adopted by the Board in March 2010 and approved by our stockholders in May 2010. It was last amended and restated by the Board in April 2013 and our stockholders approved the amended and restated 2010 Plan in May 2013. The Board further amended the 2010 Plan in 2014, 2016 and 2018, and our stockholders approved each of those amendments.

The purpose of the 2010 Plan is to assist in the recruitment, retention and motivation of employees, outside directors and consultants who are in a position to make material contributions to our long-term success and the creation of stockholder value. The 2010 Plan offers a significant incentive to encourage our employees, outside directors and consultants by enabling those individuals to acquire shares of our common stock, thereby increasing their proprietary interest in the growth and success of our Company.

The 2010 Plan provides for the direct award or sale of shares of common stock (including restricted shares), the award of RSUs and stock appreciation rights, the award of performance shares and the grant of incentive stock options to purchase common stock intended to qualify for preferential tax treatment under Section 422 of the Internal Revenue Code of 1986, as amended (the “Code”), and nonstatutory stock options to purchase common stock that do not qualify for such treatment under the Code. All employees, including officers, of the Company or any subsidiary, non-employee directors of the Company and any consultant who performs services for the Company or any subsidiary are eligible to purchase shares of common stock and to receive awards of shares, restricted shares, performance shares, RSUs or stock appreciation rights or grants of nonstatutory stock options. Only employees are eligible to receive grants of incentive stock options. As of December 31, 2018, 1,374 employees (including officers) and non-employee directors would have been eligible to purchase common stock and to receive awards under the 2010 Plan.

Administration

The 2010 Plan is administered by the Compensation Committee. Subject to the limitations set forth in the plan, the Compensation Committee has the authority to determine, among other things, to whom awards will be granted, the number of shares subject to awards, the term during which an option or stock appreciation right may be exercised and the rate at which the awards may vest or be earned, including any performance criteria to which they may be subject. The Compensation Committee also has the authority to determine the consideration and methodology of payment for awards. The Board has created a secondary committee, the Non-Management Stock Option Committee, which is

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authorized to make awards and grants under the 2010 Plan to eligible individuals other than members of the Board, the “Section 16 officers,” and employees who hold the title of Senior Vice President or above.

Maximum Shares and Award Limits

A total of 36,753,475 shares of common stock are currently reserved for issuance under the 2010 Plan. As of March 12, 2019, the Company had outstanding options to purchase an aggregate of 13,435,299 shares of common stock (with exercise prices ranging from $12.46 to $138.52 per share) under the 2010 Plan, outstanding RSUs covering 1,494,294 shares, and outstanding performance shares pursuant to which a maximum of 480,495 shares could be issued and had 4,932,837 shares of common stock available for issuance under the 2010 Plan (or 12,632,837 shares of common stock including the 7,700,000 shares subject to stockholder approval at the Annual Meeting). As of March 12, 2019, the Company had outstanding options to purchase an aggregate of 13,435,299 shares of common stock under the 2010 Plan at a weighted average exercise price of $76.72 per share and with a weighted average remaining contractual term of 1.73 years. The 2010 Plan replaced the 1991 Stock Plan and the 1993 Directors’ Stock Option Plan. Shares that are subject to awards that expire, terminate or are cancelled under either the 1991 Stock Plan or the 1993 Directors’ Stock Option Plan will not be made available for future awards under the 2010 Plan. Other than outstanding options to purchase common stock under the 1993 Directors’ Stock Option Plan and the 2010 Plan, outstanding RSUs and performance shares under the 2010 Plan, and 66,666 outstanding RSUs granted outside of the 2010 Plan to Hervé Hoppenot, the Company had no other outstanding awards as of March 12, 2019, and no shares remain available for future issuance under either the 1991 Stock Plan or the 1993 Directors’ Stock Option Plan. No one award recipient may receive awards under the 2010 Plan in any calendar year that relate to more than 800,000 shares of common stock. If the proposed amendments are approved by stockholders at the Annual Meeting, each “full value” award such as an award of RSUs, restricted shares or performance shares (that is, any sales or awards of shares other than upon exercise of options or other than pursuant to sales at purchase prices at least equal to the fair market value of the shares) will reduce the total share pool available under the 2010 Plan by 2.0 shares, and each stock option and any other non-full value award will reduce the total share pool by 1.0 share for each underlying award share granted. In addition, other than automatic grants to outside directors, awards for no more than 5% of the total number of shares of common stock reserved for issuance under the 2010 Plan may vest sooner than 12 months from the date of grant.

These limitations shall be adjusted as appropriate and equitable in the event of a stock dividend, stock split, reclassification of stock or similar events. If an award made under the 2010 Plan expires without having been exercised in full, or if any restricted shares, RSUs or performance shares are forfeited or repurchased by Company due to failure to vest, then the corresponding shares will again become available for awards under the 2010 Plan. Upon the settlement of stock appreciation rights, all of the shares subject to any such stock appreciation right will reduce the number of shares available under the 2010 Plan, regardless of the number of shares actually issued. If any award is paid in cash rather than shares of common stock, the payment of cash will not reduce the number of available shares. The Company may grant awards under other plans or programs, which may be settled in shares of common stock issued under the 2010 Plan. Such shares shall be treated like shares issued in settlement of RSUs and, when issued, will reduce the number of shares of common stock available for issuance under the 2010 Plan.

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Stock Options

The terms of any grants of stock options under the 2010 Plan will be set forth in a stock option agreement to be entered into between the Company and the recipient. The Compensation Committee will determine the terms and conditions of such option grants, which need not be identical. Stock options may provide for the accelerated exercisability in the event of the award recipient’s death, disability, or retirement or other events and may provide for expiration prior to the end of its term in the event of the termination of the award recipient’s service. The Compensation Committee may modify, extend or assume outstanding options or may accept the cancellation of outstanding options in return for the grant of new options for the same or a different number of shares and at the same or a different exercise price, or in return for the grant of the same or a different number of shares. However, outstanding options may not be modified to lower the exercise price, nor may outstanding options be assumed or accepted for cancellation in return for the grant of new options with a lower exercise price, unless approved by the Company’s stockholders. In no event will the Company purchase or assume in exchange for cash any stock option whose exercise price exceeds the fair market value of the underlying shares of common stock.

The exercise price of each option will be set by the Compensation Committee, subject to the following limits. The exercise price of an incentive stock option cannot be less than 100% of the fair market value of a share of common stock on the date the option is granted, and in the event an option recipient is deemed to be a 10% owner of our Company or one of our subsidiaries, the exercise price of an incentive stock option cannot be less than 110% of the fair market value of a share of common stock on the date the option is granted. The exercise price of a nonstatutory stock option cannot be less than 100% of the fair market value of a share of common stock on the date the option is granted. On March 12, 2019, the closing price for our common stock on The Nasdaq Global Select Market was $84.90. The maximum period in which an option may be exercised will be fixed by the Compensation Committee and included in each stock option agreement but cannot exceed ten years in the case of an incentive stock option, and in the event an option recipient is deemed to be a 10% owner of our Company or one of our subsidiaries, the maximum period for an incentive stock option granted to that person cannot exceed five years. In addition, no option recipient may be granted incentive stock options that are exercisable for the first time in any calendar year for common stock having a total fair market value (determined as of the option grant) in excess of $100,000.

The exercise price for the exercise of a stock option may be paid in cash or, to the extent that the stock option agreement so provides, by surrendering shares of common stock, by delivery of an irrevocable direction to a securities broker to sell shares and to deliver all or part of the sale proceeds to the Company in payment of the aggregate exercise price, by delivery of an irrevocable direction to a securities broker or lender to pledge shares, as security for a loan, and to deliver all or part of the loan proceeds to the Company in payment of the aggregate exercise price, by delivering a full-recourse promissory note, or in any other form that is consistent with applicable laws, regulations and rules. Options generally will be nontransferable except in the event of the option recipient’s death.

Stock options granted under the 2010 Plan must be exercised by the optionee before the expiration of such option. Each stock option agreement will set forth the extent to which the option recipient will have the right to exercise the option following the termination of the recipient’s service with us, and the right to exercise the option of any executors or administrators of the award recipient’s estate or any person who has acquired such options directly from the award recipient by bequest or inheritance.

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Automatic Option Grants to Directors

As discussed above under “Description of Amendments,” if the proposed amendments are approved by our stockholders at the Annual Meeting, the initial grants of 25,000 options to new nonemployee “outside” directors would be eliminated, and the annual grants made to outside directors following the conclusion of the Annual Meeting and each future annual meeting of our stockholders would be changed from a grant of 15,000 options to a grant consisting of 75% nonstatutory options and 25% RSUs having an aggregate grant date fair value of $500,000. The number of shares subject to the nonstatutory options will be determined by dividing 75% of $500,000 (or $375,000) by the Black-Scholes value of one such option, based on the average closing sale price for our shares on The Nasdaq Global Select Market over the 30 consecutive trading days concluding with the last trading day prior to the grant date, rounded down to the nearest whole share. The number of shares subject to the RSUs will be determined by dividing 25% of $500,000 (or $125,000) by such 30 trading day average price, rounded down to the nearest whole share. The exercise price of the options will be equal to the fair market value on the date of the grant, and the options will have a term of ten years. Each outside director who is not initially elected at a regular annual meeting of our stockholders will receive awards within 10 business days of his or her election having an aggregate grant date fair value of a pro rata portion of $500,000, determined based on the number of full calendar months remaining from the date of election until the next regular annual meeting divided by 12. Such outside director’s awards will consist of 75% nonstatutory options and 25% RSUs determined in a manner similar to that used for the annual awards to outside directors following the conclusion of the regular annual meeting, except that the values of the awards to such outside director will be determined as of the grant date of such awards. All annual awards to outside directors will vest (and in the case of options, become exercisable) on the earlier of the first anniversary of the date of grant or immediately prior to the next regular annual meeting of our stockholders.

Options granted to outside directors will become fully vested if a change in control occurs with respect to the Company during the director’s service. The Board may from time to time increase the number of shares subject to an annual grant if the Board determines that the increase is necessary to induce individuals to become or remain non-employee directors, or to address an increase in the duties or responsibilities of a non-employee director. The Board may also determine that the exercise price of such an option shall be greater than the fair market value of the common stock on the date of grant and that the option shall be exercisable on a different schedule than stated above.

Restricted Shares

The terms of any awards of restricted shares under the 2010 Plan will be set forth in a restricted share agreement to be entered into between the Company and the recipient. The Compensation Committee will determine the terms and conditions of the restricted share agreements, which need not be identical. Restricted share awards generally will be subject to vesting requirements of a minimum period of three years, and may be subject to transfer restrictions. Award recipients who are granted restricted shares generally have all of the rights of a stockholder with respect to those shares. Restricted shares may be issued for consideration as the Compensation Committee may determine, including cash, cash equivalents, full-recourse promissory notes, past services and future services.

Restricted Stock Units

The terms of any awards of RSUs under the 2010 Plan will be set forth in an RSU agreement to be entered into between the Company and the recipient. The Compensation Committee will determine the terms and conditions of the RSU agreements, which need not be identical. RSUs give an award recipient

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the right to acquire a specified number of shares of common stock, or at the Compensation Committee’s discretion, cash, or a combination of common stock and cash, at a future date upon the satisfaction of certain vesting conditions based upon a vesting schedule or performance criteria established by the Compensation Committee. RSUs generally will be subject to vesting requirements of a minimum period of three years. RSUs may be granted in consideration of a reduction in the award recipient’s other compensation, but no cash consideration is required of the award recipient. Unlike restricted shares, the stock underlying RSUs will not be issued until the stock units have vested, and recipients of RSUs generally will have no voting or dividend rights prior to the time of issuance of any common stock upon settlement.

Stock Appreciation Rights

The terms of any awards of stock appreciation rights under the 2010 Plan will be set forth in an agreement to be entered into between the Company and the recipient. The Compensation Committee will determine the terms, conditions and restrictions of any such agreements, which need not be identical. A stock appreciation right generally entitles the award recipient to receive a payment upon exercise equal to the amount by which the fair market value of a share of common stock on the date of exercise exceeds the value of a share of common stock on the date of grant. The exercise price of a stock appreciation right cannot be less than 100% of the fair market value of a share of common stock on the date the stock appreciation right is granted. The amount payable upon the exercise of a stock appreciation right may be settled in cash or by the issuance of shares of common stock.

Performance Shares

The terms of any awards of performance shares under the 2010 Plan will be set forth in an agreement to be entered into between the Company and the recipient. The Compensation Committee will determine the terms, conditions and restrictions of any such agreements, which need not be identical.

Performance shares give an award recipient the right to acquire a specified number of shares of common stock, or at the Compensation Committee’s discretion, cash, or a combination of common stock and cash, at a future date, based on performance criteria set forth in the performance share agreement. The actual number of performance shares eligible for settlement may be larger or smaller than the number included in the original award, based on the performance criteria. Performance shares may be granted in consideration of a reduction in the award recipient’s other compensation, but no cash consideration is required of the award recipient. An award of performance shares generally will vest only if the award recipient performs services for the entire performance period (or if less, one year). Recipients of performance shares generally will have no voting or dividend rights prior to the time of issuance of any common stock upon settlement.

Qualifying Performance Criteria

The 2010 Plan sets forth performance criteria that may be used in the case of performance shares and certain other awards intended to qualify for the “performance-based compensation” exemption from the corporate deduction limit under Section 162(m) of the Code. The “performance-based compensation” exemption has been repealed effective for tax years beginning after December 31, 2017, subject to certain transition rules for previously granted awards, as described below under “Certain Federal Income Tax Aspects of Awards Under the Plan—Code Section 162(m).” The Compensation Committee may, but is not required to, apply the performance criteria set forth in the 2010 Plan to performance shares and other awards granted in 2019 and future years.

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Proposal 3 Proposal to Amend the Amended and Restated 2010 Stock Incentive Plan |  |

To qualify as a “performance-based compensation,” the number of shares or other benefits granted, issued, retainable or vested under an award may be made subject to the attainment of performance goals for a specified period of time relating to one or more of the following performance criteria, either individually, alternatively or in any combination, applied to either us as a whole or to a business unit or subsidiary, either individually, alternatively or in any combination, and measured either annually or cumulatively over a period of years, on an absolute basis or relative to a pre-established target, to previous years’ or quarter’s results or to the performance of one or more comparable companies or a designated comparison group or index, in each case as specified by the Compensation Committee in the award: (a) cash flow (including operating cash flow), (b) earnings per share, (c) earnings before any combination of interest, taxes, depreciation, or amortization, (d) return on equity, (e) total stockholder return, (f) share price performance, (g) return on capital, (h) return on assets or net assets, (i) revenue, (j) income or net income, (k) operating income or net operating income, (l) operating profit or net operating profit, (m) operating margin or profit margin (including as a percentage of revenue), (n) return on operating revenue, (o) return on invested capital, (p) market segment shares, (q) economic profit, (r) achievement of target levels of discovery and/or development of products, including but not limited to regulatory achievements, (s) achievement of research and development objectives, and (t) formation of joint ventures, strategic relationships or other commercial, research or development collaborations. The Compensation Committee may appropriately adjust any evaluation of performance under a qualifying performance criteria to exclude any of the following events that occur during a performance period: (i) asset write-downs, (ii) litigation or claim judgments or settlements, (iii) the effect of changes in tax law, accounting principles or other such laws or provisions affecting reported results, (iv) accruals for reorganization and restructuring programs and (v) any extraordinary, nonrecurring items disclosed in the Company’s financial statements or in management’s discussion and analysis of financial condition and results of operations appearing in our annual report to stockholders for the applicable year. If applicable, the Compensation Committee will determine the qualifying performance criteria and any permitted exclusions for events described in the preceding sentence not later than the 90th day of the performance period, and will determine and certify the extent to which the qualifying performance criteria have been met. For awards intended to qualify as “performance-based compensation” under Section 162(m) of the Code, the Compensation Committee may not in any event increase the amount of compensation payable under the 2010 Plan upon the attainment of qualifying performance criteria to an award recipient who is a “covered employee” within the meaning of Section 162(m) of the Code.

Amendment and Termination

No awards may be granted under the 2010 Plan, as amended, after March 18, 2021 or, if the proposed amendments are approved by stockholders, after June 30, 2021. The Board may amend or terminate the 2010 Plan at any time, but an amendment will not become effective without the approval of the Company’s stockholders to the extent required by applicable laws, regulations or rules. No amendment or termination of the 2010 Plan will affect an award recipient’s rights under outstanding awards without the award recipient’s consent.

Effect of Certain Corporate Events

In the event of a subdivision of the outstanding common stock or a combination or consolidation of the outstanding common stock (by reclassification or otherwise) into a lesser number of shares, a spin-off or a similar occurrence, or declaration of a dividend payable in common stock or, if in an amount that has a material effect on the price of the shares, in cash, the Compensation Committee will make appropriate adjustments in the number of shares covered by outstanding awards and the exercise price of outstanding options and stock appreciation rights, and the number of shares available under the 2010 Plan.

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|  | Proposal 3 Proposal to Amend the Amended and Restated 2010 Stock Incentive Plan

In the event of a merger or other reorganization, subject to any acceleration provisions in the agreement relating to an award, outstanding awards will be treated in the manner provided in the agreement of merger or reorganization. That agreement may provide for the assumption of outstanding awards by the surviving corporation or its parent, for their continuation by the Company (if the Company is the surviving corporation), for the substitution by the surviving corporation or its parent of its own awards, or for the acceleration of the exercisability of awards followed by the cancellation of those awards. The agreement of merger or reorganization may also provide for the cancellation of outstanding awards, with a payment of the value of those awards (without regard as to whether those awards have vested or are exercisable) as of the closing date of the merger or reorganization. In such an event, the payment may be in cash or securities, be paid in installments, be deferred until the underlying award would have vested, become exercisable or settled under the agreement relating to the award, and may be subject to vesting and performance criteria no less favorable to the recipient than under the agreement relating to the award, in all cases without the recipients’ consent.

Certain Federal Income Tax Aspects of Awards Under the Plan

This is a brief summary of the federal income tax aspects of awards that may be made under the 2010 Plan based on existing U.S. federal income tax laws. This summary provides only the basic tax rules. It does not describe a number of special tax rules, including the alternative minimum tax and various elections that may be applicable under certain circumstances. It also does not reflect provisions of the income tax laws of any municipality, state or foreign country in which a holder may reside, nor does it reflect the tax consequences of a holder’s death. The tax consequences of awards under 2010 Plan depend upon the type of award and, if the award is to an executive officer, whether compensation paid to the officer is subject to the tax deduction limit imposed by Section 162(m) of the Code.

Incentive Stock Options

The recipient of an incentive stock option generally will not be taxed upon grant of the option. Federal income taxes are generally imposed only when the shares of common stock from exercised incentive stock options are disposed of, by sale or otherwise. The amount by which the fair market value of the common stock on the date of exercise exceeds the exercise price is, however, included in determining the option recipient’s liability for the alternative minimum tax. If the incentive stock option recipient does not sell or dispose of the shares of common stock until more than one year after the receipt of the shares and two years after the option was granted, then, upon sale or disposition of the shares, the difference between the exercise price and the market value of the shares of common stock as of the date of exercise will be treated as a capital gain, and not ordinary income. If a recipient fails to hold the shares for the minimum required time the recipient will recognize ordinary income in the year of disposition generally in an amount equal to any excess of the market value of the common stock on the date of exercise (or, if less, the amount realized or disposition of the shares) over the exercise price paid for the shares. Any further gain (or loss) realized by the recipient generally will be taxed as short-term or long-term gain (or loss) depending on the holding period. We will generally be entitled to a tax deduction at the same time and in the same amount as ordinary income is recognized by the option recipient.

Nonstatutory Stock Options

The recipient of stock options not qualifying as incentive stock options generally will not be taxed upon the grant of the option. Federal income taxes are generally due from a recipient of nonstatutory stock options when the stock options are exercised. The excess of the fair market value of the common

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Proposal 3 Proposal to Amend the Amended and Restated 2010 Stock Incentive Plan |  |

stock purchased on such date over the exercise price of the option is taxed as ordinary income. Thereafter, the tax basis for the acquired shares is equal to the amount paid for the shares plus the amount of ordinary income recognized by the recipient. We will generally be entitled to a tax deduction at the same time and in the same amount as ordinary income is recognized by the option recipient by reason of the exercise of the option.

Other Awards

Recipients who receive RSU awards will generally recognize ordinary income when they receive shares upon settlement of the awards, in an amount equal to the fair market value of the shares at that time. Recipients who receive awards of restricted shares subject to a vesting requirement will generally recognize ordinary income at the time vesting occurs, in an amount equal to the fair market value of the shares at that time minus the amount, if any, paid for the shares. However, a recipient who receives restricted shares which are not vested may, within 30 days of the date the shares are transferred, elect in accordance with Section 83(b) of the Code to recognize ordinary compensation income at the time of transfer of the shares rather than upon the vesting dates. Recipients who receive stock appreciation rights will generally recognize ordinary income upon exercise in an amount equal to the excess of the fair market value of the underlying shares of common stock on the exercise date and cash received, if any, over the exercise price. Recipients who receive performance shares will generally recognize ordinary income at the time of settlement, in an amount equal to the cash received, if any, and the fair market value of any shares received. We will generally be entitled to a tax deduction at the same time and in the same amount as ordinary income is recognized by the recipient.

Code Section 162(m)

Section 162(m) of the Code generally disallows a tax deduction to us for annual compensation in excess of $1,000,000 paid to certain executive officers. Prior to 2018, however, we could deduct compensation above $1,000,000 if it was “performance-based compensation” within the meaning of Section 162(m). Stock options and performance shares granted prior to 2018 were intended to qualify as performance-based compensation. The approval of our amended and restated 2010 Plan by our stockholders in 2013 satisfied one of the requirements for the performance-based compensation exemption.

The Section 162(m) exemption for performance-based compensation has been repealed, effective for tax years beginning after December 31, 2017, subject to a transition rule for amounts payable pursuant to written binding contracts in effect on November 2, 2017. We believe that outstanding stock options granted prior to November 2, 2017 qualify for this transition rule, and thus retain their status as deductible performance-based compensation.

New Plan Benefits

The Compensation Committee has not made any determination with respect to future awards under the 2010 Plan and, except for automatic grants to non-employee “outside” directors, awards and the terms of any awards under the plan for the current year or any future year are not determinable. As described above, the 2010 Plan provides for the automatic grant of awards to outside directors. If stockholders approve the proposed amendments to the 2010 Plan, each outside director nominee who will continue to serve as a member of the Board will receive a grant consisting of 75% nonstatutory options and 25% RSUs having an aggregate grant date fair value of $500,000.

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|  | Proposal 3 Proposal to Amend the Amended and Restated 2010 Stock Incentive Plan

Required Vote

Approval of the amendments to the 2010 Plan requires the affirmative vote of a majority of the shares present and entitled to vote.

|  | The Board recommends a vote “FOR” the Amendment to the Company’s Amended and Restated 2010 Stock Incentive Plan

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Proposal 4

Ratification of Independent Registered Public

Accounting Firm

The Audit Committee has appointed the firm of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2019, subject to reconsideration by the Audit Committee should our stockholders fail to ratify such appointment at the Annual Meeting or should the Audit Committee not approve Ernst & Young LLP’s audit plan for the fiscal year ending December 31, 2019. Ernst & Young LLP has audited our financial statements since the Company’s inception in 1991. Representatives of Ernst & Young LLP are expected to be present at the Annual Meeting. They will have an opportunity to make a statement, if they desire to do so, and will be available to respond to appropriate questions.

Principal Accountant Fees and Services

The following table sets forth the aggregate fees billed or expected to be billed by Ernst & Young LLP for audit and other services rendered.

|  | Year Ended December 31, |
|  | 2018 |  |  | 2017 |
|  | (in thousands) |
Audit Fees(1) |  | $ | 2,174 |  |  | $ | 2,017 |
Audit-related Fees(2) |  |  | — |  |  |  | 75 |
|  | $ | 2,174 |  |  | $ | 2,092 |

(1) | Audit fees include fees billed for the audit of the Company’s annual statements and reviews of the Company’s quarterly financial statements, including the Company’s Annual Report on Form 10-K, the audit of the Company’s internal control over financial reporting, and include fees for SEC registration statements and consultation on accounting standards or transactions.

(2) | Audit-related fees include fees billed for consultations concerning the PeopleSoft upgrade, auditing of intellectual property transfer, information technology testing procedures and the PeopleSoft controls environment, and consultations concerning financial and accounting matters not classified as audit services.

The Audit Committee considered whether the provision of the services other than the audit services is compatible with maintaining Ernst & Young LLP’s independence.

Pre-Approval Policies and Procedures

The Audit Committee has established a policy to pre-approve all audit and permissible non-audit services provided by the Company’s independent registered public accounting firm. All of the services provided by the Company’s independent registered public accounting firm in 2018 and 2017 were pre-approved.

Required Vote

Ratification will require the affirmative vote of a majority of the shares present and entitled to vote. Stockholder ratification of the selection of Ernst & Young LLP as the Company’s independent registered public accounting firm is not required by the Company’s Bylaws or otherwise. However, the

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|  | Proposal 4 Ratification of Independent Registered Public Accounting Firm

Board is submitting the selection of Ernst & Young LLP to the stockholders for ratification as a matter of corporate practice. If the stockholders fail to ratify the selection, the Audit Committee will reconsider whether or not to retain that firm. Even if the selection is ratified, the Audit Committee in its discretion may direct the appointment of a different independent registered public accounting firm at any time during the year if the Audit Committee determines that such a change would be in the best interests of the Company and its stockholders.

|  | The Board recommends a vote “FOR” Ratification of Ernst & Young LLP as the Company’s independent registered public accounting.

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Proposal 5

Stockholder Proposal

Proposal 5 set forth below was submitted to the Company by Dundas I. Flaherty and Sandra J. Kulli, of 3749 Malibu Vista Drive, Malibu, California 90265. Mr. Flaherty and Ms. Kulli state that, as of November 13, 2018, they own in the aggregate 110,120 shares of our common stock and that they intend to hold those shares until after the date of the 2019 Annual Meeting. Mr. Flaherty’s and Ms. Kulli’s proposal is printed below verbatim. The Company is not responsible for the contents of this proposal or the supporting statement of Mr. Flaherty and Ms. Kulli. Mr. Flaherty and Ms. Kulli have advised the Company that they intend to present the proposal at our Annual Meeting. Our Board recommends a vote AGAINST the proposal for the reasons set forth following the proposal.

STOCKHOLDER PROPOSAL FOR AN INDEPENDENT BOARD CHAIR

RESOLVED: Stockholders of Incyte Corporation urge the Board of Directors to take the steps necessary to adopt a policy, with amendments to governing documents as needed, so that, to the extent feasible, the Chairman of the Board shall be an independent director who has not previously served as an executive officer of the Company. The policy should be implemented so as not to violate any contractual obligations and should specify the process for selecting a new independent chairman if the Chairman ceases to be independent between annual meetings of shareholders or if no independent director is available and willing to serve as Chairman.

SUPPORTING STATEMENT

Our CEO currently serves as Chairman of the Board of Directors. In our view, the Chairman should be an independent director, who has not previously served as an executive, in order to provide robust oversight and accountability of management, and to facilitate effective deliberation of corporate strategy, which we believe, is difficult to accomplish when the CEO also serves as chairman. Even with robust responsibilities, we believe the position of a lead independent director is inadequate to this task because ultimate responsibility for board leadership remains with the chairman/CEO.

We believe that these considerations are particularly compelling at this time. Approximately five years ago, the company essentially operated as a biotechnology startup with one FDA-approved product, ruxolitinib, with other product possibilities based primarily on related small-molecule medicinal chemistry science.

Since then, Incyte has successfully pursued the commercial potential of ruxolitinib, with excellent sales growth, run clinical trials demonstrating benefit in treating several diseases besides myelofibrosis, and received FDA approval for additional indications.

However, Incyte has enjoyed less success with other products. The Company had high hopes for epacadostat, a novel molecule thought to synergize with anti-cancer breakthroughs such as Keytruda and Opdivo, and baricitinib, for rheumatoid arthritis partnered with Eli Lilly and Company.

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|  | Proposal 5 Stockholder Proposal

Neither product succeeded as previewed. Incyte stopped late-stage clinical trials of epacadostat in April 2018, citing lack of efficacy, and has not announced plans to continue developing it. Baricitinib, once believed by securities analysts to have high potential, is now not expected to achieve such potential, after delays and difficulties with FDA approval and safety concerns.

Despite success with ruxolitinib, Incyte’s stock today is about half its value when hopes for epacadostat were high. Indeed, as of late 2018, the stock price was approximately the same as it was five years ago.

In our view, Incyte’s general lack of success with new products since 2014 argues in favor of adding board leadership to challenge management on its plans and strategy, particularly. Separating the roles of Chairman and CEO can help better align the Board’s interests with shareholders’ interests and improve Board-management dialogues on successful new products to help make Incyte an outstanding performer.

We urge you to vote FOR this proposal.

BOARD OF DIRECTORS’ STATEMENT IN OPPOSITION TO PROPOSAL 5

Our Board of Directors unanimously recommends a vote “AGAINST” Proposal 5. The Board has considered Proposal 5, and, for the reasons described below, believes that the proposal is not in the best interests of the Company or its stockholders.

Summary. Our Board is committed to high standards of corporate governance. Our current leadership structure and governing documents permit the roles of Chairman and CEO to be filled by the same or different individuals. Where the Chairman and CEO roles are filled by the same individual, our Corporate Governance Guidelines require the independent directors on our Board to appoint a Lead Independent Director.

The Board values its flexibility to select, from time to time, a leadership structure that it believes is most able to serve our Company’s and stockholders’ best interests based on the qualifications of individuals available and circumstances existing at the time. As such, the Board periodically evaluates whether combining or separating the roles of Chairman and CEO is in the best interests of our Company and our stockholders.

Currently, the Board believes that it is in the best interests of our stockholders to have Hervé Hoppenot, our President and CEO, serve as Chairman, coupled with Julian C. Baker — a managing member of the general partner of our largest stockholder (Baker Bros. Advisors LP and affiliated entities (the “Baker Funds”)) — serving as our Lead Independent Director. Previously, however, the Board had separated the Chairman and CEO roles, including during the beginning of Mr. Hoppenot’s tenure as CEO. The Board retains the authority to modify this structure as it deems appropriate.

The Board believes that a policy limiting its flexibility to choose, consistent with its fiduciary duties, a leadership structure that in the Board’s view enables our Company to most effectively execute its strategy and business plans to maximize stockholder value is not only unnecessary but would also be detrimental to our Company and our stockholders.

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Proposal 5 Stockholder Proposal |  |

Board Commitment to Independence. The Board maintains a strong commitment to ensuring Board independence so that it is able to maintain effective oversight of management. The Board’s commitment to independence includes:

| ✓ | Annual appointment of a strong Lead Independent Director, who also currently represents our largest stockholder, the Baker Funds, thereby ensuring strong representation of stockholder interests

| ✓ | Robust duties of the Lead Independent Director, which include:

| • |  | presiding at all meetings of the Board at which the Chairman is not present, including executive sessions of the independent directors

| • |  | serving as liaison between the Chairman/CEO and the other independent directors

| - | Mr. Baker is actively involved with our Company and devotes a significant amount of his time and energy to fulfilling his responsibilities as Lead Independent Director. Mr. Baker meets regularly, and works closely with, our Chairman and CEO and other senior members of management; also, he facilitates communication among the independent directors on our Board and speaks regularly with each independent director, promoting the candid exchange of ideas among Board members

| • |  | approving information sent to the Board

| • |  | approving meeting agendas for the Board

| - | Mr. Baker provides guidance with respect to, in addition to approving, the agendas

| • |  | approving meeting schedules to assure that there is sufficient time for discussion of all agenda items

| • |  | authority to call meetings of the independent directors

| • |  | being available for consultation with stockholders, when appropriate

| - | during 2018, Mr. Baker held discussions with several of our leading stockholders, who collectively represented approximately 28% of our common stock (which is in addition to the approximately 16% owned by the Baker Funds, meaning approximately 44% of our common stock was represented throughout these discussions; moreover, Mr. Baker’s engagement with our stockholders has continued during this 2019 proxy season

| ✓ | Review, at least annually, of the Company’s strategic plan and the following year’s capital and operating budgets

| ✓ | Annual election of all directors, ensuring accountability to stockholders

| ✓ | Regular executive sessions of the independent, non-management directors — without Mr. Hoppenot — to review Company performance, CEO performance, management effectiveness, proposed programs and transactions and the Board meeting agenda items

| ✓ | Requirement that only independent directors serve on the Audit Committee, the Compensation Committee and the Nominating and Corporate Governance Committee

| ✓ | Requirement that a majority of the Board be comprised of independent directors

| - | currently, all members of the Board other than Mr. Hoppenot are independent directors

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|  | Proposal 5 Stockholder Proposal

| ✓ | Corporate Governance Guidelines providing that the Board may have access to Company management and employees and its own advisors, at the Board’s discretion.

Benefits of Current Combined Leadership Structure. The Board believes that the Company and our stockholders have been best served by having Mr. Hoppenot in the role of Chairman and CEO and Mr. Baker as Lead Independent Director for the following reasons:

| ✓ | Unique Knowledge of our Business. Mr. Hoppenot is most familiar with our business, our management and employees, and the unique near-and longer-term challenges we face. Because of his knowledge and extensive experience regarding our operations, the highly-regulated biopharmaceutical industry and the markets around the world in which we compete, Mr. Hoppenot is the director best suited to identify strategic opportunities and focus the activities of the Board. Mr. Hoppenot’s day-to-day insight into our challenges and opportunities facilitates a timely deliberation by the Board of important matters.

| ✓ | Accountability to All Stakeholders. As Chairman and CEO, Mr. Hoppenot uniquely has accountability to the Board, to stockholders and to the employees that help every day to make our Company a successful company. Whether our Company faces successes or failure, Mr. Hoppenot is the person who must face the Board to account for our Company’s actions, who must face the employees who put their trust in him and our Company and, most importantly, the stockholders who own our Company. In fact, in 2018, Mr. Hoppenot presented directly to stockholders, analysts and the public over 20 times through presentations at regular and frequent investor conferences, through quarterly earnings conference calls with extensive question-and-answer sessions, and through individual and small-group stockholder meetings. Mr. Hoppenot serves as an important bridge between the Board and management and provides critical leadership for carrying out our strategic initiatives and confronting our challenges. Through his extensive and frequent engagement with stockholders, Mr. Hoppenot is in the best position to have a deep understanding of the concerns of the owners of our Company and is in the best position to ensure those concerns are communicated to, and deliberated on by, our Board on a regular basis. The Board believes that Mr. Hoppenot brings a unique, stockholder-focused insight to assist our Company to most effectively execute its strategy and business plans to maximize stockholder value.

| ✓ | Effective Action on Stockholder Feedback. The substantial and sustained engagement with our stockholders by Mr. Hoppenot — as our Chairman and CEO — and Mr. Baker — as our Lead Independent Director — and their collective and detailed knowledge of stockholder concerns have ensured that stockholder interests in significant governance and compensation enhancements are brought before the Board in a meaningful and timely way. The significant governance and compensation changes enacted following and in response to stockholder feedback in recent years are detailed above in this proxy statement under “Stockholder Engagement”, starting on page 6, and include:

| ○ |  | Aligning the compensation of our Board of Directors to that of our peers

| ○ |  | Enhancing pay-for-performance by using performance-based shares in executive compensation

| ○ |  | Requiring majority voting for directors in uncontested elections

| ○ |  | Adopting a 3-year cash clawback policy for executives

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Proposal 5 Stockholder Proposal |  |

| ○ |  | Requiring that all directors and executive officers hold a minimum amount of Incyte equity

| ○ |  | Imposing a 12-month minimum vesting period for employee equity awards generally

| ○ |  | Eliminating tax gross-ups on perquisites

| ○ |  | Prohibiting hedging transactions in Incyte stock by directors and officers

| ○ |  | Increasing transparency in our discussion of compensation practices and our corporate goals

| ✓ | Our Board is Stronger and More Effective. The current leadership structure provides the Board with more complete and timely information about our Company, a unified structure and consistent leadership direction internally and externally, and provides a collaborative environment for Board decision-making. The strength and effectiveness of the communications between Mr. Hoppenot as our Chairman and Mr. Baker as our Lead Independent Director result in effective Board oversight of the issues, plans and prospects of our Company.

Strategic Flexibility Helps Maintain Competitive Position with Our Peers. Our Board currently believes it is in the best interest of the stockholders that Mr. Hoppenot act as Chairman and CEO. As stated above, the Board has separated the Chairman and CEO roles in the past. The Board considers its leadership structure every year. In the future, circumstances may lead the Board to believe that separating the roles is in the best interests of our stockholders at that time. The proposed requirement of Proposal 5 that the Chairman and CEO roles must be separated would restrict your Board from doing what it thinks is in your best interests at any given time. Of the 16 companies in our current executive compensation peer group, 75% provide their boards with the strategic flexibility to structure their leadership as they believe to be in the best interests of their respective stockholders. The strategic inflexibility proposed by Proposal 5 would force us into a competitive disadvantage against the nimble peer companies with whom we compete.

Conclusion and Recommendation AGAINST Proposal 5. The strong leadership role of the Board’s independent directors in the oversight of our Company is evident from the independent composition of the Board aside from our CEO, the exclusively independent composition of the Board’s Audit, Compensation and Nominating and Corporate Governance Committees, and the functioning of the Board’s independent directors and Lead Independent Director, who is also a principal in the general partner of the Baker Funds, our largest stockholder. It is important that the Board continues to be able to assess all relevant facts and circumstances, in fulfilment of its fiduciary duty, to determine the leadership structure that is best suited to meet the needs of our Company at any given time. Accordingly, the Board believes that adoption of a fixed policy requiring an independent Chairman is not in the best interests of stockholders.

|  | The Board recommends a vote “AGAINST” Proposal 5

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Security Ownership of Certain Beneficial Owners and Management

The following table sets forth certain information as of March 12, 2019, as to shares of our common stock beneficially owned by: (i) each person who is known to us to own beneficially more than 5% of our common stock, (ii) each of our directors, (iii) each of our executive officers named under “Executive Compensation—Summary Compensation Table” and (iv) all of our directors and executive officers as a group. Ownership information is based upon information furnished by the respective individuals or entities, as the case may be. Unless otherwise indicated below, the address of each beneficial owner listed on the table is c/o Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, DE 19803. The percentage of our common stock beneficially owned is based on 214,264,527 shares outstanding as of March 12, 2019. In addition, shares issuable pursuant to options or convertible securities that may be acquired within 60 days of March 12, 2019 are deemed to be issued and outstanding and have been treated as outstanding in calculating and determining the beneficial ownership and percentage ownership of those persons possessing those securities, but not for any other individuals.

Name and Address of Beneficial Owner(1) |  | Shares Beneficially Owned(#)(1) |  |  | Percentages Beneficially Owned(%)(1) |
5% Stockholders |  |  |  |  |  |  |  |
Felix J. Baker (2) |  |  | 34,536,176 |  |  |  | 16.1 |
Baker Bros. Advisors LP and affiliated entities (2) |  |  | 34,426,607 |  |  |  | 16.1 |
The Vanguard Group and affiliates (3) |  |  | 18,818,239 |  |  |  | 8.8 |
Wellington Management Group LLP (4) |  |  | 15,619,858 |  |  |  | 7.3 |
BlackRock, Inc. (5) |  |  | 15,262,962 |  |  |  | 7.1 |
Named Executive Officers and Directors |  |  |  |  |  |  |  |
Hervé Hoppenot (6) |  |  | 587,216 |  |  |  | * |
David W. Gryska (7) |  |  | 44,991 |  |  |  | * |
Reid Huber (8) |  |  | 118,305 |  |  |  | * |
Steven H. Stein (9) |  |  | 60,298 |  |  |  | * |
Wenqing Yao (10) |  |  | 205,781 |  |  |  | * |
Maria E. Pasquale (11) |  |  | 14,333 |  |  |  | * |
Julian C. Baker (2) |  |  | 34,533,759 |  |  |  | 16.1 |
Jean-Jacques Bienaimé (12) |  |  | 96,896 |  |  |  | * |
Paul A. Brooke (13) |  |  | 393,929 |  |  |  | * |
Paul J. Clancy (14) |  |  | 90,000 |  |  |  | * |
Wendy L. Dixon (15) |  |  | 198,533 |  |  |  | * |
Jacqualyn A. Fouse (16) |  |  | 33,316 |  |  |  | * |
Paul A. Friedman (17) |  |  | 451,511 |  |  |  | * |
All directors and executive officers as a group (16 persons)(18) |  |  | 36,955,642 |  |  |  | 17.1 |

* | Represents less than 1% of our common stock.

(1) | To our knowledge, the persons named in the table have sole voting and investment power with respect to all shares of common stock shown as beneficially owned by them, subject to community property laws where applicable and the information contained in the notes to this table.

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Security Ownership of Certain Beneficial Owners and Management |  |

(2) | Baker Bros. Advisors LP is the investment adviser to 667, L.P., Baker Brothers Life Sciences, L.P. and 14159 L.P. (“Baker Funds”). Baker Bros. Advisors (GP), LLC is the sole general partner of Baker Bros. Advisors LP. Julian C. Baker and Felix J. Baker are the managing members of Baker Bros. Advisors (GP), LLC. The address for Baker Bros. Advisors LP, the Baker Funds, Julian C. Baker and Felix J. Baker is 860 Washington Street, 3rd Floor, New York, New York 10014. Pursuant to the management agreements, as amended, among Baker Bros. Advisors LP, the Baker Funds and their respective general partners, the Baker Funds’ respective general partners relinquished to Baker Bros. Advisors LP all discretion and authority with respect to the investment and voting power of the securities held by the Baker Funds, and thus Baker Bros. Advisors LP has complete and unlimited discretion and authority with respect to the Baker Funds’ investments and voting power over investments. According to an amended Schedule 13D filed February 27, 2019, the total number of shares of our common stock beneficially owned includes shares directly held as follows:

Holder |  | Shares |
667, L.P. |  |  | 4,290,108 |
Baker Brothers Life Sciences, L.P. |  |  | 29,150,637 |
14159, L.P. |  |  | 692,706 |
Julian C. Baker |  |  | 196,788 |
Felix J. Baker |  |  | 61,049 |
Entities affiliated with Julian C. Baker and Felix J. Baker |  |  | 48,520 |

Pursuant to an agreement between Baker Bros. Advisors LP and Julian C. Baker, Baker Bros. Advisors LP has sole voting and dispositive power with respect to 138,156 shares owned directly by Julian C. Baker that were received by Mr. Baker either upon exercise of options or in lieu of cash fees in connection with serving as a member of our Board of Directors and with respect to 155,000 shares subject to options exercisable within 60 days of March 12, 2019 that are held by Julian C. Baker and that are included in the number of shares shown as beneficially owned.

(3) | According to an amended Schedule 13G filed February 12, 2019, filed by The Vanguard Group (“Vanguard”), Vanguard, in its capacity as investment adviser, may be deemed to beneficially own all shares listed in the table, and has sole dispositive power with respect to 18,568,103 shares, shared dispositive power with respect to 250,136 shares, sole voting power with respect to 218,648 shares and shared voting power with respect to 36,199 shares. The number of shares reported as beneficially owned by Vanguard in the amended Schedule 13G includes 11,113,220 shares representing 5.2% of our outstanding common stock, that Vanguard Specialized Funds – Vanguard Health Care Fund separately reported as beneficially owned in a Schedule 13G filed January 31, 2019. The address of the principal place of business of Vanguard is 100 Vanguard Blvd., Malvern, Pennsylvania 19355.

(4) | According to an amended Schedule 13G filed February 12, 2019, filed by Wellington Management Group LLP (“Wellington”), Wellington, in its capacity as investment adviser, may be deemed to beneficially own all shares listed in the table, and has shared dispositive power with respect to all such shares and shared voting power with respect to 2,921,938 shares. The address of the principal place of business of Wellington is 280 Congress Street, Boston, Massachusetts 02110.

(5) | According to an amended Schedule 13G filed February 4, 2019, filed by BlackRock, Inc. (“BlackRock”), BlackRock, in its capacity as investment adviser, may be deemed to beneficially own all shares listed in the table and has sole voting power with respect to 13,877,927 shares. The address of the principal place of business of BlackRock is 55 East 52nd Street, New York, New York, 10022.

(6) | Includes 434,379 shares subject to options exercisable within 60 days of March 12, 2019. Does not include 87,728 shares underlying RSUs and 20,971 shares underlying performance shares that will remain unvested within 60 days of March 12, 2019.

(7) | Mr. Gryska resigned as Executive Vice President and Chief Financial Officer effective December 2019. Includes 44,158 shares subject to options exercisable within 60 days of March 12, 2019.

(8) | Dr. Huber resigned as Executive Vice President and Chief Scientific Officer effective November 2019. Includes 91,711 shares subject to options exercisable within 60 days of March 12, 2019.

(9) | Includes 51,941 shares subject to options exercisable within 60 days of March 12, 2019. Does not include 5,416 shares underlying RSUs and 5,389 shares underlying performance shares that will remain unvested within 60 days of March 12, 2019.

84 | Proxy Statement 2019 |  |

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|  | Security Ownership of Certain Beneficial Owners and Management

(10) | Includes 176,788 shares subject to options exercisable within 60 days of March 12, 2019. Does not include 5,416 shares underlying RSUs and 5,389 shares underlying performance shares that will remain unvested within 60 days of March 12, 2019.

(11) | Ms. Pasquale was appointed Executive Vice President and General Counsel effective April 2018. Includes 11,156 shares subject to options exercisable within 60 days of March 12, 2019. Does not include 4,446 shares underlying RSUs and 5,389 shares underlying performance shares that will remain unvested within 60 days of March 12, 2019.

(12) | Includes 90,000 shares subject to options exercisable within 60 days of March 12, 2019.

(13) | Includes 155,000 shares subject to options exercisable within 60 days of March 12, 2019.

(14) | Includes 90,000 shares subject to options exercisable within 60 days of March 12, 2019.

(15) | Includes 188,314 shares subject to options exercisable within 60 days of March 12, 2019.

(16) | Includes 32,604 shares subject to options exercisable within 60 days of March 12, 2019.

(17) | Includes 182,500 shares subject to options exercisable within 60 days of March 12, 2019.

(18) | Includes shares included pursuant to the second paragraph of note (2) and notes (6), (9), (10), (11), (12), (13), (14), (15), (16), and (17) above and 250,737 shares subject to options exercisable within 60 days of March 12, 2019 held by other executive officers of the Company. Does not include 133,639 shares underlying RSUs and 53,305 shares underlying performance shares that will remain unvested within 60 days of March 12, 2019.

|  | Proxy Statement 2019 | 85

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Other Matters

Section 16(a) Beneficial Ownership Reporting Compliance

Under the securities laws of the United States, our directors, executive officers and any persons holding more than 10% of our common stock are required to report their initial ownership of our common stock and any subsequent changes in that ownership to the Securities and Exchange Commission. Specific due dates for these reports have been established and we are required to identify in this Proxy Statement those persons who failed to timely file these reports. Based solely on our review of the copies of such forms received by us, or written representation from certain reporting persons, we believe that all of the filing requirements for such persons were satisfied for 2018.

Stockholder Proposals for the 2020 Annual Meeting

To be considered for inclusion in the Company’s proxy statement for the Company’s 2020 Annual Meeting of Stockholders, stockholder proposals must be received by the Secretary of the Company no later than November 26, 2019. These proposals also must comply with the proxy proposal submission rules of the Securities and Exchange Commission under Rule 14a-8.

A stockholder proposal not included in the Company’s proxy statement for the 2020 Annual Meeting will be ineligible for presentation at the meeting unless the stockholder gives timely notice of the proposal in writing to the Secretary of the Company at the principal executive offices of the Company, provides the information required by the Company’s Bylaws, and otherwise complies with the provisions of the Company’s Bylaws. To be timely, our Bylaws provide that the Company must have received the stockholder’s notice not less than 90 days nor more than 120 days prior to the first anniversary of the preceding year’s annual meeting of stockholders. However, in the event that the 2020 Annual Meeting is called for a date that is more than 30 days before or more than 60 days after the first anniversary date of the preceding year’s annual meeting of stockholders, notice by the stockholder to be timely must be so received by the Secretary of the Company not later than the close of business on the later of (1) the 90th day prior to the date of the meeting and (2) the 10th day following the first public announcement or disclosure of the date of the 2020 Annual Meeting.

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Annual Report

We will furnish without charge, upon written request of any person who was a stockholder or beneficial owner of common stock at the close of business on March 12, 2019, the record date, a copy of our Annual Report on Form 10-K, including the financial statements, the financial statement schedules, and all exhibits. The written request should be sent to: Investor Relations Department, Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, DE 19803.

Whether you intend to be present at the Annual Meeting or not, we urge you to vote by telephone, the internet, or by signing and mailing the enclosed proxy promptly.

By Order of the Board of Directors
Hervé Hoppenot
President and Chief Executive Officer

March 21, 2019

|  | Proxy Statement 2019 | 87

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Appendix A

Note Regarding Forward-Looking Statements

Except for the historical information set forth herein, the matters set forth in this proxy statement contain predictions, estimates and other forward-looking statements, including without limitation statements regarding: our belief that our pipeline may provide us near-term opportunities for additional revenue growth and increased diversity, our expectations regarding NDA submissions for pemigatinib, itacitinib and capmatinib, our expectations regarding the timing of clinical trial results for ruxolitinib and itacitinib in GVHD, parsaclisib, INCMGA0012, ruxolitinib cream in vitiligo and baricitinib, our beliefs regarding the benefits and effects of our compensation policies and methods, and our expectations to continue to expand our workforce.

These forward-looking statements are based on our current expectations and are subject to risks and uncertainties that may cause actual results to differ materially, including unanticipated delays in obtaining results from clinical trials, the ability to enroll sufficient numbers of subjects for our clinical trials, risks relating to further research and development and the results of clinical trials, the effects of market competition, and other risks detailed from time to time in our reports filed with the Securities and Exchange Commission, including our Form 10-K for the year ended December 31, 2018. We disclaim any intent or obligation to update these forward looking statements.

|  | Proxy Statement 2019 | A-1

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Appendix B

INCYTE CORPORATION

AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

(As Amended and Restated on March 18, 2019)

INCYTE CORPORATION

AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

##### Table of Contents

Table of Contents

|  |  |  | Page |
SECTION 1. |  | ESTABLISHMENT AND PURPOSE |  |  | 1 |
SECTION 2. |  | DEFINITIONS |  |  | 1 |
(a) |  | “Affiliate” |  |  | 1 |
(b) |  | “Award” |  |  | 1 |
(c) |  | “Board of Directors” |  |  | 1 |
(d) |  | “Change in Control” |  |  | 1 |
(e) |  | “Code” |  |  | 2 |
(f) |  | “Committee” |  |  | 2 |
(g) |  | “Corporation” |  |  | 2 |
(h) |  | “Consultant” |  |  | 2 |
(i) |  | “Employee” |  |  | 3 |
(j) |  | “Exchange Act” |  |  | 3 |
(k) |  | “Exercise Price” |  |  | 3 |
(l) |  | “Fair Market Value” |  |  | 3 |
(m) |  | “ISO” |  |  | 3 |
(n) |  | “Nonstatutory Option” or “NSO” |  |  | 4 |
(o) |  | “Offeree” |  |  | 4 |
(p) |  | “Option” |  |  | 4 |
(q) |  | “Optionee” |  |  | 4 |
(r) |  | “Outside Director” |  |  | 4 |
(s) |  | “Parent” |  |  | 4 |
(t) |  | “Participant” |  |  | 4 |
(u) |  | “Performance Shares” |  |  | 4 |
(v) |  | “Performance Share Agreement” |  |  | 4 |
(w) |  | “Plan” |  |  | 4 |
(x) |  | “Purchase Price” |  |  | 4 |
(y) |  | “Qualifying Performance Criteria” |  |  | 4 |
(z) |  | “Restricted Share” |  |  | 4 |
(aa) |  | “Restricted Share Agreement” |  |  | 5 |
(bb) |  | “Restricted Stock Unit” |  |  | 5 |
(cc) |  | “Restricted Stock Unit Agreement” |  |  | 5 |
(dd) |  | “SAR” |  |  | 5 |

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AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

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##### Table of Contents

(ee) |  | “SAR Agreement” |  |  | 5 |
(ff) |  | “Service” |  |  | 5 |
(gg) |  | “Share” |  |  | 5 |
(hh) |  | “Stock” |  |  | 5 |
(ii) |  | “Stock Option Agreement” |  |  | 5 |
(jj) |  | “Subsidiary” |  |  | 5 |
(kk) |  | “Total and Permanent Disability” |  |  | 6 |
SECTION 3. |  | ADMINISTRATION |  |  | 6 |
(a) |  | Committee Composition |  |  | 6 |
(b) |  | Committee for Non-Officer Grants |  |  | 6 |
(c) |  | Committee Procedures |  |  | 6 |
(d) |  | Committee Responsibilities |  |  | 7 |
SECTION 4. |  | ELIGIBILITY |  |  | 8 |
(a) |  | General Rule |  |  | 8 |
(b) |  | Ten-Percent Stockholders |  |  | 8 |
(c) |  | Attribution Rules |  |  | 8 |
(d) |  | Outstanding Stock |  |  | 8 |
SECTION 5. |  | STOCK SUBJECT TO PLAN |  |  | 8 |
(a) |  | Basic Limitation |  |  | 8 |
(b) |  | Award Limitation |  |  | 9 |
(c) |  | Additional Shares |  |  | 9 |
SECTION 6. |  | RESTRICTED SHARES |  |  | 9 |
(a) |  | Restricted Share Agreement |  |  | 9 |
(b) |  | Payment for Awards |  |  | 10 |
(c) |  | Vesting |  |  | 10 |
(d) |  | Voting and Dividend Rights |  |  | 10 |
(e) |  | Restrictions on Transfer of Shares |  |  | 10 |
SECTION 7. |  | TERMS AND CONDITIONS OF OPTIONS |  |  | 10 |
(a) |  | Stock Option Agreement |  |  | 10 |
(b) |  | Number of Shares |  |  | 10 |
(c) |  | Exercise Price |  |  | 11 |
(d) |  | Withholding Taxes |  |  | 11 |
(e) |  | Exercisability and Term |  |  | 11 |
(f) |  | Exercise of Options |  |  | 11 |
(g) |  | Effect of Change in Control |  |  | 11 |
(h) |  | No Rights as a Stockholder |  |  | 12 |

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AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

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(i) |  | Modification, Extension and Assumption of Options |  |  | 12 |
(j) |  | Restrictions on Transfer of Shares |  |  | 12 |
(k) |  | Buyout Provisions |  |  | 12 |
SECTION 8. |  | PAYMENT FOR SHARES |  |  | 12 |
(a) |  | General Rule |  |  | 12 |
(b) |  | Surrender of Stock |  |  | 12 |
(c) |  | Services Rendered |  |  | 13 |
(d) |  | Cashless Exercise |  |  | 13 |
(e) |  | Exercise/Pledge |  |  | 13 |
(f) |  | Promissory Note |  |  | 13 |
(g) |  | Other Forms of Payment |  |  | 13 |
(h) |  | Limitations under Applicable Law |  |  | 13 |
SECTION 9. |  | STOCK APPRECIATION RIGHTS |  |  | 13 |
(a) |  | SAR Agreement |  |  | 13 |
(b) |  | Number of Shares |  |  | 13 |
(c) |  | Exercise Price |  |  | 14 |
(d) |  | Exercisability and Term |  |  | 14 |
(e) |  | Effect of Change in Control |  |  | 14 |
(f) |  | Exercise of SARs |  |  | 14 |
(g) |  | Modification or Assumption of SARs |  |  | 14 |
(h) |  | Buyout Provisions |  |  | 14 |
SECTION 10. |  | RESTRICTED STOCK UNITS |  |  | 15 |
(a) |  | Restricted Stock Unit Agreement |  |  | 15 |
(b) |  | Payment for Awards |  |  | 15 |
(c) |  | Vesting Conditions |  |  | 15 |
(d) |  | Voting and Dividend Rights |  |  | 15 |
(e) |  | Form and Time of Settlement of Restricted Stock Units |  |  | 15 |
(f) |  | Death of Recipient |  |  | 16 |
(g) |  | Creditors’ Rights |  |  | 16 |
SECTION 11. |  | PERFORMANCE SHARES |  |  | 16 |
(a) |  | Performance Shares and Performance Share Agreement |  |  | 16 |
(b) |  | Payment for Awards |  |  | 16 |
(c) |  | Terms of Performance Share Awards |  |  | 17 |
(d) |  | Voting and Dividend Rights |  |  | 17 |
(e) |  | Form and Time of Settlement of Performance Shares |  |  | 17 |
(f) |  | Death of Recipient |  |  | 18 |
(g) |  | Creditors’ Rights |  |  | 18 |

INCYTE CORPORATION

AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

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##### Table of Contents

SECTION 12. |  | AUTOMATIC GRANTS TO OUTSIDE DIRECTORS |  |  | 18 |
(a) |  | Annual Grants |  |  | 18 |
(b) |  | Vesting Conditions |  |  | 19 |
(c) |  | Award Agreement |  |  | 19 |
(d) |  | Additional Grants |  |  | 19 |
SECTION 13. |  | ADJUSTMENT OF SHARES; REORGANIZATIONS |  |  | 19 |
(a) |  | Adjustments |  |  | 19 |
(b) |  | Dissolution or Liquidation |  |  | 20 |
(c) |  | Reorganizations |  |  | 20 |
(d) |  | Reservation of Rights |  |  | 22 |
SECTION 14. |  | DEFERRAL OF AWARDS |  |  | 22 |
(a) |  | Committee Powers |  |  | 22 |
(b) |  | General Rules |  |  | 22 |
(c) |  | Code Section 409A |  |  | 23 |
SECTION 15. |  | PAYMENT OF DIRECTOR’S FEES IN SECURITIES |  |  | 23 |
(a) |  | Effective Date |  |  | 23 |
(b) |  | Elections to Receive NSOs, Restricted Shares or Restricted Stock Units |  |  | 23 |
(c) |  | Number and Terms of NSOs, Restricted Shares or Restricted Stock Units |  |  | 23 |
SECTION 16. |  | AWARDS UNDER OTHER PLANS |  |  | 24 |
SECTION 17. |  | LEGAL AND REGULATORY REQUIREMENTS |  |  | 24 |
SECTION 18. |  | WITHHOLDING TAXES |  |  | 24 |
(a) |  | General |  |  | 24 |
(b) |  | Share Withholding |  |  | 24 |
SECTION 19. |  | OTHER PROVISIONS APPLICABLE TO AWARDS |  |  | 24 |
(a) |  | Transferability |  |  | 24 |
(b) |  | Qualifying Performance Criteria |  |  | 25 |
(c) |  | Vesting Restrictions on Awards |  |  | 26 |
SECTION 20. |  | NO EMPLOYMENT RIGHTS |  |  | 26 |
SECTION 21. |  | APPLICABLE LAW |  |  | 26 |
SECTION 22. |  | DURATION AND AMENDMENTS |  |  | 26 |
(a) |  | Term of the Plan |  |  | 26 |
(b) |  | Right to Amend or Terminate the Plan |  |  | 26 |
(c) |  | Effect of Termination |  |  | 26 |

INCYTE CORPORATION

AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

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##### Table of Contents

INCYTE CORPORATION

AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

SECTION 1. | ESTABLISHMENT AND PURPOSE.

The Plan was adopted by the Board of Directors on March 19, 2010, amended and restated on March 8, 2011, April 18, 2012, and April 17, 2013, amended on January 7, 2014, March 4, 2014, April 22, 2014, March 16, 2016 and March 2, 2018, and further amended and restated on March 18, 2019. The purpose of the Plan is to promote the long-term success of the Corporation and the creation of stockholder value by (a) encouraging Employees, Outside Directors and Consultants to focus on critical long-range objectives, (b) encouraging the attraction and retention of Employees, Outside Directors and Consultants with exceptional qualifications and (c) linking Employees, Outside Directors and Consultants directly to stockholder interests through increased stock ownership. The Plan seeks to achieve this purpose by providing for Awards in the form of Restricted Shares, Restricted Stock Units, Performance Shares, Options (which may constitute ISOs or NSOs) and SARs.

SECTION 2. | DEFINITIONS.

| (a) | “Affiliate” shall mean any entity other than a Subsidiary, if the Corporation and/or one or more Subsidiaries own not less than 50% of such entity.

| (b) | “Award” shall mean any award of an Option, a SAR, Restricted Shares, Restricted Stock Units or Performance Shares under the Plan.

| (c) | “Board of Directors” shall mean the Board of Directors of the Corporation, as constituted from time to time.

| (d) | “Change in Control” shall mean the occurrence of any of the following events:

| (i) | A change in the composition of the Board of Directors, as a result of which fewer than one-half of the incumbent directors are directors who either:

| (A) | Had been directors of the Corporation 24 months prior to such change; or

| (B) | Were elected, or nominated for election, to the Board of Directors with the affirmative votes of at least a majority of the directors who had been directors of the Corporation 24 months prior to such change and who were still in office at the time of the election or nomination; or

| (ii) | Any “person” (as defined below) by the acquisition or aggregation of securities is or becomes the beneficial owner (as defined in Rule 13d-3 of

INCYTE CORPORATION

AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

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##### Table of Contents

| the Exchange Act), directly or indirectly, of securities of the Corporation representing 50% or more of the combined voting power of the Corporation’s then outstanding securities ordinarily (and apart from rights accruing under special circumstances) having the right to vote at elections of directors (the “Base Capital Stock”); except that any change in the relative beneficial ownership of the Corporation’s securities by any person resulting solely from a reduction in the aggregate number of outstanding shares of Base Capital Stock, and any decrease thereafter in such person’s ownership of securities, shall be disregarded until such person increases in any manner, directly or indirectly, such person’s beneficial ownership of any securities of the Corporation; or

| (iii) | The consummation of a merger or consolidation of the Corporation with or into another entity or any other corporate reorganization, if persons who were not stockholders of the Corporation immediately prior to such merger, consolidation or other reorganization own immediately after such merger, consolidation or other reorganization 50% or more of the voting power of the outstanding securities of (A) the continuing or surviving entity and (B) any direct or indirect parent corporation of such continuing or surviving entity; or

| (iv) | The consummation of the sale, transfer or other disposition of all or substantially all of the assets of the Corporation.

For purposes of subsection (d)(ii) above, the term “person” shall have the same meaning as when used in Sections 13(d) and 14(d) of the Exchange Act but shall exclude (1) a trustee or other fiduciary holding securities under an employee benefit plan maintained by the Corporation or a Parent or Subsidiary and (2) a corporation owned directly or indirectly by the stockholders of the Corporation in substantially the same proportions as their ownership of the Stock.

Any other provision of this Section 2(d) notwithstanding, a transaction shall not constitute a Change in Control if its sole purpose is to change the state of the Corporation’s incorporation or to create a holding company that will be owned in substantially the same proportions by the persons who held the Corporation’s securities immediately before such a transaction.

| (e) | “Code” shall mean the Internal Revenue Code of 1986, as amended.

| (f) | “Committee” shall mean the committee designated by the Board of Directors to administer the Plan, as described in Section 3 hereof (or in the absence of such designation, the Board of Directors itself).

| (g) | “Corporation” shall mean Incyte Corporation, a Delaware corporation.

| (h) | “Consultant” shall mean a consultant or advisor who provides bona fide services to the Corporation, a Parent, a Subsidiary or an Affiliate as an independent

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AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

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##### Table of Contents

| contractor (not including service as a member of the Board of Directors) or a member of the board of directors of a Parent or a Subsidiary, in each case who is not an Employee.

| (i) | “Employee” shall mean any individual who is a common-law employee of the Corporation, a Parent, a Subsidiary or an Affiliate.

| (j) | “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended.

| (k) | “Exercise Price” shall mean (a) in the case of an Option, the amount for which one Share may be purchased upon exercise of such Option, as specified in the applicable Stock Option Agreement, and (b) in the case of a SAR, an amount, as specified in the applicable SAR Agreement, which is subtracted from the Fair Market Value of one Share in determining the amount payable upon exercise of such SAR.

| (l) | “Fair Market Value” with respect to a Share, shall mean the market price of one Share, determined by the Committee as follows:

| (i) | If the Stock was traded on The Nasdaq Stock Market, then the Fair Market Value shall be equal to the last reported sale price reported for such date by The Nasdaq Stock Market; or

| (ii) | If the Stock was not traded on The Nasdaq Stock Market but was traded on another United States stock exchange on the date in question, then the Fair Market Value shall be equal to the closing price reported for such date by the applicable composite-transactions report; or

| (iii) | If the Stock was traded over-the-counter on the date in question, then the Fair Market Value shall be equal to the last reported sale price reported for such date by the OTC Bulletin Board or, if not so reported, shall be equal to the closing sale price quoted for such date by OTC Markets Group Inc. or similar organization or, if no last reported or closing sale price is reported, shall be equal to the mean between the last reported representative bid and asked prices quoted for such date by the OTC Bulletin Board or, if the Stock is not quoted on the OTC Bulletin Board, by OTC Markets Group Inc. or similar organization; or

| (iv) | If none of the foregoing provisions is applicable, then the Fair Market Value shall be determined by the Committee in good faith on such basis as it deems appropriate.

In all cases, the determination of Fair Market Value by the Committee shall be conclusive and binding on all persons.

| (m) | “ISO” shall mean an employee incentive stock option described in Section 422 of the Code.

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AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

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##### Table of Contents

| (n) | “Nonstatutory Option” or “NSO” shall mean an employee stock option that is not an ISO.

| (o) | “Offeree” shall mean an individual to whom the Committee has offered the right to acquire Shares under the Plan (other than upon exercise of an Option).

| (p) | “Option” shall mean an ISO or Nonstatutory Option granted under the Plan and entitling the holder to purchase Shares.

| (q) | “Optionee” shall mean an individual or estate who holds an Option or SAR.

| (r) | “Outside Director” shall mean a member of the Board of Directors who is not an Employee or a Consultant.

| (s) | “Parent” shall mean any corporation or other entity (other than the Corporation) in an unbroken chain of corporations or other entities ending with the Corporation, if each of the corporations or other entities other than the Corporation owns stock possessing 50% or more of the total combined voting power of all classes of stock in one of the other corporations in such chain. A corporation or other entity that attains the status of a Parent on a date after the adoption of the Plan shall be a Parent commencing as of such date.

| (t) | “Participant” shall mean an individual or estate who holds an Award.

| (u) | “Performance Shares” shall mean a bookkeeping entry representing the Corporation’s obligation to deliver Shares (or distribute cash) on a future date in accordance with the provisions of a Performance Share Agreement.

| (v) | “Performance Share Agreement” shall mean the agreement between the Corporation and the recipient of Performance Shares that contains the terms, conditions and restrictions pertaining to such Performance Shares.

| (w) | “Plan” shall mean this Amended and Restated 2010 Stock Incentive Plan of Incyte Corporation, as amended from time to time.

| (x) | “Purchase Price” shall mean the consideration for which one Share may be acquired under the Plan (other than upon exercise of an Option), as specified by the Committee.

| (y) | “Qualifying Performance Criteria” shall have the meaning set forth in Section 19(b).

| (z) | “Restricted Share” shall mean a Share awarded under the Plan and subject to the terms, conditions and restrictions set forth in a Restricted Share Agreement.

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AMENDED AND RESTATED 2010 STOCK INCENTIVE PLAN

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##### Table of Contents

| (aa) | “Restricted Share Agreement” shall mean the agreement between the Corporation and the recipient of a Restricted Share that contains the terms, conditions and restrictions pertaining to such Restricted Shares.

| (bb) | “Restricted Stock Unit” shall mean a bookkeeping entry representing the Corporation’s obligation to deliver one Share (or distribute cash) on a future date in accordance with the provisions of a Restricted Stock Unit Agreement.

| (cc) | “Restricted Stock Unit Agreement” shall mean the agreement between the Corporation and the recipient of a Restricted Stock Unit that contains the terms, conditions and restrictions pertaining to such Restricted Stock Unit.

| (dd) | “SAR” shall mean a stock appreciation right granted under the Plan.

| (ee) | “SAR Agreement” shall mean the agreement between the Corporation and an Optionee that contains the terms, conditions and restrictions pertaining to his or her SAR.

| (ff) | “Service” shall mean service as an Employee, Consultant or Outside Director, subject to such further limitations as may be set forth in the Plan or the applicable Stock Option Agreement, SAR Agreement, Restricted Share Agreement, Restricted Stock Unit Agreement or Performance Share Agreement. Service does not terminate when an Employee goes on a bona fide leave of absence, that was approved by the Corporation in writing, if the terms of the leave provide for continued Service crediting, or when continued Service crediting is required by applicable law. However, for purposes of determining whether an Option is entitled to ISO status, an Employee’s employment will be treated as terminating 90 days after such Employee went on leave, unless such Employee’s right to return to active work is guaranteed by law or by a contract. Service terminates in any event when the approved leave ends, unless such Employee immediately returns to active work. The Corporation shall be entitled to determine in its sole discretion which leaves of absence count toward Service, and when Service terminates for all purposes under the Plan.

| (gg) | “Share” shall mean one share of Stock, as adjusted in accordance with Section 13 (if applicable).

| (hh) | “Stock” shall mean the common stock of the Corporation, $.001 par value per share.

| (ii) | “Stock Option Agreement” shall mean the agreement between the Corporation and an Optionee that contains the terms, conditions and restrictions pertaining to such Option.

| (jj) | “Subsidiary” shall mean any corporation, if the Corporation or one or more other Subsidiaries own not less than 50% of the total combined voting power of all classes of outstanding stock of such corporation. A corporation that attains the status of a Subsidiary on a date after the adoption of the Plan shall be considered a Subsidiary commencing as of such date.

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| (kk) | “Total and Permanent Disability” shall mean that the Optionee is unable to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted, or can be expected to last for a continuous period of not less than one year.

SECTION 3. | ADMINISTRATION.

| (a) | Committee Composition. The Plan shall be administered by the Board of Directors or a Committee appointed by the Board of Directors. The Committee shall consist of two or more members of the Board of Directors. In addition, to the extent required by the Board of Directors, the composition of the Committee shall satisfy (i) such requirements as the Securities and Exchange Commission may establish for administrators acting under plans intended to qualify for exemption under Rule 16b-3 (or its successor) under the Exchange Act; and (ii) such requirements as the Internal Revenue Service may establish for outside directors acting under plans intended to qualify for exemption under Section 162(m)(4)(C) of the Code.

| (b) | Committee for Non-Officer Grants. The Board of Directors may also appoint one or more separate committees of the Board of Directors, each composed of one or more members of the Board of Directors who need not satisfy the requirements of Section 3(a), who may administer the Plan with respect to Employees who are not considered officers or directors of the Corporation under Section 16 of the Exchange Act, may grant Awards under the Plan to such Employees and may determine all terms of such grants. Within the limitations of the preceding sentence, any reference in the Plan to the Committee shall include such committee or committees appointed pursuant to the preceding sentence. To the extent permitted by applicable laws, the Board of Directors may also authorize one or more officers of the Corporation to designate Employees, other than persons subject to Section 16 of the Exchange Act, to receive Awards and to determine the number of such Awards to be received by such Employees.

| (c) | Committee Procedures. The Board of Directors shall designate one of the members of the Committee as chairman. The Committee may hold meetings at such times and places as it shall determine. The acts of a majority of the Committee members present at meetings at which a quorum exists, or acts reduced to or approved in writing (including via email) by all Committee members, shall be valid acts of the Committee.

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| (d) | Committee Responsibilities. Subject to the provisions of the Plan, the Committee shall have full authority and discretion to take the following actions:

| (i) | To interpret the Plan and to apply its provisions;

| (ii) | To adopt, amend or rescind rules, procedures and forms relating to the Plan;

| (iii) | To adopt, amend or terminate sub-plans established for the purpose of satisfying applicable foreign laws, including qualifying for preferred tax treatment under applicable foreign tax laws;

| (iv) | To authorize any person to execute, on behalf of the Corporation, any instrument required to carry out the purposes of the Plan;

| (v) | To determine when Awards are to be granted under the Plan;

| (vi) | To select the Offerees and Optionees;

| (vii) | To determine the number of Shares to be made subject to each Award;

| (viii) | To prescribe the terms and conditions of each Award, including the Exercise Price, the Purchase Price, the performance criteria, the performance period, and the vesting or duration of the Award (including accelerating the vesting of Awards, either at the time of the Award or thereafter, without the consent of the Participant), to determine whether an Option is to be classified as an ISO or as a Nonstatutory Option, and to specify the provisions of the agreement relating to such Award;

| (ix) | To amend any outstanding Award agreement, subject to applicable legal restrictions and to the consent of the Participant if the Participant’s rights or obligations would be materially impaired;

| (x) | To prescribe the consideration for the grant of each Award or other right under the Plan and to determine the sufficiency of such consideration;

| (xi) | To determine the disposition of each Award or other right under the Plan in the event of a Participant’s divorce or dissolution of marriage;

| (xii) | To determine whether Awards under the Plan will be granted in replacement of other grants under an incentive or other compensation plan of an acquired business;

| (xiii) | To correct any defect, supply any omission, or reconcile any inconsistency in the Plan or any Award agreement;

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| (xiv) | To establish or verify the extent of satisfaction of any performance goals or other conditions applicable to the grant, issuance, exercisability, vesting and/or ability to retain any Award; and

| (xv) | To take any other actions deemed necessary or advisable for the administration of the Plan.

Subject to the requirements of applicable law, the Committee may designate persons other than members of the Committee to carry out its responsibilities and may prescribe such conditions and limitations as it may deem appropriate, except that the Committee may not delegate its authority with regard to the selection for participation of or the granting of Awards under the Plan to persons subject to Section 16 of the Exchange Act. All decisions, interpretations and other actions of the Committee shall be final and binding on all Participants, and all persons deriving their rights from a Participant. No member of the Committee shall be liable for any action that he or she has taken or has failed to take in good faith with respect to the Plan or any Award.

SECTION 4. | ELIGIBILITY.

| (a) | General Rule. Only Employees shall be eligible for the grant of ISOs. Only Employees, Consultants and Outside Directors shall be eligible for the grant of Restricted Shares, Restricted Stock Units, Performance Shares, Nonstatutory Options or SARs.

| (b) | Ten-Percent Stockholders. An Employee who owns more than 10% of the total combined voting power of all classes of outstanding stock of the Corporation, a Parent or Subsidiary shall not be eligible for the grant of an ISO unless such grant satisfies the requirements of Section 422(c)(5) of the Code.

| (c) | Attribution Rules. For purposes of Section 4(b) above, in determining stock ownership, an Employee shall be deemed to own the stock owned, directly or indirectly, by or for such Employee’s brothers, sisters, spouse, ancestors and lineal descendants. Stock owned, directly or indirectly, by or for a corporation, partnership, estate or trust shall be deemed to be owned proportionately by or for its stockholders, partners or beneficiaries.

| (d) | Outstanding Stock. For purposes of Section 4(b) above, “outstanding stock” shall include all stock actually issued and outstanding immediately after the grant but shall not include shares authorized for issuance under outstanding options held by the Employee or by any other person.

SECTION 5. | STOCK SUBJECT TO PLAN.

| (a) | Basic Limitation. Shares offered under the Plan shall be authorized but unissued Shares or treasury Shares. The aggregate number of Shares authorized for issuance as Awards under the Plan shall not exceed 44,453,475. The limitation of this Section 5(a) shall be subject to adjustment pursuant to Section 13. Any

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| Shares issued in connection with Options and SARs shall be counted against this limitation as one Share for every one Share so issued. Any Shares issued in connection with Awards other than Options and SARs shall be counted against this limitation as 2.0 Shares for every one Share so issued. The number of Shares that are subject to Awards outstanding at any time under the Plan shall not exceed the number of Shares which then remain available for issuance under the Plan. The Corporation, during the term of the Plan, shall at all times reserve and keep available sufficient Shares to satisfy the requirements of the Plan. Shares tendered or withheld in full or partial payment of the Exercise Price of an Award or to satisfy tax withholding obligations in connection with an Award, and Shares issued under an Award that are purchased by the Corporation on the open market, shall not be available for future issuance under the Plan.

| (b) | Award Limitation. Subject to the provisions of Section 13, no Participant may receive Awards under the Plan in any calendar year that relate to more than 800,000 Shares.

| (c) | Additional Shares. If an Award expires or becomes unexercisable without having been exercised in full, or, with respect to Restricted Shares, Restricted Stock Units or Performance Shares, is forfeited to or repurchased by the Corporation due to failure to vest, the unpurchased Shares (or for Awards other than Options or SARs the forfeited or repurchased Shares) which were subject thereto will become available for future grant or sale under the Plan (unless the Plan has terminated). With respect to SARs, when a stock settled SAR is exercised, all of the Shares subject to the SAR shall be counted against the number of Shares available for future grant or sale under the Plan, regardless of the number of Shares actually issued pursuant to such exercise. Shares that have actually been issued under the Plan under any Award will not be returned to the Plan and will not become available for future distribution under the Plan; provided, however, that if Shares issued pursuant to Awards of Restricted Shares, Restricted Stock Units or Performance Shares are repurchased by the Corporation or are forfeited to the Corporation, such Shares will become available for future grant under the Plan. To the extent an Award under the Plan is paid out in cash rather than Shares, such cash payment will not result in reducing the number of Shares available for issuance under the Plan.

SECTION 6. | RESTRICTED SHARES.

| (a) | Restricted Share Agreement. Each grant of Restricted Shares under the Plan shall be evidenced by a Restricted Share Agreement between the recipient and the Corporation. Such Restricted Shares shall be subject to all applicable terms of the Plan and may be subject to any other terms that are not inconsistent with the Plan. The provisions of the various Restricted Share Agreements entered into under the Plan need not be identical.

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| (b) | Payment for Awards. Restricted Shares may be sold or awarded under the Plan for such consideration as the Committee may determine, including cash, cash equivalents, full-recourse promissory notes, past services and future services.

| (c) | Vesting. Each Award of Restricted Shares shall vest over a minimum period of three years of the Participant’s Service, subject to Section 19(c). Vesting shall occur, in full or in installments, upon satisfaction of such Service requirement and such other conditions specified in the Restricted Share Agreement. A Restricted Share Agreement may provide for accelerated vesting in the event of the Participant’s death, Total and Permanent Disability or retirement or other events. The Committee may determine, at the time of granting Restricted Shares or thereafter, that all or part of such Restricted Shares shall become vested upon a Change in Control. Except as may be set forth in a Restricted Share Agreement, vesting of the Restricted Shares shall cease on the termination of the Participant’s Service.

| (d) | Voting and Dividend Rights. The holders of Restricted Shares awarded under the Plan shall have the same voting, dividend and other rights as the Corporation’s other stockholders. A Restricted Share Agreement, however, may require that the holders of Restricted Shares invest any cash dividends received in additional Restricted Shares. Such additional Restricted Shares shall be subject to the same conditions and restrictions as the Award with respect to which the dividends were paid.

| (e) | Restrictions on Transfer of Shares. Restricted Shares shall be subject to such rights of repurchase, rights of first refusal or other restrictions as the Committee may determine. Such restrictions shall be set forth in the applicable Restricted Share Agreement and shall apply in addition to any general restrictions that may apply to all holders of Shares.

SECTION 7. | TERMS AND CONDITIONS OF OPTIONS.

| (a) | Stock Option Agreement. Each grant of an Option under the Plan shall be evidenced by a Stock Option Agreement between the Optionee and the Corporation. Such Option shall be subject to all applicable terms and conditions of the Plan and may be subject to any other terms and conditions which are not inconsistent with the Plan and which the Committee deems appropriate for inclusion in a Stock Option Agreement. The Stock Option Agreement shall specify whether the Option is an ISO or an NSO. The provisions of the various Stock Option Agreements entered into under the Plan need not be identical. Options may be granted in consideration of a reduction in the Optionee’s other compensation.

| (b) | Number of Shares. Each Stock Option Agreement shall specify the number of Shares that are subject to the Option (subject to adjustment in accordance with Section 13).

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| (c) | Exercise Price. Each Stock Option Agreement shall specify the Exercise Price. The Exercise Price of an ISO shall not be less than 100% of the Fair Market Value of a Share on the date of grant, except as otherwise provided in Section 4(b), and the Exercise Price of an NSO shall not be less 100% of the Fair Market Value of a Share on the date of grant. Subject to the foregoing in this Section 7(c), the Exercise Price under any Option shall be determined by the Committee at its sole discretion. The Exercise Price shall be payable in one of the forms described in Section 8.

| (d) | Withholding Taxes. As a condition to the exercise of an Option, the Optionee shall make such arrangements as the Corporation may require for the satisfaction of any federal, state, local or foreign withholding tax obligations that may arise in connection with such exercise. The Optionee shall also make such arrangements as the Corporation may require for the satisfaction of any federal, state, local or foreign withholding tax obligations that may arise in connection with the disposition of Shares acquired by exercising an Option.

| (e) | Exercisability and Term. Each Stock Option Agreement shall specify the date when all or any installment of the Option is to become exercisable, subject to Section 12(c) in the case of automatic Option grants to Outside Directors and to Section 19(c) for all other Option grants. The Stock Option Agreement shall also specify the term of the Option; provided, however, that the term of an ISO shall in no event exceed 10 years from the date of grant (five years for Employees described in Section 4(b)). A Stock Option Agreement may provide for accelerated exercisability in the event of the Optionee’s death, Total and Permanent Disability or retirement or other events and may provide for expiration prior to the end of its term in the event of the termination of the Optionee’s Service. Options may be awarded in combination with SARs, and such an Award may provide that the Options will not be exercisable unless the related SARs are forfeited. Subject to the foregoing in this Section 7(e), the Committee at its sole discretion shall determine when all or any installment of an Option is to become exercisable and when an Option is to expire.

| (f) | Exercise of Options. Each Stock Option Agreement shall set forth the extent to which the Optionee shall have the right to exercise the Option following termination of the Optionee’s Service with the Corporation and its Subsidiaries, and the right to exercise the Option of any executors or administrators of the Optionee’s estate or any person who has acquired such Option(s) directly from the Optionee by bequest or inheritance. Such provisions shall be determined in the sole discretion of the Committee, need not be uniform among all Options issued pursuant to the Plan, and may reflect distinctions based on the reasons for termination of Service.

| (g) | Effect of Change in Control. The Committee may determine, at the time of granting an Option or thereafter, that such Option shall become exercisable as to all or part of the Shares subject to such Option upon a Change in Control.

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| (h) | No Rights as a Stockholder. An Optionee, or a permitted transferee of an Optionee, shall have no rights as a stockholder of the Corporation with respect to any Shares covered by the Option until the date of the issuance of the Shares underlying the Option upon a valid exercise thereof.

| (i) | Modification, Extension and Assumption of Options. Within the limitations of the Plan, the Committee may modify, extend or assume outstanding Options or may accept the cancellation of outstanding Options (whether granted by the Corporation or another issuer) in return for the grant of new Options for the same or a different number of Shares and at the same or a different Exercise Price; provided, however, that the Committee may not modify outstanding Options to lower the Exercise Price nor may the Committee assume or accept the cancellation of outstanding Options in return for the grant of new Options or SARs with a lower Exercise Price, unless such action has been approved by the Corporation’s stockholders. The foregoing notwithstanding, no modification of an Option shall, without the consent of the Optionee, materially impair such Optionee’s rights or increase his or her obligations under such Option.

| (j) | Restrictions on Transfer of Shares. Any Shares issued upon exercise of an Option shall be subject to such special forfeiture conditions, rights of repurchase, rights of first refusal and other transfer restrictions as the Committee may determine. Such restrictions shall be set forth in the applicable Stock Option Agreement and shall apply in addition to any general restrictions that may apply to all holders of Shares.

| (k) | Buyout Provisions. Except with respect to an Option whose Exercise Price exceeds the Fair Market Value of the Shares subject to the Option, the Committee may at any time (a) offer to buy out for a payment in cash or cash equivalents an Option previously granted or (b) authorize an Optionee to elect to cash out an Option previously granted, in either case at such time and based upon such terms and conditions as the Committee shall establish.

SECTION 8. | PAYMENT FOR SHARES.

| (a) | General Rule. The entire Exercise Price or Purchase Price of Shares issued under the Plan shall be payable in lawful money of the United States of America at the time when such Shares are purchased, except as provided in Section 8(b) through Section 8(g) below.

| (b) | Surrender of Stock. To the extent that a Stock Option Agreement so provides, payment may be made all or in part by surrendering, or attesting to the ownership of, Shares which have already been owned by the Optionee or his representative. Such Shares shall be valued at their Fair Market Value on the date when the new Shares are purchased under the Plan. The Optionee shall not surrender, or attest to the ownership of, Shares in payment of the Exercise Price if such action would cause the Corporation to recognize compensation expense (or additional compensation expense) with respect to the Option for financial reporting purposes.

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| (c) | Services Rendered. At the discretion of the Committee, Shares may be awarded under the Plan in consideration of services rendered to the Corporation or a Subsidiary prior to the award. If Shares are awarded without the payment of a Purchase Price in cash, the Committee shall make a determination (at the time of the award) of the value of the services rendered by the Offeree and the sufficiency of the consideration to meet the requirements of Section 6(b).

| (d) | Cashless Exercise. To the extent that a Stock Option Agreement so provides, payment may be made all or in part by delivery (on a form prescribed by the Committee) of an irrevocable direction to a securities broker to sell Shares and to deliver all or part of the sale proceeds to the Corporation in payment of the aggregate Exercise Price.

| (e) | Exercise/Pledge. To the extent that a Stock Option Agreement so provides, payment may be made all or in part by delivery (on a form prescribed by the Committee) of an irrevocable direction to a securities broker or lender to pledge Shares, as security for a loan, and to deliver all or part of the loan proceeds to the Corporation in payment of the aggregate Exercise Price.

| (f) | Promissory Note. To the extent that a Stock Option Agreement or Restricted Share Agreement so provides, payment may be made all or in part by delivering (on a form prescribed by the Corporation) a full-recourse promissory note.

| (g) | Other Forms of Payment. To the extent that a Stock Option Agreement or Restricted Share Agreement so provides, payment may be made in any other form that is consistent with applicable laws, regulations and rules.

| (h) | Limitations under Applicable Law. Notwithstanding anything herein or in a Stock Option Agreement or Restricted Share Agreement to the contrary, payment may not be made in any form that is unlawful, as determined by the Committee in its sole discretion.

SECTION 9. | STOCK APPRECIATION RIGHTS.

| (a) | SAR Agreement. Each grant of a SAR under the Plan shall be evidenced by a SAR Agreement between the Optionee and the Corporation. Such SAR shall be subject to all applicable terms of the Plan and may be subject to any other terms that are not inconsistent with the Plan. The provisions of the various SAR Agreements entered into under the Plan need not be identical. SARs may be granted in consideration of a reduction in the Optionee’s other compensation.

| (b) | Number of Shares. Each SAR Agreement shall specify the number of Shares to which the SAR pertains and shall provide for the adjustment of such number in accordance with Section 13.

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| (c) | Exercise Price. Each SAR Agreement shall specify the Exercise Price, which shall not be less than 100% of the Fair Market Value of a Share on the date of grant. A SAR Agreement may specify an Exercise Price that varies in accordance with a predetermined formula while the SAR is outstanding.

| (d) | Exercisability and Term. Each SAR Agreement shall specify the date when all or any installment of the SAR is to become exercisable, subject to Section 19(c). The SAR Agreement shall also specify the term of the SAR. A SAR Agreement may provide for accelerated exercisability in the event of the Optionee’s death, Total and Permanent Disability or retirement or other events. Except as may be set forth in a SAR Agreement, vesting of the SAR shall cease on the termination of the Participant’s Service. SARs may be awarded in combination with Options, and such an Award may provide that the SARs will not be exercisable unless the related Options are forfeited. A SAR may be included in an ISO only at the time of grant but may be included in an NSO at the time of grant or thereafter. A SAR granted under the Plan may provide that it will be exercisable only in the event of a Change in Control.

| (e) | Effect of Change in Control. The Committee may determine, at the time of granting a SAR or thereafter, that such SAR shall become fully exercisable as to all Shares subject to such SAR upon a Change in Control.

| (f) | Exercise of SARs. Upon exercise of a SAR, the Optionee (or any person having the right to exercise the SAR after his or her death) shall receive from the Corporation (a) Shares, (b) cash or (c) a combination of Shares and cash, as the Committee shall determine. The amount of cash and/or the Fair Market Value of Shares received upon exercise of SARs shall, in the aggregate, be equal to the amount by which the Fair Market Value (on the date of surrender) of the Shares subject to the SARs exceeds the Exercise Price.

| (g) | Modification or Assumption of SARs. Within the limitations of the Plan, the Committee may modify, extend or assume outstanding SARs or may accept the cancellation of outstanding SARs (whether granted by the Corporation or by another issuer) in return for the grant of new SARs for the same or a different number of Shares and at the same or a different exercise price; provided, however, that the Committee may not modify outstanding SARs to lower the Exercise Price nor may the Committee assume or accept the cancellation of outstanding SARs in return for the grant of new SARs or Options with a lower Exercise Price, unless such action has been approved by the Corporation’s stockholders. The foregoing notwithstanding, no modification of a SAR shall, without the consent of the holder, materially impair his or her rights or obligations under such SAR.

| (h) | Buyout Provisions. Except with respect to a SAR whose Exercise Price exceeds the Fair Market Value of the Shares subject to the SAR, the Committee may at any time (a) offer to buy out for a payment in cash or cash equivalents a SAR

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| previously granted, or (b) authorize an Optionee to elect to cash out a SAR previously granted, in either case at such time and based upon such terms and conditions as the Committee shall establish.

SECTION 10. | RESTRICTED STOCK UNITS.

| (a) | Restricted Stock Unit Agreement. Each grant of Restricted Stock Units under the Plan shall be evidenced by a Restricted Stock Unit Agreement between the recipient and the Corporation. Such Restricted Stock Units shall be subject to all applicable terms of the Plan and may be subject to any other terms that are not inconsistent with the Plan. The provisions of the various Restricted Stock Unit Agreements entered into under the Plan need not be identical. Restricted Stock Units may be granted in consideration of a reduction in the recipient’s other compensation.

| (b) | Payment for Awards. To the extent that an Award is granted in the form of Restricted Stock Units, no cash consideration shall be required of the Award recipients.

| (c) | Vesting Conditions. Each Award of Restricted Stock Units shall vest over a minimum period of three years of the Participant’s Service, subject to Section 19(c). Vesting shall occur, in full or in installments, upon satisfaction of such Service requirement and such other conditions specified in the Restricted Stock Unit Agreement. A Restricted Stock Unit Agreement may provide for accelerated vesting in the event of the Participant’s death, Total and Permanent Disability or retirement or other events. The Committee may determine, at the time of granting Restricted Stock Units or thereafter, that all or part of such Restricted Stock Units shall become vested in the event that a Change in Control occurs with respect to the Corporation. Except as may be set forth in a Restricted Stock Unit Agreement, vesting of the Restricted Stock Units shall cease on the termination of the Participant’s Service.

| (d) | Voting and Dividend Rights. The holders of Restricted Stock Units shall have no voting rights. Prior to settlement or forfeiture, any Restricted Stock Unit awarded under the Plan may, at the Committee’s discretion, carry with it a right to dividend equivalents. Such right entitles the holder to be credited with an amount equal to all cash dividends paid on one Share while the Restricted Stock Unit is outstanding. Dividend equivalents may be converted into additional Restricted Stock Units. Settlement of dividend equivalents may be made in the form of cash, in the form of Shares, or in a combination of both. Prior to distribution, any dividend equivalents which are not paid shall be subject to the same conditions and restrictions (including without limitation, any forfeiture conditions) as the Restricted Stock Units to which they attach.

| (e) | Form and Time of Settlement of Restricted Stock Units. Settlement of vested Restricted Stock Units may be made in the form of (a) cash, (b) Shares or (c) any

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| combination of both, as determined by the Committee. The actual number of Restricted Stock Units eligible for settlement may be larger or smaller than the number included in the original Award, based on predetermined performance factors. Methods of converting Restricted Stock Units into cash may include (without limitation) a method based on the average Fair Market Value of Shares over a series of trading days. A Restricted Stock Unit Agreement may provide that vested Restricted Stock Units may be settled in a lump sum or in installments. A Restricted Stock Unit Agreement may provide that the distribution may occur or commence when all vesting conditions applicable to the Restricted Stock Units have been satisfied or have lapsed, or it may be deferred to any later date. The amount of a deferred distribution may be increased by an interest factor or by dividend equivalents. Until an Award of Restricted Stock Units is settled, the number of such Restricted Stock Units shall be subject to adjustment pursuant to Section 13.

| (f) | Death of Recipient. Any Restricted Stock Units that become payable after the recipient’s death shall be distributed to the recipient’s beneficiary or beneficiaries. Each recipient of Restricted Stock Units under the Plan shall designate one or more beneficiaries for this purpose by filing the prescribed form with the Corporation. A beneficiary designation may be changed by filing the prescribed form with the Corporation at any time before the Award recipient’s death. If no beneficiary was designated or if no designated beneficiary survives the Award recipient, then any Restricted Stock Units that become payable after the recipient’s death shall be distributed to the recipient’s estate.

| (g) | Creditors’ Rights. A holder of Restricted Stock Units shall have no rights other than those of a general creditor of the Corporation. Restricted Stock Units represent an unfunded and unsecured obligation of the Corporation, subject to the terms and conditions of the applicable Restricted Stock Unit Agreement.

SECTION 11. | PERFORMANCE SHARES.

| (a) | Performance Shares and Performance Share Agreement. Each grant of Performance Shares under the Plan shall be evidenced by a Performance Share Agreement between the recipient and the Corporation. Such Performance Shares shall be subject to all applicable terms of the Plan and may be subject to any other terms that are not inconsistent with the Plan. The provisions of the various Performance Share Agreements entered into under the Plan need not be identical. Performance Shares may be granted in consideration of a reduction in the recipient’s other compensation.

| (b) | Payment for Awards. To the extent that an Award is granted in the form of Performance Shares, no cash consideration shall be required of the Award recipients.

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| (c) | Terms of Performance Share Awards. The Committee shall determine the terms of Performance Share Awards, which may include subjecting such Awards to the attainment of “Qualifying Performance Criteria” as described in Section 19(b) of the Plan. Each Performance Share Agreement shall set forth the number of Shares subject to such Performance Share Award, the Qualifying Performance Criteria and the performance period. Subject to Section 19(c), the Participant shall be required to perform Service for the entire performance period (or if less, one year) in order to be eligible to receive payment under the Performance Share Award. Except as otherwise provided in the Performance Share Agreement, the Performance Share Award shall terminate upon the termination of the Participant’s Service. Prior to settlement, the Committee shall determine the extent to which Performance Shares have been earned. Performance periods may overlap and the holders may participate simultaneously with respect to Performance Shares Awards that are subject to different performance periods and different Qualifying Performance Criteria. The number of Shares may be fixed or may vary in accordance with such Qualifying Performance Criteria as may be determined by the Committee. A Performance Share Agreement may provide for accelerated vesting in the event of the Participant’s death, Total and Permanent Disability or retirement or other events. The Committee may determine, at the time of granting Performance Share Awards or thereafter, that all or part of the Performance Shares shall become vested upon a Change in Control.

| (d) | Voting and Dividend Rights. The holders of Performance Shares shall have no voting rights with respect to such Performance Shares. Prior to settlement or forfeiture, any Performance Share awarded under the Plan may, at the Committee’s discretion, carry with it a right to dividend equivalents. Such right entitles the holder to be credited with an amount equal to all cash dividends paid on one Share while the Performance Share is outstanding. Dividend equivalents may be converted into additional Performance Shares. Settlement of dividend equivalents may be made in the form of cash, in the form of Shares, or in a combination of both. Prior to distribution, any dividend equivalents which are not paid shall be subject to the same conditions and restrictions (including without limitation, any forfeiture conditions) as the Performance Shares to which they attach.

| (e) | Form and Time of Settlement of Performance Shares. Settlement of Performance Shares may be made in the form of (a) cash, (b) Shares or (c) any combination of both, as determined by the Committee and set forth in the Performance Share Agreements. The actual number of Performance Shares eligible for settlement may be larger or smaller than the number included in the original Award, based on the Qualifying Performance Criteria. Methods of converting Performance Shares into cash may include (without limitation) a method based on the average Fair Market Value of Shares over a series of trading days. A Performance Share Agreement may provide that Performance Shares may be settled in a lump sum or in installments. A Performance Share Agreement may provide that the distribution may occur or commence when all vesting conditions applicable to the

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| Performance Shares have been satisfied or have lapsed, or it may be deferred to any later date. The amount of a deferred distribution may be increased by an interest factor or by dividend equivalents. Until an Award of Performance Shares is settled, the number of such Performance Shares shall be subject to adjustment pursuant to Section 13.

| (f) | Death of Recipient. Any Performance Share Award that becomes payable after the recipient’s death shall be distributed to the recipient’s beneficiary or beneficiaries. Each recipient of a Performance Share Award under the Plan shall designate one or more beneficiaries for this purpose by filing the prescribed form with the Corporation. A beneficiary designation may be changed by filing the prescribed form with the Corporation at any time before the Award recipient’s death. If no beneficiary was designated or if no designated beneficiary survives the Award recipient, then any Performance Share Award that becomes payable after the recipient’s death shall be distributed to the recipient’s estate.

| (g) | Creditors’ Rights. A holder of Performance Shares shall have no rights other than those of a general creditor of the Corporation. Performance Shares represent an unfunded and unsecured obligation of the Corporation, subject to the terms and conditions of the applicable Performance Share Agreement.

SECTION 12. | AUTOMATIC GRANTS TO OUTSIDE DIRECTORS

| (a) | Annual Grants. On the first business day following the conclusion of each regular annual meeting of the Corporation’s stockholders beginning with the 2019 annual meeting, each Outside Director who will continue serving as a member of the Board of Directors thereafter shall receive Awards having an aggregate grant date fair value of $500,000, of which 75% shall be Nonstatutory Options and 25% shall be Restricted Stock Units. The number of Shares subject to such Nonstatutory Options shall be determined by dividing 75% of $500,000 (or $375,000) by the Black-Scholes value of one such Option, based on the average closing sale price for the Stock on The Nasdaq Global Select Market (or such other United States stock exchange or over-the-counter market on which the Stock is then traded) over the 30 consecutive trading days concluding with the last trading day prior to the grant date, rounded down to the nearest whole Share. The number of Shares subject to such Restricted Stock Units shall be determined by dividing 25% of $500,000 (or $125,000) by such 30 trading day average price, rounded down to the nearest whole Share. Each Outside Director who is not initially elected at a regular annual meeting of the Corporation’s stockholders in 2019 or a subsequent year shall receive Awards within 10 business days of his or her election having an aggregate grant date fair value of a pro rata portion of $500,000, such pro rata portion to be determined based on the number of full calendar months remaining from the date of election until the next regular annual meeting of the Corporation’s stockholders divided by 12. Such Outside Director’s Awards shall consist of 75% Nonstatutory Options and 25% Restricted Stock Units determined in a manner similar to that used for the annual Awards to

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| Outside Directors following the conclusion of the regular annual meeting of the Corporation’s stockholders, except that the values of the Awards to such Outside Director shall be determined as of the grant date of such Awards.

| (b) | Vesting Conditions. Except as set forth in the next succeeding sentence and in the last sentence of this Subsection (b), each Award granted under Subsection (a) of this Section 12 shall become vested and (in the case of Options) exercisable in full on the first anniversary of the date of grant; provided, however, that each such Award shall become vested and exercisable in full immediately prior to the next regular annual meeting of the Corporation’s stockholders following such date of grant in the event such meeting occurs prior to such first anniversary date. Except as set forth in the last sentence of this Subsection (b), each Award granted under Subsection (a) to Outside Directors who were not initially elected at a regular annual meeting of the Corporation’s stockholders shall become vested and exercisable in full immediately prior to the next regular annual meeting of the Corporation’s stockholders following the date of grant. Notwithstanding the foregoing, each Award granted under Subsection (a) above that is outstanding shall become vested and exercisable in full in the event that a Change in Control occurs with respect to the Corporation.

| (c) | Award Agreement. All grants to Outside Directors under this Section 12 shall be evidenced by a Stock Option Agreement or Restricted Stock Unit Agreement, as applicable, between the Outside Director and the Corporation. Such Awards shall be subject to all applicable terms and conditions of the Plan and may be subject to other terms and conditions that are not inconsistent with the Plan and that the Board of Directors deems appropriate for inclusion in a Stock Option Agreement or Restricted Stock Unit Agreement, as applicable.

| (d) | Additional Grants. Notwithstanding the foregoing provisions of this Section 12, the Board of Directors may from time to time increase the amount of the annual grant of Awards under Section 12(a) to any Outside Director to the extent the Board of Directors determines necessary to induce an Outside Director to become or remain an Outside Director or to reflect an increase in the duties or responsibilities of the Outside Director, subject to all terms and conditions of the Plan otherwise applicable to grants of Awards. Each such Award may become vested and exercisable on the same schedule as set forth in Section 12(b) or on a different schedule, as the Board of Directors in each case shall determine.

SECTION 13. | ADJUSTMENT OF SHARES; REORGANIZATIONS.

| (a) | Adjustments. In the event of a subdivision of the outstanding Stock, a declaration of a dividend payable in Shares, a declaration of a dividend payable in a form other than Shares in an amount that has a material effect on the Fair Market Value of Shares, a combination or consolidation of the outstanding Stock (by reclassification or otherwise) into a lesser number of Shares, a recapitalization, a

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| spin-off or a similar occurrence, the Committee shall make appropriate and equitable adjustments in:

| (i) | The numerical limitations set forth in Sections 5(a) and (b);

| (ii) | The number of Shares covered by all outstanding Awards; and

| (iii) | The Exercise Price under each outstanding Option and SAR.

| (b) | Dissolution or Liquidation. To the extent not previously exercised or settled, all outstanding Awards shall terminate immediately prior to the dissolution or liquidation of the Corporation.

| (c) | Reorganizations. In the event the Corporation is party to a merger or other reorganization, subject to any vesting acceleration provisions in an Award agreement, outstanding Awards shall be treated in the manner provided in the agreement of merger or reorganization (including as the same may be amended). Such agreement shall not be required to treat all Awards or individual types of Awards similarly in the merger or reorganization; provided, however, that such agreement shall provide for one of the following with respect to all outstanding Awards (as applicable):

| (i) | The continuation of the outstanding Award by the Corporation, if the Corporation is a surviving corporation;

| (ii) | The assumption of the outstanding Award by the surviving corporation or its parent or subsidiary;

| (iii) | The substitution by the surviving corporation or its parent or subsidiary of its own award for the outstanding Award;

| (iv) | Full exercisability or vesting and accelerated expiration of the outstanding Award, followed by the cancellation of such Award;

| (v) | The cancellation of an outstanding Option or SAR and a payment to the Optionee equal to the excess of (i) the Fair Market Value of the Shares subject to such Option or SAR (whether or not such Option or SARs is then exercisable or such Shares are then vested) as of the closing date of such merger or reorganization over (ii) its aggregate Exercise Price. Such payment may be made in the form of cash, cash equivalents, or securities of the surviving corporation or its parent with a Fair Market Value equal to the required amount. Such payment may be made in installments and may be deferred until the date or dates when such Option or SAR would have become exercisable or such Shares would have vested. Such payment may be subject to vesting based on the Optionee’s continuing Service, provided that the vesting schedule shall not be less favorable to the Optionee than the schedule under which such Option or SAR would

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| have become exercisable or such Shares would have vested (including any vesting acceleration provisions). If the Exercise Price of the Shares subject to any Option or SAR exceeds the Fair Market Value of the Shares subject thereto, then such Option or SAR may be cancelled without making a payment to the Optionee with respect thereto. For purposes of this Subsection (v), the Fair Market Value of any security shall be determined without regard to any vesting conditions that may apply to such security;

| (vi) | The cancellation of an outstanding Restricted Stock Unit and a payment to the Participant equal to the Fair Market Value of the Shares subject to such Restricted Stock Unit (whether or not such Restricted Stock Unit is then vested) as of the closing date of such merger or other reorganization. Such payment may be made in the form of cash, cash equivalents, or securities of the surviving corporation or its parent with a Fair Market Value equal to the required amount. Such payment may be made in installments and may be deferred until the date or dates when such Restricted Stock Unit would have vested. Such payment may be subject to vesting based on the Participant’s continuing Service, provided that the vesting schedule shall not be less favorable to the Participant than the schedule under which such Restricted Stock Unit would have vested (including any vesting acceleration provisions). For purposes of this Subsection (vi), the Fair Market Value of any security shall be determined without regard to any vesting conditions that may apply to such security; or

| (vii) | The cancellation of an outstanding Performance Share Award and a payment to the Participant equal to the Fair Market Value of the target Shares subject to such Performance Share Award (whether or not such Performance Share Award is then vested) as of the closing date of such merger or reorganization. Such payment may be made in the form of cash, cash equivalents, or securities of the surviving corporation or its parent with a Fair Market Value equal to the required amount. Such payment may be made in installments and may be deferred until the date or dates when such Performance Share Award would have settled. Such payment may be subject to the Participant’s continuing Service and the achievement of performance criteria that are based on the performance criteria set forth in the Performance Share Award, with such changes that may necessary to give effect to the merger or other reorganization, provided that the performance period shall not be less favorable to the Participant than the performance period under such Performance Share Award (including any vesting acceleration provisions). For purposes of this Subsection (vii), the Fair Market Value of any security shall be determined without regard to any vesting conditions that may apply to such security.

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| (d) | Reservation of Rights. Except as provided in Section 13, a Participant shall have no rights by reason of the occurrence of (or relating to) any merger or other reorganization, any transaction described in Section 13(a), or any transaction that results in an increase or decrease in the number of shares of stock of any class of the Corporation. Any issue by the Corporation of shares of stock of any class, or securities convertible into shares of stock of any class, shall not affect, and no adjustment by reason thereof shall be made with respect to, Awards. The grant of an Award pursuant to the Plan shall not affect in any way the right or power of the Corporation to effect any merger or other reorganization, any transaction described in Section 13(a), any dissolution or liquidation of the Corporation or any transaction that results in an increase or decrease in the number of shares of stock of any class of the Corporation.

SECTION 14. | DEFERRAL OF AWARDS.

| (a) | Committee Powers. The Committee in its sole discretion may permit or require a Participant to:

| (i) | Have cash that otherwise would be paid to such Participant as a result of the exercise of a SAR or the settlement of Restricted Stock Units or Performance Shares credited to a deferred compensation account established for such Participant by the Committee as an entry on the Corporation’s books;

| (ii) | Have Shares that otherwise would be delivered to such Participant as a result of the exercise of an Option or SAR converted into an equal number of Restricted Stock Units; or

| (iii) | Have Shares that otherwise would be delivered to such Participant as a result of the exercise of an Option or SAR or the settlement of Restricted Stock Units or Performance Shares converted into amounts credited to a deferred compensation account established for such Participant by the Committee as an entry on the Corporation’s books. Such amounts shall be determined by reference to the Fair Market Value of such Shares as of the date when they otherwise would have been delivered to such Participant.

| (b) | General Rules. A deferred compensation account established under this Section 14 may be credited with interest or other forms of investment return, as determined by the Committee. A Participant for whom such an account is established shall have no rights other than those of a general creditor of the Corporation. Such an account shall represent an unfunded and unsecured obligation of the Corporation and shall be subject to the terms and conditions of the applicable agreement between such Participant and the Corporation. If the deferral or conversion of Awards is permitted or required, the Committee in its sole discretion may establish rules, procedures and forms pertaining to such Awards, including (without limitation) the settlement of deferred compensation accounts established under this Section 14.

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| (c) | Code Section 409A. Notwithstanding the foregoing, any deferrals of Award payments in respect of an Award held by a Participant who is subject to United States federal income tax shall be subject to the applicable requirements of Section 409A of the Code and the Treasury Regulations promulgated thereunder. To the extent that the Committee determines that any Award granted under the Plan is subject to Section 409A of the Code, the Award agreement evidencing such Award shall incorporate the terms and conditions required by Section 409A of the Code. In the event that following the grant of an Award the Committee determines that such Award may be subject to Section 409A of the Code, the Committee may adopt such amendments to the applicable Award agreement or adopt other policies and procedures (including amendments, policies and procedures with retroactive effect), or take any other actions, that the Committee determines are necessary or appropriate to (a) exempt the Award from Section 409A of the Code and/or preserve the intended tax treatment of the benefits provided with respect to the Award, or (b) comply with the requirements of Section 409A of the Code and the Treasury Regulations promulgated thereunder and thereby avoid the application of any penalty taxes under such Section.

SECTION 15. | PAYMENT OF DIRECTOR’S FEES IN SECURITIES

| (a) | Effective Date. No provision of this Section 15 shall be effective unless and until the Board has determined to implement such provision.

| (b) | Elections to Receive NSOs, Restricted Shares or Restricted Stock Units. An Outside Director may elect to receive his or her annual retainer payment and/or meeting fees from the Corporation in the form of cash, NSOs, Restricted Shares or Restricted Stock Units, or a combination thereof, as determined by the Board. Such NSOs, Restricted Shares or Restricted Stock Units shall be issued under the Plan. An election under this Section 15 shall be filed with the Corporation on the prescribed form. For the avoidance of doubt, any Awards issued to an Outside Director pursuant to this Section 15 shall not be counted towards the limit on annual Awards to the Outside Director prescribed by Section 12(a).

| (c) | Number and Terms of NSOs, Restricted Shares or Restricted Stock Units. The number of NSOs, Restricted Shares or Restricted Stock Units to be granted to Outside Directors in lieu of annual retainers and meeting fees that would otherwise be paid in cash shall be calculated in a manner determined by the Board. The term of such NSOs, Restricted Shares or Restricted Stock Units shall also be determined by the Board.

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SECTION 16. | AWARDS UNDER OTHER PLANS.

The Corporation may grant awards under other plans or programs. Such awards may be settled in the form of Shares issued under this Plan. Such Shares shall be treated for all purposes under the Plan like Shares issued in settlement of Restricted Stock Units and shall, when issued, reduce the number of Shares available under Section 5.

SECTION 17. | LEGAL AND REGULATORY REQUIREMENTS.

Shares shall not be issued under the Plan unless the issuance and delivery of such Shares complies with (or is exempt from) all applicable requirements of law, including (without limitation) the Securities Act of 1933, as amended, the rules and regulations promulgated thereunder, state securities laws and regulations and the regulations of any stock exchange on which the Corporation’s securities may then be listed, and the Corporation has obtained the approval or favorable ruling from any governmental agency which the Corporation determines is necessary or advisable. The Corporation shall not be liable to a Participant or other persons as to: (a) the non-issuance or sale of Shares as to which the Corporation has been unable to obtain from any regulatory body having jurisdiction the authority deemed by the Corporation’s counsel to be necessary to the lawful issuance and sale of any Shares under the Plan; and (b) any tax consequences expected, but not realized, by any Participant or other person due to the receipt, exercise or settlement of any Award granted under the Plan.

SECTION 18. | WITHHOLDING TAXES.

| (a) | General. To the extent required by applicable federal, state, local or foreign law, a Participant or his or her successor shall make arrangements satisfactory to the Corporation for the satisfaction of any withholding tax obligations that arise in connection with the Plan. The Corporation shall not be required to issue any Shares or make any cash payment under the Plan until such obligations are satisfied.

| (b) | Share Withholding. The Corporation may permit a Participant to satisfy all or part of his or her withholding or income tax obligations by having the Corporation withhold all or a portion of any Shares that otherwise would be issued to him or her or by surrendering all or a portion of any Shares that he or she previously acquired. Such Shares shall be valued at their Fair Market Value on the date when taxes otherwise would be withheld in cash. In no event may a Participant have Shares withheld that would otherwise be issued to him or her in excess of the number necessary to satisfy the legally required minimum tax withholding.

SECTION 19. | OTHER PROVISIONS APPLICABLE TO AWARDS.

| (a) | Transferability. Unless the agreement evidencing an Award (or an amendment thereto authorized by the Committee) expressly provides otherwise, no Award granted under this Plan, nor any interest in such Award, may be assigned, conveyed, gifted, pledged, hypothecated or otherwise transferred in any manner (prior to the vesting and lapse of any and all restrictions applicable to Shares issued under such Award), other than by will, by designation of a beneficiary

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| (which shall be a family member or family trust) delivered to the Company, or by the laws of descent and distribution; provided, however, that an ISO may be transferred or assigned only to the extent consistent with Section 422 of the Code. Notwithstanding the foregoing, in no event may a Participant sell or otherwise transfer for value any Award granted under the Plan or any interest in such an Award, other than Shares issued to the Participant that are no longer subject to vesting or other restrictions under the terms of the applicable Award. Any purported sale, assignment, conveyance, gift, pledge, hypothecation or transfer in violation of this Section 19(a) shall be void and unenforceable against the Corporation.

| (b) | Qualifying Performance Criteria. The number of Shares or other benefits granted, issued, retainable and/or vested under an Award may be made subject to the attainment of performance goals for a specified period of time relating to one or more of the following performance criteria, either individually, alternatively or in any combination, applied to either the Corporation as a whole or to a business unit or Subsidiary, either individually, alternatively or in any combination, and measured either annually or cumulatively over a period of years, on an absolute basis or relative to a pre-established target, to previous years’ or quarter’s results or to the performance of one or more comparable companies or a designated comparison group or index, in each case as specified by the Committee in the Award: (a) cash flow (including operating cash flow), (b) earnings per share, (c) (i) earnings before interest, (ii) earnings before interest and taxes, (iii) earnings before interest, taxes and depreciation, (iv) earnings before interest, taxes, depreciation and amortization, or (iv) earnings before any combination of such expenses or deductions, (d) return on equity, (e) total stockholder return, (f) share price performance, (g) return on capital, (h) return on assets or net assets, (i) revenue, (j) income or net income, (k) operating income or net operating income, (l) operating profit or net operating profit, (m) operating margin or profit margin (including as a percentage of revenue), (n) return on operating revenue, (o) return on invested capital, (p) market segment shares, (q) economic profit, (r) achievement of target levels of discovery and/or development of products, including but not limited to regulatory achievements, (s) achievement of research and development objectives, or (t) formation of joint ventures, strategic relationships or other commercial, research or development collaborations (“Qualifying Performance Criteria”). The Committee may appropriately adjust any evaluation of performance under a Qualifying Performance Criteria to exclude any of the following events that occur during a performance period: (i) asset write-downs, (ii) litigation or claim judgments or settlements, (iii) the effect of changes in tax law, accounting principles or other such laws or provisions affecting reported results, (iv) accruals for reorganization and restructuring programs and (v) any extraordinary, nonrecurring items to be disclosed in the Corporation’s financial statements (including footnotes) for the applicable year and/or in management’s discussion and analysis of the financial condition and results of operations appearing in the Corporation’s annual report to stockholders for the applicable year. If applicable, the Committee shall determine the

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| Qualifying Performance Criteria and any permitted exclusions pursuant to the preceding sentence not later than the 90th day of the performance period, and shall determine and certify, for each Participant (or for all Participants), the extent to which the Qualifying Performance Criteria have been met. The Committee may not in any event increase the amount of compensation payable under the Plan upon the attainment of a Qualifying Performance Criteria to a Participant who is a “covered employee” within the meaning of Section 162(m) of the Code.

| (c) | Vesting Restrictions on Awards. Except with respect to a maximum of five percent (5%) of the total number of Shares authorized under the Plan or, in the case of automatic grants to Outside Directors, as otherwise permitted under Section 12(b), no Award may vest sooner than twelve (12) months from the date of grant.

SECTION 20. | NO EMPLOYMENT RIGHTS.

No provision of the Plan, nor any Award granted under the Plan, shall be construed to give any person any right to become, to be treated as, or to remain an Employee. The Corporation and its Subsidiaries reserve the right to terminate any person’s Service at any time and for any reason, with or without notice.

SECTION 21. | APPLICABLE LAW.

The Plan shall be construed and enforced in accordance with the law of the State of Delaware, without reference to its principles of conflicts of law.

SECTION 22. | DURATION AND AMENDMENTS.

| (a) | Term of the Plan. The Plan, as set forth herein, shall terminate automatically on June 30, 2021 and may be terminated on any earlier date pursuant to Subsection (b) below.

| (b) | Right to Amend or Terminate the Plan. The Board of Directors may amend or terminate the Plan at any time and from time to time. Rights and obligations under any Award granted before amendment of the Plan shall not be materially impaired by such amendment, except with consent of the Participant. An amendment of the Plan shall be subject to the approval of the Corporation’s stockholders only to the extent required by applicable laws, regulations or rules.

| (c) | Effect of Termination. No Awards shall be granted under the Plan after the termination thereof. The termination of the Plan shall not affect Awards previously granted under the Plan.

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|  |  |  | Your vote matters - here’s how to vote!
|  |  |  | You may vote online or by phone instead of mailing this card.
|  |  |  |  |  | Votes submitted electronically must be received by 11:59pm, (EDT), on April 25, 2019
|  |  |  |  |  | Online
|  |  |  |  |  | Go to www.envisionreports.com/INCY or scan the QR code – login details are located in the shaded bar below.
|  |  |  |  |  | Phone Call toll free 1-800-652-VOTE (8683) within the USA, US territories and Canada
Using a black ink pen, mark your votes with an X as shown in this example. Please do not write outside the designated areas. |  |  |  |  |  | Save paper, time and money! Sign up for electronic delivery at www.envisionreports.com/INCY

IF VOTING BY MAIL, SIGN, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE.

A |  | Proposals – The Board of Directors recommend a vote FOR all the nominees listed and FOR Proposals 2-4 and AGAINST Proposal 5.

1. Election of Directors:

|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | +
|  | For |  | Against |  | Abstain |  |  |  | For |  | Against |  | Abstain |  |  |  | For |  | Against |  | Abstain |  |
01 - Julian C. Baker |  | ☐ |  | ☐ |  | ☐ |  | 02 - Jean-Jacques Bienaimé |  | ☐ |  | ☐ |  | ☐ |  | 03 - Paul A. Brooke |  | ☐ |  | ☐ |  | ☐ |  |
04 - Paul J. Clancy |  | ☐ |  | ☐ |  | ☐ |  | 05 - Wendy L. Dixon |  | ☐ |  | ☐ |  | ☐ |  | 06 - Jacqualyn A. Fouse |  | ☐ |  | ☐ |  | ☐ |  |
07 - Paul A. Friedman |  | ☐ |  | ☐ |  | ☐ |  | 08 - Hervé Hoppenot |  | ☐ |  | ☐ |  | ☐ |  |  |  |  |  |  |  |  |  |

|  | For |  | Against |  | Abstain |  |  |  | For |  | Against |  | Abstain
2. To approve, on a non-binding, advisory basis, the compensation of the Company’s named executive officers |  | ☐ |  | ☐ |  | ☐ |  | 3. To approve amendments to the Company’s Amended and Restated 2010 Stock Incentive Plan |  | ☐ |  | ☐ |  | ☐
4. To ratify the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for 2019. |  | ☐ |  | ☐ |  | ☐ |  | 5. To vote on a stockholder proposal, if properly presented, described in more detail in the proxy statement. |  | ☐ |  | ☐ |  | ☐
6. In their discretion. upon such other business as may properly come before the meeting or any adjournment thereof. |  |  |  |  |  |  |  |  |  |  |  |  |  |

B |  | Authorized Signatures – This section must be completed for your vote to count. Please date and sign below.

Please sign exactly as name(s) appears hereon. Joint owners should each sign. When signing as attorney, executor, administrator, corporate officer, trustee, guardian, or custodian, please give full title.

Date (mm/dd/yyyy) – Please print date below. |  |  |  | Signature 1 – Please keep signature within the box. |  |  |  | Signature 2 – Please keep signature within the box.
/ / |  |  |  |  |  |  |  |

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Important notice regarding the Internet availability of proxy materials for the Annual Meeting of Stockholders.

The Proxy Statement and the Annual Report on Form 10-K for the year ended December 31, 2018 are available at http://www.envisionreports.com/incy

|  |  |  | Small steps make an impact. Help the environment by consenting to receive electronic delivery, sign up at www.envisionreports.com/INCY |  |  |  |

IF VOTING BY MAIL, SIGN, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE.

PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

For Annual Meeting – April 26, 2019

HERVÉ HOPPENOT, CHRISTIANA STAMOULIS and MARIA E. PASQUALE, or any of them, each with the power of substitution, are hereby authorized to represent as proxies and vote with respect to the proposals set forth below and in the discretion of such proxies on all other matters that may be properly presented for action all shares of stock of Incyte Corporation (the “Company”) the undersigned is entitled to vote at the Annual Meeting of Stockholders of the Company to be held at the Company’s offices at 1815 Augustine Cut-Off, Wilmington, Delaware 19803, on Friday, April 26, 2019 at 1:00 p.m., Eastern Daylight Time, or at any postponement or adjournment thereof, and instructs said proxies to vote as follows:

Shares represented by this proxy will be voted as directed by the stockholder. If no such directions are indicated, the proxies will have authority to vote FOR each director nominee, FOR items 2, 3 and 4, and AGAINST item 5 and in accordance with the discretion of the proxies on any other matters as may properly come before the Annual Meeting.

(continued and to be signed on reverse side)

C |  | Non-Voting Items

Change of Address – Please print new address below. |  |  |  | Comments – Please print your comments below.